IMP

Process View

Homo sapiens

17 genes annotated in human

negative regulation of protein kinase b signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein kinase b signaling"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of protein kinase b signaling" (in gray)

Name	Description	Probability	Func Analog Organism
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.717
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.704
PTEN	phosphatase and tensin homolog	0.654
MPDZ	multiple PDZ domain protein	0.481
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.297
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.285
GUCY2C	guanylate cyclase 2C (heat stable enterotoxin receptor)	0.223
EGFR	epidermal growth factor receptor	0.221
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.216
TBC1D10A	TBC1 domain family, member 10A	0.200
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.148	Human
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.123
ADRB1	adrenergic, beta-1-, receptor	0.123
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.115
ADRB2	adrenergic, beta-2-, receptor, surface	0.115
EZR	ezrin	0.109
GHR	growth hormone receptor	0.099
GRB10	growth factor receptor-bound protein 10	0.090
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.088
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.086	Human
CAV1	caveolin 1, caveolae protein, 22kDa	0.085
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.079
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.064
PSEN2	presenilin 2 (Alzheimer disease 4)	0.062
BAI1	brain-specific angiogenesis inhibitor 1	0.061
DMD	dystrophin	0.054
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.051
GAB1	GRB2-associated binding protein 1	0.051
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.051
ADAM17	ADAM metallopeptidase domain 17	0.049
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.049
PXN	paxillin	0.044
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.043
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.040
FOXD3	forkhead box D3	0.040
FYN	FYN oncogene related to SRC, FGR, YES	0.040
TSC1	tuberous sclerosis 1	0.039
ZNF746	zinc finger protein 746	0.039
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.037
UTRN	utrophin	0.037
BCR	breakpoint cluster region	0.036
EFNA1	ephrin-A1	0.034
SOX2	SRY (sex determining region Y)-box 2	0.034
BMI1	BMI1 polycomb ring finger oncogene	0.034
SCRIB	scribbled homolog (Drosophila)	0.033
LAT	linker for activation of T cells	0.032
ADORA2A	adenosine A2a receptor	0.032
GRB7	growth factor receptor-bound protein 7	0.030
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.030
EFNA5	ephrin-A5	0.028
CTNND1	catenin (cadherin-associated protein), delta 1	0.026
RAB6A	RAB6A, member RAS oncogene family	0.026
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.025
KLF6	Kruppel-like factor 6	0.025
WASL	Wiskott-Aldrich syndrome-like	0.023
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.021
GOPC	golgi-associated PDZ and coiled-coil motif containing	0.020
YAP1	Yes-associated protein 1	0.019
DAPK1	death-associated protein kinase 1	0.018
USP46	ubiquitin specific peptidase 46	0.018
CLTC	clathrin, heavy chain (Hc)	0.017
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.017
PDZK1	PDZ domain containing 1	0.016	Human
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.016
DSCAML1	Down syndrome cell adhesion molecule like 1	0.016
FCHSD2	FCH and double SH3 domains 2	0.016
SSTR3	somatostatin receptor 3	0.015
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.015
PEF1	penta-EF-hand domain containing 1	0.014
PDCD6IP	programmed cell death 6 interacting protein	0.014
SH3GL3	SH3-domain GRB2-like 3	0.014
PHLPP2	PH domain and leucine rich repeat protein phosphatase 2	0.014
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.014
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.013
GLTPD1	glycolipid transfer protein domain containing 1	0.013
DPYSL4	dihydropyrimidinase-like 4	0.012
SMAD7	SMAD family member 7	0.012
CDH5	cadherin 5, type 2 (vascular endothelium)	0.011
EPHB3	EPH receptor B3	0.011	Human
RAB14	RAB14, member RAS oncogene family	0.011
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.011
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.011
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.011
SLC26A3	solute carrier family 26, member 3	0.011
XIAP	X-linked inhibitor of apoptosis	0.010
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.010
CSK	c-src tyrosine kinase	0.010
CTBP1	C-terminal binding protein 1	0.010