IMP

Process View

Homo sapiens

4 genes annotated in human

decidualization

The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "decidualization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "decidualization" (in gray)

Name	Description	Probability	Func Analog Organism
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.779
PLAU	plasminogen activator, urokinase	0.488
JUN	jun proto-oncogene	0.130
RARA	retinoic acid receptor, alpha	0.115
NCOR2	nuclear receptor corepressor 2	0.103
RXRA	retinoid X receptor, alpha	0.092
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.083
RANBP3	RAN binding protein 3	0.074
HNF4A	hepatocyte nuclear factor 4, alpha	0.072
SMAD3	SMAD family member 3	0.067
NCOA1	nuclear receptor coactivator 1	0.062
HIPK2	homeodomain interacting protein kinase 2	0.059
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.049
FOSL1	FOS-like antigen 1	0.049
ARHGEF40	Rho guanine nucleotide exchange factor (GEF) 40	0.048
ZC3H12A	zinc finger CCCH-type containing 12A	0.048
PDLIM7	PDZ and LIM domain 7 (enigma)	0.045
HR	hairless homolog (mouse)	0.040
SOCS3	suppressor of cytokine signaling 3	0.035
PLAT	plasminogen activator, tissue	0.034
SOCS2	suppressor of cytokine signaling 2	0.033
RGS2	regulator of G-protein signaling 2, 24kDa	0.032
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.031
EPAS1	endothelial PAS domain protein 1	0.031
APLP2	amyloid beta (A4) precursor-like protein 2	0.030
SKIL	SKI-like oncogene	0.030
NPC2	Niemann-Pick disease, type C2	0.028
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.028
EP300	E1A binding protein p300	0.027
ANXA2	annexin A2	0.027
CXCL3	chemokine (C-X-C motif) ligand 3	0.026
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.025
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.024
SPHK1	sphingosine kinase 1	0.023
CSTA	cystatin A (stefin A)	0.023
JUND	jun D proto-oncogene	0.023
NCOA3	nuclear receptor coactivator 3	0.023
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.023
NCOA6	nuclear receptor coactivator 6	0.021
SMAD9	SMAD family member 9	0.021
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.021
DEDD	death effector domain containing	0.020	Mouse
CXXC5	CXXC finger protein 5	0.020
CCND1	cyclin D1	0.020
IL6	interleukin 6 (interferon, beta 2)	0.019
EPO	erythropoietin	0.019
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.019
BATF2	basic leucine zipper transcription factor, ATF-like 2	0.018
IL8	interleukin 8	0.018
PLAUR	plasminogen activator, urokinase receptor	0.018
ORM1	orosomucoid 1	0.018
AMBP	alpha-1-microglobulin/bikunin precursor	0.018
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.017
GFPT2	glutamine-fructose-6-phosphate transaminase 2	0.017
FOSL2	FOS-like antigen 2	0.017
DUSP1	dual specificity phosphatase 1	0.016
BHLHE40	basic helix-loop-helix family, member e40	0.016
PVR	poliovirus receptor	0.016
GRN	granulin	0.016
STC1	stanniocalcin 1	0.015	Rat
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.015
ZFYVE9	zinc finger, FYVE domain containing 9	0.015
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.015
ESR2	estrogen receptor 2 (ER beta)	0.015
MED25	mediator complex subunit 25	0.015
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.014
HBEGF	heparin-binding EGF-like growth factor	0.014
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.014
CSRNP1	cysteine-serine-rich nuclear protein 1	0.014
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.014
PPARA	peroxisome proliferator-activated receptor alpha	0.014	Human
CREBBP	CREB binding protein	0.014
TRIB1	tribbles homolog 1 (Drosophila)	0.014
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.013
CARHSP1	calcium regulated heat stable protein 1, 24kDa	0.013
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.013
RAB5C	RAB5C, member RAS oncogene family	0.013
VEGFA	vascular endothelial growth factor A	0.013
PTHLH	parathyroid hormone-like hormone	0.013
ATF3	activating transcription factor 3	0.013
IL1B	interleukin 1, beta	0.013
SERTAD1	SERTA domain containing 1	0.013
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.013
KLF4	Kruppel-like factor 4 (gut)	0.013
AR	androgen receptor	0.013
SPRED1	sprouty-related, EVH1 domain containing 1	0.012
IER2	immediate early response 2	0.012
CXCL2	chemokine (C-X-C motif) ligand 2	0.012
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.012
CCND2	cyclin D2	0.012
PGR	progesterone receptor	0.012
C6orf106	chromosome 6 open reading frame 106	0.012
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.012
SREBF2	sterol regulatory element binding transcription factor 2	0.012
SPSB1	splA/ryanodine receptor domain and SOCS box containing 1	0.012
ADIPOR1	adiponectin receptor 1	0.012
ANGPTL4	angiopoietin-like 4	0.011
S100A10	S100 calcium binding protein A10	0.011
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.011
LIFR	leukemia inhibitory factor receptor alpha	0.011
INHBA	inhibin, beta A	0.011
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.011
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.011
RUNX1	runt-related transcription factor 1	0.011
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.011
MCM3AP	minichromosome maintenance complex component 3 associated protein	0.011
GADD45B	growth arrest and DNA-damage-inducible, beta	0.011
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.011
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.011
NEU1	sialidase 1 (lysosomal sialidase)	0.011
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.011
CTSD	cathepsin D	0.011
PTGES	prostaglandin E synthase	0.011
KCNE4	potassium voltage-gated channel, Isk-related family, member 4	0.011
EPHA2	EPH receptor A2	0.011
ARNT	aryl hydrocarbon receptor nuclear translocator	0.010
HMOX1	heme oxygenase (decycling) 1	0.010
ADAM11	ADAM metallopeptidase domain 11	0.010
GPRC5A	G protein-coupled receptor, family C, group 5, member A	0.010
ATXN3	ataxin 3	0.010
CLCF1	cardiotrophin-like cytokine factor 1	0.010
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.010
CISH	cytokine inducible SH2-containing protein	0.010
TIMP1	TIMP metallopeptidase inhibitor 1	0.010
TUBB2B	tubulin, beta 2B	0.010
PTN	pleiotrophin	0.010
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.010