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Homo sapiens

10 genes annotated in human

negative regulation of defense response to virus

Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of defense response to virus"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of defense response to virus" (in gray)

Name	Description	Probability	Func Analog Organism
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.983
IFIT1	interferon-induced protein with tetratricopeptide repeats 1	0.879
IFIT5	interferon-induced protein with tetratricopeptide repeats 5	0.729	Human
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.712	Human
IFIT3	interferon-induced protein with tetratricopeptide repeats 3	0.704	Human
DICER1	dicer 1, ribonuclease type III	0.690	Human
IFIT2	interferon-induced protein with tetratricopeptide repeats 2	0.629	Human
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.472	Human
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.332	Human
PCBP1	poly(rC) binding protein 1	0.232	Human
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.206	Human
IFI44L	interferon-induced protein 44-like	0.160
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.129
CMPK2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.098
SAMD9	sterile alpha motif domain containing 9	0.098
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.095
FBXL15	F-box and leucine-rich repeat protein 15	0.090
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.079
IFI44	interferon-induced protein 44	0.070
HERC5	hect domain and RLD 5	0.068
TARBP2	TAR (HIV-1) RNA binding protein 2	0.065
PARP9	poly (ADP-ribose) polymerase family, member 9	0.064
CYLD	cylindromatosis (turban tumor syndrome)	0.061
ISG15	ISG15 ubiquitin-like modifier	0.055
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.054
ZFYVE9	zinc finger, FYVE domain containing 9	0.051
SMAD4	SMAD family member 4	0.050
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.049	Human
DTX3L	deltex 3-like (Drosophila)	0.046
PCBP2	poly(rC) binding protein 2	0.032
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.031	Human
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.031
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.031
PABPC1	poly(A) binding protein, cytoplasmic 1	0.030
APOL6	apolipoprotein L, 6	0.029
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.029	Human
ANKRD13A	ankyrin repeat domain 13A	0.028
SAMD9L	sterile alpha motif domain containing 9-like	0.028
IFIH1	interferon induced with helicase C domain 1	0.027	Human
LAP3	leucine aminopeptidase 3	0.023
TNRC6C	trinucleotide repeat containing 6C	0.021
QKI	quaking homolog, KH domain RNA binding (mouse)	0.020
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.019
RANBP3	RAN binding protein 3	0.019
HNRNPL	heterogeneous nuclear ribonucleoprotein L	0.018
PARP14	poly (ADP-ribose) polymerase family, member 14	0.016
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.016
EPSTI1	epithelial stromal interaction 1 (breast)	0.016
TDRD7	tudor domain containing 7	0.016
ZNFX1	zinc finger, NFX1-type containing 1	0.016
TRIM25	tripartite motif containing 25	0.013
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.013
USP18	ubiquitin specific peptidase 18	0.013
LGALS3	lectin, galactoside-binding, soluble, 3	0.013
ZFP28	zinc finger protein 28 homolog (mouse)	0.013
TNRC6A	trinucleotide repeat containing 6A	0.012
STAMBP	STAM binding protein	0.011
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.011
KAT2B	K(lysine) acetyltransferase 2B	0.011
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.011
THAP11	THAP domain containing 11	0.010
SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	0.010