IMP

Process View

Homo sapiens

1 genes annotated in human

t helper 1 cell activation

The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t helper 1 cell activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "t helper 1 cell activation" (in gray)

Name	Description	Probability	Func Analog Organism
CCR5	chemokine (C-C motif) receptor 5	1.000
CXCL9	chemokine (C-X-C motif) ligand 9	0.919
IDE	insulin-degrading enzyme	0.855
CXCL2	chemokine (C-X-C motif) ligand 2	0.823
IL8	interleukin 8	0.799
CCL2	chemokine (C-C motif) ligand 2	0.795	Human
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.700	Human
CCL4	chemokine (C-C motif) ligand 4	0.677	Human
IL1B	interleukin 1, beta	0.662
CXCL10	chemokine (C-X-C motif) ligand 10	0.659
CCL8	chemokine (C-C motif) ligand 8	0.528	Human
DPP4	dipeptidyl-peptidase 4	0.521
CCL13	chemokine (C-C motif) ligand 13	0.518	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.396
CCL5	chemokine (C-C motif) ligand 5	0.368	Human
CCL22	chemokine (C-C motif) ligand 22	0.368	Human
CCR7	chemokine (C-C motif) receptor 7	0.330
IL6	interleukin 6 (interferon, beta 2)	0.317
TRAF1	TNF receptor-associated factor 1	0.212
CCR4	chemokine (C-C motif) receptor 4	0.203
CD83	CD83 molecule	0.203
CXCL3	chemokine (C-X-C motif) ligand 3	0.197
CXCL13	chemokine (C-X-C motif) ligand 13	0.193
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.188
CCL7	chemokine (C-C motif) ligand 7	0.187	Human
ICAM1	intercellular adhesion molecule 1	0.172
CCL19	chemokine (C-C motif) ligand 19	0.155	Human
RGS1	regulator of G-protein signaling 1	0.147
VCAM1	vascular cell adhesion molecule 1	0.120
IFNG	interferon, gamma	0.109
CCL20	chemokine (C-C motif) ligand 20	0.096	Human
IL7R	interleukin 7 receptor	0.096
CCR1	chemokine (C-C motif) receptor 1	0.092
TNF	tumor necrosis factor	0.087
IL10	interleukin 10	0.085
IL2RB	interleukin 2 receptor, beta	0.077
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.076
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.072
CXCL5	chemokine (C-X-C motif) ligand 5	0.067
BCL2A1	BCL2-related protein A1	0.058
SELE	selectin E	0.056
CCL11	chemokine (C-C motif) ligand 11	0.053	Human
FPR3	formyl peptide receptor 3	0.051
UBD	ubiquitin D	0.048
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.047
LAMP3	lysosomal-associated membrane protein 3	0.043
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.040
CH25H	cholesterol 25-hydroxylase	0.036
EBI3	Epstein-Barr virus induced 3	0.036
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.033
CD69	CD69 molecule	0.032
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.032
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.032
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.031
PLEK	pleckstrin	0.031
IL1RN	interleukin 1 receptor antagonist	0.031
XCL2	chemokine (C motif) ligand 2	0.030	Human
IL21R	interleukin 21 receptor	0.029
C1QB	complement component 1, q subcomponent, B chain	0.029
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.029
CCL21	chemokine (C-C motif) ligand 21	0.029
DARC	Duffy blood group, chemokine receptor	0.029
IDO1	indoleamine 2,3-dioxygenase 1	0.028
IL2RA	interleukin 2 receptor, alpha	0.028
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.028
ADAMDEC1	ADAM-like, decysin 1	0.028
GZMK	granzyme K (granzyme 3; tryptase II)	0.028
CCR3	chemokine (C-C motif) receptor 3	0.027
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.026
IL32	interleukin 32	0.026
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.026
IL18RAP	interleukin 18 receptor accessory protein	0.024
IL1R2	interleukin 1 receptor, type II	0.024
INHBA	inhibin, beta A	0.024
STAT4	signal transducer and activator of transcription 4	0.024
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.023
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.022
MSC	musculin	0.021
SLAMF8	SLAM family member 8	0.021
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.021
IL1A	interleukin 1, alpha	0.021
XCL1	chemokine (C motif) ligand 1	0.019
NNMT	nicotinamide N-methyltransferase	0.019
IL2RG	interleukin 2 receptor, gamma	0.019
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.018
ARRB1	arrestin, beta 1	0.018
SRGN	serglycin	0.018
IL13	interleukin 13	0.017
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.017
CCL17	chemokine (C-C motif) ligand 17	0.017	Human
GNLY	granulysin	0.017
SLAMF7	SLAM family member 7	0.017
CCL3	chemokine (C-C motif) ligand 3	0.015	Human
CD40	CD40 molecule, TNF receptor superfamily member 5	0.015
SOD2	superoxide dismutase 2, mitochondrial	0.015
PRF1	perforin 1 (pore forming protein)	0.014
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.014
CCL1	chemokine (C-C motif) ligand 1	0.014	Human
CD209	CD209 molecule	0.014
CMKLR1	chemokine-like receptor 1	0.013
IL10RA	interleukin 10 receptor, alpha	0.013
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.013
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.013
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.013
PI3	peptidase inhibitor 3, skin-derived	0.013
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.012
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.012
IL18R1	interleukin 18 receptor 1	0.012
GPR109B	G protein-coupled receptor 109B	0.012
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.012
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.012
RGS16	regulator of G-protein signaling 16	0.011
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.011
CXCR6	chemokine (C-X-C motif) receptor 6	0.011
CXCR3	chemokine (C-X-C motif) receptor 3	0.011
CD80	CD80 molecule	0.010
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.010
TNFRSF4	tumor necrosis factor receptor superfamily, member 4	0.010
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.010