IMP

Process View

Homo sapiens

2 genes annotated in human

negative regulation of fibroblast growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of fibroblast growth factor receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of fibroblast growth factor receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.968
SPRY2	sprouty homolog 2 (Drosophila)	0.816	Mouse Fly
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.786
TESK1	testis-specific kinase 1	0.687
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.514
SH3KBP1	SH3-domain kinase binding protein 1	0.452
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.436
STMN2	stathmin-like 2	0.280
FN1	fibronectin 1	0.191
ZFYVE9	zinc finger, FYVE domain containing 9	0.153
PSEN1	presenilin 1	0.143
SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	0.095	Mouse Fly
HIC1	hypermethylated in cancer 1	0.094
JUP	junction plakoglobin	0.088
TGFB1	transforming growth factor, beta 1	0.085
TIMP2	TIMP metallopeptidase inhibitor 2	0.080
SCARB2	scavenger receptor class B, member 2	0.074
VCAN	versican	0.070
TCF4	transcription factor 4	0.068
SFRP4	secreted frizzled-related protein 4	0.065
FZD1	frizzled homolog 1 (Drosophila)	0.061
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.058
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.055
DUSP6	dual specificity phosphatase 6	0.050
SPRY4	sprouty homolog 4 (Drosophila)	0.048	Zebrafish Fly
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.047
THBS2	thrombospondin 2	0.047	Human
NGF	nerve growth factor (beta polypeptide)	0.047
C9orf25	chromosome 9 open reading frame 25	0.046
TIMP3	TIMP metallopeptidase inhibitor 3	0.046
MARCKS	myristoylated alanine-rich protein kinase C substrate	0.046
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.044
BGN	biglycan	0.043
SALL2	sal-like 2 (Drosophila)	0.043
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.043
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.041
SH2B2	SH2B adaptor protein 2	0.041
COMP	cartilage oligomeric matrix protein	0.041	Human
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.041
NTM	neurotrimin	0.040
ANGPTL2	angiopoietin-like 2	0.039
GLIS2	GLIS family zinc finger 2	0.039
TPP1	tripeptidyl peptidase I	0.039
TNIK	TRAF2 and NCK interacting kinase	0.039
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.038
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.037
THY1	Thy-1 cell surface antigen	0.036
MXRA5	matrix-remodelling associated 5	0.035
FAP	fibroblast activation protein, alpha	0.035
CYR61	cysteine-rich, angiogenic inducer, 61	0.035
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.034
GSK3B	glycogen synthase kinase 3 beta	0.033
CPD	carboxypeptidase D	0.032
CTNNBIP1	catenin, beta interacting protein 1	0.031
ETV5	ets variant 5	0.030
SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	0.029
RET	ret proto-oncogene	0.029
RHOQ	ras homolog gene family, member Q	0.028
COL11A1	collagen, type XI, alpha 1	0.028
WISP1	WNT1 inducible signaling pathway protein 1	0.027
HEXB	hexosaminidase B (beta polypeptide)	0.027
ITSN1	intersectin 1 (SH3 domain protein)	0.027
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.026
AR	androgen receptor	0.026
FGF2	fibroblast growth factor 2 (basic)	0.026
COL1A1	collagen, type I, alpha 1	0.026
COL5A1	collagen, type V, alpha 1	0.026
SFRP2	secreted frizzled-related protein 2	0.025
PRRX1	paired related homeobox 1	0.025
INHBA	inhibin, beta A	0.025
AEBP1	AE binding protein 1	0.024
FAM198B	family with sequence similarity 198, member B	0.023
ADAM12	ADAM metallopeptidase domain 12	0.023
SDC2	syndecan 2	0.022
POSTN	periostin, osteoblast specific factor	0.022
CTSB	cathepsin B	0.021
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.021
WNT4	wingless-type MMTV integration site family, member 4	0.020
FBN1	fibrillin 1	0.020
LOXL2	lysyl oxidase-like 2	0.020
THBS4	thrombospondin 4	0.019	Human
DPYSL2	dihydropyrimidinase-like 2	0.019
COL16A1	collagen, type XVI, alpha 1	0.019
CRIP2	cysteine-rich protein 2	0.019
BMP1	bone morphogenetic protein 1	0.019
LAMP1	lysosomal-associated membrane protein 1	0.019
EDNRA	endothelin receptor type A	0.019
EMD	emerin	0.019
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.019
TMEM127	transmembrane protein 127	0.019
JAG1	jagged 1	0.019
TTR	transthyretin	0.018
FSTL1	follistatin-like 1	0.018
ASPN	asporin	0.017
TWIST1	twist homolog 1 (Drosophila)	0.017
WDYHV1	WDYHV motif containing 1	0.017
IGFBP5	insulin-like growth factor binding protein 5	0.017
FERMT2	fermitin family member 2	0.017
LUM	lumican	0.017
CALD1	caldesmon 1	0.017
SMAD1	SMAD family member 1	0.017
SULF1	sulfatase 1	0.017
NOTCH2	notch 2	0.016
TDGF1	teratocarcinoma-derived growth factor 1	0.016
ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1	0.016
TNC	tenascin C	0.016
HAS2	hyaluronan synthase 2	0.016
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.016
NCSTN	nicastrin	0.016
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.015
AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	0.015
LRRC15	leucine rich repeat containing 15	0.015
GREM1	gremlin 1	0.015
SPP1	secreted phosphoprotein 1	0.014
STC1	stanniocalcin 1	0.014
ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	0.014
COL5A2	collagen, type V, alpha 2	0.014
F3	coagulation factor III (thromboplastin, tissue factor)	0.014
CTSL1	cathepsin L1	0.014
ITM2B	integral membrane protein 2B	0.014
PCOLCE	procollagen C-endopeptidase enhancer	0.014
GJA1	gap junction protein, alpha 1, 43kDa	0.014
SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.014
PSAP	prosaposin	0.014
RHOD	ras homolog gene family, member D	0.014
GPR137B	G protein-coupled receptor 137B	0.013
SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.013
QKI	quaking homolog, KH domain RNA binding (mouse)	0.013
TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	0.013
AXIN1	axin 1	0.013
A2M	alpha-2-macroglobulin	0.013
MFGE8	milk fat globule-EGF factor 8 protein	0.013
COL6A3	collagen, type VI, alpha 3	0.013
NOTCH3	notch 3	0.013
KCNE4	potassium voltage-gated channel, Isk-related family, member 4	0.013
FNDC1	fibronectin type III domain containing 1	0.013
SEMA5B	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.013
CRTAP	cartilage associated protein	0.013
COL1A2	collagen, type I, alpha 2	0.013
MFAP5	microfibrillar associated protein 5	0.012
CREB5	cAMP responsive element binding protein 5	0.012
UNC5B	unc-5 homolog B (C. elegans)	0.012
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.012
CHPF	chondroitin polymerizing factor	0.012
ZBTB16	zinc finger and BTB domain containing 16	0.012
OSTF1	osteoclast stimulating factor 1	0.012
SLIT2	slit homolog 2 (Drosophila)	0.012
WDR73	WD repeat domain 73	0.012
EGR3	early growth response 3	0.012
LAMP2	lysosomal-associated membrane protein 2	0.012
ACSL4	acyl-CoA synthetase long-chain family member 4	0.012
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.012
EPAS1	endothelial PAS domain protein 1	0.012
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.012
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.012
APP	amyloid beta (A4) precursor protein	0.012
PTK7	PTK7 protein tyrosine kinase 7	0.012
ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	0.012
CRABP2	cellular retinoic acid binding protein 2	0.012
CTSK	cathepsin K	0.012
TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0.012
SORCS2	sortilin-related VPS10 domain containing receptor 2	0.011
SCPEP1	serine carboxypeptidase 1	0.011
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.011
PLXDC1	plexin domain containing 1	0.011
PMP22	peripheral myelin protein 22	0.011
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.011
EGR2	early growth response 2	0.011
OLFML2B	olfactomedin-like 2B	0.011
FBLN1	fibulin 1	0.011
CELF2	CUGBP, Elav-like family member 2	0.011
SFRP1	secreted frizzled-related protein 1	0.011
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.011
MXRA8	matrix-remodelling associated 8	0.011
PDPN	podoplanin	0.010
TPST1	tyrosylprotein sulfotransferase 1	0.010
VEGFC	vascular endothelial growth factor C	0.010
DPYSL3	dihydropyrimidinase-like 3	0.010
AMIGO2	adhesion molecule with Ig-like domain 2	0.010
ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif, 10	0.010
CD80	CD80 molecule	0.010
SPRED2	sprouty-related, EVH1 domain containing 2	0.010
SLIT3	slit homolog 3 (Drosophila)	0.010
APLP2	amyloid beta (A4) precursor-like protein 2	0.010
BTRC	beta-transducin repeat containing	0.010
GAS1	growth arrest-specific 1	0.010
ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.010
TAL1	T-cell acute lymphocytic leukemia 1	0.010
CSAD	cysteine sulfinic acid decarboxylase	0.010
SNAI2	snail homolog 2 (Drosophila)	0.010
AHR	aryl hydrocarbon receptor	0.010
COL8A1	collagen, type VIII, alpha 1	0.010