IMP

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Homo sapiens

3 genes annotated in human

Multi-species View

negative regulation of type 2 immune response

GO:0002829

Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of type 2 immune response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of type 2 immune response" (in gray)

Name	Description	Probability	Func Analog Organism
IL4R	interleukin 4 receptor	1.000
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.988
NCOR2	nuclear receptor corepressor 2	0.760
TMEM173	transmembrane protein 173	0.465
IL4	interleukin 4	0.400
MAVS	mitochondrial antiviral signaling protein	0.397
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.305
HDAC5	histone deacetylase 5	0.268
IFNA16	interferon, alpha 16	0.237	Human
PCDH9	protocadherin 9	0.227
IFNA4	interferon, alpha 4	0.155
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.153
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.130
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.119
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.102
IFNA10	interferon, alpha 10	0.090	Human
IL2RG	interleukin 2 receptor, gamma	0.086
PPAP2B	phosphatidic acid phosphatase type 2B	0.078
STAT2	signal transducer and activator of transcription 2, 113kDa	0.077
IFNA21	interferon, alpha 21	0.073	Human
IFNA14	interferon, alpha 14	0.073
IFNA17	interferon, alpha 17	0.072
HDAC9	histone deacetylase 9	0.065
MVP	major vault protein	0.057
JUN	jun proto-oncogene	0.053
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.043
NPTN	neuroplastin	0.043
CYLC1	cylicin, basic protein of sperm head cytoskeleton 1	0.042
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.038
RAB11FIP2	RAB11 family interacting protein 2 (class I)	0.037
MBOAT7	membrane bound O-acyltransferase domain containing 7	0.036
JUNB	jun B proto-oncogene	0.036
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.034
LITAF	lipopolysaccharide-induced TNF factor	0.034
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.033
ACVR1	activin A receptor, type I	0.033
IFNA13	interferon, alpha 13	0.032
KDM2A	lysine (K)-specific demethylase 2A	0.032
LRP10	low density lipoprotein receptor-related protein 10	0.031
IFNA7	interferon, alpha 7	0.028	Human
TRAF3IP3	TRAF3 interacting protein 3	0.028
FGL2	fibrinogen-like 2	0.027
TSPYL4	TSPY-like 4	0.026
C6orf10	chromosome 6 open reading frame 10	0.026
IFNA2	interferon, alpha 2	0.026
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.026
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.025
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.023
EP300	E1A binding protein p300	0.023
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.023
SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	0.023
EBF1	early B-cell factor 1	0.022
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.022
HCFC1	host cell factor C1 (VP16-accessory protein)	0.022
TCIRG1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	0.022
PPARA	peroxisome proliferator-activated receptor alpha	0.022
HDAC4	histone deacetylase 4	0.022
OR2B2	olfactory receptor, family 2, subfamily B, member 2	0.021
SELL	selectin L	0.021
IFNA5	interferon, alpha 5	0.021	Human
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.020
TRIM48	tripartite motif containing 48	0.020
STATH	statherin	0.020
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.019
CXCR6	chemokine (C-X-C motif) receptor 6	0.019
GYPB	glycophorin B (MNS blood group)	0.019
UBQLN2	ubiquilin 2	0.019
CD40LG	CD40 ligand	0.018
OR52A1	olfactory receptor, family 52, subfamily A, member 1	0.018
TAS2R7	taste receptor, type 2, member 7	0.018
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.018
PGRMC2	progesterone receptor membrane component 2	0.018
CLEC5A	C-type lectin domain family 5, member A	0.017
MEF2A	myocyte enhancer factor 2A	0.017
GYPA	glycophorin A (MNS blood group)	0.017
CSN3	casein kappa	0.017
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.017
NFIL3	nuclear factor, interleukin 3 regulated	0.017
PNRC1	proline-rich nuclear receptor coactivator 1	0.017
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.017
PHF12	PHD finger protein 12	0.016
HTN1	histatin 1	0.016
HTN3	histatin 3	0.016
IL21	interleukin 21	0.016
SEMG2	semenogelin II	0.016
ZBTB16	zinc finger and BTB domain containing 16	0.016
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.016
ANXA11	annexin A11	0.016
SASH3	SAM and SH3 domain containing 3	0.016
PGR	progesterone receptor	0.016
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.016
IRF4	interferon regulatory factor 4	0.015
FGL1	fibrinogen-like 1	0.015
RRH	retinal pigment epithelium-derived rhodopsin homolog	0.015
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.015
BCOR	BCL6 corepressor	0.015
SLCO1B1	solute carrier organic anion transporter family, member 1B1	0.015
SPO11	SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)	0.015
ANGPTL3	angiopoietin-like 3	0.015
RNF11	ring finger protein 11	0.015
CD1C	CD1c molecule	0.014
CAMSAP1L1	calmodulin regulated spectrin-associated protein 1-like 1	0.014
SNTG1	syntrophin, gamma 1	0.014
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.014
CLEC4A	C-type lectin domain family 4, member A	0.014
PSMD5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	0.014
LY86	lymphocyte antigen 86	0.014
IFNA8	interferon, alpha 8	0.014	Human
ARIH2	ariadne homolog 2 (Drosophila)	0.014
CYLC2	cylicin, basic protein of sperm head cytoskeleton 2	0.014
OSBPL1A	oxysterol binding protein-like 1A	0.014
IL10	interleukin 10	0.014
IAPP	islet amyloid polypeptide	0.014
COLEC10	collectin sub-family member 10 (C-type lectin)	0.014
AFM	afamin	0.014
CFP	complement factor properdin	0.013
JAK1	Janus kinase 1	0.013
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.013
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.013
IFNG	interferon, gamma	0.013
OR7A10	olfactory receptor, family 7, subfamily A, member 10	0.013
CLDN17	claudin 17	0.013
CRISP1	cysteine-rich secretory protein 1	0.013
LIPF	lipase, gastric	0.013
MEF2C	myocyte enhancer factor 2C	0.013
LECT2	leukocyte cell-derived chemotaxin 2	0.013
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.013
CSN1S1	casein alpha s1	0.013
C6orf120	chromosome 6 open reading frame 120	0.013
NMBR	neuromedin B receptor	0.013
MORC1	MORC family CW-type zinc finger 1	0.013
TAS2R8	taste receptor, type 2, member 8	0.013
THAP11	THAP domain containing 11	0.013
TSHB	thyroid stimulating hormone, beta	0.012
SLC22A13	solute carrier family 22 (organic anion transporter), member 13	0.012
F13B	coagulation factor XIII, B polypeptide	0.012
RGSL1	regulator of G-protein signaling like 1	0.012
ARRDC3	arrestin domain containing 3	0.012
IL5	interleukin 5 (colony-stimulating factor, eosinophil)	0.012
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.012
CLEC7A	C-type lectin domain family 7, member A	0.012
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.012
BIN2	bridging integrator 2	0.012
FABP2	fatty acid binding protein 2, intestinal	0.012
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.012
GCNT4	glucosaminyl (N-acetyl) transferase 4, core 2	0.012
SLCO1B3	solute carrier organic anion transporter family, member 1B3	0.012
SAP30L	SAP30-like	0.012
SI	sucrase-isomaltase (alpha-glucosidase)	0.012
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.011
BTBD3	BTB (POZ) domain containing 3	0.011
ASCL3	achaete-scute complex homolog 3 (Drosophila)	0.011
PPEF2	protein phosphatase, EF-hand calcium binding domain 2	0.011
MS4A5	membrane-spanning 4-domains, subfamily A, member 5	0.011
GPR22	G protein-coupled receptor 22	0.011
SPATA16	spermatogenesis associated 16	0.011
CCR5	chemokine (C-C motif) receptor 5	0.011
CLEC4E	C-type lectin domain family 4, member E	0.011
CCR9	chemokine (C-C motif) receptor 9	0.011
CFHR2	complement factor H-related 2	0.011
SCN11A	sodium channel, voltage-gated, type XI, alpha subunit	0.011
TAPBP	TAP binding protein (tapasin)	0.011
CCR6	chemokine (C-C motif) receptor 6	0.011
ZNF157	zinc finger protein 157	0.011
SERPINB10	serpin peptidase inhibitor, clade B (ovalbumin), member 10	0.011
CD4	CD4 molecule	0.011
CD86	CD86 molecule	0.011
ADAM2	ADAM metallopeptidase domain 2	0.011
BTG2	BTG family, member 2	0.011
NACC1	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	0.011
GNAT2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	0.011
CSN2	casein beta	0.011
TM4SF20	transmembrane 4 L six family member 20	0.011
TAAR2	trace amine associated receptor 2	0.011
CYBB	cytochrome b-245, beta polypeptide	0.011
ZEB1	zinc finger E-box binding homeobox 1	0.011
GPRC6A	G protein-coupled receptor, family C, group 6, member A	0.011
OR10H3	olfactory receptor, family 10, subfamily H, member 3	0.011
ZNF81	zinc finger protein 81	0.011
CTNNA3	catenin (cadherin-associated protein), alpha 3	0.011
TMPRSS11B	transmembrane protease, serine 11B	0.011
BAGE	B melanoma antigen	0.011
ODAM	odontogenic, ameloblast asssociated	0.011
CDH9	cadherin 9, type 2 (T1-cadherin)	0.011
HNF4G	hepatocyte nuclear factor 4, gamma	0.011
ACCN5	amiloride-sensitive cation channel 5, intestinal	0.011
ART4	ADP-ribosyltransferase 4 (Dombrock blood group)	0.011
KRTAP1-1	keratin associated protein 1-1	0.011
FSHR	follicle stimulating hormone receptor	0.011
HIST1H3J	histone cluster 1, H3j	0.011
GNGT1	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1	0.011
IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	0.011
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.011
CLEC10A	C-type lectin domain family 10, member A	0.011
CCR4	chemokine (C-C motif) receptor 4	0.011
C11orf40	chromosome 11 open reading frame 40	0.011
NTS	neurotensin	0.011
ARHGAP5	Rho GTPase activating protein 5	0.011
C9	complement component 9	0.011
SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	0.011
GYPE	glycophorin E (MNS blood group)	0.011
MMP27	matrix metallopeptidase 27	0.011
PDC	phosducin	0.011
CTAGE1	cutaneous T-cell lymphoma-associated antigen 1	0.010
PLAC1	placenta-specific 1	0.010
IL2	interleukin 2	0.010
SIRT1	sirtuin 1	0.010
PDE6C	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	0.010
HESX1	HESX homeobox 1	0.010
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.010
C13orf26	chromosome 13 open reading frame 26	0.010
HIST1H4A	histone cluster 1, H4a	0.010
ANXA10	annexin A10	0.010
HYAL4	hyaluronoglucosaminidase 4	0.010
OMG	oligodendrocyte myelin glycoprotein	0.010
CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	0.010
PRIC285	peroxisomal proliferator-activated receptor A interacting complex 285	0.010
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.010
C12orf50	chromosome 12 open reading frame 50	0.010
IFNA6	interferon, alpha 6	0.010	Human
RNF133	ring finger protein 133	0.010
PSG2	pregnancy specific beta-1-glycoprotein 2	0.010
TAS2R16	taste receptor, type 2, member 16	0.010