IMP

Process View

Homo sapiens

12 genes annotated in human

muscle adaptation

A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "muscle adaptation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "muscle adaptation" (in gray)

Name	Description	Probability	Func Analog Organism
TNNI1	troponin I type 1 (skeletal, slow)	0.850	Mouse
TRIM63	tripartite motif containing 63	0.825	Rat
TNNC1	troponin C type 1 (slow)	0.809	Mouse
TTN	titin	0.744
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.532
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.455
SNTG2	syntrophin, gamma 2	0.390
MYOZ1	myozenin 1	0.291
PRKAR2A	protein kinase, cAMP-dependent, regulatory, type II, alpha	0.268
KLF6	Kruppel-like factor 6	0.251
ITPR2	inositol 1,4,5-trisphosphate receptor, type 2	0.232
MRPL41	mitochondrial ribosomal protein L41	0.198
EP300	E1A binding protein p300	0.195
BMPR1B	bone morphogenetic protein receptor, type IB	0.187
ESR1	estrogen receptor 1	0.178
ITGB1BP3	integrin beta 1 binding protein 3	0.169
RICTOR	RPTOR independent companion of MTOR, complex 2	0.132
MEF2A	myocyte enhancer factor 2A	0.130
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.130
HDAC4	histone deacetylase 4	0.124
MAPT	microtubule-associated protein tau	0.100
EIF3F	eukaryotic translation initiation factor 3, subunit F	0.091
ACTA1	actin, alpha 1, skeletal muscle	0.090	Rat
TNNT2	troponin T type 2 (cardiac)	0.089
TNNI2	troponin I type 2 (skeletal, fast)	0.087
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.086
TRPC3	transient receptor potential cation channel, subfamily C, member 3	0.077
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.069
ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	0.066
DES	desmin	0.063
MEF2C	myocyte enhancer factor 2C	0.058	Mouse
VPS29	vacuolar protein sorting 29 homolog (S. cerevisiae)	0.057
HDAC9	histone deacetylase 9	0.055
MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	0.051
TCAP	titin-cap (telethonin)	0.049
ACTN2	actinin, alpha 2	0.048
CREBBP	CREB binding protein	0.047
CALCA	calcitonin-related polypeptide alpha	0.046
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.045
MAPK1	mitogen-activated protein kinase 1	0.042
IGF2R	insulin-like growth factor 2 receptor	0.042
CYLD	cylindromatosis (turban tumor syndrome)	0.040
NRIP1	nuclear receptor interacting protein 1	0.039
MBNL1	muscleblind-like (Drosophila)	0.039
C3orf15	chromosome 3 open reading frame 15	0.037
TNNT1	troponin T type 1 (skeletal, slow)	0.036	Mouse
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.036
TRIM55	tripartite motif containing 55	0.035
MYL3	myosin, light chain 3, alkali; ventricular, skeletal, slow	0.035
MYOZ2	myozenin 2	0.033
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.033
COASY	CoA synthase	0.033
PDPK1	3-phosphoinositide dependent protein kinase-1	0.032
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.031
ITPR3	inositol 1,4,5-trisphosphate receptor, type 3	0.031
MYH6	myosin, heavy chain 6, cardiac muscle, alpha	0.031
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.031	Mouse
TBX5	T-box 5	0.030
NCOR1	nuclear receptor corepressor 1	0.030
YAP1	Yes-associated protein 1	0.029
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.029
MYCBP	c-myc binding protein	0.028
SP1	Sp1 transcription factor	0.028
JUN	jun proto-oncogene	0.027
KLF13	Kruppel-like factor 13	0.027
NCOA1	nuclear receptor coactivator 1	0.026
ETNK2	ethanolamine kinase 2	0.026
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.026
TNNI3	troponin I type 3 (cardiac)	0.025
NOMO1	NODAL modulator 1	0.024
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.024
COX6A2	cytochrome c oxidase subunit VIa polypeptide 2	0.023
ACACA	acetyl-CoA carboxylase alpha	0.022
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.022
MYLK2	myosin light chain kinase 2	0.022
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.021
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.021
CKM	creatine kinase, muscle	0.021
CTBP1	C-terminal binding protein 1	0.021
NCOA3	nuclear receptor coactivator 3	0.021
TNNT3	troponin T type 3 (skeletal, fast)	0.020
TRIM43	tripartite motif containing 43	0.019
DLG2	discs, large homolog 2 (Drosophila)	0.019
HDAC5	histone deacetylase 5	0.019
AR	androgen receptor	0.019
DCN	decorin	0.018
MYOG	myogenin (myogenic factor 4)	0.018	Mouse
LDB3	LIM domain binding 3	0.018
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.018
MAPK6	mitogen-activated protein kinase 6	0.018
FGFR1	fibroblast growth factor receptor 1	0.018
NOG	noggin	0.018
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.017
PRKCQ	protein kinase C, theta	0.017
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.017
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.017
FAF1	Fas (TNFRSF6) associated factor 1	0.017
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.017
OPRD1	opioid receptor, delta 1	0.017
NEB	nebulin	0.017
CHD3	chromodomain helicase DNA binding protein 3	0.017
VASP	vasodilator-stimulated phosphoprotein	0.016
IRF2	interferon regulatory factor 2	0.016
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.016
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.016
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.016
GSN	gelsolin	0.015
ACTC1	actin, alpha, cardiac muscle 1	0.015
DYSF	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.015
AXIN1	axin 1	0.015
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.014
ESR2	estrogen receptor 2 (ER beta)	0.014
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.014
SGCA	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	0.014
TRPC6	transient receptor potential cation channel, subfamily C, member 6	0.014	Human
ARRDC3	arrestin domain containing 3	0.014
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.014
JPH2	junctophilin 2	0.014
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.013
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.013
BBS10	Bardet-Biedl syndrome 10	0.013
TRPC4	transient receptor potential cation channel, subfamily C, member 4	0.013	Human
TRPC5	transient receptor potential cation channel, subfamily C, member 5	0.013	Human
ZEB2	zinc finger E-box binding homeobox 2	0.013
HIPK2	homeodomain interacting protein kinase 2	0.013
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.013
CIAPIN1	cytokine induced apoptosis inhibitor 1	0.012
HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	0.012
HIST1H3B	histone cluster 1, H3b	0.012
HIST1H4F	histone cluster 1, H4f	0.012
DCAF6	DDB1 and CUL4 associated factor 6	0.012
CAV3	caveolin 3	0.012
HAND2	heart and neural crest derivatives expressed 2	0.012
NCOA2	nuclear receptor coactivator 2	0.012
TNNC2	troponin C type 2 (fast)	0.012
OSBP2	oxysterol binding protein 2	0.012
BCL2	B-cell CLL/lymphoma 2	0.012
ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	0.012
MYBPC3	myosin binding protein C, cardiac	0.012
CDK17	cyclin-dependent kinase 17	0.011
BIN1	bridging integrator 1	0.011
SEMA6C	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	0.011
TRIM54	tripartite motif containing 54	0.011
FLNC	filamin C, gamma	0.011
MIF4GD	MIF4G domain containing	0.011
MARK1	MAP/microtubule affinity-regulating kinase 1	0.011
TSEN15	tRNA splicing endonuclease 15 homolog (S. cerevisiae)	0.011
SMAD1	SMAD family member 1	0.011
ACHE	acetylcholinesterase	0.011
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.011
BTK	Bruton agammaglobulinemia tyrosine kinase	0.010
HAP1	huntingtin-associated protein 1	0.010
SRL	sarcalumenin	0.010
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.010
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.010
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.010
GRIA4	glutamate receptor, ionotrophic, AMPA 4	0.010
MYBPH	myosin binding protein H	0.010
TF	transferrin	0.010
TCF4	transcription factor 4	0.010
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.010