IMP

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Homo sapiens

3 genes annotated in human

luteolysis

The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy.

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Known genes in the process in human Include functional analogs

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Gene Predictions

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Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "luteolysis" (in gray)

Name	Description	Probability	Func Analog Organism
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	1.000
CPE	carboxypeptidase E	0.999
LRDD	leucine-rich repeats and death domain containing	0.985
RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.939
RAI1	retinoic acid induced 1	0.898
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.812
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.724
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.568
HNRNPL	heterogeneous nuclear ribonucleoprotein L	0.553
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.407
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	0.339
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.242
VEGFC	vascular endothelial growth factor C	0.231
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.227
KCNRG	potassium channel regulator	0.199
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.164
MFAP4	microfibrillar-associated protein 4	0.145
PTN	pleiotrophin	0.136
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.123
RGS4	regulator of G-protein signaling 4	0.122
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.120
SLIT2	slit homolog 2 (Drosophila)	0.118
FAP	fibroblast activation protein, alpha	0.099
CHRD	chordin	0.083
GIGYF1	GRB10 interacting GYF protein 1	0.081
SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.078
FLRT2	fibronectin leucine rich transmembrane protein 2	0.076
RXRA	retinoid X receptor, alpha	0.076
PCDH12	protocadherin 12	0.074
LTBP1	latent transforming growth factor beta binding protein 1	0.074
LAMA4	laminin, alpha 4	0.073
PPP1R1B	protein phosphatase 1, regulatory (inhibitor) subunit 1B	0.069
LTBP4	latent transforming growth factor beta binding protein 4	0.069
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.069
CCL21	chemokine (C-C motif) ligand 21	0.067
OMD	osteomodulin	0.064
PCDH17	protocadherin 17	0.063
OLFM2	olfactomedin 2	0.061
ECM1	extracellular matrix protein 1	0.060
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.058
COL14A1	collagen, type XIV, alpha 1	0.057
MMP13	matrix metallopeptidase 13 (collagenase 3)	0.054	Rat
SKP2	S-phase kinase-associated protein 2 (p45)	0.050
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.048
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.046
SFRP4	secreted frizzled-related protein 4	0.044
RBMS3	RNA binding motif, single stranded interacting protein 3	0.043
CACNB1	calcium channel, voltage-dependent, beta 1 subunit	0.042
SVEP1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.041
SLCO2A1	solute carrier organic anion transporter family, member 2A1	0.041
PIP4K2B	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	0.040
FMOD	fibromodulin	0.040
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.040
INHBA	inhibin, beta A	0.039
NOV	nephroblastoma overexpressed gene	0.037
IGF1	insulin-like growth factor 1 (somatomedin C)	0.037
MYH11	myosin, heavy chain 11, smooth muscle	0.037
PTPRB	protein tyrosine phosphatase, receptor type, B	0.037
ZNF331	zinc finger protein 331	0.037
SCG5	secretogranin V (7B2 protein)	0.035
CHRDL1	chordin-like 1	0.034
PDPN	podoplanin	0.034
SLIT3	slit homolog 3 (Drosophila)	0.033
DPT	dermatopontin	0.033
LENG8	leukocyte receptor cluster (LRC) member 8	0.032
PTHLH	parathyroid hormone-like hormone	0.032
JAM2	junctional adhesion molecule 2	0.031
FMO1	flavin containing monooxygenase 1	0.029
BNC2	basonuclin 2	0.029
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.029
GLI3	GLI family zinc finger 3	0.029
STEAP1	six transmembrane epithelial antigen of the prostate 1	0.027
ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	0.027	Human
WNT2	wingless-type MMTV integration site family member 2	0.027
EPHA3	EPH receptor A3	0.027
STMN2	stathmin-like 2	0.026
OLFML1	olfactomedin-like 1	0.025
BCHE	butyrylcholinesterase	0.025
FRZB	frizzled-related protein	0.025
ZG16B	zymogen granule protein 16 homolog B (rat)	0.025
SLC7A11	solute carrier family 7, (cationic amino acid transporter, y+ system) member 11	0.024
KIAA0913	KIAA0913	0.024
CDH5	cadherin 5, type 2 (vascular endothelium)	0.024
ESM1	endothelial cell-specific molecule 1	0.024
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.023
NAV3	neuron navigator 3	0.023
SNCAIP	synuclein, alpha interacting protein	0.022
NTM	neurotrimin	0.022
SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.022
F10	coagulation factor X	0.022
TCF21	transcription factor 21	0.022
RAD54L2	RAD54-like 2 (S. cerevisiae)	0.022
ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	0.022
SELE	selectin E	0.022
ZNF205	zinc finger protein 205	0.022
MEGF6	multiple EGF-like-domains 6	0.021
THBS4	thrombospondin 4	0.021
LDB2	LIM domain binding 2	0.021
CNTNAP1	contactin associated protein 1	0.021
COL13A1	collagen, type XIII, alpha 1	0.020
PRRX1	paired related homeobox 1	0.020
ACVRL1	activin A receptor type II-like 1	0.020
TNXB	tenascin XB	0.020
KCNC4	potassium voltage-gated channel, Shaw-related subfamily, member 4	0.019
SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	0.019
FBLN1	fibulin 1	0.019
LOX	lysyl oxidase	0.019
FBXL7	F-box and leucine-rich repeat protein 7	0.018
MYCT1	myc target 1	0.018
IL13RA2	interleukin 13 receptor, alpha 2	0.018
ITGA8	integrin, alpha 8	0.018
CCL20	chemokine (C-C motif) ligand 20	0.018
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.018
VIP	vasoactive intestinal peptide	0.018
PRRX2	paired related homeobox 2	0.017
WNT5A	wingless-type MMTV integration site family, member 5A	0.017
PGF	placental growth factor	0.017
MEIS2	Meis homeobox 2	0.017
KIAA1462	KIAA1462	0.017
TREM2	triggering receptor expressed on myeloid cells 2	0.017
OGN	osteoglycin	0.017
CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	0.017
SMCR7	Smith-Magenis syndrome chromosome region, candidate 7	0.017
LTBP2	latent transforming growth factor beta binding protein 2	0.017
APAF1	apoptotic peptidase activating factor 1	0.017
LRRN3	leucine rich repeat neuronal 3	0.017
CDKAL1	CDK5 regulatory subunit associated protein 1-like 1	0.016
COL21A1	collagen, type XXI, alpha 1	0.016
ERP27	endoplasmic reticulum protein 27	0.016
ANGPTL2	angiopoietin-like 2	0.016
LAMA2	laminin, alpha 2	0.016
STC1	stanniocalcin 1	0.016
GKAP1	G kinase anchoring protein 1	0.016
PLXDC1	plexin domain containing 1	0.016
PALM	paralemmin	0.016
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.016
HOXD10	homeobox D10	0.016
PTPRG	protein tyrosine phosphatase, receptor type, G	0.015
GPC3	glypican 3	0.015
SCG2	secretogranin II	0.015
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.015
TGFB3	transforming growth factor, beta 3	0.015
PGM5	phosphoglucomutase 5	0.015
CXCL3	chemokine (C-X-C motif) ligand 3	0.015
CCDC21	coiled-coil domain containing 21	0.015
SPON1	spondin 1, extracellular matrix protein	0.015
LYVE1	lymphatic vessel endothelial hyaluronan receptor 1	0.015
S100A2	S100 calcium binding protein A2	0.015
ADAM33	ADAM metallopeptidase domain 33	0.015
GAP43	growth associated protein 43	0.014
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.014
MSC	musculin	0.014
LPPR4	lipid phosphate phosphatase-related protein type 4	0.014
GFPT2	glutamine-fructose-6-phosphate transaminase 2	0.014
COL6A1	collagen, type VI, alpha 1	0.014
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.014
TFPI2	tissue factor pathway inhibitor 2	0.014
CORIN	corin, serine peptidase	0.014
TRPC6	transient receptor potential cation channel, subfamily C, member 6	0.014
EFCAB4B	EF-hand calcium binding domain 4B	0.014
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.014
EMCN	endomucin	0.014
SPAG8	sperm associated antigen 8	0.014
C20orf103	chromosome 20 open reading frame 103	0.013
C4orf31	chromosome 4 open reading frame 31	0.013
MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	0.013
CLSTN2	calsyntenin 2	0.013
HES1	hairy and enhancer of split 1, (Drosophila)	0.013
JAG2	jagged 2	0.013
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.013
COL5A1	collagen, type V, alpha 1	0.013
ASPN	asporin	0.013
GLT8D2	glycosyltransferase 8 domain containing 2	0.013
CNIH3	cornichon homolog 3 (Drosophila)	0.013
PDGFD	platelet derived growth factor D	0.013
DOC2B	double C2-like domains, beta	0.013
PTPRD	protein tyrosine phosphatase, receptor type, D	0.013
USF1	upstream transcription factor 1	0.013
GTF2I	general transcription factor IIi	0.013
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.013
PRELP	proline/arginine-rich end leucine-rich repeat protein	0.013
SEMA3G	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	0.013
STAC	SH3 and cysteine rich domain	0.013
CCL7	chemokine (C-C motif) ligand 7	0.013
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.012
COL11A1	collagen, type XI, alpha 1	0.012
ZFHX4	zinc finger homeobox 4	0.012
C1QTNF1	C1q and tumor necrosis factor related protein 1	0.012
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.012
TRO	trophinin	0.012
CD248	CD248 molecule, endosialin	0.012
PRR3	proline rich 3	0.012
RGS5	regulator of G-protein signaling 5	0.012
SLC16A7	solute carrier family 16, member 7 (monocarboxylic acid transporter 2)	0.012
DARC	Duffy blood group, chemokine receptor	0.012
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.012
LRRC32	leucine rich repeat containing 32	0.012
TRIP6	thyroid hormone receptor interactor 6	0.012
S100A3	S100 calcium binding protein A3	0.012
PTX3	pentraxin 3, long	0.012
PAMR1	peptidase domain containing associated with muscle regeneration 1	0.012
PLAT	plasminogen activator, tissue	0.012
ECM2	extracellular matrix protein 2, female organ and adipocyte specific	0.012
PLN	phospholamban	0.012
LIMS2	LIM and senescent cell antigen-like domains 2	0.012
PTGFR	prostaglandin F receptor (FP)	0.012
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	0.012
FGF3	fibroblast growth factor 3	0.012
PCDH18	protocadherin 18	0.012
OPCML	opioid binding protein/cell adhesion molecule-like	0.012
RERGL	RERG/RAS-like	0.012
DGKI	diacylglycerol kinase, iota	0.012
ITPRIPL1	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	0.012
MFAP5	microfibrillar associated protein 5	0.011
CST1	cystatin SN	0.011
UTP20	UTP20, small subunit (SSU) processome component, homolog (yeast)	0.011
SSTR2	somatostatin receptor 2	0.011
TCF4	transcription factor 4	0.011
MEOX1	mesenchyme homeobox 1	0.011
STEAP4	STEAP family member 4	0.011
FBN2	fibrillin 2	0.011
GUCY1A2	guanylate cyclase 1, soluble, alpha 2	0.011
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.011	Rat
COLEC12	collectin sub-family member 12	0.011
PDE1A	phosphodiesterase 1A, calmodulin-dependent	0.011
RBP4	retinol binding protein 4, plasma	0.011
ISLR	immunoglobulin superfamily containing leucine-rich repeat	0.011
TMEM158	transmembrane protein 158 (gene/pseudogene)	0.011
BCL2	B-cell CLL/lymphoma 2	0.011
MOCS3	molybdenum cofactor synthesis 3	0.011
SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	0.011
WNT3	wingless-type MMTV integration site family, member 3	0.011
ADAMTS3	ADAM metallopeptidase with thrombospondin type 1 motif, 3	0.011
CCDC3	coiled-coil domain containing 3	0.011
PLA2G5	phospholipase A2, group V	0.011
SEMA7A	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	0.011
NOVA2	neuro-oncological ventral antigen 2	0.011
TMSB4Y	thymosin beta 4, Y-linked	0.011
CTSG	cathepsin G	0.011
GNB5	guanine nucleotide binding protein (G protein), beta 5	0.011
BAIAP2	BAI1-associated protein 2	0.011
MARCO	macrophage receptor with collagenous structure	0.011
RASSF9	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	0.011
OLFML3	olfactomedin-like 3	0.011
PLVAP	plasmalemma vesicle associated protein	0.011
BDKRB1	bradykinin receptor B1	0.011
PDE3A	phosphodiesterase 3A, cGMP-inhibited	0.011
CXCL14	chemokine (C-X-C motif) ligand 14	0.011
BOC	Boc homolog (mouse)	0.011
CALCRL	calcitonin receptor-like	0.010
GPX7	glutathione peroxidase 7	0.010
WNT2B	wingless-type MMTV integration site family, member 2B	0.010
ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6	0.010
ENPEP	glutamyl aminopeptidase (aminopeptidase A)	0.010
C7	complement component 7	0.010
IL1RL1	interleukin 1 receptor-like 1	0.010
CHRNA5	cholinergic receptor, nicotinic, alpha 5	0.010
MED25	mediator complex subunit 25	0.010
ZNF385D	zinc finger protein 385D	0.010
PICK1	protein interacting with PRKCA 1	0.010
NACAD	NAC alpha domain containing	0.010
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.010
GSTT1	glutathione S-transferase theta 1	0.010