IMP

Process View

Homo sapiens

1 genes annotated in human

foramen ovale closure

The morphogenetic process in which the foramen ovale closes after birth, to prevent blood flow between the right and left atria. In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. Closure of the foramen ovale after birth stops this blood flow.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "foramen ovale closure"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "foramen ovale closure" (in gray)

Name	Description	Probability	Func Analog Organism
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	1.000
GATA4	GATA binding protein 4	0.985
TBX5	T-box 5	0.594	Human
PRF1	perforin 1 (pore forming protein)	0.428
ACAN	aggrecan	0.228
HOXD12	homeobox D12	0.159
CXCR3	chemokine (C-X-C motif) receptor 3	0.115
MSX1	msh homeobox 1	0.113
TBX1	T-box 1	0.098	Human
KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	0.089
GATA5	GATA binding protein 5	0.082
CXCR6	chemokine (C-X-C motif) receptor 6	0.068
GJC2	gap junction protein, gamma 2, 47kDa	0.048
HOXC11	homeobox C11	0.046
LTK	leukocyte receptor tyrosine kinase	0.036
SIM2	single-minded homolog 2 (Drosophila)	0.035
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.035
MAPK4	mitogen-activated protein kinase 4	0.034
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.034
DLL4	delta-like 4 (Drosophila)	0.032
SIX2	SIX homeobox 2	0.032
GATA3	GATA binding protein 3	0.031
FOXF1	forkhead box F1	0.031
FOXD2	forkhead box D2	0.029
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.029
IL12RB1	interleukin 12 receptor, beta 1	0.029
IRX5	iroquois homeobox 5	0.028
HOXB13	homeobox B13	0.027
CD160	CD160 molecule	0.027
COL2A1	collagen, type II, alpha 1	0.027
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.027
FASLG	Fas ligand (TNF superfamily, member 6)	0.027
PYY	peptide YY	0.026
PAX9	paired box 9	0.026
MYH8	myosin, heavy chain 8, skeletal muscle, perinatal	0.026
CD7	CD7 molecule	0.025
MYF6	myogenic factor 6 (herculin)	0.025
HOXD9	homeobox D9	0.025
HOXD11	homeobox D11	0.024
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.024
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.023
DLX4	distal-less homeobox 4	0.023
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.023
KLHL35	kelch-like 35 (Drosophila)	0.023
SOX1	SRY (sex determining region Y)-box 1	0.023
MYH6	myosin, heavy chain 6, cardiac muscle, alpha	0.022
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.022
FAM46A	family with sequence similarity 46, member A	0.022
BANP	BTG3 associated nuclear protein	0.022
ZNF80	zinc finger protein 80	0.022
PML	promyelocytic leukemia	0.021
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.021
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.021
EMX1	empty spiracles homeobox 1	0.021
XCL2	chemokine (C motif) ligand 2	0.020
CNTFR	ciliary neurotrophic factor receptor	0.020
HOXA11	homeobox A11	0.020
NELL1	NEL-like 1 (chicken)	0.020
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.020
ITIH3	inter-alpha (globulin) inhibitor H3	0.020
MMD2	monocyte to macrophage differentiation-associated 2	0.019
OCA2	oculocutaneous albinism II	0.019
ATOH8	atonal homolog 8 (Drosophila)	0.019
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.019
CHRNG	cholinergic receptor, nicotinic, gamma	0.019
FOXF2	forkhead box F2	0.019
PTGDR	prostaglandin D2 receptor (DP)	0.018
HOXD3	homeobox D3	0.018
WNT1	wingless-type MMTV integration site family, member 1	0.018
HTR1E	5-hydroxytryptamine (serotonin) receptor 1E	0.017
ATP8B3	ATPase, aminophospholipid transporter, class I, type 8B, member 3	0.017
TXK	TXK tyrosine kinase	0.017
GPA33	glycoprotein A33 (transmembrane)	0.017
SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	0.017
PHOX2B	paired-like homeobox 2b	0.017
TRPM1	transient receptor potential cation channel, subfamily M, member 1	0.017
NPTX1	neuronal pentraxin I	0.017
BGLAP	bone gamma-carboxyglutamate (gla) protein	0.017
CSPG4	chondroitin sulfate proteoglycan 4	0.017
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.016
FGF3	fibroblast growth factor 3	0.016
EN2	engrailed homeobox 2	0.016
LDB3	LIM domain binding 3	0.016
SKAP1	src kinase associated phosphoprotein 1	0.016
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.016
CD101	CD101 molecule	0.016
DMRT3	doublesex and mab-3 related transcription factor 3	0.016
TGM5	transglutaminase 5	0.015
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.015
PHOX2A	paired-like homeobox 2a	0.015
PFDN1	prefoldin subunit 1	0.015
NKD2	naked cuticle homolog 2 (Drosophila)	0.015
IFNG	interferon, gamma	0.015
MAPK7	mitogen-activated protein kinase 7	0.015
CALCA	calcitonin-related polypeptide alpha	0.015
PAX3	paired box 3	0.015
PLEKHA4	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	0.015
EOMES	eomesodermin	0.014	Human
LBX1	ladybird homeobox 1	0.014
IGHMBP2	immunoglobulin mu binding protein 2	0.014
SIX3	SIX homeobox 3	0.014
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.014
PPP1R12C	protein phosphatase 1, regulatory (inhibitor) subunit 12C	0.014
FOXL1	forkhead box L1	0.014
ZACN	zinc activated ligand-gated ion channel	0.014
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.014
HOXA2	homeobox A2	0.014
LMO1	LIM domain only 1 (rhombotin 1)	0.014
OAF	OAF homolog (Drosophila)	0.014
HOXC5	homeobox C5	0.014
KIR3DS1	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	0.014
NKX3-2	NK3 homeobox 2	0.014
GABRB2	gamma-aminobutyric acid (GABA) A receptor, beta 2	0.014
B4GALNT1	beta-1,4-N-acetyl-galactosaminyl transferase 1	0.014
POU4F2	POU class 4 homeobox 2	0.014
PAX2	paired box 2	0.014
SSTR5	somatostatin receptor 5	0.014
CD6	CD6 molecule	0.014
TBX21	T-box 21	0.014	Human
POU3F1	POU class 3 homeobox 1	0.013
NOVA2	neuro-oncological ventral antigen 2	0.013
COL13A1	collagen, type XIII, alpha 1	0.013
GCM2	glial cells missing homolog 2 (Drosophila)	0.013
PKNOX2	PBX/knotted 1 homeobox 2	0.013
BNC1	basonuclin 1	0.013
DGKQ	diacylglycerol kinase, theta 110kDa	0.013
TCHH	trichohyalin	0.013
C1orf94	chromosome 1 open reading frame 94	0.013
PRAC	prostate cancer susceptibility candidate	0.013
NGB	neuroglobin	0.013
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.013
SEMG2	semenogelin II	0.013
PLA2G5	phospholipase A2, group V	0.013
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.013
PRDM13	PR domain containing 13	0.013
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.013
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.013
GFI1	growth factor independent 1 transcription repressor	0.013
VAX2	ventral anterior homeobox 2	0.013
BFSP2	beaded filament structural protein 2, phakinin	0.013
FLT4	fms-related tyrosine kinase 4	0.013
TLX1	T-cell leukemia homeobox 1	0.013
NKX2-8	NK2 homeobox 8	0.013
SCUBE3	signal peptide, CUB domain, EGF-like 3	0.013
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.013
EVX1	even-skipped homeobox 1	0.013
MXRA8	matrix-remodelling associated 8	0.013
NEUROD2	neurogenic differentiation 2	0.012
MCAM	melanoma cell adhesion molecule	0.012
TSKS	testis-specific serine kinase substrate	0.012
MEOX2	mesenchyme homeobox 2	0.012
PRPH	peripherin	0.012
HOXC10	homeobox C10	0.012
IL2RB	interleukin 2 receptor, beta	0.012
NCR3	natural cytotoxicity triggering receptor 3	0.012
STMN2	stathmin-like 2	0.012
MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	0.012
DCC	deleted in colorectal carcinoma	0.012
FOXL2	forkhead box L2	0.012
SIX1	SIX homeobox 1	0.012
PITX2	paired-like homeodomain 2	0.012
ALX4	ALX homeobox 4	0.012
HOXB8	homeobox B8	0.012
HOXA3	homeobox A3	0.012
POU6F1	POU class 6 homeobox 1	0.012
OTOP2	otopetrin 2	0.012
KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.012
SHOX2	short stature homeobox 2	0.012
ICOS	inducible T-cell co-stimulator	0.012
SLAMF6	SLAM family member 6	0.012
GNAT1	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	0.012
HOXC8	homeobox C8	0.012
IL12RB2	interleukin 12 receptor, beta 2	0.012
CDX2	caudal type homeobox 2	0.012
HTRA3	HtrA serine peptidase 3	0.012
KCNIP2	Kv channel interacting protein 2	0.012
SIM1	single-minded homolog 1 (Drosophila)	0.012
HBE1	hemoglobin, epsilon 1	0.011
GH2	growth hormone 2	0.011
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.011
HOXC4	homeobox C4	0.011
ALOX15	arachidonate 15-lipoxygenase	0.011
EBF4	early B-cell factor 4	0.011
AFF2	AF4/FMR2 family, member 2	0.011
GPR1	G protein-coupled receptor 1	0.011
IRX4	iroquois homeobox 4	0.011
KDM5D	lysine (K)-specific demethylase 5D	0.011
CDKL1	cyclin-dependent kinase-like 1 (CDC2-related kinase)	0.011
CLCF1	cardiotrophin-like cytokine factor 1	0.011
LAMB4	laminin, beta 4	0.011
KCNK13	potassium channel, subfamily K, member 13	0.011
SPTB	spectrin, beta, erythrocytic	0.011
TIGIT	T cell immunoreceptor with Ig and ITIM domains	0.011
SFTPC	surfactant protein C	0.011
ADRA1A	adrenergic, alpha-1A-, receptor	0.011
KLRC4	killer cell lectin-like receptor subfamily C, member 4	0.011
SLCO2A1	solute carrier organic anion transporter family, member 2A1	0.011
DGKG	diacylglycerol kinase, gamma 90kDa	0.011
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.011
CHRDL2	chordin-like 2	0.011
HOXD13	homeobox D13	0.011
KCNC4	potassium voltage-gated channel, Shaw-related subfamily, member 4	0.011
LHX3	LIM homeobox 3	0.011
SRPK3	SRSF protein kinase 3	0.011
CORIN	corin, serine peptidase	0.011
PDE3A	phosphodiesterase 3A, cGMP-inhibited	0.011
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.011
CHODL	chondrolectin	0.011
RGS9	regulator of G-protein signaling 9	0.011
GSTT1	glutathione S-transferase theta 1	0.011
CPNE5	copine V	0.010
GPR15	G protein-coupled receptor 15	0.010
UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	0.010
GPR101	G protein-coupled receptor 101	0.010
NT5C1A	5'-nucleotidase, cytosolic IA	0.010
GATA2	GATA binding protein 2	0.010
POU4F1	POU class 4 homeobox 1	0.010
SIT1	signaling threshold regulating transmembrane adaptor 1	0.010
TMSB4Y	thymosin beta 4, Y-linked	0.010
BFSP1	beaded filament structural protein 1, filensin	0.010
EDDM3A	epididymal protein 3A	0.010
EXOC3L2	exocyst complex component 3-like 2	0.010
TRPC3	transient receptor potential cation channel, subfamily C, member 3	0.010
RAB33A	RAB33A, member RAS oncogene family	0.010
BTN1A1	butyrophilin, subfamily 1, member A1	0.010
NR2F1	nuclear receptor subfamily 2, group F, member 1	0.010
SLAMF7	SLAM family member 7	0.010
HOXD1	homeobox D1	0.010