IMP

Process View

Homo sapiens

22 genes annotated in human

negative regulation of lipid biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of lipid biosynthetic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of lipid biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.802	Human
HNF4A	hepatocyte nuclear factor 4, alpha	0.780
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.758
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.662
AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	0.657	Human
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.492
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.462
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.425	Human
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.399	Human
BMPR1A	bone morphogenetic protein receptor, type IA	0.377
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.361
APOA1	apolipoprotein A-I	0.279	Human
NCOR2	nuclear receptor corepressor 2	0.244
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.220	Human
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.177
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.172
BCL3	B-cell CLL/lymphoma 3	0.165
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.148
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.138	Human
VEGFA	vascular endothelial growth factor A	0.136	Human
NRP1	neuropilin 1	0.086
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.083
HP	haptoglobin	0.080
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.075
APOC1	apolipoprotein C-I	0.068
APOE	apolipoprotein E	0.066
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.064
ALB	albumin	0.057
BMPR1B	bone morphogenetic protein receptor, type IB	0.057
LDLR	low density lipoprotein receptor	0.054
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.052
SREBF2	sterol regulatory element binding transcription factor 2	0.047
A2M	alpha-2-macroglobulin	0.047
RXRA	retinoid X receptor, alpha	0.044
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.042
KLB	klotho beta	0.039
NOG	noggin	0.034
HR	hairless homolog (mouse)	0.033
PRDX1	peroxiredoxin 1	0.030
RARA	retinoic acid receptor, alpha	0.028
ATF5	activating transcription factor 5	0.027
PGF	placental growth factor	0.024	Human
COL2A1	collagen, type II, alpha 1	0.022
APOC3	apolipoprotein C-III	0.021
NCOA1	nuclear receptor coactivator 1	0.021
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.021
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.021
APOA2	apolipoprotein A-II	0.020
FGF18	fibroblast growth factor 18	0.020
ZFYVE9	zinc finger, FYVE domain containing 9	0.019
TNIP2	TNFAIP3 interacting protein 2	0.019
ESRRG	estrogen-related receptor gamma	0.019
EP300	E1A binding protein p300	0.018
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.017
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.016
JAG2	jagged 2	0.015
APOC2	apolipoprotein C-II	0.015
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.015
COL6A1	collagen, type VI, alpha 1	0.014
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.014
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.014
WNT11	wingless-type MMTV integration site family, member 11	0.013	Human
FGA	fibrinogen alpha chain	0.013
SMAD9	SMAD family member 9	0.013
CCDC6	coiled-coil domain containing 6	0.013
EGR1	early growth response 1	0.013
LCAT	lecithin-cholesterol acyltransferase	0.013
NR5A2	nuclear receptor subfamily 5, group A, member 2	0.012
TNIP1	TNFAIP3 interacting protein 1	0.012
FGF4	fibroblast growth factor 4	0.012
PTPRB	protein tyrosine phosphatase, receptor type, B	0.012
CCNE1	cyclin E1	0.012
NOTCH1	notch 1	0.012
BTRC	beta-transducin repeat containing	0.012
CREBBP	CREB binding protein	0.012
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.011
BHLHE40	basic helix-loop-helix family, member e40	0.011
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.011
WIF1	WNT inhibitory factor 1	0.011
APOC4	apolipoprotein C-IV	0.011
FSTL1	follistatin-like 1	0.011
FBLN1	fibulin 1	0.011
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.011
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.010
ACAA1	acetyl-CoA acyltransferase 1	0.010
RRN3	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	0.010
RCOR1	REST corepressor 1	0.010
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.010