IMP
Process View
cerebellar purkinje cell layer development
The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
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Click on a gene's description to view its network relationships with genes known to be involved in "cerebellar purkinje cell layer development"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Pdia4 | protein disulfide isomerase family A, member 4 | 0.416 | ||
| Hsp90b1 | heat shock protein 90, beta, member 1 | 0.228 | ||
| Hsp90aa1 | heat shock protein 90, alpha (cytosolic), class A member 1 | 0.129 | ||
| Pdia6 | protein disulfide isomerase family A, member 6 | 0.101 | ||
| Dlgap3 | discs, large (Drosophila) homolog-associated protein 3 | 0.095 | ||
| Yars | tyrosyl-tRNA synthetase | 0.082 | ||
| Mgat3 | mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase | 0.081 | ||
| Sncb | synuclein, beta | 0.074 | ||
| Pdia3 | protein disulfide isomerase family A, member 3 | 0.072 | ||
| Tnr | tenascin R | 0.072 | ||
| Racgap1 | Rac GTPase-activating protein 1 | 0.068 | ||
| Dnajb11 | DnaJ (Hsp40) homolog, subfamily B, member 11 | 0.061 | ||
| Mpp3 | membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) | 0.060 | ||
| Gria4 | glutamate receptor, ionotrophic, AMPA 4 | 0.056 | ||
| Nrg2 | neuregulin 2 | 0.048 | ||
| Camk4 | calcium/calmodulin-dependent protein kinase IV | 0.045 | ||
| Hpcal4 | hippocalcin-like 4 | 0.041 | ||
| Creld2 | cysteine-rich with EGF-like domains 2 | 0.039 | ||
| Cckbr | cholecystokinin B receptor | 0.037 | ||
| Unc5a | unc-5 homolog A (C. elegans) | 0.037 | ||
| Grin2a | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.036 | ||
| Hsph1 | heat shock 105/110 protein 1 | 0.035 | ||
| Syt3 | synaptotagmin III | 0.032 | ||
| Camk2n2 | calcium/calmodulin-dependent protein kinase II inhibitor 2 | 0.030 | ||
| Rnf207 | ring finger protein 207 | 0.030 | ||
| Nfasc | neurofascin | 0.028 | ||
| Lin7b | lin-7 homolog b (C. elegans) | 0.028 | ||
| Kalrn | kalirin, RhoGEF kinase | 0.027 | ||
| Abp10 | annexin V-binding protein ABP-10 | 0.027 | ||
| Dpp6 | dipeptidylpeptidase 6 | 0.026 | ||
| Zfp382 | zinc finger protein 382 | 0.026 | ||
| Cdk1 | cyclin-dependent kinase 1 | 0.026 | ||
| Sh3gl2 | SH3-domain GRB2-like 2 | 0.026 | ||
| Lhx5 | LIM homeobox 5 | 0.025 | Mouse | |
| Gabrb3 | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 0.025 | ||
| Shisa7 | shisa homolog 7 (Xenopus laevis) | 0.024 | ||
| Armcx2 | armadillo repeat containing, X-linked 2 | 0.024 | ||
| Kcnc3 | potassium voltage gated channel, Shaw-related subfamily, member 3 | 0.024 | ||
| Amh | anti-Mullerian hormone | 0.024 | ||
| Atp2b3 | ATPase, Ca++ transporting, plasma membrane 3 | 0.023 | ||
| Cplx2 | complexin 2 | 0.023 | ||
| Grin1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.023 | ||
| Slc24a2 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 | 0.022 | ||
| Mcm6 | minichromosome maintenance complex component 6 | 0.021 | ||
| Hes3 | hairy and enhancer of split 3 (Drosophila) | 0.021 | ||
| Kifc1 | kinesin family member C1 | 0.021 | ||
| Gars | glycyl-tRNA synthetase | 0.021 | ||
| Sbp | spermine binding protein | 0.020 | ||
| B3gat1 | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | 0.020 | ||
| Ppp1r9a | protein phosphatase 1, regulatory (inhibitor) subunit 9A | 0.020 | ||
| Kcnj6 | potassium inwardly-rectifying channel, subfamily J, member 6 | 0.020 | ||
| Kcnip3 | Kv channel interacting protein 3, calsenilin | 0.020 | ||
| Rnf165 | ring finger protein 165 | 0.019 | ||
| Camk1g | calcium/calmodulin-dependent protein kinase IG | 0.019 | ||
| Faah | fatty acid amide hydrolase | 0.019 | ||
| Dnajc3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.019 | ||
| Gata3 | GATA binding protein 3 | 0.019 | ||
| Robo1 | roundabout homolog 1 (Drosophila) | 0.019 | ||
| Syt7 | synaptotagmin VII | 0.019 | ||
| Gjd2 | gap junction protein, delta 2 | 0.019 | ||
| Kcnd2 | potassium voltage-gated channel, Shal-related subfamily, member 2 | 0.019 | ||
| Foxa2 | forkhead box A2 | 0.019 | ||
| Spc25 | SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) | 0.018 | ||
| Gria1 | glutamate receptor, ionotropic, AMPA 1 | 0.018 | ||
| Pip4k2c | phosphatidylinositol-5-phosphate 4-kinase, type II, gamma | 0.018 | ||
| Pcsk2 | proprotein convertase subtilisin/kexin type 2 | 0.018 | ||
| Uso1 | USO1 homolog, vesicle docking protein (yeast) | 0.018 | ||
| Map1b | microtubule-associated protein 1B | 0.018 | ||
| Pola1 | polymerase (DNA directed), alpha 1 | 0.018 | ||
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.018 | ||
| Aurkb | aurora kinase B | 0.018 | ||
| Ryr2 | ryanodine receptor 2, cardiac | 0.017 | ||
| Dlg4 | discs, large homolog 4 (Drosophila) | 0.017 | ||
| Syt12 | synaptotagmin XII | 0.016 | ||
| Prp2l1 | proline rich protein 2-like 1 | 0.016 | ||
| Arnt2 | aryl hydrocarbon receptor nuclear translocator 2 | 0.016 | ||
| Kcnb1 | potassium voltage gated channel, Shab-related subfamily, member 1 | 0.016 | ||
| Rexo1 | REX1, RNA exonuclease 1 homolog (S. cerevisiae) | 0.016 | ||
| Chrm3 | cholinergic receptor, muscarinic 3 | 0.016 | ||
| Klk1c10 | T-kininogenase | 0.016 | ||
| Gabrb1 | gamma-aminobutyric acid (GABA) A receptor, beta 1 | 0.015 | ||
| Cntn1 | contactin 1 | 0.015 | ||
| Brca1 | breast cancer 1 | 0.015 | ||
| Fbxo23 | F-box only protein 23 | 0.015 | ||
| Pou6f1 | POU class 6 homeobox 1 | 0.015 | ||
| Gabbr2 | gamma-aminobutyric acid (GABA) B receptor 2 | 0.015 | ||
| Fam63b | family with sequence similarity 63, member B | 0.015 | ||
| Accn2 | amiloride-sensitive cation channel 2, neuronal | 0.015 | ||
| Cdk5r1 | cyclin-dependent kinase 5, regulatory subunit 1 | 0.015 | ||
| Tpo | thyroid peroxidase | 0.015 | ||
| Crhr1 | corticotropin releasing hormone receptor 1 | 0.014 | ||
| Rph3a | rabphilin 3A | 0.014 | ||
| Slc1a6 | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 | 0.014 | ||
| Ctnnd2 | catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) | 0.014 | ||
| Hrnbp3 | hexaribonucleotide binding protein 3 | 0.014 | ||
| Gna11 | guanine nucleotide binding protein, alpha 11 | 0.014 | ||
| Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 | 0.014 | Mouse | |
| Apc | adenomatous polyposis coli | 0.014 | ||
| Grm8 | glutamate receptor, metabotropic 8 | 0.014 | ||
| Sptbn4 | spectrin, beta, non-erythrocytic 4 | 0.013 | ||
| Pip4k2b | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | 0.013 | ||
| Chrm1 | cholinergic receptor, muscarinic 1 | 0.013 | ||
| Ccne1 | cyclin E1 | 0.013 | ||
| Slc17a7 | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 | 0.013 | ||
| Slit1 | slit homolog 1 (Drosophila) | 0.013 | ||
| Foxm1 | forkhead box M1 | 0.013 | ||
| Ccnb1 | cyclin B1 | 0.013 | ||
| Col9a1 | collagen, type IX, alpha 1 | 0.013 | ||
| Cryga | crystallin, gamma A | 0.013 | ||
| Lin7a | lin-7 homolog a (C. elegans) | 0.013 | ||
| Aqp4 | aquaporin 4 | 0.012 | ||
| Cdc20 | cell division cycle 20 homolog (S. cerevisiae) | 0.012 | ||
| Alcam | activated leukocyte cell adhesion molecule | 0.012 | ||
| Kcnc2 | potassium voltage gated channel, Shaw-related subfamily, member 2 | 0.012 | ||
| Kcnt1 | potassium channel, subfamily T, member 1 | 0.012 | ||
| Camk2a | calcium/calmodulin-dependent protein kinase II alpha | 0.012 | ||
| Akap14 | A kinase (PRKA) anchor protein 14 | 0.012 | ||
| Camk2b | calcium/calmodulin-dependent protein kinase II beta | 0.012 | ||
| Psd | pleckstrin and Sec7 domain containing | 0.012 | ||
| Dck | deoxycytidine kinase | 0.012 | ||
| Cenpi | centromere protein I | 0.012 | ||
| Hspd1 | heat shock protein 1 (chaperonin) | 0.012 | ||
| Astn1 | astrotactin 1 | 0.012 | ||
| Cacna1d | calcium channel, voltage-dependent, L type, alpha 1D subunit | 0.012 | ||
| Dnaja1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.012 | ||
| Foxd4 | forkhead box D4 | 0.012 | ||
| Cltc | clathrin, heavy chain (Hc) | 0.012 | ||
| Plk4 | polo-like kinase 4 (Drosophila) | 0.012 | ||
| Ckmt1 | creatine kinase, mitochondrial 1 | 0.012 | ||
| Mtmr9 | myotubularin related protein 9 | 0.012 | ||
| Cntfr | ciliary neurotrophic factor receptor | 0.012 | ||
| Hrk | harakiri, BCL2 interacting protein (contains only BH3 domain) | 0.011 | ||
| Rab3c | RAB3C, member RAS oncogene family | 0.011 | ||
| Znf536 | zinc finger protein 536 | 0.011 | ||
| Rem2 | RAS (RAD and GEM) like GTP binding 2 | 0.011 | ||
| Kcnn2 | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 | 0.011 | ||
| Syn1 | synapsin I | 0.011 | ||
| Matk | megakaryocyte-associated tyrosine kinase | 0.011 | ||
| Nrxn1 | neurexin 1 | 0.011 | ||
| Mki67 | antigen identified by monoclonal antibody Ki-67 | 0.011 | ||
| Barhl2 | BarH-like homeobox 2 | 0.011 | ||
| Insrr | insulin receptor-related receptor | 0.011 | ||
| Trpc4 | transient receptor potential cation channel, subfamily C, member 4 | 0.011 | ||
| Chga | chromogranin A | 0.011 | ||
| Robo2 | roundabout homolog 2 (Drosophila) | 0.011 | ||
| Fam57b | family with sequence similarity 57, member B | 0.011 | ||
| Cdh22 | cadherin 22 | 0.011 | ||
| Zfp94 | zinc finger protein 94 | 0.011 | ||
| B4galnt1 | beta-1,4-N-acetyl-galactosaminyl transferase 1 | 0.011 | ||
| Manf | mesencephalic astrocyte-derived neurotrophic factor | 0.011 | ||
| RGD1560171 | similar to PRO0149 protein | 0.011 | ||
| Iqsec3 | IQ motif and Sec7 domain 3 | 0.010 | ||
| Kctd15 | potassium channel tetramerisation domain containing 15 | 0.010 | ||
| Lphn3 | latrophilin 3 | 0.010 | ||
| Dlgap5 | discs, large (Drosophila) homolog-associated protein 5 | 0.010 | ||
| Abat | 4-aminobutyrate aminotransferase | 0.010 | ||
| Sel1l | sel-1 suppressor of lin-12-like (C. elegans) | 0.010 | ||
| Map6 | microtubule-associated protein 6 | 0.010 | ||
| Supt5h | suppressor of Ty 5 homolog (S. cerevisiae) | 0.010 | ||
| Sipa1l1 | signal-induced proliferation-associated 1 like 1 | 0.010 | ||
| Mcf2l | MCF.2 cell line derived transforming sequence-like | 0.010 | ||
| Adap1 | ArfGAP with dual PH domains 1 | 0.010 | ||
| Fgd4 | FYVE, RhoGEF and PH domain containing 4 | 0.010 | ||
| Spag5 | sperm associated antigen 5 | 0.010 | ||
| Foxi2 | forkhead box I2 | 0.010 | ||
| Camkk2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | 0.010 | ||
| Clcn2 | chloride channel 2 | 0.010 | ||
| Ncam1 | neural cell adhesion molecule 1 | 0.010 | ||
| Grm5 | glutamate receptor, metabotropic 5 | 0.010 | ||
| Rtn4r | reticulon 4 receptor | 0.010 |