IMP

Process View

Danio rerio

2 genes annotated in zebrafish

negative regulation of wnt signaling pathway involved in heart development

Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of wnt signaling pathway involved in heart development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of wnt signaling pathway involved in heart development" (in gray)

Name	Description	Probability	Func Analog Organism
mespa	mesoderm posterior a	0.878	Mouse
tbx16	T-box gene 16	0.751
wnt5b	wingless-type MMTV integration site family, member 5b	0.704
pcdh8	protocadherin 8	0.612
eve1	even-skipped-like1	0.508
her7	hairy and enhancer of split related-7	0.475
tbx6	T-box gene 6	0.469
admp	anti-dorsalizing morphogenic protein	0.432
chd	chordin	0.427
flh	floating head	0.370
lft2	lefty2	0.361
bmp4	bone morphogenetic protein 4	0.361
sox17	SRY-box containing gene 17	0.311	Mouse
tbx24	T-box 24	0.276
msxc	muscle segment homeobox C	0.268
has2	hyaluronan synthase 2	0.219
her1	hairy-related 1	0.213
her5	hairy-related 5	0.208
dlx3b	distal-less homeobox gene 3b	0.199
foxd5	forkhead box D5	0.184
lft1	lefty1	0.150
dkk1b	dickkopf 1b	0.137	Mouse
fn1	fibronectin 1	0.124
gata5	GATA-binding protein 5	0.120
ved	ventrally expressed dharma/bozozok antagonist	0.116
cdx4	caudal type homeo box transcription factor 4	0.111
tll1	tolloid-like 1	0.100
foxa3	forkhead box A3	0.097
vent	ventral expressed homeobox	0.090
sox32	SRY-box containing gene 32	0.087	Mouse
pkd2	polycystic kidney disease 2	0.084
smo	smoothened homolog (Drosophila)	0.084
ndr2	nodal-related 2	0.079
spint1a	serine peptidase inhibitor, Kunitz type 1 a	0.075
foxi1	forkhead box I1	0.066
nog1	noggin 1	0.065
osr1	odd-skipped related 1 (Drosophila)	0.064
klf4	Kruppel-like factor 4	0.062
bmp7a	bone morphogenetic protein 7a	0.061
wnt11	wingless-type MMTV integration site family, member 11	0.053
msgn1	mesogenin 1	0.051
mespb	mesoderm posterior b	0.050	Mouse
bmp2b	bone morphogenetic protein 2b	0.050	Human
prickle1a	prickle-like 1 (Drosophila) a	0.050
fbn2b	fibrillin 2b	0.049
tp63	tumor protein p63	0.046
ntla	no tail a	0.043
hoxb1b	homeo box B1b	0.042
dld	deltaD	0.041
LOC100536023	hypothetical protein LOC100536023	0.041
vox	ventral homeobox	0.039
aplnra	apelin receptor a	0.036
snai1a	snail homolog 1a (Drosophila)	0.031
oep	one-eyed pinhead	0.031
fzd10	frizzled homolog 10	0.029
perp	PERP, TP53 apoptosis effector	0.029
cdx1a	caudal type homeo box transcription factor 1 a	0.027
mtp	microsomal triglyceride transfer protein	0.026
cdh1	cadherin 1, epithelial	0.026
acvr1b	activin A receptor, type IB	0.025
hnf1ba	HNF1 homeobox Ba	0.024
ndr1	nodal-related 1	0.023
cdh2	cadherin 2, neuronal	0.023
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.023
nrarpa	notch-regulated ankyrin repeat protein a	0.023
tagln2	transgelin 2	0.023
fgf8a	fibroblast growth factor 8 a	0.022
shhb	sonic hedgehog b	0.022
nkd1	naked cuticle homolog 1 (Drosophila)	0.021
drl	draculin	0.021
dharma	dharma	0.021
hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.020
gata4	GATA-binding protein 4	0.018
sesn1	sestrin 1	0.018
pnx	posterior neuron-specific homeobox	0.018
znfl2a	zinc finger-like gene 2a	0.017
her3	hairy-related 3	0.017
nkx2.5	NK2 transcription factor related 5	0.017
dspa	desmoplakin a	0.017
hoxc8a	homeo box C8a	0.017
mesp2	mesoderm posterior 2 homolog (mouse)	0.017
six4a	sine oculis homeobox homolog 4a	0.017
bon	bonnie and clyde	0.016
aplnrb	apelin receptor b	0.015
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.015
sp5l	Sp5 transcription factor-like	0.015
gli1	GLI-Kruppel family member 1	0.015
tbx1	T-box 1	0.014
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.014
szl	sizzled	0.014
sp7	Sp7 transcription factor	0.014
snai1b	snail homolog 1b (Drosophila)	0.014
bmp2a	bone morphogenetic protein 2a	0.014	Human
myf5	myogenic factor 5	0.014
gpc4	glypican 4	0.013
lamb1a	laminin, beta 1a	0.013
og9x	OG9 homeobox gene	0.012
krt8	keratin 8	0.012
nkx2.7	NK2 transcription factor related 7	0.012
im:7138239	im:7138239	0.012
wnt10a	wingless-type MMTV integration site family, member 10a	0.012
apoeb	apolipoprotein Eb	0.012
hhex	hematopoietically expressed homeobox	0.012
sparc	secreted acidic cysteine rich glycoprotein	0.012
ppl	periplakin	0.011
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.011
spry4	sprouty (Drosophila) homolog 4	0.011
dlx4b	distal-less homeobox gene 4b	0.011
myod1	myogenic differentiation 1	0.011
zgc:171426	zgc:171426	0.011
ihha	Indian hedgehog homolog a	0.011
six4b	sine oculis homeobox homolog 4b	0.011
zgc:85975	zgc:85975	0.010
krt4	keratin 4	0.010
spry2	sprouty homolog 2	0.010