The network for 'activation of protein kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation of protein kinase activity

Any process that initiates the activity of an inactive protein kinase.

Drosophila melanogaster
Name Description Probability Func Analog Organism
rl rolled 0.928
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.834
Dad Daughters against dpp 0.781
kay kayak 0.739
phl pole hole 0.736
ttk tramtrack 0.486
hep hemipterous 0.401
rictor rapamycin-insensitive companion of Tor 0.374
Fhos CG42610 gene product from transcript CG42610-RC 0.352
bsk basket 0.319
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.306
aop anterior open 0.298
Atg1 Autophagy-specific gene 1 0.275
Akt1 CG4006 gene product from transcript CG4006-RA 0.242
Ras85D Ras oncogene at 85D 0.232
chico CG5686 gene product from transcript CG5686-RB 0.221
babo baboon 0.211
Mad Mothers against dpp 0.202
par-1 CG8201 gene product from transcript CG8201-RA 0.190
Egfr Epidermal growth factor receptor 0.158
Jra Jun-related antigen 0.157
dia diaphanous 0.128
Sara Smad anchor for receptor activation 0.124
InR Insulin-like receptor 0.117
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.105
spas spastin 0.100
Smox Smad on X 0.094
Smg1 CG32743 gene product from transcript CG32743-RA 0.093
Src42A Src oncogene at 42A 0.093
Tl Toll 0.093
Gap1 GTPase-activating protein 1 0.091
puc puckered 0.089
Alk CG8250 gene product from transcript CG8250-RA 0.086
pan pangolin 0.085
htl heartless 0.083
Plc21C Phospholipase C at 21C 0.083
Dab Disabled 0.081
S6k RPS6-p70-protein kinase 0.080
Pkn Protein kinase related to protein kinase N 0.079
sd scalloped 0.077
CG31048 CG31048 gene product from transcript CG31048-RB 0.077
drpr draper 0.075
sr stripe 0.075
dm diminutive 0.074
caz cabeza 0.074
spi spitz 0.070
sev sevenless 0.067
Pk61C Protein kinase 61C 0.065
ftz-f1 ftz transcription factor 1 0.065
Atf-2 Activating transcription factor-2 0.064
btl breathless 0.063
Su(H) Suppressor of Hairless 0.062
rok Rho-kinase 0.056
Cdc42 CG12530 gene product from transcript CG12530-RA 0.054
kug kugelei 0.052
bnl branchless 0.049
cbs centrosomin's beautiful sister 0.045
CG1347 CG1347 gene product from transcript CG1347-RB 0.045
sty sprouty 0.042
wun wunen 0.040
Dcr-2 Dicer-2 0.039
CG5794 CG5794 gene product from transcript CG5794-RB 0.038
Tao-1 CG14217 gene product from transcript CG14217-RF 0.037
mys myospheroid 0.036
Cbl CG7037 gene product from transcript CG7037-RB 0.036
sax saxophone 0.035
numb CG3779 gene product from transcript CG3779-RB 0.034
Abl Abl tyrosine kinase 0.033
zfh1 Zn finger homeodomain 1 0.033
ex expanded 0.032
scb scab 0.032
Pten CG5671 gene product from transcript CG5671-RB 0.032
Rac2 CG8556 gene product from transcript CG8556-RA 0.032
Hs6st Heparan sulfate 6-O-sulfotransferase 0.032
slpr slipper 0.031
rho rhomboid 0.031
trio CG18214 gene product from transcript CG18214-RA 0.031
Eip71CD Ecdysone-induced protein 28/29kD 0.031
Dip3 Dorsal interacting protein 3 0.030
lqf liquid facets 0.029
yki yorkie 0.028
baz bazooka 0.028
Lar Leukocyte-antigen-related-like 0.028
insc inscuteable 0.028
Stat92E Signal-transducer and activator of transcription protein at 92E 0.027
mask multiple ankyrin repeats single KH domain 0.026
dys dysfusion 0.026
Lk6 CG17342 gene product from transcript CG17342-RA 0.026
ninaE neither inactivation nor afterpotential E 0.026
Mrtf Myocardin-related transcription factor 0.026
drongo CG3365 gene product from transcript CG3365-RH 0.025
daw dawdle 0.025
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.025
trpl trp-like 0.025
mbc myoblast city 0.024
pyr pyramus 0.024
Mmp1 Matrix metalloproteinase 1 0.024
mew multiple edematous wings 0.024
myoglianin CG1838 gene product from transcript CG1838-RD 0.023
jeb jelly belly 0.023
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
mpk-1 Protein MPK-1 0.107
bar-1 Protein BAR-1 0.071
let-60 Protein LET-60 0.053
zfp-3 Protein ZFP-3 0.053
unc-10 Protein UNC-10 0.048
npp-7 Protein NPP-7 0.035
mlk-1 Protein MLK-1 0.029
cec-1 Protein CEC-1 0.028
daf-1 Protein DAF-1 0.027
mek-2 Protein MEK-2 0.026
meg-2 Protein MEG-2 0.024
nhr-34 Protein NHR-34 0.022
K10D6.4 Protein K10D6.4 0.021
nhr-6 Protein NHR-6 0.021
nhr-79 Protein NHR-79 0.020
K07C11.4 Protein K07C11.4 0.020
gsk-3 Protein GSK-3 0.018
tps-1 Protein TPS-1 0.018
sur-2 Protein SUR-2 0.018
clh-5 Protein CLH-5 0.018
nhr-65 Protein NHR-65 0.017
sax-7 Protein SAX-7 0.016
K08E3.5 Protein K08E3.5 0.016
CELE_Y57G11C.22 Protein Y57G11C.22 0.015
smf-3 Protein SMF-3 0.015
chd-7 Protein CHD-7 0.014
cst-1 Protein CST-1 0.014
pig-1 Protein PIG-1 0.014
cutl-24 Protein CUTL-24 0.014
mef-2 Protein MEF-2 0.014
zer-1 Protein ZER-1 0.014
dpy-22 Protein DPY-22 0.013
kal-1 Protein KAL-1 0.013
ist-1 Protein IST-1 0.012
C11E4.6 Protein C11E4.6 0.012
egl-18 Protein EGL-18 0.012
lin-59 Protein LIN-59 0.011
eor-2 Protein EOR-2 0.011
tmc-2 Protein TMC-2 0.011
smf-2 Protein SMF-2 0.011
abl-1 Protein ABL-1 0.011
K02A6.2 Protein K02A6.2 0.011
gsr-1 Protein GSR-1 0.010
unc-38 Protein UNC-38 0.010
amph-1 Protein AMPH-1 0.010
mpst-3 Protein MPST-3 0.010
ksr-1 Protein KSR-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.000
FGFR2 fibroblast growth factor receptor 2 0.999
TRAF6 TNF receptor-associated factor 6 0.999
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.999
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.999
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.999
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.998
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.998
FGF1 fibroblast growth factor 1 (acidic) 0.997
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.997
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.996
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.996
TGFB1 transforming growth factor, beta 1 0.995
IRAK2 interleukin-1 receptor-associated kinase 2 0.995
FGFR1 fibroblast growth factor receptor 1 0.994
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.993
IL1R1 interleukin 1 receptor, type I 0.993
CAV1 caveolin 1, caveolae protein, 22kDa 0.987
STK11 serine/threonine kinase 11 0.987
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.984
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.982
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.980
BCAR1 breast cancer anti-estrogen resistance 1 0.973
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.963
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.951
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.950
TOLLIP toll interacting protein 0.949
NRP1 neuropilin 1 0.942
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.939
MAPK14 mitogen-activated protein kinase 14 0.931
TEK TEK tyrosine kinase, endothelial 0.927
VEGFA vascular endothelial growth factor A 0.926
GRB2 growth factor receptor-bound protein 2 0.925
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.921
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.920
AXL AXL receptor tyrosine kinase 0.907
TRAF3 TNF receptor-associated factor 3 0.898
MAPK8 mitogen-activated protein kinase 8 0.898
PDPK1 3-phosphoinositide dependent protein kinase-1 0.898
MYD88 myeloid differentiation primary response gene (88) 0.898
GAB1 GRB2-associated binding protein 1 0.885
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.874
MET met proto-oncogene (hepatocyte growth factor receptor) 0.869
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.867
LRRK2 leucine-rich repeat kinase 2 0.856
BMPR1A bone morphogenetic protein receptor, type IA 0.853
PLCG1 phospholipase C, gamma 1 0.853
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.852
TRAF1 TNF receptor-associated factor 1 0.852
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.851
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.827
SH3KBP1 SH3-domain kinase binding protein 1 0.827
DLG1 discs, large homolog 1 (Drosophila) 0.813
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.808
IGF1R insulin-like growth factor 1 receptor 0.793
BIRC3 baculoviral IAP repeat containing 3 0.786
BBS10 Bardet-Biedl syndrome 10 0.777
FSTL1 follistatin-like 1 0.773
UBC ubiquitin C 0.741
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.736
MAPK1 mitogen-activated protein kinase 1 0.734
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.731
BIRC2 baculoviral IAP repeat containing 2 0.729
TGFB3 transforming growth factor, beta 3 0.725
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.709
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.708
MAP2K7 mitogen-activated protein kinase kinase 7 0.700
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.694
GRB7 growth factor receptor-bound protein 7 0.688
LAT linker for activation of T cells 0.685
GH1 growth hormone 1 0.685
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.673
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.672
JAK2 Janus kinase 2 0.671
ARAF v-raf murine sarcoma 3611 viral oncogene homolog 0.649
SOCS1 suppressor of cytokine signaling 1 0.645
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.641
PTPRB protein tyrosine phosphatase, receptor type, B 0.625
FKBP1A FK506 binding protein 1A, 12kDa 0.623
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.620
MPDZ multiple PDZ domain protein 0.612
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.590
BMP2 bone morphogenetic protein 2 0.578
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.571
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.562
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.559
SQSTM1 sequestosome 1 0.558
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.554
BCL10 B-cell CLL/lymphoma 10 0.544
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.540
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.534
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.534
FAS Fas (TNF receptor superfamily, member 6) 0.517
MAPK3 mitogen-activated protein kinase 3 0.508
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.500
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.487
CSNK1E casein kinase 1, epsilon 0.485
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.477
SMAD7 SMAD family member 7 0.476
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.260
Cd4 Cd4 molecule 0.161
Fgfr2 fibroblast growth factor receptor 2 0.156
RT1-Ba RT1 class II, locus Ba 0.141
Jak2 Janus kinase 2 0.133
RGD1564664 similar to LOC387763 protein 0.120
Pnlip pancreatic lipase 0.117
Tbx3 T-box 3 0.110
Glp1r glucagon-like peptide 1 receptor 0.109
Sirpa signal-regulatory protein alpha 0.102
Prph2 peripherin 2 0.097
Egfr epidermal growth factor receptor 0.094
Inpp5d inositol polyphosphate-5-phosphatase D 0.089
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.089
Tgfbr2 transforming growth factor, beta receptor II 0.087
Mprip myosin phosphatase Rho interacting protein 0.084
Irs1 insulin receptor substrate 1 0.080
Mpeg1 macrophage expressed 1 0.079
Grb2 growth factor receptor bound protein 2 0.074
Ptafr platelet-activating factor receptor 0.074
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.072
Ptpn7 protein tyrosine phosphatase, non-receptor type 7 0.071
Plau plasminogen activator, urokinase 0.070
Stat6 signal transducer and activator of transcription 6 0.070
Mapk1 mitogen activated protein kinase 1 0.069
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.068
Nrp1 neuropilin 1 0.067
Sox17 SRY (sex determining region Y)-box 17 0.067
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.063
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.063
Smad3 SMAD family member 3 0.062
Calcrl calcitonin receptor-like 0.062
Atp12a ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.061
Itgam integrin, alpha M 0.060
Olr1278 olfactory receptor 1278 0.060
Bcl2 B-cell CLL/lymphoma 2 0.059
Drd1a dopamine receptor D1A 0.059
Rorb RAR-related orphan receptor B 0.059
Jak1 Janus kinase 1 0.058
Bcan brevican 0.058
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.058
RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase 0.058
Usf2 upstream transcription factor 2, c-fos interacting 0.057
Sh2b3 SH2B adaptor protein 3 0.057
Fgfr1 Fibroblast growth factor receptor 1 0.056
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.055
Hoxb8 homeo box B8 0.055
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.054
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.054
Cdh17 cadherin 17 0.054
Cast calpastatin 0.054
Agtr1a angiotensin II receptor, type 1a 0.052
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.051
Calcr calcitonin receptor 0.051
Trhr thyrotropin releasing hormone receptor 0.051
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.051
Cd38 CD38 molecule 0.051
Oprk1 opioid receptor, kappa 1 0.051
Mapk9 mitogen-activated protein kinase 9 0.051
Tacr1 tachykinin receptor 1 0.050
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.050
Flt1 FMS-related tyrosine kinase 1 0.050
Phox2a paired-like homeobox 2a 0.049
Shox2 short stature homeobox 2 0.048
Nrp2 neuropilin 2 0.048
Notch1 Notch homolog 1, translocation-associated (Drosophila) 0.048
Grm7 glutamate receptor, metabotropic 7 0.047
Tgfb1 transforming growth factor, beta 1 0.047
Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 0.046
Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.046
Gabra5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.046
Prkcd protein kinase C, delta 0.045
Slc7a12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 0.045
Met met proto-oncogene 0.045
Pla2g2c phospholipase A2, group IIC 0.045
Gfra2 GDNF family receptor alpha 2 0.045
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.045
Slc5a7 solute carrier family 5 (choline transporter), member 7 0.044
Cntn3 contactin 3 (plasmacytoma associated) 0.044
Foxj1 forkhead box J1 0.043
Mmp10 matrix metallopeptidase 10 0.043
Ghrl ghrelin/obestatin prepropeptide 0.043
Gpr45 G protein-coupled receptor 45 0.043
Zfp382 zinc finger protein 382 0.043
Npy5r neuropeptide Y receptor Y5 0.042
Ccnd3 cyclin D3 0.042
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.041
Sypl2 synaptophysin-like 2 0.041
Dchs1 dachsous 1 (Drosophila) 0.041
Kcnf1 potassium voltage-gated channel, subfamily F, member 1 0.041
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.041
Cbl Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.041
Chrnb3 cholinergic receptor, nicotinic, beta 3 0.040
Pdgfb platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.040
C5ar1 complement component 5a receptor 1 0.040
Prx periaxin 0.040
Tgm1 transglutaminase 1, K polypeptide 0.040
Ciita class II, major histocompatibility complex, transactivator 0.039
Creb1 cAMP responsive element binding protein 1 0.039
Necab1 N-terminal EF-hand calcium binding protein 1 0.039
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
PBS2 Pbs2p 0.862
SSK2 Ssk2p 0.724
SSK1 Ssk1p 0.650
ROM2 Rom2p 0.161
SSK22 Ssk22p 0.128
MSG5 Msg5p 0.100
BCK1 Bck1p 0.099
STE5 Ste5p 0.086
BCK2 Bck2p 0.080
PKH1 Pkh1p 0.043
CDC55 Cdc55p 0.042
TUS1 Tus1p 0.036
BEM3 Bem3p 0.035
STE2 Ste2p 0.028
RGD2 Rgd2p 0.028
RGD1 Rgd1p 0.027
BNI1 Bni1p 0.026
SIP1 Sip1p 0.024
STE11 Ste11p 0.023
ZDS1 Zds1p 0.018
TRX2 Trx2p 0.017
GAL83 Gal83p 0.015
SRD1 Srd1p 0.014
ARP10 Arp10p 0.013
YMR086W hypothetical protein 0.013
FUS2 Fus2p 0.012
YLR162W hypothetical protein 0.012
SOG2 Sog2p 0.012
DBF2 Dbf2p 0.012
YJR085C hypothetical protein 0.011
YOL038C-A hypothetical protein 0.011
YLR264C-A hypothetical protein 0.011
YTA6 Yta6p 0.011
FUS3 Fus3p 0.011
YPR157W hypothetical protein 0.011
LEU2 Leu2p 0.010
ATG11 Atg11p 0.010
PKH3 Pkh3p 0.010
ATG14 Atg14p 0.010