The network for 'regulation of cellular response to insulin stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cellular response to insulin stimulus

Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus.

Drosophila melanogaster
Name Description Probability Func Analog Organism
InR Insulin-like receptor 0.740
Akt1 CG4006 gene product from transcript CG4006-RA 0.595
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.473
Pten CG5671 gene product from transcript CG5671-RB 0.390
Ide Insulin degrading metalloproteinase 0.303
dm diminutive 0.299
gig gigas 0.231
Pk61C Protein kinase 61C 0.204
chico CG5686 gene product from transcript CG5686-RB 0.187
kis kismet 0.182
RanBPM Ran-binding protein M 0.179
babo baboon 0.166
scyl scylla 0.150
Mad Mothers against dpp 0.147
S6k RPS6-p70-protein kinase 0.135
Ilp2 Insulin-like peptide 2 0.113
Lk6 CG17342 gene product from transcript CG17342-RA 0.107
Smox Smad on X 0.106
CG14815 CG14815 gene product from transcript CG14815-RA 0.093
path pathetic 0.087
CG8443 CG8443 gene product from transcript CG8443-RA 0.086
p38b CG7393 gene product from transcript CG7393-RA 0.075
Thor CG8846 gene product from transcript CG8846-RA 0.071
dco discs overgrown 0.069
pico CG11940 gene product from transcript CG11940-RA 0.069
Ilp6 Insulin-like peptide 6 0.065
foxo forkhead box, sub-group O 0.058
didum dilute class unconventional myosin 0.057
slmb supernumerary limbs 0.057
Sin3A CG8815 gene product from transcript CG8815-RC 0.054
MTF-1 Metal response element-binding Transcription Factor-1 0.052
rictor rapamycin-insensitive companion of Tor 0.050
Ork1 Open rectifier K[+] channel 1 0.048
CG17273 CG17273 gene product from transcript CG17273-RA 0.044
LIMK1 LIM-kinase1 0.044
Lnk CG17367 gene product from transcript CG17367-RC 0.043
Fatp Fatty acid (long chain) transport protein 0.042
HLH106 Helix loop helix protein 106 0.042
ttm50 tiny tim 50 0.032
bun bunched 0.032
Kap3 Kinesin associated protein 3 0.029
rl rolled 0.027
Atg8a Autophagy-specific gene 8a 0.026
TER94 CG2331 gene product from transcript CG2331-RA 0.026
Su(dx) Suppressor of deltex 0.026
klg klingon 0.026
Pdp1 PAR-domain protein 1 0.025
sNPF short neuropeptide F precursor 0.025
cher cheerio 0.024
CycG Cyclin G 0.023
Pp2B-14D Protein phosphatase 2B at 14D 0.023
blw bellwether 0.022
p53 CG33336 gene product from transcript CG33336-RB 0.022
Gadd45 CG11086 gene product from transcript CG11086-RA 0.022
pzg putzig 0.022
lqf liquid facets 0.022
CG14937 CG14937 gene product from transcript CG14937-RA 0.021
Myo31DF Myosin 31DF 0.021
Coq2 Coenzyme Q biosynthesis protein 2 0.021
sNPF-R short neuropeptide F receptor 0.021
rdgB retinal degeneration B 0.021
inaE inactivation no afterpotential E 0.020
Spargel CG9809 gene product from transcript CG9809-RB 0.019
Dcr-1 Dicer-1 0.019
pasha partner of drosha 0.019
Pka-C1 cAMP-dependent protein kinase 1 0.019
magu CG2264 gene product from transcript CG2264-RD 0.017
Clk Clock 0.017
CalpA Calpain-A 0.017
Sema-5c Semaphorin-5c 0.017
CG8155 CG8155 gene product from transcript CG8155-RA 0.016
bwa brain washing 0.016
B4 CG9239 gene product from transcript CG9239-RA 0.016
slik Sterile20-like kinase 0.016
Gclc Glutamate-cysteine ligase catalytic subunit 0.016
mav maverick 0.015
rap retina aberrant in pattern 0.015
unc-104 CG8566 gene product from transcript CG8566-RB 0.015
Invadolysin CG3953 gene product from transcript CG3953-RA 0.015
CG8451 CG8451 gene product from transcript CG8451-RA 0.015
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.015
CaMKII Calcium/calmodulin-dependent protein kinase II 0.015
Atg1 Autophagy-specific gene 1 0.014
Gef64C Guanine nucleotide exchange factor GEF64C 0.014
Nf1 Neurofibromin 1 0.014
hppy happyhour 0.014
CG3308 CG3308 gene product from transcript CG3308-RA 0.014
melt melted 0.014
Tsp42Ef Tetraspanin 42Ef 0.013
ninaC neither inactivation nor afterpotential C 0.013
CG3837 CG3837 gene product from transcript CG3837-RA 0.013
mnb minibrain 0.013
Tsc1 CG6147 gene product from transcript CG6147-RA 0.012
ttv tout-velu 0.012
Marf Mitochondrial assembly regulatory factor 0.012
sxc super sex combs 0.012
CG9007 CG9007 gene product from transcript CG9007-RA 0.012
CG13890 CG13890 gene product from transcript CG13890-RA 0.012
t tan 0.012
Gbeta76C G protein beta-subunit 76C 0.012
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.994
INSR insulin receptor 0.985
NCOA1 nuclear receptor coactivator 1 0.984
GRB10 growth factor receptor-bound protein 10 0.972
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.904
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.707
IRS2 insulin receptor substrate 2 0.700
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.615
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.612
FYN FYN oncogene related to SRC, FGR, YES 0.470
CREBBP CREB binding protein 0.468
IRS1 insulin receptor substrate 1 0.417
PRKCA protein kinase C, alpha 0.391
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.380
GRB2 growth factor receptor-bound protein 2 0.301
CUL1 cullin 1 0.272
NCF1 neutrophil cytosolic factor 1 0.270
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.261
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.197
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.190
FBXW11 F-box and WD repeat domain containing 11 0.172
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.151
SH2B1 SH2B adaptor protein 1 0.150
TSC2 tuberous sclerosis 2 0.149
SIRT1 sirtuin 1 0.126
FMR1 fragile X mental retardation 1 0.120
SH3RF1 SH3 domain containing ring finger 1 0.109
BCL3 B-cell CLL/lymphoma 3 0.098
PRKCZ protein kinase C, zeta 0.097
PLCG1 phospholipase C, gamma 1 0.096
IGF1R insulin-like growth factor 1 receptor 0.094
CREB1 cAMP responsive element binding protein 1 0.089
RARA retinoic acid receptor, alpha 0.080
NOXA1 NADPH oxidase activator 1 0.079
TSC1 tuberous sclerosis 1 0.074
BTRC beta-transducin repeat containing 0.072
IL1RAP interleukin 1 receptor accessory protein 0.071
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.063
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.062
CAV1 caveolin 1, caveolae protein, 22kDa 0.056
EEF2K eukaryotic elongation factor-2 kinase 0.053
JAK2 Janus kinase 2 0.053
SORBS3 sorbin and SH3 domain containing 3 0.053
MAPT microtubule-associated protein tau 0.051
SORBS1 sorbin and SH3 domain containing 1 0.051
STAT5B signal transducer and activator of transcription 5B 0.049
RICTOR RPTOR independent companion of MTOR, complex 2 0.047
MAPK3 mitogen-activated protein kinase 3 0.047
SKP1 S-phase kinase-associated protein 1 0.046
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.044
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.043
NCK1 NCK adaptor protein 1 0.043
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.043
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.043
PRKCB protein kinase C, beta 0.042
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.040
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.040
YAP1 Yes-associated protein 1 0.039
RHOU ras homolog gene family, member U 0.039
C17orf28 chromosome 17 open reading frame 28 0.038
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.037
IL1R1 interleukin 1 receptor, type I 0.037
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.037
LIMS1 LIM and senescent cell antigen-like domains 1 0.036
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.035
CREBZF CREB/ATF bZIP transcription factor 0.035
ITGB1BP3 integrin beta 1 binding protein 3 0.034
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 0.034
YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.031
KAT2B K(lysine) acetyltransferase 2B 0.030
RAB6A RAB6A, member RAS oncogene family 0.029
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.028
TRIM9 tripartite motif containing 9 0.027
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.027
EP300 E1A binding protein p300 0.026
NCF4 neutrophil cytosolic factor 4, 40kDa 0.025
COASY CoA synthase 0.025
EPOR erythropoietin receptor 0.024
SOCS3 suppressor of cytokine signaling 3 0.023
MAPK14 mitogen-activated protein kinase 14 0.023
PDPK1 3-phosphoinositide dependent protein kinase-1 0.022
CEP250 centrosomal protein 250kDa 0.022
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.021
COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) 0.021
FOXO3 forkhead box O3 0.021
GSK3B glycogen synthase kinase 3 beta 0.021
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.020
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.020
CAV2 caveolin 2 0.020
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.020
NOP58 NOP58 ribonucleoprotein homolog (yeast) 0.020
SOS1 son of sevenless homolog 1 (Drosophila) 0.020
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.019
ACACA acetyl-CoA carboxylase alpha 0.019
PTK2B PTK2B protein tyrosine kinase 2 beta 0.019
SH2D1A SH2 domain containing 1A 0.019
STMN2 stathmin-like 2 0.018
CSNK1G3 casein kinase 1, gamma 3 0.018
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.018
PTEN phosphatase and tensin homolog 0.018
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Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 1.000
Insr insulin receptor 0.902
Jak2 Janus kinase 2 0.438
Egfr epidermal growth factor receptor 0.389
Fyn Fyn proto-oncogene 0.388
Clock circadian locomotor output cycles kaput 0.333
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.321
Irs2 insulin receptor substrate 2 0.249
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.173
Ldb3 LIM domain binding 3 0.157
Per2 period homolog 2 (Drosophila) 0.156
Lipe lipase, hormone sensitive 0.146
Nos1 nitric oxide synthase 1, neuronal 0.141
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.129
Prkce protein kinase C, epsilon 0.128
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.120
Plcg1 phospholipase C, gamma 1 0.118
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.117
Tsc2 tuberous sclerosis 2 0.113
Dok2 docking protein 2 0.099
Dok1 docking protein 1 0.088
Inpp5d inositol polyphosphate-5-phosphatase D 0.086
Irs1 insulin receptor substrate 1 0.083
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.081
Src Rous sarcoma oncogene 0.079
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.077
Igf1r insulin-like growth factor I receptor 0.076
Cbl Casitas B-lineage lymphoma 0.072
Lep leptin 0.071
Nf1 neurofibromatosis 1 0.071
Grb2 growth factor receptor bound protein 2 0.070
Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C 0.067
Ghr growth hormone receptor 0.066
Stat5a signal transducer and activator of transcription 5A 0.065
Smad3 MAD homolog 3 (Drosophila) 0.065
Tsc1 tuberous sclerosis 1 0.064
Esr1 estrogen receptor 1 (alpha) 0.061
Vav2 vav 2 oncogene 0.061
Tgfb1 transforming growth factor, beta 1 0.060
Foxo1 forkhead box O1 0.059
Stat5b signal transducer and activator of transcription 5B 0.059
Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 0.058
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.054
Csf1 colony stimulating factor 1 (macrophage) 0.054
Igf2r insulin-like growth factor 2 receptor 0.052
Ep300 E1A binding protein p300 0.051
Stat3 signal transducer and activator of transcription 3 0.050
Il1a interleukin 1 alpha 0.049
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.049
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.047
Socs1 suppressor of cytokine signaling 1 0.046
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.046
Agtr1a angiotensin II receptor, type 1a 0.045
Cav1 caveolin 1, caveolae protein 0.043
Gab2 growth factor receptor bound protein 2-associated protein 2 0.043
Nsf N-ethylmaleimide sensitive fusion protein 0.042
Nos3 nitric oxide synthase 3, endothelial cell 0.041
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.041
Il1r1 interleukin 1 receptor, type I 0.041
Pnpla2 patatin-like phospholipase domain containing 2 0.040
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.040
Cry1 cryptochrome 1 (photolyase-like) 0.040
Fmr1 fragile X mental retardation syndrome 1 homolog 0.040
Socs2 suppressor of cytokine signaling 2 0.039
Pparg peroxisome proliferator activated receptor gamma 0.038
Nr1h4 nuclear receptor subfamily 1, group H, member 4 0.038
Foxo4 forkhead box O4 0.038
Cish cytokine inducible SH2-containing protein 0.036
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.036
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.035
Fcgr2b Fc receptor, IgG, low affinity IIb 0.035
Tbk1 TANK-binding kinase 1 0.034
Plxna1 plexin A1 0.034
Tek endothelial-specific receptor tyrosine kinase 0.033
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.033
Apoa1 apolipoprotein A-I 0.033
Blnk B-cell linker 0.032
Il6st interleukin 6 signal transducer 0.032
Jak1 Janus kinase 1 0.031
Vhl von Hippel-Lindau tumor suppressor 0.030
Npc1 Niemann Pick type C1 0.030
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.030
Socs3 suppressor of cytokine signaling 3 0.030
Fas Fas (TNF receptor superfamily member 6) 0.030
Apoc4 apolipoprotein C-IV 0.030
Ate1 arginyltransferase 1 0.030
Fxr1 fragile X mental retardation gene 1, autosomal homolog 0.029
Cry2 cryptochrome 2 (photolyase-like) 0.029
Per1 period homolog 1 (Drosophila) 0.028
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.028
Nf2 neurofibromatosis 2 0.028
Il1b interleukin 1 beta 0.028
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.027
Grb10 growth factor receptor bound protein 10 0.027
Vav3 vav 3 oncogene 0.027
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.027
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.027
Asb6 ankyrin repeat and SOCS box-containing 6 0.027
Il6 interleukin 6 0.026
Efnb1 ephrin B1 0.026
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Rattus norvegicus
Name Description Probability Func Analog Organism
Sirpa signal-regulatory protein alpha 0.216
LOC100363783 rCG53773-like 0.060
Cfp complement factor properdin 0.047
Mobkl2a MOB1, Mps One Binder kinase activator-like 2A (yeast) 0.037
Cd14 CD14 molecule 0.036
Cd83 CD83 molecule 0.031
Rnf10 ring finger protein 10 0.029
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.028
Sema6b sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 0.027
Slc4a2 solute carrier family 4 (anion exchanger), member 2 0.027
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.025
Il1b interleukin 1 beta 0.024
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.024
Tgfb1 transforming growth factor, beta 1 0.023
Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.022
Cugbp2 CUG triplet repeat, RNA binding protein 2 0.022
Hist1h1a histone cluster 1, H1a 0.021
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.020
Bcl3 B-cell CLL/lymphoma 3 0.020
Map3k11 mitogen-activated protein kinase kinase kinase 11 0.020
Zyx zyxin 0.019
Eef2 eukaryotic translation elongation factor 2 0.019
Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.018
Grb2 growth factor receptor bound protein 2 0.018
Tpt1 tumor protein, translationally-controlled 1 0.018
Sbno2 strawberry notch homolog 2 (Drosophila) 0.017
Unc5b unc-5 homolog B (C. elegans) 0.017
Ralgds ral guanine nucleotide dissociation stimulator 0.017
Arhgap4 Rho GTPase activating protein 4 0.017
Lmna lamin A 0.016
Stat3 signal transducer and activator of transcription 3 0.016
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.016
Cd37 CD37 molecule 0.016
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.016
Bid BH3 interacting domain death agonist 0.016
Ampd1 adenosine monophosphate deaminase 1 (isoform M) 0.016
Itgb7 integrin, beta 7 0.015
Fth1 ferritin, heavy polypeptide 1 0.015
Stat6 signal transducer and activator of transcription 6 0.015
Jak2 Janus kinase 2 0.015
Arl5c ADP-ribosylation factor-like 5C 0.015
Metap2 methionyl aminopeptidase 2 0.015
Ptpro protein tyrosine phosphatase, receptor type, O 0.015
Pkn2 protein kinase N2 0.014
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.014
Sort1 sortilin 1 0.013
Fmnl1 formin-like 1 0.013
Pou2f2 POU class 2 homeobox 2 0.013
Mpp3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 0.013
Ppp1r9b protein phosphatase 1, regulatory subunit 9B 0.013
Alb albumin 0.012
Itgam integrin, alpha M 0.012
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.012
Stat5b signal transducer and activator of transcription 5B 0.012
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.012
Prkcb protein kinase C, beta 0.012
Rab1b RAB1B, member RAS oncogene family 0.012
Cebpe CCAAT/enhancer binding protein (C/EBP), epsilon 0.012
Grin2d glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.011
Sla src-like adaptor 0.011
Jak3 Janus kinase 3 0.011
Ptprs protein tyrosine phosphatase, receptor type, S 0.011
Fga fibrinogen alpha chain 0.011
Foxp4 forkhead box P4 0.011
Syngr2 synaptogyrin 2 0.011
Il1r2 interleukin 1 receptor, type II 0.011
Il2rg interleukin 2 receptor, gamma 0.011
Socs2 suppressor of cytokine signaling 2 0.011
Sbk1 SH3-binding domain kinase 1 0.011
Ppard peroxisome proliferator-activated receptor delta 0.010
Acbd5 acyl-Coenzyme A binding domain containing 5 0.010
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.010
Hoxb7 homeo box B7 0.010
Vav1 vav 1 guanine nucleotide exchange factor 0.010
Egr4 early growth response 4 0.010
Dock8 dedicator of cytokinesis 8 0.010
Phkg1 phosphorylase kinase, gamma 1 0.010
Trib1 tribbles homolog 1 (Drosophila) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism