The network for 'eye development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

eye development

The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.

Drosophila melanogaster
Name Description Probability Func Analog Organism
spen split ends 1.000
dac dachshund 1.000
Ten-m Tenascin major 0.999
nmo nemo 0.998
sns sticks and stones 0.998
Gug Grunge 0.996
argos CG4531 gene product from transcript CG4531-RA 0.996
eyg eyegone 0.996
hipk homeodomain interacting protein kinase 0.993
hbs hibris 0.988
Lis-1 Lissencephaly-1 0.987
slou slouch 0.986
E(spl) Enhancer of split 0.986
fl(2)d female lethal d 0.986
Tom Twin of m4 0.979
nej nejire 0.979
ro rough 0.975
ato atonal 0.975
eya eyes absent 0.972
klar klarsicht 0.971
wts warts 0.966
dm diminutive 0.965
rst roughest 0.965
bif bifocal 0.958
so sine oculis 0.956
disco disconnected 0.955
ebi CG4063 gene product from transcript CG4063-RA 0.954
ed echinoid 0.954
dsh dishevelled 0.953
Peb Protein ejaculatory bulb 0.948
Rac1 CG2248 gene product from transcript CG2248-RA 0.943
Kap-alpha3 karyopherin alpha3 0.939
yki yorkie 0.938
Dsor1 Downstream of raf1 0.934
amos absent MD neurons and olfactory sensilla 0.933
csw corkscrew 0.930
Vang Van Gogh 0.926
G-salpha60A G protein salpha 60A 0.926
fz frizzled 0.924
HLHm7 E(spl) region transcript m7 0.922
tkv thickveins 0.920
S6kII RPS6-protein kinase-II 0.919
phl pole hole 0.919
lz lozenge 0.918
C3G CG42328 gene product from transcript CG42328-RC 0.918
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.915
yrt yurt 0.913
sev sevenless 0.912
ex expanded 0.909
CadN Cadherin-N 0.909
ttk tramtrack 0.908
HLHmdelta E(spl) region transcript mdelta 0.907
cno canoe 0.904
btl breathless 0.903
Hop Hsp70/Hsp90 organizing protein homolog 0.898
B-H1 BarH1 0.897
sax saxophone 0.896
pie pineapple eye 0.896
Mi-2 CG8103 gene product from transcript CG8103-RA 0.896
stan starry night 0.895
esg escargot 0.894
kirre kin of irre 0.893
trio CG18214 gene product from transcript CG18214-RA 0.892
pnt pointed 0.890
nkd naked cuticle 0.888
nub nubbin 0.888
arr arrow 0.887
sty sprouty 0.885
frc fringe connection 0.884
ara araucan 0.883
Rala Ras-related protein 0.883
trc tricornered 0.882
scrib scribbled 0.879
cutlet CG33122 gene product from transcript CG33122-RA 0.878
Gef26 CG9491 gene product from transcript CG9491-RB 0.873
ft fat 0.871
Rab11 Rab-protein 11 0.862
Smox Smad on X 0.861
wg wingless 0.860
sd scalloped 0.855
neur neuralized 0.850
Ser Serrate 0.848
ci cubitus interruptus 0.846
cnk connector enhancer of ksr 0.844
mask multiple ankyrin repeats single KH domain 0.844
fz2 frizzled 2 0.840
CtBP C-terminal Binding Protein 0.839
rg rugose 0.833
tsh teashirt 0.832
crb crumbs 0.829
lola longitudinals lacking 0.826
Mob2 CG11711 gene product from transcript CG11711-RC 0.824
fng fringe 0.824
elav embryonic lethal abnormal vision 0.823
Traf4 TNF-receptor-associated factor 4 0.823
Pten CG5671 gene product from transcript CG5671-RB 0.821
lqf liquid facets 0.820
cindr CIN85 and CD2AP orthologue 0.812
CG11347 CG11347 gene product from transcript CG11347-RE 0.812
dpp decapentaplegic 0.811
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cdh2 cadherin 2, neuronal 1.000
pax2a paired box gene 2a 0.999
gdf6a growth differentiation factor 6a 0.997
shha sonic hedgehog a 0.996
pvrl1a poliovirus receptor-related 1a 0.995
flh floating head 0.995
fgf3 fibroblast growth factor 3 0.992
pax6b paired box gene 6b 0.991
rx1 retinal homeobox gene 1 0.991
atoh7 atonal homolog 7 0.990
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.988
foxg1a forkhead box G1a 0.987
ift88 intraflagellar transport 88 homolog 0.986
lef1 lymphocyte enhancer binding factor 1 0.984
atoh1a atonal homolog 1a 0.982
dctn1a dynactin 1a 0.982
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.977
pax6a paired box gene 6a 0.976
foxd3 forkhead box D3 0.975
irx1a iroquois homeobox protein 1, a 0.974
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.972
tbx2b T-box 2b 0.972
runx1 runt-related transcription factor 1 0.970
tal1 T-cell acute lymphocytic leukemia 1 0.969
rx2 retinal homeobox gene 2 0.968
guca1c guanylate cyclase activator 1C 0.967
kif17 kinesin family member 17 0.961
fezf2 FEZ family zinc finger 2 0.959
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.958
znf703 zinc finger protein 703 0.955
tyr tyrosinase 0.952
sox3 SRY-box containing gene 3 0.951
isl1 islet1 0.951
tfap2a transcription factor AP-2 alpha 0.948
eya1 eyes absent homolog 1 0.948
dla deltaA 0.945
six3b sine oculis homeobox homolog 3b 0.945
gbx2 gastrulation brain homeo box 2 0.943
lhx1a LIM homeobox 1a 0.938
gdnf glial cell derived neurotrophic factor 0.933
alcama activated leukocyte cell adhesion molecule a 0.932
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.929
otx2 orthodenticle homolog 2 0.927
traf4a tnf receptor-associated factor 4a 0.926
cntn1a contactin 1a 0.922
kdrl kinase insert domain receptor like 0.917
ndr2 nodal-related 2 0.916
barhl2 BarH-like 2 0.916
six4b sine oculis homeobox homolog 4b 0.915
sox2 SRY-box containing gene 2 0.912
otpb orthopedia homolog b 0.911
kita kit receptor a 0.909
neurod neurogenic differentiation 0.907
pea3 ETS-domain transcription factor pea3 0.901
wnt11r wingless-type MMTV integration site family, member 11, related 0.900
sox1a SRY-box containing gene 1a 0.900
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.898
cmyb transcription factor cmyb 0.897
wnt5b wingless-type MMTV integration site family, member 5b 0.897
gli1 GLI-Kruppel family member 1 0.894
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.892
zgc:112329 zgc:112329 0.891
snai1b snail homolog 1b (Drosophila) 0.889
bmp2b bone morphogenetic protein 2b 0.888
bmper BMP binding endothelial regulator 0.887
hhip hedgehog interacting protein 0.886
wnt10a wingless-type MMTV integration site family, member 10a 0.884
her1 hairy-related 1 0.877
ahctf1 AT hook containing transcription factor 1 0.874
fgf8a fibroblast growth factor 8 a 0.873
crb2a crumbs homolog 2a 0.872
foxp2 forkhead box P2 0.870
fgfr1a fibroblast growth factor receptor 1a 0.869
gli2a GLI-Kruppel family member GLI2a 0.866
chd chordin 0.864
tp53 tumor protein p53 0.864
vcana versican a 0.864
rx3 retinal homeobox gene 3 0.862
shhb sonic hedgehog b 0.861
notch2 notch homolog 2 0.861
wnt11 wingless-type MMTV integration site family, member 11 0.861
dlx4a distal-less homeobox gene 4a 0.859
chd7 chromodomain helicase DNA binding protein 7 0.859
dlx3b distal-less homeobox gene 3b 0.858
fzd8a frizzled homolog 8a 0.857
ptpra protein tyrosine phosphatase, receptor type, A 0.852
gata4 GATA-binding protein 4 0.852
foxa2 forkhead box A2 0.852
notch3 notch homolog 3 0.847
gata3 GATA-binding protein 3 0.845
si:ch211-173o4.2 si:ch211-173o4.2 0.842
scinla scinderin like a 0.841
lamb1a laminin, beta 1a 0.840
lama1 laminin, alpha 1 0.838
pmela premelanosome protein a 0.836
ptf1a pancreas specific transcription factor, 1a 0.834
tbx5a T-box 5a 0.833
spry4 sprouty (Drosophila) homolog 4 0.829
vax2 ventral anterior homeobox 2 0.826
jag1b jagged 1b 0.826
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Homo sapiens
Name Description Probability Func Analog Organism
ESR1 estrogen receptor 1 0.894
TP53 tumor protein p53 0.832
EGFR epidermal growth factor receptor 0.805
RB1 retinoblastoma 1 0.779
SMAD4 SMAD family member 4 0.647
CREBBP CREB binding protein 0.570
HDAC1 histone deacetylase 1 0.570
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.548
NCOR1 nuclear receptor corepressor 1 0.472
ENG endoglin 0.450
COL1A1 collagen, type I, alpha 1 0.432
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.412
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.410
PBX1 pre-B-cell leukemia homeobox 1 0.400
CTBP1 C-terminal binding protein 1 0.396
APC adenomatous polyposis coli 0.395
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.383
SP1 Sp1 transcription factor 0.374
NCOR2 nuclear receptor corepressor 2 0.353
ATXN1 ataxin 1 0.345
JUN jun proto-oncogene 0.337
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.336
EP300 E1A binding protein p300 0.335
NOTCH3 notch 3 0.327
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.319
FGFR1 fibroblast growth factor receptor 1 0.303
MCM7 minichromosome maintenance complex component 7 0.298
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.292
RBBP4 retinoblastoma binding protein 4 0.290
MYOD1 myogenic differentiation 1 0.278
SMAD3 SMAD family member 3 0.269
COL4A1 collagen, type IV, alpha 1 0.244
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.243
SKIL SKI-like oncogene 0.237
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.229
PML promyelocytic leukemia 0.219
PRMT1 protein arginine methyltransferase 1 0.214
SMAD2 SMAD family member 2 0.211
HIPK2 homeodomain interacting protein kinase 2 0.205
COL4A2 collagen, type IV, alpha 2 0.195
PTEN phosphatase and tensin homolog 0.191
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.185
MDFI MyoD family inhibitor 0.182
POU3F2 POU class 3 homeobox 2 0.178
RUNX1 runt-related transcription factor 1 0.173
FUS fused in sarcoma 0.168
NFYA nuclear transcription factor Y, alpha 0.166
CSNK1E casein kinase 1, epsilon 0.154
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.153
JAG1 jagged 1 0.149
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.148
GRB2 growth factor receptor-bound protein 2 0.139
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.135
NRP1 neuropilin 1 0.132
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.130
CRYBB2 crystallin, beta B2 0.127
APP amyloid beta (A4) precursor protein 0.127
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.126
ANAPC7 anaphase promoting complex subunit 7 0.125
TGIF1 TGFB-induced factor homeobox 1 0.122
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.122
BMPR1A bone morphogenetic protein receptor, type IA 0.122
MAPK8 mitogen-activated protein kinase 8 0.122
HTT huntingtin 0.119
CAV1 caveolin 1, caveolae protein, 22kDa 0.118
PPARA peroxisome proliferator-activated receptor alpha 0.118
NOTCH1 notch 1 0.111
LMO4 LIM domain only 4 0.111
NCOA1 nuclear receptor coactivator 1 0.110
JUNB jun B proto-oncogene 0.109
CTSA cathepsin A 0.106
SOX2 SRY (sex determining region Y)-box 2 0.104
SMAD1 SMAD family member 1 0.102
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.100
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.099
SOX11 SRY (sex determining region Y)-box 11 0.098
VEGFA vascular endothelial growth factor A 0.094
NOSTRIN nitric oxide synthase trafficker 0.092
FGF1 fibroblast growth factor 1 (acidic) 0.091
ZFYVE9 zinc finger, FYVE domain containing 9 0.090
PSAP prosaposin 0.088
HIC1 hypermethylated in cancer 1 0.087
CRYBB3 crystallin, beta B3 0.086
SOX1 SRY (sex determining region Y)-box 1 0.085
BBS4 Bardet-Biedl syndrome 4 0.083
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.081
WNT3A wingless-type MMTV integration site family, member 3A 0.078
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.076
UBC ubiquitin C 0.075
CTSD cathepsin D 0.075
CBX4 chromobox homolog 4 0.075
E2F1 E2F transcription factor 1 0.074
PBRM1 polybromo 1 0.074
MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.074
MAPK1 mitogen-activated protein kinase 1 0.074
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.074
SMAD7 SMAD family member 7 0.074
RARA retinoic acid receptor, alpha 0.073
INADL InaD-like (Drosophila) 0.072
BMI1 BMI1 polycomb ring finger oncogene 0.069
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Actb actin, beta 0.483
Fos FBJ osteosarcoma oncogene 0.455
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.384
Junb jun B proto-oncogene 0.285
Mip major intrinsic protein of lens fiber 0.243
Mgp matrix Gla protein 0.240
Tmsb4x thymosin beta 4, X-linked 0.232
Foxd3 forkhead box D3 0.231
Egr1 early growth response 1 0.228
Opn1sw opsin 1 (cone pigments), short-wave-sensitive 0.225
Flt1 FMS-related tyrosine kinase 1 0.210
Casp3 caspase 3 0.181
Adam17 ADAM metallopeptidase domain 17 0.170
Pax4 paired box 4 0.164
St18 suppression of tumorigenicity 18 0.160
Cryba4 crystallin, beta A4 0.147
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.146
Cltc clathrin, heavy chain (Hc) 0.133
Neurod2 neurogenic differentiation 2 0.132
Sp1 Sp1 transcription factor 0.127
Btg2 BTG family, member 2 0.126
Aebp1 AE binding protein 1 0.125
Crygb crystallin, gamma B 0.121
Tgfbr2 transforming growth factor, beta receptor II 0.120
Lim2 lens intrinsic membrane protein 2 0.116
Foxe3 forkhead box E3 0.110
Cryaa crystallin, alpha A 0.110
Vom1r97 vomeronasal 1 receptor 97 0.105
Grifin galectin-related inter-fiber protein 0.104
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.103
Col1a2 collagen, type I, alpha 2 0.103
Gabra3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.102
Egr2 early growth response 2 0.101
Amelx amelogenin X chromosome 0.100
Shc3 SHC (Src homology 2 domain containing) transforming protein 3 0.099
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.094
Copb2 coatomer protein complex, subunit beta 2 (beta prime) 0.088
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.087
Crybb3 crystallin, beta B3 0.087
Atxn1 ataxin 1 0.083
Dusp6 dual specificity phosphatase 6 0.083
Grasp GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.083
Col1a1 collagen, type I, alpha 1 0.082
Pdgfb platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.080
Bmp7 bone morphogenetic protein 7 0.079
Dusp1 dual specificity phosphatase 1 0.079
Col5a2 collagen, type V, alpha 2 0.079
Fgfr2 fibroblast growth factor receptor 2 0.077
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.076
Pspn persephin 0.075
Agtr1b angiotensin II receptor, type 1b 0.075
Chgb chromogranin B 0.074
Esr2 estrogen receptor 2 (ER beta) 0.074
Oprm1 opioid receptor, mu 1 0.073
Cngb1 cyclic nucleotide gated channel beta 1 0.072
Chrnb4 cholinergic receptor, nicotinic, beta 4 0.072
Hoxc4 homeo box C4 0.072
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) 0.071
Col3a1 collagen, type III, alpha 1 0.069
Galr3 galanin receptor 3 0.067
Fgf11 fibroblast growth factor 11 0.067
Ncam1 neural cell adhesion molecule 1 0.067
Hist1h1d histone cluster 1, H1d 0.067
Dlg4 discs, large homolog 4 (Drosophila) 0.065
Eef2 eukaryotic translation elongation factor 2 0.064
Gjd2 gap junction protein, delta 2 0.064
Col8a1 collagen, type VIII, alpha 1 0.063
Syt6 synaptotagmin VI 0.063
Bcl2 B-cell CLL/lymphoma 2 0.063
Akap12 A kinase (PRKA) anchor protein 12 0.062
Foxd1 forkhead box D1 0.062
Mgat3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 0.060
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.059
Adrb1 adrenergic, beta-1-, receptor 0.058
Sstr5 somatostatin receptor 5 0.058
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.057
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.057
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.057
Edn1 endothelin 1 0.057
Slc12a5 solute carrier family 12 (potassium-chloride transporter), member 5 0.055
Dab2 disabled homolog 2 (Drosophila) 0.055
RGD1564560 similar to RCK 0.055
Ctsc cathepsin C 0.055
Stat5b signal transducer and activator of transcription 5B 0.055
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.054
Socs3 suppressor of cytokine signaling 3 0.054
Nrarp Notch-regulated ankyrin repeat protein 0.054
Rin1 Ras and Rab interactor 1 0.054
Ctsk cathepsin K 0.053
Vax2 ventral anterior homeobox 2 0.052
LOC679931 hypothetical protein LOC679931 0.052
Aanat arylalkylamine N-acetyltransferase 0.051
Rabac1 Rab acceptor 1 (prenylated) 0.050
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.050
Gpc1 glypican 1 0.050
Barhl2 BarH-like homeobox 2 0.049
Runx1 runt-related transcription factor 1 0.049
Itgb1 integrin, beta 1 0.047
Plxdc2 plexin domain containing 2 0.047
Apoe apolipoprotein E 0.046
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism