The network for 'negative regulation of alpha beta t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of alpha beta t cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.

Homo sapiens
Name Description Probability Func Analog Organism
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 1.000
PILRA paired immunoglobin-like type 2 receptor alpha 0.998
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.997
CCR5 chemokine (C-C motif) receptor 5 0.994
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.983
IL4R interleukin 4 receptor 0.973
TFF1 trefoil factor 1 0.958
DRD2 dopamine receptor D2 0.953
CCL4 chemokine (C-C motif) ligand 4 0.930
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.912
HK3 hexokinase 3 (white cell) 0.872
SIGLEC7 sialic acid binding Ig-like lectin 7 0.853
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.827
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.824
CCR1 chemokine (C-C motif) receptor 1 0.813
IL1B interleukin 1, beta 0.765
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.713
CD2AP CD2-associated protein 0.712
IL2RG interleukin 2 receptor, gamma 0.668
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.627
CXCL9 chemokine (C-X-C motif) ligand 9 0.582
IL8 interleukin 8 0.579
CCL22 chemokine (C-C motif) ligand 22 0.572
CCL13 chemokine (C-C motif) ligand 13 0.551
CXCL10 chemokine (C-X-C motif) ligand 10 0.546
CCL5 chemokine (C-C motif) ligand 5 0.541
TRAF1 TNF receptor-associated factor 1 0.539
DPP4 dipeptidyl-peptidase 4 0.484
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.440
CCL7 chemokine (C-C motif) ligand 7 0.393
CD33 CD33 molecule 0.388
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.361
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.334
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.307
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.307
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.297
IL1RN interleukin 1 receptor antagonist 0.292
SIGLEC9 sialic acid binding Ig-like lectin 9 0.277
CCL8 chemokine (C-C motif) ligand 8 0.245
CCR7 chemokine (C-C motif) receptor 7 0.244
CCL3 chemokine (C-C motif) ligand 3 0.230
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.227
CD300C CD300c molecule 0.213
NLRP3 NLR family, pyrin domain containing 3 0.209
TYMP thymidine phosphorylase 0.202
CYTH4 cytohesin 4 0.197
SLAMF8 SLAM family member 8 0.195
VSIG4 V-set and immunoglobulin domain containing 4 0.190
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 0.184
IL4 interleukin 4 0.182
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.171
PLEK pleckstrin 0.156
CD86 CD86 molecule 0.156
CCR4 chemokine (C-C motif) receptor 4 0.156
CXCL13 chemokine (C-X-C motif) ligand 13 0.150
PCDH9 protocadherin 9 0.146
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 0.138
CCL2 chemokine (C-C motif) ligand 2 0.135
IFNG interferon, gamma 0.133
CD40 CD40 molecule, TNF receptor superfamily member 5 0.132
TNF tumor necrosis factor 0.130
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 0.128
TREM1 triggering receptor expressed on myeloid cells 1 0.127
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.123
EBI3 Epstein-Barr virus induced 3 0.122
AQP9 aquaporin 9 0.121
A2M alpha-2-macroglobulin 0.121
CXCL3 chemokine (C-X-C motif) ligand 3 0.120
EPOR erythropoietin receptor 0.116
IL10 interleukin 10 0.116
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.115
FPR3 formyl peptide receptor 3 0.114
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 0.113
PTAFR platelet-activating factor receptor 0.110
CCR3 chemokine (C-C motif) receptor 3 0.110
CCL11 chemokine (C-C motif) ligand 11 0.110
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.109
SKI v-ski sarcoma viral oncogene homolog (avian) 0.108
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.106
CXCL2 chemokine (C-X-C motif) ligand 2 0.105
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 0.103
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.100
SELE selectin E 0.099
MARCO macrophage receptor with collagenous structure 0.099
CCL3L3 chemokine (C-C motif) ligand 3-like 3 0.095
SIGLEC10 sialic acid binding Ig-like lectin 10 0.094
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.094
CCL19 chemokine (C-C motif) ligand 19 0.093
RNF11 ring finger protein 11 0.093
FPR2 formyl peptide receptor 2 0.093
TRADD TNFRSF1A-associated via death domain 0.092
AOAH acyloxyacyl hydrolase (neutrophil) 0.091
CCL21 chemokine (C-C motif) ligand 21 0.090
SIRPA signal-regulatory protein alpha 0.090
IL6 interleukin 6 (interferon, beta 2) 0.088
CH25H cholesterol 25-hydroxylase 0.086
CXCL5 chemokine (C-X-C motif) ligand 5 0.083
C2 complement component 2 0.080
CD80 CD80 molecule 0.079
NOD2 nucleotide-binding oligomerization domain containing 2 0.079
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Stat3 signal transducer and activator of transcription 3 0.989
Gli3 GLI-Kruppel family member GLI3 0.985
Tnf tumor necrosis factor 0.919
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.852
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.830
Myd88 myeloid differentiation primary response gene 88 0.735
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.695
Il6st interleukin 6 signal transducer 0.562
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.559
Rc3h1 RING CCCH (C3H) domains 1 0.520
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.448
Ifng interferon gamma 0.414
Jak2 Janus kinase 2 0.355
Lepr leptin receptor 0.350
Cyld cylindromatosis (turban tumor syndrome) 0.296
Lta lymphotoxin A 0.277
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.250
Traf6 TNF receptor-associated factor 6 0.245
Fas Fas (TNF receptor superfamily member 6) 0.240
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.231
Gli2 GLI-Kruppel family member GLI2 0.230
Zeb1 zinc finger E-box binding homeobox 1 0.223
Il6 interleukin 6 0.211
Pten phosphatase and tensin homolog 0.204
Pthlh parathyroid hormone-like peptide 0.182
Socs1 suppressor of cytokine signaling 1 0.182
Socs3 suppressor of cytokine signaling 3 0.179
Cd40 CD40 antigen 0.170
S1pr2 sphingosine-1-phosphate receptor 2 0.168
Fgf10 fibroblast growth factor 10 0.157
Igh immunoglobulin heavy chain complex 0.133
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.133
Ikzf1 IKAROS family zinc finger 1 0.130
Ren1 renin 1 structural 0.118
Bcl3 B-cell leukemia/lymphoma 3 0.117
Il4 interleukin 4 0.112
Foxp3 forkhead box P3 0.111
Ctnnb1 catenin (cadherin associated protein), beta 1 0.104
Fgfr2 fibroblast growth factor receptor 2 0.099
Stat5a signal transducer and activator of transcription 5A 0.098
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.090
Rnf11 ring finger protein 11 0.090
Kit kit oncogene 0.090
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.085
Stat6 signal transducer and activator of transcription 6 0.084
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.079
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.077
Fgfr3 fibroblast growth factor receptor 3 0.076
Nos2 nitric oxide synthase 2, inducible 0.071
Egfr epidermal growth factor receptor 0.064
Zbtb37 zinc finger and BTB domain containing 37 0.063
Ptch1 patched homolog 1 0.060
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.057
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.056
Il1r1 interleukin 1 receptor, type I 0.055
Fgf9 fibroblast growth factor 9 0.055
Ccl2 chemokine (C-C motif) ligand 2 0.055
Trpv1 transient receptor potential cation channel, subfamily V, member 1 0.054
Rac1 RAS-related C3 botulinum substrate 1 0.053
Il2rg interleukin 2 receptor, gamma chain 0.052
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.049
Stat5b signal transducer and activator of transcription 5B 0.049
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.048
Sh2b2 SH2B adaptor protein 2 0.048
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.046
Plcg1 phospholipase C, gamma 1 0.046
Foxn1 forkhead box N1 0.046
Traf2 TNF receptor-associated factor 2 0.044
Twist2 twist homolog 2 (Drosophila) 0.044
Sox9 SRY-box containing gene 9 0.041
Cul5 cullin 5 0.041
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.041
Smad6 MAD homolog 6 (Drosophila) 0.041
Atp11c ATPase, class VI, type 11C 0.040
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.038
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.038
Shh sonic hedgehog 0.037
Prdm1 PR domain containing 1, with ZNF domain 0.036
Rc3h2 ring finger and CCCH-type zinc finger domains 2 0.036
Il2rb interleukin 2 receptor, beta chain 0.036
Trp53 transformation related protein 53 0.034
Il10ra interleukin 10 receptor, alpha 0.033
Rag1 recombination activating gene 1 0.033
Pim1 proviral integration site 1 0.032
Grb10 growth factor receptor bound protein 10 0.030
Il3ra interleukin 3 receptor, alpha chain 0.030
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.029
Fes feline sarcoma oncogene 0.029
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.028
Tmem64 transmembrane protein 64 0.027
Neurog3 neurogenin 3 0.027
Tcra T-cell receptor alpha chain 0.026
Bdkrb2 bradykinin receptor, beta 2 0.026
Acvrl1 activin A receptor, type II-like 1 0.025
Rps6ka3 ribosomal protein S6 kinase polypeptide 3 0.025
Cd40lg CD40 ligand 0.025
Bmp7 bone morphogenetic protein 7 0.025
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.025
Socs5 suppressor of cytokine signaling 5 0.024
Irf5 interferon regulatory factor 5 0.024
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Madcam1 mucosal vascular addressin cell adhesion molecule 1 0.036
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.028
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.028
Ceacam3 carcinoembryonic antigen-related cell adhesion molecule 3 0.025
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.022
Olr442 olfactory receptor 442 0.018
Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 0.017
Gjb4 gap junction protein, beta 4 0.017
Dspp dentin sialophosphoprotein 0.016
Gja5 gap junction protein, alpha 5 0.014
Adrb3 adrenergic, beta-3-, receptor 0.014
Slc22a13 solute carrier family 22 (organic anion transporter), member 13 0.014
Crhr2 corticotropin releasing hormone receptor 2 0.013
Avp arginine vasopressin 0.012
Pacs1 phosphofurin acidic cluster sorting protein 1 0.012
Opn1sw opsin 1 (cone pigments), short-wave-sensitive 0.012
Dlg4 discs, large homolog 4 (Drosophila) 0.010
Olr1493 olfactory receptor gene Olr1493 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism