The network for 'endocytic recycling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endocytic recycling

The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.

Homo sapiens
Name Description Probability Func Analog Organism
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.853
SYNRG synergin, gamma 0.772
TBK1 TANK-binding kinase 1 0.530
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.518
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.491
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.421
CYLD cylindromatosis (turban tumor syndrome) 0.398
EHD1 EH-domain containing 1 0.353
PDPK1 3-phosphoinositide dependent protein kinase-1 0.330
OPTN optineurin 0.216
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.210
GDI2 GDP dissociation inhibitor 2 0.206
AZI2 5-azacytidine induced 2 0.198
OCRL oculocerebrorenal syndrome of Lowe 0.191
TANK TRAF family member-associated NFKB activator 0.167
SYK spleen tyrosine kinase 0.164
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.158
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.156
LDOC1 leucine zipper, down-regulated in cancer 1 0.150
RPTOR regulatory associated protein of MTOR, complex 1 0.150
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.130
TRAF2 TNF receptor-associated factor 2 0.123
RAB1A RAB1A, member RAS oncogene family 0.120
SCHIP1 schwannomin interacting protein 1 0.117
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 0.109
RAB11A RAB11A, member RAS oncogene family 0.108
FADS2 fatty acid desaturase 2 0.092
GOLGA2 golgin A2 0.080
SORT1 sortilin 1 0.077
ATF2 activating transcription factor 2 0.076
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.075
RAD18 RAD18 homolog (S. cerevisiae) 0.068
RAB8A RAB8A, member RAS oncogene family 0.067
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.063
ANKFY1 ankyrin repeat and FYVE domain containing 1 0.061
UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog) 0.060
MTF1 metal-regulatory transcription factor 1 0.059
EXOC4 exocyst complex component 4 0.058
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.058
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.055
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.052
RAB5A RAB5A, member RAS oncogene family 0.051
IRF3 interferon regulatory factor 3 0.050
TBKBP1 TBK1 binding protein 1 0.049
RAB10 RAB10, member RAS oncogene family 0.048
MICALL1 MICAL-like 1 0.047
IGF2R insulin-like growth factor 2 receptor 0.045
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.045
DHCR7 7-dehydrocholesterol reductase 0.044
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 0.042
EPS15 epidermal growth factor receptor pathway substrate 15 0.031
UBASH3B ubiquitin associated and SH3 domain containing B 0.031
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.029
TBC1D17 TBC1 domain family, member 17 0.028
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.026
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 0.025
RNF11 ring finger protein 11 0.024
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.024
EEA1 early endosome antigen 1 0.023
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 0.022
ROD1 ROD1 regulator of differentiation 1 (S. pombe) 0.021
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.020
UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog) 0.020
CLTC clathrin, heavy chain (Hc) 0.019
SPHAR S-phase response (cyclin related) 0.018
M6PR mannose-6-phosphate receptor (cation dependent) 0.018
IL4R interleukin 4 receptor 0.018
PTRF polymerase I and transcript release factor 0.017
UBE2G1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.016
SNX6 sorting nexin 6 0.016
FXR2 fragile X mental retardation, autosomal homolog 2 0.015
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.015
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.015
RAB14 RAB14, member RAS oncogene family 0.015
BIN1 bridging integrator 1 0.014
MAP7D1 MAP7 domain containing 1 0.014
TRIM23 tripartite motif containing 23 0.013
AGFG1 ArfGAP with FG repeats 1 0.013
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.013
EHD4 EH-domain containing 4 0.013
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.012
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.012
AP1B1 adaptor-related protein complex 1, beta 1 subunit 0.012
TIFA TRAF-interacting protein with forkhead-associated domain 0.012
STON2 stonin 2 0.011
DEPTOR DEP domain containing MTOR-interacting protein 0.011
FCHO2 FCH domain only 2 0.011
TNIP1 TNFAIP3 interacting protein 1 0.011
DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.010
YTHDF3 YTH domain family, member 3 0.010
TRAF3 TNF receptor-associated factor 3 0.010
BLNK B-cell linker 0.010
ARF6 ADP-ribosylation factor 6 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rab1 Rab-protein 1 0.127
sec6 CG5341 gene product from transcript CG5341-RA 0.090
vib vibrator 0.071
mats mob as tumor suppressor 0.054
Rab11 Rab-protein 11 0.047
Rab2 Rab-protein 2 0.042
didum dilute class unconventional myosin 0.037
bip2 CG2009 gene product from transcript CG2009-RA 0.036
Klc Kinesin light chain 0.035
CG4567 CG4567 gene product from transcript CG4567-RA 0.033
Tab2 TAK1-associated binding protein 2 0.030
Vps16A Vacuolar protein sorting 16A 0.027
sec8 CG2095 gene product from transcript CG2095-RA 0.024
Npc1a Niemann-Pick type C-1a 0.021
Rala Ras-related protein 0.020
mfrn mitoferrin 0.020
Dlic Dynein light intermediate chain 0.020
BG4 CG12297 gene product from transcript CG12297-RA 0.019
Rbsn-5 Rabenosyn-5 0.017
CanB2 Calcineurin B2 0.017
key kenny 0.017
bsk basket 0.016
wdb widerborst 0.016
Ack CG14992 gene product from transcript CG14992-RA 0.016
nudE CG8104 gene product from transcript CG8104-RB 0.015
AGO2 Argonaute 2 0.015
Lis-1 Lissencephaly-1 0.015
Rab7 Rab-protein 7 0.014
cdm cadmus 0.014
Madm MLF1-adaptor molecule 0.013
RagA CG11968 gene product from transcript CG11968-RA 0.013
sec5 CG8843 gene product from transcript CG8843-RA 0.013
l(1)G0144 lethal (1) G0144 0.012
Khc Kinesin heavy chain 0.012
ush u-shaped 0.012
rok Rho-kinase 0.012
Taz Tafazzin 0.012
CYLD cylindromatosis 0.011
tacc transforming acidic coiled-coil protein 0.011
Ubc-E2H CG2257 gene product from transcript CG2257-RA 0.011
Rheb CG1081 gene product from transcript CG1081-RA 0.011
sw short wing 0.011
shrb shrub 0.011
Ilk Integrin linked kinase 0.011
mop myopic 0.011
Atg6 Autophagy-specific gene 6 0.010
Hip14 Huntingtin-interacting protein 14 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.034
Rab11a RAB11a, member RAS oncogene family 0.025
Rictor RPTOR independent companion of MTOR, complex 2 0.017
Tsc1 tuberous sclerosis 1 0.015
Bcl2 B-cell leukemia/lymphoma 2 0.015
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.015
Mapkap1 mitogen-activated protein kinase associated protein 1 0.013
Fech ferrochelatase 0.012
Tank TRAF family member-associated Nf-kappa B activator 0.012
Ctnna1 catenin (cadherin associated protein), alpha 1 0.011
Rptor regulatory associated protein of MTOR, complex 1 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.035
Psmb1 proteasome (prosome, macropain) subunit, beta type 1 0.030
Atp5l ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G 0.023
Cox6a1 cytochrome c oxidase, subunit VIa, polypeptide 1 0.022
Tceb2 transcription elongation factor B (SIII), polypeptide 2 0.021
Rpl36al ribosomal protein L36a-like 0.018
Cox5b cytochrome c oxidase subunit Vb 0.017
LOC301124 hypothetical LOC301124 0.017
Ndufb9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 0.017
Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.017
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.016
Cox7a2 cytochrome c oxidase subunit VIIa polypeptide 2 0.016
Ndufb5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 0.016
Timm13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.015
RGD1306917 similar to RIKEN cDNA 2900010M23 0.015
RGD1304704 similar to Hypothetical protein CGI-99 0.015
Rpl18 ribosomal protein L18 0.014
Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.014
Pomp proteasome maturation protein 0.014
Ndufa13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.014
Tomm6 translocase of outer mitochondrial membrane 6 homolog (yeast) 0.014
Ndufb10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 0.014
Atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d 0.013
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.013
Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.013
Cyc1 cytochrome c-1 0.013
Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII 0.013
Tmed2 transmembrane emp24 domain trafficking protein 2 0.013
Cox7c cytochrome c oxidase, subunit VIIc 0.013
Nme2 non-metastatic cells 2, protein (NM23B) expressed in 0.013
LOC688869 similar to cytochrome c oxidase, subunit VIb polypeptide 1 0.013
Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 0.013
Rps11 ribosomal protein S11 0.012
Hspe1 heat shock protein 1 (chaperonin 10) 0.012
Tomm20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.012
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.012
Ndufa2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 0.012
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.012
Eif3i eukaryotic translation initiation factor 3, subunit I 0.012
Lsmd1 LSM domain containing 1 0.012
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.012
Ndufb2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 0.012
Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.012
Atp5e ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 0.012
Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 0.011
Atp5j2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2 0.011
LOC100363539 mitochondrial ribosomal protein L33-like 0.011
LOC100359498 ribosomal protein L35a-like 0.011
Ssr4 signal sequence receptor, delta 0.011
Rpl10a ribosomal protein L10A 0.011
Ndufa11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11 0.011
Mrps7 mitochondrial ribosomal protein S7 0.011
Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 0.011
Atp5d ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 0.011
Rpl11 ribosomal protein L11 0.011
Mrpl27 mitochondrial ribosomal protein L27 0.011
Mrpl20 mitochondrial ribosomal protein L20 0.011
Timm8b translocase of inner mitochondrial membrane 8 homolog b (yeast) 0.011
Grpel1 GrpE-like 1, mitochondrial 0.011
Caprin1 cell cycle associated protein 1 0.010
Park7 Parkinson disease (autosomal recessive, early onset) 7 0.010
Rps5 ribosomal protein S5 0.010
Rpl15 ribosomal protein L15 0.010
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.010
Atp6v1f ATPase, H transporting, lysosomal V1 subunit F 0.010
Psmd8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism