The network for 'positive regulation of macrophage chemotaxis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of macrophage chemotaxis

Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
CCR5 chemokine (C-C motif) receptor 5 1.000
CCL4 chemokine (C-C motif) ligand 4 1.000
CXCL9 chemokine (C-X-C motif) ligand 9 0.999
IL8 interleukin 8 0.997
CCL8 chemokine (C-C motif) ligand 8 0.997
CXCL10 chemokine (C-X-C motif) ligand 10 0.997
IL1B interleukin 1, beta 0.987
CXCL2 chemokine (C-X-C motif) ligand 2 0.981
CCL2 chemokine (C-C motif) ligand 2 0.979
CCR1 chemokine (C-C motif) receptor 1 0.978
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.977
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.968
CCL5 chemokine (C-C motif) ligand 5 0.967
CXCL3 chemokine (C-X-C motif) ligand 3 0.953
IL6 interleukin 6 (interferon, beta 2) 0.947
CXCL11 chemokine (C-X-C motif) ligand 11 0.919
CCL13 chemokine (C-C motif) ligand 13 0.904
PLEK pleckstrin 0.842
ICAM1 intercellular adhesion molecule 1 0.839
IDE insulin-degrading enzyme 0.789
CD163 CD163 molecule 0.711
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.704
IL7R interleukin 7 receptor 0.701
CXCL13 chemokine (C-X-C motif) ligand 13 0.697
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.655
DPP4 dipeptidyl-peptidase 4 0.605
SLAMF8 SLAM family member 8 0.595
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.588
CTNND1 catenin (cadherin-associated protein), delta 1 0.573
CXCL5 chemokine (C-X-C motif) ligand 5 0.570
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.538
MS4A4A membrane-spanning 4-domains, subfamily A, member 4 0.525
IFNG interferon, gamma 0.501
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.435
CLEC7A C-type lectin domain family 7, member A 0.432
CCR7 chemokine (C-C motif) receptor 7 0.423
CCL3 chemokine (C-C motif) ligand 3 0.419
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.405
GNLY granulysin 0.379
TGFB1 transforming growth factor, beta 1 0.373
CCL20 chemokine (C-C motif) ligand 20 0.370
IL2RB interleukin 2 receptor, beta 0.368
CCL7 chemokine (C-C motif) ligand 7 0.357
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.347
VCAM1 vascular cell adhesion molecule 1 0.322
CCL22 chemokine (C-C motif) ligand 22 0.319
LAT linker for activation of T cells 0.296
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.295
MET met proto-oncogene (hepatocyte growth factor receptor) 0.290
FPR3 formyl peptide receptor 3 0.276
CD83 CD83 molecule 0.275
RGS1 regulator of G-protein signaling 1 0.265
PLAUR plasminogen activator, urokinase receptor 0.253
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.250
AQP9 aquaporin 9 0.250
C5AR1 complement component 5a receptor 1 0.246
TNF tumor necrosis factor 0.237
IL18RAP interleukin 18 receptor accessory protein 0.229
BCL2A1 BCL2-related protein A1 0.218
SELE selectin E 0.215
PLAU plasminogen activator, urokinase 0.211
TREM1 triggering receptor expressed on myeloid cells 1 0.196
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.196
IDO1 indoleamine 2,3-dioxygenase 1 0.192
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.189
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.188
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.188
CCL19 chemokine (C-C motif) ligand 19 0.187
MSR1 macrophage scavenger receptor 1 0.186
INHBA inhibin, beta A 0.179
GAB1 GRB2-associated binding protein 1 0.166
C3AR1 complement component 3a receptor 1 0.157
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.156
CH25H cholesterol 25-hydroxylase 0.156
IL10 interleukin 10 0.150
MPEG1 macrophage expressed 1 0.149
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.145
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.143
ADAMDEC1 ADAM-like, decysin 1 0.142
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.135
UBD ubiquitin D 0.134
STAB1 stabilin 1 0.130
FPR1 formyl peptide receptor 1 0.126
NNMT nicotinamide N-methyltransferase 0.121
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.121
LAMP3 lysosomal-associated membrane protein 3 0.120
GZMK granzyme K (granzyme 3; tryptase II) 0.120
SLAMF7 SLAM family member 7 0.117
CYBB cytochrome b-245, beta polypeptide 0.116
C1QB complement component 1, q subcomponent, B chain 0.113
PTPRE protein tyrosine phosphatase, receptor type, E 0.113
TLR2 toll-like receptor 2 0.112
SRGN serglycin 0.108
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.105
CD68 CD68 molecule 0.101
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.101
ENG endoglin 0.099
VCAN versican 0.093
PRF1 perforin 1 (pore forming protein) 0.089
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.085
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
cdh5 cadherin 5 0.958
mitfa microphthalmia-associated transcription factor a 0.938
etv2 ets variant gene 2 0.741
tie1 endothelium-specific receptor tyrosine kinase 1 0.719
cmyb transcription factor cmyb 0.594
fli1a friend leukemia integration 1a 0.505
runx1 runt-related transcription factor 1 0.476
tal1 T-cell acute lymphocytic leukemia 1 0.419
sox7 SRY-box containing gene 7 0.305
tie2 endothelium-specific receptor tyrosine kinase 2 0.233
kdrl kinase insert domain receptor like 0.212
gata1a GATA binding protein 1a 0.212
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.172
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.162
csf1ra colony stimulating factor 1 receptor, a 0.150
dll4 delta-like 4 (Drosophila) 0.126
hbbe1.1 hemoglobin beta embryonic-1.1 0.108
flt4 fms-related tyrosine kinase 4 0.094
mpx myeloid-specific peroxidase 0.092
si:ch211-235f6.2 si:ch211-235f6.2 0.090
bnc2 basonuclin 2 0.082
hbae1 hemoglobin alpha embryonic-1 0.078
si:ch73-60e21.1 si:ch73-60e21.1 0.077
vegfc vascular endothelial growth factor c 0.070
dusp5 dual specificity phosphatase 5 0.062
sox10 SRY-box containing gene 10 0.058
aox3 aldehyde oxidase 3 0.054
ednrb1 endothelin receptor B 0.054
dab2 disabled homolog 2 (Drosophila) 0.051
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.050
si:ch211-212m21.5 si:ch211-212m21.5 0.047
lyz lysozyme 0.042
nrp1a neuropilin 1a 0.041
pnp4a purine nucleoside phosphorylase 4a 0.039
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.035
ltk leukocyte tyrosine kinase 0.034
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.034
gpr182 G protein-coupled receptor 182 0.033
tmem88a transmembrane protein 88 a 0.030
lmo2 LIM domain only 2 (rhombotin-like 1) 0.029
cyp1a cytochrome P450, family 1, subfamily A 0.028
lcp1 lymphocyte cytosolic plastin 1 0.028
fli1b friend leukemia integration 1b 0.028
gch2 GTP cyclohydrolase 2 0.028
stab2 stabilin 2 0.027
rbm24a RNA binding motif protein 24a 0.025
pax7b paired box gene 7b 0.025
mcamb melanoma cell adhesion molecule b 0.023
vegfaa vascular endothelial growth factor Aa 0.023
vsg1 vessel-specific 1 0.022
fabp11a fatty acid binding protein 11a 0.022
prox1 prospero-related homeobox gene 1 0.021
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.021
esama endothelial cell adhesion molecule a 0.020
vmhc ventricular myosin heavy chain 0.019
mmp9 matrix metalloproteinase 9 0.019
slc45a2 solute carrier family 45, member 2 0.018
hspg2 heparan sulfate proteoglycan 2 0.018
gfi1.1 growth factor independent 1.1 0.018
plxnd1 plexin D1 0.018
tgfb3 transforming growth factor, beta 3 0.017
klf2a Kruppel-like factor 2a 0.016
yrk Yes-related kinase 0.016
kita kit receptor a 0.015
efnb2a ephrin B2a 0.015
tyr tyrosinase 0.015
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.015
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.014
six1b sine oculis homeobox homolog 1b 0.014
pmela premelanosome protein a 0.013
cdh23 cadherin-like 23 0.013
ntn4 netrin 4 0.013
fev FEV (ETS oncogene family) 0.013
tbx5a T-box 5a 0.012
ccbe1 collagen and calcium binding EGF domains 1 0.012
osr1 odd-skipped related 1 (Drosophila) 0.012
wu:fj39b01 wu:fj39b01 0.012
col12a1 collagen, type XII, alpha 1 0.012
aqp8a.1 aquaporin 8a, tandem duplicate 1 0.011
mrc1a mannose receptor, C type 1a 0.011
clec14a C-type lectin domain family 14, member A 0.010
tbx20 T-box 20 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Ccr2 chemokine (C-C motif) receptor 2 0.993
Msr1 macrophage scavenger receptor 1 0.951
Ccr1 chemokine (C-C motif) receptor 1 0.804
Il1b interleukin 1 beta 0.717
Fcgr1 Fc receptor, IgG, high affinity I 0.690
Cd44 CD44 antigen 0.636
Ccl3 chemokine (C-C motif) ligand 3 0.518
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.516
Clec4e C-type lectin domain family 4, member e 0.508
Cybb cytochrome b-245, beta polypeptide 0.479
Cdh5 cadherin 5 0.463
Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.437
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.435
Clec4d C-type lectin domain family 4, member d 0.417
Slfn4 schlafen 4 0.395
Il1rn interleukin 1 receptor antagonist 0.357
Csf1 colony stimulating factor 1 (macrophage) 0.354
C3ar1 complement component 3a receptor 1 0.352
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.338
Fpr1 formyl peptide receptor 1 0.329
Ccr5 chemokine (C-C motif) receptor 5 0.302
C5ar1 complement component 5a receptor 1 0.279
Tlr4 toll-like receptor 4 0.275
Selp selectin, platelet 0.244
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.235
Cd14 CD14 antigen 0.214
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.200
Thbs1 thrombospondin 1 0.194
Slfn1 schlafen 1 0.194
Lilrb3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.189
Ush1g Usher syndrome 1G homolog (human) 0.185
Ush1c Usher syndrome 1C homolog (human) 0.174
Saa3 serum amyloid A 3 0.159
F10 coagulation factor X 0.154
Lyz2 lysozyme 2 0.149
Il1a interleukin 1 alpha 0.147
Gm14548 predicted gene 14548 0.142
Lox lysyl oxidase 0.139
Ccl7 chemokine (C-C motif) ligand 7 0.135
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.134
Mmp8 matrix metallopeptidase 8 0.132
Ccl9 chemokine (C-C motif) ligand 9 0.129
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.129
Mmp9 matrix metallopeptidase 9 0.126
Tlr2 toll-like receptor 2 0.125
Marco macrophage receptor with collagenous structure 0.118
Dab2 disabled homolog 2 (Drosophila) 0.118
Has1 hyaluronan synthase1 0.115
Mdm2 transformed mouse 3T3 cell double minute 2 0.113
Fcgr4 Fc receptor, IgG, low affinity IV 0.102
Grxcr1 glutaredoxin, cysteine rich 1 0.100
Col1a1 collagen, type I, alpha 1 0.098
Cxcl2 chemokine (C-X-C motif) ligand 2 0.098
Ccl4 chemokine (C-C motif) ligand 4 0.087
Osmr oncostatin M receptor 0.086
Cx3cr1 chemokine (C-X3-C) receptor 1 0.085
Nos3 nitric oxide synthase 3, endothelial cell 0.080
Tbxas1 thromboxane A synthase 1, platelet 0.078
AF251705 cDNA sequence AF251705 0.076
Clec4a2 C-type lectin domain family 4, member a2 0.075
Slc10a6 solute carrier family 10 (sodium/bile acid cotransporter family), member 6 0.072
Col8a1 collagen, type VIII, alpha 1 0.071
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.069
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.067
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.066
Itgam integrin alpha M 0.066
Aoah acyloxyacyl hydrolase 0.058
Tyrobp TYRO protein tyrosine kinase binding protein 0.058
Il6 interleukin 6 0.057
Ncf1 neutrophil cytosolic factor 1 0.057
Irg1 immunoresponsive gene 1 0.053
Ccl8 chemokine (C-C motif) ligand 8 0.050
Ifitm6 interferon induced transmembrane protein 6 0.049
Plaur plasminogen activator, urokinase receptor 0.046
Ccl6 chemokine (C-C motif) ligand 6 0.046
Folr2 folate receptor 2 (fetal) 0.045
Sykb spleen tyrosine kinase 0.044
Il1r1 interleukin 1 receptor, type I 0.044
Mmp3 matrix metallopeptidase 3 0.044
Whrn whirlin 0.042
Ccl12 chemokine (C-C motif) ligand 12 0.040
Ear2 eosinophil-associated, ribonuclease A family, member 2 0.040
Ch25h cholesterol 25-hydroxylase 0.040
Fcgr2b Fc receptor, IgG, low affinity IIb 0.039
Lcp2 lymphocyte cytosolic protein 2 0.039
Chi3l3 chitinase 3-like 3 0.038
Clec4n C-type lectin domain family 4, member n 0.037
Thbs2 thrombospondin 2 0.035
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.034
Tgfb1 transforming growth factor, beta 1 0.033
Mmp12 matrix metallopeptidase 12 0.032
Gdf15 growth differentiation factor 15 0.031
Cd180 CD180 antigen 0.030
Pcdh15 protocadherin 15 0.030
Mx2 myxovirus (influenza virus) resistance 2 0.030
Itgax integrin alpha X 0.028
Slpi secretory leukocyte peptidase inhibitor 0.027
Sirpa signal-regulatory protein alpha 0.026
Cdh23 cadherin 23 (otocadherin) 0.026
Cd86 CD86 antigen 0.026
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
C1qc complement component 1, q subcomponent, C chain 0.153
Cd14 CD14 molecule 0.144
Timp1 TIMP metallopeptidase inhibitor 1 0.082
Icam1 intercellular adhesion molecule 1 0.053
Cxcl10 chemokine (C-X-C motif) ligand 10 0.047
Igsf6 immunoglobulin superfamily, member 6 0.038
Cd68 Cd68 molecule 0.036
Il1b interleukin 1 beta 0.033
Fcer1g Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.027
C5ar1 complement component 5a receptor 1 0.026
Nkg7 natural killer cell group 7 sequence 0.025
Pld4 phospholipase D family, member 4 0.023
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.023
Cd4 Cd4 molecule 0.021
Hck hemopoietic cell kinase 0.020
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.019
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.019
Il2rg interleukin 2 receptor, gamma 0.017
Folr2 folate receptor 2 (fetal) 0.017
Laptm5 lysosomal protein transmembrane 5 0.017
Cxcl16 chemokine (C-X-C motif) ligand 16 0.017
Ly86 lymphocyte antigen 86 0.016
Ptprc protein tyrosine phosphatase, receptor type, C 0.016
Clec4a3 C-type lectin domain family 4, member a3 0.016
Plek pleckstrin 0.015
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.015
Tyrobp Tyro protein tyrosine kinase binding protein 0.014
Cd86 CD86 molecule 0.014
Il2rb interleukin 2 receptor, beta 0.013
Cmklr1 chemokine-like receptor 1 0.013
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.012
Itgam integrin, alpha M 0.012
Gzmb granzyme B 0.012
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.011
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.011
Prf1 perforin 1 (pore forming protein) 0.011
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.011
Xcl1 chemokine (C motif) ligand 1 0.011
Arhgdib Rho, GDP dissociation inhibitor (GDI) beta 0.011
Git1 G protein-coupled receptor kinase interacting ArfGAP 1 0.010
Cd3g CD3 molecule, gamma 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism