The network for 'cellular response to xenobiotic stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to xenobiotic stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.

Homo sapiens
Name Description Probability Func Analog Organism
GSTM1 glutathione S-transferase mu 1 0.999
GSTM2 glutathione S-transferase mu 2 (muscle) 0.999
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.997
S100B S100 calcium binding protein B 0.990
RARA retinoic acid receptor, alpha 0.969
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 0.965
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.952
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 0.951
S100A4 S100 calcium binding protein A4 0.950
RXRA retinoid X receptor, alpha 0.948
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.941
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 0.932
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 0.913
S100A1 S100 calcium binding protein A1 0.878
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.850
S100A16 S100 calcium binding protein A16 0.840
S100A6 S100 calcium binding protein A6 0.811
GSTM4 glutathione S-transferase mu 4 0.799
ANXA2 annexin A2 0.785
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.695
S100A14 S100 calcium binding protein A14 0.659
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.559
MED25 mediator complex subunit 25 0.556
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.471
NCOR2 nuclear receptor corepressor 2 0.417
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 0.415
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 0.412
S100A11 S100 calcium binding protein A11 0.385
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.313
HR hairless homolog (mouse) 0.289
XIAP X-linked inhibitor of apoptosis 0.243
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.237
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 0.226
NCOA1 nuclear receptor coactivator 1 0.223
ALS2CR12 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 0.219
C6 complement component 6 0.205
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.199
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 0.191
GLYAT glycine-N-acyltransferase 0.178
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.178
GSTM3 glutathione S-transferase mu 3 (brain) 0.169
APAF1 apoptotic peptidase activating factor 1 0.156
SPOP speckle-type POZ protein 0.154
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 0.146
AREG amphiregulin 0.145
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.130
A1CF APOBEC1 complementation factor 0.127
OTC ornithine carbamoyltransferase 0.127
HIPK2 homeodomain interacting protein kinase 2 0.126
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.124
AGER advanced glycosylation end product-specific receptor 0.123
FKBP4 FK506 binding protein 4, 59kDa 0.108
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 0.103
TIMP2 TIMP metallopeptidase inhibitor 2 0.102
MASP2 mannan-binding lectin serine peptidase 2 0.097
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 0.096
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 0.094
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 0.092
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.081
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.080
GSTM5 glutathione S-transferase mu 5 0.075
KNG1 kininogen 1 0.072
S100A2 S100 calcium binding protein A2 0.071
FMO4 flavin containing monooxygenase 4 0.071
HRG histidine-rich glycoprotein 0.071
ADH6 alcohol dehydrogenase 6 (class V) 0.068
FAM46A family with sequence similarity 46, member A 0.067
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 0.063
LGALS3 lectin, galactoside-binding, soluble, 3 0.063
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.062
F9 coagulation factor IX 0.062
ESR1 estrogen receptor 1 0.062
LGALS1 lectin, galactoside-binding, soluble, 1 0.061
TMSB10 thymosin beta 10 0.060
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.059
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.059
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.058
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.057
S100A8 S100 calcium binding protein A8 0.054
XDH xanthine dehydrogenase 0.054
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.054
S100A9 S100 calcium binding protein A9 0.054
C8B complement component 8, beta polypeptide 0.054
PROX1 prospero homeobox 1 0.052
AADAC arylacetamide deacetylase (esterase) 0.051
NR1I3 nuclear receptor subfamily 1, group I, member 3 0.051
PGR progesterone receptor 0.050
ALDOB aldolase B, fructose-bisphosphate 0.050
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.049
FTL ferritin, light polypeptide 0.049
PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide 0.047
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 0.047
C8A complement component 8, alpha polypeptide 0.046
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.044
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.043
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 0.042
BHMT betaine--homocysteine S-methyltransferase 0.041
NR1H4 nuclear receptor subfamily 1, group H, member 4 0.040
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.039
TM4SF4 transmembrane 4 L six family member 4 0.039
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cyp1a cytochrome P450, family 1, subfamily A 0.649
cyp3a65 cytochrome P450, family 3, subfamily A, polypeptide 65 0.559
idh1 isocitrate dehydrogenase 1 (NADP+), soluble 0.359
mbnl2 muscleblind-like 2 (Drosophila) 0.352
cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 0.351
aqp1a.1 aquaporin 1a, tandem duplicate 1 0.333
ogn osteoglycin 0.311
sult1st4 sulfotransferase family 1, cytosolic sulfotransferase 4 0.297
cyp51 cytochrome P450, family 51 0.297
ca2 carbonic anhydrase II 0.262
pla2g12b phospholipase A2, group XIIB 0.245
epas1a endothelial PAS domain protein 1a 0.240
mao monoamine oxidase 0.200
slc9a3.2 solute carrier family 9 (sodium/hydrogen exchanger), member 3.2 0.194
slc26a6l solute carrier family 26, member 6, like 0.176
cyp2y3 cytochrome P450, family 2, subfamily Y, polypeptide 3 0.153
angptl6 angiopoietin-like 6 0.137
aldob aldolase b, fructose-bisphosphate 0.133
sult3st2 sulfotransferase family 3, cytosolic sulfotransferase 2 0.130
slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.125
lgals2b lectin, galactoside-binding, soluble, 2b 0.125
atp6v1al ATPase, H+ transporting, lysosomal V1 subunit A, like 0.122
sparc secreted acidic cysteine rich glycoprotein 0.122
cacnb2a calcium channel, voltage-dependent, beta 2a 0.121
znf711 zinc finger protein 711 0.121
apoa1 apolipoprotein A-I 0.119
chsy1 chondroitin sulfate synthase 1 0.115
si:ch211-102c2.6 si:ch211-102c2.6 0.114
si:dkey-270m17.5 si:dkey-270m17.5 0.110
sepp1a selenoprotein P, plasma, 1a 0.110
ar androgen receptor 0.108
zgc:153921 zgc:153921 0.108
slc34a2a solute carrier family 34 (sodium phosphate), member 2a 0.106
angptl3 angiopoietin-like 3 0.096
ccl-c11b chemokine CCL-C11b 0.093
mep1a.1 meprin A, alpha.1 0.090
sult1st3 sulfotransferase family 1, cytosolic sulfotransferase 3 0.089
klfd Kruppel-like factor d 0.085
gstt1b glutathione S-transferase theta 1b 0.085
dio1 deiodinase, iodothyronine, type I 0.084
igfbp2a insulin-like growth factor binding protein 2a 0.084
cyp1d1 cytochrome P450, family 1, subfamily D, polypeptide 1 0.083
sb:eu697 sb:eu697 0.082
slc16a12b solute carrier family 16 (monocarboxylic acid transporters), member 12b 0.081
sult6b1 sulfotransferase family, cytosolic, 6b, member 1 0.080
acy3.2 aspartoacylase (aminocyclase) 3.2 0.079
abca12 ATP-binding cassette, sub-family A (ABC1), member 12 0.078
nfe2l2 nuclear factor (erythroid-derived 2)-like 2 0.077
LOC790901 glucose-dependent insulinotropic polypeptide 0.076
cyp2aa1 cytochrome P450, family 2, subfamily AA, polypeptide 1 0.074
nr3c2 nuclear receptor subfamily 3, group C, member 2 0.074
ccl25b chemokine (C-C motif) ligand 25b 0.073
ctsl.1 cathepsin L.1 0.070
ptgds prostaglandin D2 synthase 0.069
card9 caspase recruitment domain family, member 9 0.067
sult3st1 sulfotransferase family 3, cytosolic sulfotransferase 1 0.066
fa2h fatty acid 2-hydroxylase 0.066
cbr1l carbonyl reductase 1-like 0.065
rnf10 ring finger protein 10 0.063
rnf11 ring finger protein 11 0.062
igf3 insulin-like growth factor 3 0.062
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.061
baxb bcl2-associated X protein, b 0.061
slc26a3 solute carrier family 26, member 3 0.061
comta catechol-O-methyltransferase a 0.060
rnasel3 ribonuclease like 3 0.060
LOC568935 ARF GTPase-activating protein GIT1-like 0.060
myo18l2 myosin XVIII-like 2 0.059
plekhg4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 0.059
hoxc13b homeo box C13b 0.058
zgc:92313 zgc:92313 0.058
nt5e 5'-nucleotidase, ecto (CD73) 0.058
sqrdl sulfide quinone reductase-like (yeast) 0.058
gstp1 glutathione S-transferase pi 0.058
aqp3a aquaporin 3a 0.057
myoc myocilin 0.057
nod1 nucleotide-binding oligomerization domain containing 1 0.055
sat1a spermidine/spermine N1-acetyltransferase 1a 0.055
slc4a1b solute carrier family 4, anion exchanger, member 1b 0.055
ctsd cathepsin D 0.054
spock3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 0.054
keap1a kelch-like ECH-associated protein 1a 0.054
arhgap29b Rho GTPase activating protein 29b 0.053
kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 0.053
vasa vasa homolog 0.053
epb41 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) 0.052
zgc:73347 zgc:73347 0.052
zgc:64106 zgc:64106 0.051
ahsg alpha-2-HS-glycoprotein 0.050
nadka NAD kinase a 0.050
igfbp1a insulin-like growth factor binding protein 1a 0.050
si:rp71-39b20.7 si:rp71-39b20.7 0.049
cyp4t8 cytochrome P450, family 4, subfamily T, polypeptide 8 0.049
fbp1a fructose-1,6-bisphosphatase 1a 0.049
sox7 SRY-box containing gene 7 0.048
LOC565839 tumor necrosis factor alpha-induced protein 2-like 0.048
lims1 LIM and senescent cell antigen-like domains 1 0.048
apoa4 apolipoprotein A-IV 0.047
cx32.3 connexin 32.3 0.046
ftr82 finTRIM family, member 82 0.046
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Ugt35a UDP-glycosyltransferase 35a 0.495
Cyp6d5 CG3050 gene product from transcript CG3050-RA 0.175
JhI-26 Juvenile hormone-inducible protein 26 0.174
Cyp6a21 CG10247 gene product from transcript CG10247-RA 0.139
y yellow 0.113
Cyp28d1 CG10833 gene product from transcript CG10833-RA 0.099
Cyp6a23 CG10242 gene product from transcript CG10242-RA 0.073
Uch Ubiquitin carboxy-terminal hydrolase 0.068
Prosbeta3 Proteasome beta3 subunit 0.059
Cyp6a9 Cytochrome P450-6a9 0.057
Cyp12a4 CG6042 gene product from transcript CG6042-RA 0.035
CG10562 CG10562 gene product from transcript CG10562-RA 0.032
sni sniffer 0.027
Cyp12a5 CG11821 gene product from transcript CG11821-RA 0.026
CG6830 CG6830 gene product from transcript CG6830-RA 0.026
Cyp12e1 CG14680 gene product from transcript CG14680-RC 0.023
LvpD Larval visceral protein D 0.023
Cyp6a2 Cytochrome P450-6a2 0.022
Jheh1 Juvenile hormone epoxide hydrolase 1 0.019
Cyp6a13 CG2397 gene product from transcript CG2397-RA 0.019
Cyp28a5 CG8864 gene product from transcript CG8864-RA 0.019
GstE6 Glutathione S transferase E6 0.017
Prosbeta7 Proteasome beta7 subunit 0.017
Cyp6a22 CG10240 gene product from transcript CG10240-RA 0.016
Acox57D-p acyl-Coenzyme A oxidase at 57D proximal 0.016
CG9360 CG9360 gene product from transcript CG9360-RA 0.015
CG6834 CG6834 gene product from transcript CG6834-RA 0.014
Pros25 Proteasome 25kD subunit 0.014
Cyp6g1 CG8453 gene product from transcript CG8453-RA 0.013
Cyp4e2 Cytochrome P450-4e2 0.013
Cyp6d4 CG12800 gene product from transcript CG12800-RA 0.012
CG2064 CG2064 gene product from transcript CG2064-RA 0.012
Cyp4p1 Cytochrome P450-4p1 0.012
Epac CG34392 gene product from transcript CG34392-RC 0.011
CG12672 CG12672 gene product from transcript CG12672-RA 0.010
Ugt86Da CG18578 gene product from transcript CG18578-RA 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Gstm1 glutathione S-transferase, mu 1 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 0.983
Gstm1 glutathione S-transferase mu 1 0.963
Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 0.963
Ephx1 epoxide hydrolase 1, microsomal 0.948
Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 0.933
Gsta3 glutathione S-transferase A3 0.897
Mgst1 microsomal glutathione S-transferase 1 0.825
Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 0.804
Apob apolipoprotein B 0.695
Ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.547
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.510
Sult1b1 sulfotransferase family, cytosolic, 1B, member 1 0.488
Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 0.478
LOC293989 cytochrome P450-like 0.470
Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 0.467
Ugt2b UDP glycosyltransferase 2 family, polypeptide B 0.463
Ugt2b37 UDP-glucuronosyltransferase 2 family, member 37 0.438
Abcb11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 0.427
Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 0.401
Mgst2 microsomal glutathione S-transferase 2 0.370
Omd osteomodulin 0.342
Gsta5 glutathione S-transferase Yc2 subunit 0.294
LOC100365112 carboxylesterase-like 0.287
Otc ornithine carbamoyltransferase 0.264
Gstm2 glutathione S-transferase mu 2 0.248
Hsph1 heat shock 105/110 protein 1 0.248
Gsta2 glutathione S-transferase A2 0.246
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.236
Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 0.227
Sult1e1 sulfotransferase family 1E, estrogen-preferring, member 1 0.221
Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 0.207
Cyb5a cytochrome b5 type A (microsomal) 0.197
Selenbp1 selenium binding protein 1 0.182
LOC100361864 UDP-glucuronosyltransferase 2B3-like 0.171
Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 0.152
Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 0.152
Akr1c14 aldo-keto reductase family 1, member C14 0.152
Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 0.149
Gstp1 glutathione S-transferase pi 1 0.141
Sult1c3 sulfotransferase family, cytosolic, 1C, member 3 0.139
Gckr glucokinase (hexokinase 4) regulator 0.134
Ces1f carboxylesterase 1F 0.131
Mettl7b methyltransferase like 7B 0.122
Ces1e carboxylesterase 1E 0.122
Crygf crystallin, gamma F 0.116
Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 0.109
Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 0.106
A1i3 alpha-1-inhibitor III 0.104
Gstt1 glutathione S-transferase theta 1 0.102
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.101
Akr1c18 aldo-keto reductase family 1, member C18 0.099
LOC100361547 Cytochrome P450, family 2, subfamily c, polypeptide 7-like 0.097
Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 0.096
Hpd 4-hydroxyphenylpyruvate dioxygenase 0.096
Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 0.094
Cyb5r3 cytochrome b5 reductase 3 0.086
Dpys dihydropyrimidinase 0.085
Abcc2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 0.081
LOC494499 LOC494499 protein 0.080
Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 0.078
Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 0.071
Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 0.069
Dhfr dihydrofolate reductase 0.068
Hprt1 hypoxanthine phosphoribosyltransferase 1 0.067
Nr5a2 nuclear receptor subfamily 5, group A, member 2 0.064
Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 0.063
Aqp9 aquaporin 9 0.061
Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 0.060
Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 0.058
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.057
Azgp1 alpha-2-glycoprotein 1, zinc-binding 0.057
Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 0.057
Ugt2b36 UDP glucuronosyltransferase 2 family, polypeptide B36 0.056
Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 0.055
Tst thiosulfate sulfurtransferase 0.055
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.054
Galnt5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) 0.052
Keg1 kidney expressed gene 1 0.051
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.049
Dpyd dihydropyrimidine dehydrogenase 0.046
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.045
Cps1 carbamoyl-phosphate synthetase 1 0.045
Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 0.044
Ces1c carboxylesterase 1C 0.044
Mbl2 mannose-binding lectin (protein C) 2 0.044
Sult2al1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring-like 1 0.043
Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 0.042
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.041
Idh1 isocitrate dehydrogenase 1 (NADP+), soluble 0.041
Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 0.040
Clrn3 clarin 3 0.040
Hes2 hairy and enhancer of split 2 (Drosophila) 0.038
Klrc2 killer cell lectin-like receptor subfamily C, member 2 0.038
Gsta4 glutathione S-transferase alpha 4 0.037
Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.037
Ppara peroxisome proliferator activated receptor alpha 0.037
Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 0.036
Slco1a1 solute carrier organic anion transporter family, member 1a1 0.035
Fabp1 fatty acid binding protein 1, liver 0.035
Pigr polymeric immunoglobulin receptor 0.034
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism