The network for 'positive regulation of natural killer cell mediated cytotoxicity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of natural killer cell mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.

Homo sapiens
Name Description Probability Func Analog Organism
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 1.000
CD84 CD84 molecule 0.998
SLAMF1 signaling lymphocytic activation molecule family member 1 0.997
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.991
SH2D1A SH2 domain containing 1A 0.982
PVRL4 poliovirus receptor-related 4 0.915
IL2RB interleukin 2 receptor, beta 0.900
GZMK granzyme K (granzyme 3; tryptase II) 0.680
SH2D1B SH2 domain containing 1B 0.628
BCR breakpoint cluster region 0.589
GBA glucosidase, beta, acid 0.472
FYB FYN binding protein 0.412
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.386
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.371
IL23A interleukin 23, alpha subunit p19 0.309
IFNG interferon, gamma 0.298
RAB14 RAB14, member RAS oncogene family 0.211
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.188
CD244 CD244 molecule, natural killer cell receptor 2B4 0.174
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.172
TJP1 tight junction protein 1 (zona occludens 1) 0.138
FASLG Fas ligand (TNF superfamily, member 6) 0.086
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 0.085
CXCR6 chemokine (C-X-C motif) receptor 6 0.081
PRF1 perforin 1 (pore forming protein) 0.077
NCSTN nicastrin 0.075
BCAR1 breast cancer anti-estrogen resistance 1 0.073
CD2 CD2 molecule 0.073
STAP2 signal transducing adaptor family member 2 0.069
INSR insulin receptor 0.068
IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) 0.064
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.059
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.053
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.050
EPHB3 EPH receptor B3 0.050
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.049
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.046
KLRG1 killer cell lectin-like receptor subfamily G, member 1 0.043
CCR5 chemokine (C-C motif) receptor 5 0.040
LMO2 LIM domain only 2 (rhombotin-like 1) 0.040
JAK1 Janus kinase 1 0.040
IL18RAP interleukin 18 receptor accessory protein 0.039
GNLY granulysin 0.035
LY9 lymphocyte antigen 9 0.034
KLRC4 killer cell lectin-like receptor subfamily C, member 4 0.033
CD8A CD8a molecule 0.032
KLRF1 killer cell lectin-like receptor subfamily F, member 1 0.031
CD247 CD247 molecule 0.030
CD160 CD160 molecule 0.029
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.028
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.027
ITK IL2-inducible T-cell kinase 0.026
JAK2 Janus kinase 2 0.026
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.026
PYHIN1 pyrin and HIN domain family, member 1 0.025
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.025
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.024
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.022
GNS glucosamine (N-acetyl)-6-sulfatase 0.022
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.021
SH2D2A SH2 domain containing 2A 0.021
XCL2 chemokine (C motif) ligand 2 0.021
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.019
GPR65 G protein-coupled receptor 65 0.018
TXK TXK tyrosine kinase 0.017
MRAS muscle RAS oncogene homolog 0.017
CD96 CD96 molecule 0.017
PRKCQ protein kinase C, theta 0.016
LEPROT leptin receptor overlapping transcript 0.016
GPR171 G protein-coupled receptor 171 0.016
CD80 CD80 molecule 0.015
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.015
CCL4 chemokine (C-C motif) ligand 4 0.014
CD28 CD28 molecule 0.014
GPR18 G protein-coupled receptor 18 0.014
CD226 CD226 molecule 0.014
STAT5B signal transducer and activator of transcription 5B 0.013
CREG1 cellular repressor of E1A-stimulated genes 1 0.013
HEXB hexosaminidase B (beta polypeptide) 0.013
CTSW cathepsin W 0.013
ITM2B integral membrane protein 2B 0.013
ATF7IP activating transcription factor 7 interacting protein 0.012
HCST hematopoietic cell signal transducer 0.012
TRAT1 T cell receptor associated transmembrane adaptor 1 0.012
SLAMF6 SLAM family member 6 0.012
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.012
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.011
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.011
EPHB2 EPH receptor B2 0.011
ICOS inducible T-cell co-stimulator 0.011
LEPROTL1 leptin receptor overlapping transcript-like 1 0.010
IRF4 interferon regulatory factor 4 0.010
CD69 CD69 molecule 0.010
CLINT1 clathrin interactor 1 0.010
CD3D CD3d molecule, delta (CD3-TCR complex) 0.010
THEMIS thymocyte selection associated 0.010
XCL1 chemokine (C motif) ligand 1 0.010
CLEC5A C-type lectin domain family 5, member A 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.952
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.913
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.907
Stat1 signal transducer and activator of transcription 1 0.798
Stat5b signal transducer and activator of transcription 5B 0.794
Fasl Fas ligand (TNF superfamily, member 6) 0.711
Icos inducible T-cell co-stimulator 0.696
B2m beta-2 microglobulin 0.601
Gzmk granzyme K 0.581
H2-K1 histocompatibility 2, K1, K region 0.508
Stat5a signal transducer and activator of transcription 5A 0.369
Gzma granzyme A 0.348
Gzmb granzyme B 0.318
Xcl1 chemokine (C motif) ligand 1 0.289
Irf9 interferon regulatory factor 9 0.283
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.270
Tapbp TAP binding protein 0.250
Ncr1 natural cytotoxicity triggering receptor 1 0.249
Il18r1 interleukin 18 receptor 1 0.229
Il18rap interleukin 18 receptor accessory protein 0.219
H2-Q7 histocompatibility 2, Q region locus 7 0.187
Itgax integrin alpha X 0.139
H2-D1 histocompatibility 2, D region locus 1 0.122
Il10 interleukin 10 0.112
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.108
Trim21 tripartite motif-containing 21 0.100
Klra8 killer cell lectin-like receptor, subfamily A, member 8 0.100
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.093
Stat3 signal transducer and activator of transcription 3 0.088
Slamf1 signaling lymphocytic activation molecule family member 1 0.086
Cd244 CD244 natural killer cell receptor 2B4 0.084
Cd7 CD7 antigen 0.080
Klrb1a killer cell lectin-like receptor subfamily B member 1A 0.079
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.074
Ctsw cathepsin W 0.072
Emr4 EGF-like module containing, mucin-like, hormone receptor-like sequence 4 0.069
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.067
Cd180 CD180 antigen 0.066
Dpep3 dipeptidase 3 0.063
Ubd ubiquitin D 0.062
Aoah acyloxyacyl hydrolase 0.058
Il2rb interleukin 2 receptor, beta chain 0.056
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.055
Pilra paired immunoglobin-like type 2 receptor alpha 0.055
Itk IL2-inducible T-cell kinase 0.054
Nfil3 nuclear factor, interleukin 3, regulated 0.053
Slamf7 SLAM family member 7 0.053
BC147527 cDNA sequence BC147527 0.051
Nkg7 natural killer cell group 7 sequence 0.051
Sh2d2a SH2 domain protein 2A 0.050
Spna1 spectrin alpha 1 0.049
Ccr3 chemokine (C-C motif) receptor 3 0.047
Klra7 killer cell lectin-like receptor, subfamily A, member 7 0.047
Parp14 poly (ADP-ribose) polymerase family, member 14 0.047
Lepr leptin receptor 0.043
Prf1 perforin 1 (pore forming protein) 0.042
Bex6 brain expressed gene 6 0.041
H2-Q8 histocompatibility 2, Q region locus 8 0.041
H2-Eb1 histocompatibility 2, class II antigen E beta 0.040
Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 0.040
Pyhin1 pyrin and HIN domain family, member 1 0.040
Ctsb cathepsin B 0.038
Cp ceruloplasmin 0.037
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.035
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.035
Gzmc granzyme C 0.035
Cd160 CD160 antigen 0.034
Gbp7 guanylate binding protein 7 0.033
Il6 interleukin 6 0.032
Lair1 leukocyte-associated Ig-like receptor 1 0.032
Cd96 CD96 antigen 0.031
Irgm2 immunity-related GTPase family M member 2 0.030
Ctsd cathepsin D 0.030
Fpr1 formyl peptide receptor 1 0.029
Il4ra interleukin 4 receptor, alpha 0.028
Stat2 signal transducer and activator of transcription 2 0.028
Pilrb1 paired immunoglobin-like type 2 receptor beta 1 0.027
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.027
Ccr9 chemokine (C-C motif) receptor 9 0.027
Ear2 eosinophil-associated, ribonuclease A family, member 2 0.026
Cd3e CD3 antigen, epsilon polypeptide 0.025
Il2ra interleukin 2 receptor, alpha chain 0.025
Klra3 killer cell lectin-like receptor, subfamily A, member 3 0.025
H2-Q6 histocompatibility 2, Q region locus 6 0.025
Il6st interleukin 6 signal transducer 0.024
Gbp2 guanylate binding protein 2 0.024
Il2 interleukin 2 0.024
Itgae integrin alpha E, epithelial-associated 0.024
Plbd2 phospholipase B domain containing 2 0.023
Gcet2 germinal center expressed transcript 2 0.023
Itga4 integrin alpha 4 0.023
Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C 0.023
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.023
Cd3g CD3 antigen, gamma polypeptide 0.023
Irgm1 immunity-related GTPase family M member 1 0.022
Ccr5 chemokine (C-C motif) receptor 5 0.022
Pparg peroxisome proliferator activated receptor gamma 0.022
Cxcr6 chemokine (C-X-C motif) receptor 6 0.022
Sh2d1b1 SH2 domain protein 1B1 0.022
AA408251 expressed sequence AA408251 0.021
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Rattus norvegicus
Name Description Probability Func Analog Organism
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.266
Cd2 Cd2 molecule 0.068
Cd247 Cd247 molecule 0.059
Gzmk granzyme K 0.057
Prf1 perforin 1 (pore forming protein) 0.046
Sh2d1a SH2 domain protein 1A 0.046
Gimap4 GTPase, IMAP family member 4 0.035
Cd5 Cd5 molecule 0.035
Apol3 apolipoprotein L, 3 0.034
Gzmb granzyme B 0.034
Cd3g CD3 molecule, gamma 0.030
Xcl1 chemokine (C motif) ligand 1 0.030
Mcpt8 mast cell protease 8 0.024
Ptprcap protein tyrosine phosphatase, receptor type, C-associated protein 0.021
Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 0.020
Il2rb interleukin 2 receptor, beta 0.020
Dcaf7 DDB1 and CUL4 associated factor 7 0.020
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.017
Unc45b unc-45 homolog B (C. elegans) 0.017
Nkg7 natural killer cell group 7 sequence 0.017
Gimap6 GTPase, IMAP family member 6 0.017
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.016
Cd8a CD8a molecule 0.015
Zap70 zeta-chain (TCR) associated protein kinase 0.015
Spn sialophorin 0.015
Myc myelocytomatosis oncogene 0.015
Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a 0.014
Txnrd1 thioredoxin reductase 1 0.013
Klrb1a killer cell lectin-like receptor subfamily B, member 1A 0.013
Gimap5 GTPase, IMAP family member 5 0.013
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.012
Cd96 CD96 molecule 0.012
Ddr1 discoidin domain receptor tyrosine kinase 1 0.012
Sept1 septin 1 0.012
Rhoh ras homolog gene family, member H 0.012
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.012
Gzma granzyme A 0.012
Gzmc granzyme C 0.012
Cdc2l5 cell division cycle 2-like 5 (cholinesterase-related cell division controller) 0.012
Faim3 Fas apoptotic inhibitory molecule 3 0.011
Usp9x ubiquitin specific peptidase 9, X-linked 0.011
Gimap1 GTPase, IMAP family member 1 0.011
Sox7 SRY (sex determining region Y)-box 7 0.011
P2ry10 purinergic receptor P2Y, G-protein coupled, 10 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism