The network for 'cardiac muscle cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac muscle cell development

The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.

Homo sapiens
Name Description Probability Func Analog Organism
TTN titin 0.880
TRIM63 tripartite motif containing 63 0.808
CDK2 cyclin-dependent kinase 2 0.544
HDAC4 histone deacetylase 4 0.418
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.401
HDAC1 histone deacetylase 1 0.326
YAP1 Yes-associated protein 1 0.309
TBX5 T-box 5 0.230
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.206
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.205
COL4A1 collagen, type IV, alpha 1 0.196
NEB nebulin 0.184
BMPR1A bone morphogenetic protein receptor, type IA 0.154
COL4A2 collagen, type IV, alpha 2 0.129
ESR1 estrogen receptor 1 0.129
FLNA filamin A, alpha 0.124
NRP1 neuropilin 1 0.106
ZYX zyxin 0.092
ATXN1 ataxin 1 0.057
PDGFA platelet-derived growth factor alpha polypeptide 0.049
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.041
MYOD1 myogenic differentiation 1 0.041
ACTN1 actinin, alpha 1 0.040
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.038
MYOZ1 myozenin 1 0.037
NOTCH1 notch 1 0.030
RBBP4 retinoblastoma binding protein 4 0.025
ACTN2 actinin, alpha 2 0.025
HNF4A hepatocyte nuclear factor 4, alpha 0.024
MYL9 myosin, light chain 9, regulatory 0.021
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.020
TCAP titin-cap (telethonin) 0.019
CREBBP CREB binding protein 0.018
FN1 fibronectin 1 0.016
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.016
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.016
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.015
CAPN3 calpain 3, (p94) 0.015
ACTN4 actinin, alpha 4 0.015
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.014
KAT2B K(lysine) acetyltransferase 2B 0.014
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.014
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.014
MAPK9 mitogen-activated protein kinase 9 0.013
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.012
AR androgen receptor 0.012
DAZAP2 DAZ associated protein 2 0.012
MYPN myopalladin 0.012
MYOG myogenin (myogenic factor 4) 0.012
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.012
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.011
MEF2A myocyte enhancer factor 2A 0.011
CCNA2 cyclin A2 0.010
ITGA7 integrin, alpha 7 0.010
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
tnnc1b troponin C type 1b (slow) 0.981
bmp4 bone morphogenetic protein 4 0.966
slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a 0.899
smyd1b SET and MYND domain containing 1b 0.861
vmhc ventricular myosin heavy chain 0.837
myl7 myosin, light polypeptide 7, regulatory 0.826
mef2cb myocyte enhancer factor 2cb 0.801
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.794
myod1 myogenic differentiation 1 0.776
nkx2.5 NK2 transcription factor related 5 0.757
desma desmin a 0.710
gja3 gap junction protein, alpha 3 0.703
atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a 0.623
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.598
wnt11r wingless-type MMTV integration site family, member 11, related 0.562
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.549
ttna titin a 0.532
rnasel1 ribonuclease like 1 0.530
tnni1al troponin I, skeletal, slow like 0.527
tnni1b troponin I, skeletal, slow b 0.498
myl1 myosin, light chain 1, alkali; skeletal, fast 0.490
smyhc1 slow myosin heavy chain 1 0.478
zgc:66286 zgc:66286 0.467
tnnc1a troponin C type 1a (slow) 0.447
tbx20 T-box 20 0.425
aldoab aldolase a, fructose-bisphosphate, b 0.425
myog myogenin 0.384
cmlc1 cardiac myosin light chain-1 0.320
hspb1 heat shock protein, alpha-crystallin-related, 1 0.302
actn2 actinin, alpha 2 0.268
actc1a actin, alpha, cardiac muscle 1a 0.263
rbm24a RNA binding motif protein 24a 0.252
tpm2 tropomyosin 2 (beta) 0.245
mybpc3 myosin binding protein C, cardiac 0.236
fabp11a fatty acid binding protein 11a 0.223
actn3b actinin alpha 3b 0.216
hspb8 heat shock protein, alpha-crystallin-related, b8 0.207
pdlim7 PDZ and LIM domain 7 0.207
spry4 sprouty (Drosophila) homolog 4 0.207
myf6 myogenic factor 6 0.201
actc1b actin, alpha, cardiac muscle 1b 0.188
unc45b unc-45 homolog B (C. elegans) 0.186
srl sarcalumenin 0.177
tnni2a.4 troponin I, skeletal, fast 2a.4 0.175
wu:fb01h12 wu:fb01h12 0.175
nppa natriuretic peptide precursor A 0.159
podxl podocalyxin-like 0.146
synpo2lb synaptopodin 2-like b 0.145
nexn nexilin (F actin binding protein) 0.145
tnnc2 troponin C type 2 (fast) 0.137
tbx5b T-box 5b 0.130
lama4 laminin, alpha 4 0.130
tnnt3b troponin T3b, skeletal, fast 0.128
dmrt2a doublesex and mab-3 related transcription factor 2a 0.122
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.120
hspb12 heat shock protein, alpha-crystallin-related, b12 0.117
adrb2a adrenergic receptor, beta 2a 0.114
myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.113
vdra vitamin D receptor a 0.111
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.105
hspb7 heat shock protein family, alpha-crystallin-related, b7 0.105
tbx5a T-box 5a 0.103
smyhc2 slow myosin heavy chain 2 0.102
wt1a wilms tumor 1a 0.101
lrrc10 leucine rich repeat containing 10 0.092
casq2 calsequestrin 2 0.089
spaw southpaw 0.086
tbx18 T-box 18 0.086
kdrl kinase insert domain receptor like 0.085
rbm24b RNA binding motif protein 24b 0.084
bmp10 bone morphogenetic protein 10 0.084
cx30.3 connexin 30.3 0.084
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.083
egr1 early growth response 1 0.080
ripk2 receptor-interacting serine-threonine kinase 2 0.080
txlnba taxilin beta a 0.080
wu:fc31e07 wu:fc31e07 0.079
popdc2 popeye domain containing 2 0.079
sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) 0.077
tnnt2a troponin T2a, cardiac 0.077
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.076
ttnb titin b 0.075
pth2 parathyroid hormone 2 0.074
has2 hyaluronan synthase 2 0.074
csrp3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.073
cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.073
lmna lamin A 0.070
fxr1 fragile X mental retardation, autosomal homolog 1 0.070
acta1b actin, alpha 1b, skeletal muscle 0.069
fabp3 fatty acid binding protein 3, muscle and heart 0.067
per3 period homolog 3 (Drosophila) 0.065
mylk3 myosin light chain kinase 3 0.065
acta1a actin, alpha 1a, skeletal muscle 0.063
tmem38a transmembrane protein 38A 0.063
casrl calcium-sensing receptor, like 0.061
vmhcl ventricular myosin heavy chain-like 0.061
me2 malic enzyme 2, NAD(+)-dependent, mitochondrial 0.060
scn12ab sodium channel, voltage gated, type XII, alpha b 0.059
ldb3a LIM-domain binding factor 3a 0.058
ndrg4 N-myc downstream regulated gene 4 0.057
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
mys myospheroid 0.012
Cg25C Collagen type IV 0.011
vg vestigial 0.011
CG12558 CG12558 gene product from transcript CG12558-RA 0.011
LanB2 Laminin B2 0.010
Mhc Myosin heavy chain 0.010
CG17658 CG17658 gene product from transcript CG17658-RA 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Hand2 heart and neural crest derivatives expressed transcript 2 1.000
Shh sonic hedgehog 0.999
Hand1 heart and neural crest derivatives expressed transcript 1 0.997
Pitx2 paired-like homeodomain transcription factor 2 0.995
Nos3 nitric oxide synthase 3, endothelial cell 0.995
Tbx3 T-box 3 0.992
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.989
Fgfr2 fibroblast growth factor receptor 2 0.988
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.987
Sox9 SRY-box containing gene 9 0.981
Foxc2 forkhead box C2 0.970
Gata4 GATA binding protein 4 0.966
Apc adenomatosis polyposis coli 0.960
Msx1 homeobox, msh-like 1 0.958
Tgfb2 transforming growth factor, beta 2 0.954
Tagln transgelin 0.954
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.952
Cox6a2 cytochrome c oxidase, subunit VI a, polypeptide 2 0.946
Prrx1 paired related homeobox 1 0.945
Ttn titin 0.944
Vegfa vascular endothelial growth factor A 0.943
Foxc1 forkhead box C1 0.942
Col1a1 collagen, type I, alpha 1 0.930
Ldb3 LIM domain binding 3 0.929
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.920
Bmp4 bone morphogenetic protein 4 0.910
Dmd dystrophin, muscular dystrophy 0.894
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.891
Fgf8 fibroblast growth factor 8 0.890
Bmp7 bone morphogenetic protein 7 0.857
Myl3 myosin, light polypeptide 3 0.846
Pax3 paired box gene 3 0.836
Cnn1 calponin 1 0.835
Gli3 GLI-Kruppel family member GLI3 0.835
Actc1 actin, alpha, cardiac muscle 1 0.833
Tnnt3 troponin T3, skeletal, fast 0.831
Meox2 mesenchyme homeobox 2 0.804
Pitx1 paired-like homeodomain transcription factor 1 0.791
Hrc histidine rich calcium binding protein 0.752
Tbx1 T-box 1 0.751
Actn2 actinin alpha 2 0.719
Smad6 MAD homolog 6 (Drosophila) 0.711
Otx2 orthodenticle homolog 2 (Drosophila) 0.709
Casq2 calsequestrin 2 0.708
Jag1 jagged 1 0.707
Sox2 SRY-box containing gene 2 0.665
Efnb2 ephrin B2 0.643
Nodal nodal 0.629
Csf1 colony stimulating factor 1 (macrophage) 0.625
Gja1 gap junction protein, alpha 1 0.623
Gsc goosecoid homeobox 0.613
Pdlim3 PDZ and LIM domain 3 0.599
Zeb1 zinc finger E-box binding homeobox 1 0.598
Sgcg sarcoglycan, gamma (dystrophin-associated glycoprotein) 0.591
Ctnnb1 catenin (cadherin associated protein), beta 1 0.586
Wt1 Wilms tumor 1 homolog 0.567
Gli2 GLI-Kruppel family member GLI2 0.557
Tgfbr2 transforming growth factor, beta receptor II 0.548
Kdr kinase insert domain protein receptor 0.542
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.542
Wnt5a wingless-related MMTV integration site 5A 0.538
Eya1 eyes absent 1 homolog (Drosophila) 0.534
Tnni2 troponin I, skeletal, fast 2 0.534
Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) 0.520
Nppa natriuretic peptide type A 0.513
Nog noggin 0.494
Yap1 yes-associated protein 1 0.494
Gata6 GATA binding protein 6 0.487
Dlx5 distal-less homeobox 5 0.482
Scn5a sodium channel, voltage-gated, type V, alpha 0.474
Sall4 sal-like 4 (Drosophila) 0.469
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.468
Xirp1 xin actin-binding repeat containing 1 0.429
Actn3 actinin alpha 3 0.428
Bmpr1a bone morphogenetic protein receptor, type 1A 0.423
Tbx15 T-box 15 0.421
Fgfr3 fibroblast growth factor receptor 3 0.417
Cav3 caveolin 3 0.416
Hspb7 heat shock protein family, member 7 (cardiovascular) 0.390
Notch1 Notch gene homolog 1 (Drosophila) 0.390
Notch2 Notch gene homolog 2 (Drosophila) 0.386
Runx2 runt related transcription factor 2 0.384
Atg12 autophagy-related 12 (yeast) 0.380
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.368
Art1 ADP-ribosyltransferase 1 0.367
Flnc filamin C, gamma 0.364
Meox1 mesenchyme homeobox 1 0.362
Sox7 SRY-box containing gene 7 0.360
Tnnc1 troponin C, cardiac/slow skeletal 0.359
Hoxd13 homeobox D13 0.355
Acvr1 activin A receptor, type 1 0.354
Ckmt2 creatine kinase, mitochondrial 2 0.351
Gja5 gap junction protein, alpha 5 0.347
Vangl2 vang-like 2 (van gogh, Drosophila) 0.347
Tcfap2a transcription factor AP-2, alpha 0.346
Ren1 renin 1 structural 0.345
Pou5f1 POU domain, class 5, transcription factor 1 0.343
Cdh5 cadherin 5 0.342
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.329
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
LOC100362824 caveolin 2-like 0.413
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.196
Myh7 myosin, heavy chain 7, cardiac muscle, beta 0.186
Top2a topoisomerase (DNA) II alpha 0.135
Cdk1 cyclin-dependent kinase 1 0.133
Alb albumin 0.129
Casq2 calsequestrin 2 (cardiac muscle) 0.128
Cdkn3 cyclin-dependent kinase inhibitor 3 0.096
Nos3 nitric oxide synthase 3, endothelial cell 0.092
Cav1 caveolin 1, caveolae protein 0.089
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.089
Myoz2 myozenin 2 0.087
LOC689399 hypothetical protein LOC689399 0.082
Myl3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.076
Tnni1 troponin I type 1 (skeletal, slow) 0.073
Spp2 secreted phosphoprotein 2 0.065
Wbp2 WW domain binding protein 2 0.060
Actg2 actin, gamma 2, smooth muscle, enteric 0.055
Ahsg alpha-2-HS-glycoprotein 0.051
Ube2c ubiquitin-conjugating enzyme E2C 0.051
Traf4af1 TRAF4 associated factor 1 0.051
LOC286980 putative pheromone receptor (Go-VN13B) 0.050
Pttg1 pituitary tumor-transforming 1 0.049
Tnni3 troponin I type 3 (cardiac) 0.048
Vom2r27 vomeronasal 2 receptor, 27 0.048
Grik3 glutamate receptor, ionotropic, kainate 3 0.046
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.044
Hspb7 heat shock protein family, member 7 (cardiovascular) 0.044
Ccnb1 cyclin B1 0.040
Proc protein C 0.040
Mb myoglobin 0.039
Scn5a sodium channel, voltage-gated, type V, alpha subunit 0.039
Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.039
Cckar cholecystokinin A receptor 0.039
Emp1 epithelial membrane protein 1 0.037
Fabp1 fatty acid binding protein 1, liver 0.037
Agtr1a angiotensin II receptor, type 1a 0.037
Pzp pregnancy-zone protein 0.037
Kif2c kinesin family member 2C 0.036
Nexn nexilin (F actin binding protein) 0.036
Hspb2 heat shock protein beta 2 0.033
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.033
Lif leukemia inhibitory factor 0.033
Cox6a2 cytochrome c oxidase, subunit VIa, polypeptide 2 0.033
Asb2 ankyrin repeat and SOCS box-containing 2 0.030
Cav2 caveolin 2 0.030
Rrm2 ribonucleotide reductase M2 0.029
Ccnb2 cyclin B2 0.029
Actn2 actinin alpha 2 0.028
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.027
Cks2 CDC28 protein kinase regulatory subunit 2 0.026
Apobec2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 0.026
Hpx hemopexin 0.026
Racgap1 Rac GTPase-activating protein 1 0.026
Thpo thrombopoietin 0.026
Actc1 actin, alpha, cardiac muscle 1 0.026
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.025
Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.024
Trim63 tripartite motif-containing 63 0.024
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.023
Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 0.022
Aebp1 AE binding protein 1 0.022
Smpx small muscle protein, X-linked 0.021
Kifc1 kinesin family member C1 0.021
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.021
Mcm6 minichromosome maintenance complex component 6 0.021
Rup2 urinary protein 2 0.020
Igfals insulin-like growth factor binding protein, acid labile subunit 0.020
Casp2 caspase 2 0.020
Pdha2 pyruvate dehydrogenase (lipoamide) alpha 2 0.020
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.019
Fgf16 fibroblast growth factor 16 0.019
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.018
Pkia protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.018
Pbsn probasin 0.017
Pgam2 phosphoglycerate mutase 2 (muscle) 0.017
Pcsk1 proprotein convertase subtilisin/kexin type 1 0.017
Tk1 thymidine kinase 1, soluble 0.017
Crisp1 cysteine-rich secretory protein 1 0.017
Atn1 atrophin 1 0.016
Myog myogenin 0.016
Ap2s1 adaptor-related protein complex 2, sigma 1 subunit 0.016
Col10a1 collagen, type X, alpha 1 0.016
Pla2g5 phospholipase A2, group V 0.016
Dlx5 distal-less homeobox 5 0.016
St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.015
Serpind1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.015
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.015
Myf6 myogenic factor 6 0.015
Cyp51 cytochrome P450, family 51 0.015
Stmn1 stathmin 1 0.015
Gc group specific component 0.015
Wipf3 WAS/WASL interacting protein family, member 3 0.015
Orm1 orosomucoid 1 0.015
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.015
Mchr1 melanin-concentrating hormone receptor 1 0.014
Fgf18 fibroblast growth factor 18 0.014
Pnmt phenylethanolamine-N-methyltransferase 0.014
Pitx3 paired-like homeodomain 3 0.014
Foxi2 forkhead box I2 0.014
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism