IMP
Process View
The network for 'positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Axin1 | axin 1 | 0.969 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.831 | |
| Mcl1 | myeloid cell leukemia sequence 1 | 0.806 | |
| Pdcd6ip | programmed cell death 6 interacting protein | 0.704 | |
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.459 | |
| Atxn2 | ataxin 2 | 0.384 | |
| Mta1 | metastasis associated 1 | 0.382 | |
| Apc | adenomatosis polyposis coli | 0.381 | |
| Dnm1 | dynamin 1 | 0.271 | |
| Gsk3b | glycogen synthase kinase 3 beta | 0.189 | |
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.130 | |
| Lrrk2 | leucine-rich repeat kinase 2 | 0.118 | |
| Bcl2l1 | BCL2-like 1 | 0.079 | |
| Smad4 | MAD homolog 4 (Drosophila) | 0.067 | |
| 2700094K13Rik | RIKEN cDNA 2700094K13 gene | 0.056 | |
| Ctnnd2 | catenin (cadherin associated protein), delta 2 | 0.048 | |
| Gtf3a | general transcription factor III A | 0.044 | |
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.042 | |
| Ccnd1 | cyclin D1 | 0.040 | |
| Rdbp | RD RNA-binding protein | 0.039 | |
| Psen1 | presenilin 1 | 0.036 | |
| Ugt8a | UDP galactosyltransferase 8A | 0.035 | |
| Fam108a | family with sequence similarity 108, member A | 0.035 | |
| Pik3r1 | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | 0.034 | |
| Snrnp25 | small nuclear ribonucleoprotein 25 (U11/U12) | 0.034 | |
| Syt9 | synaptotagmin IX | 0.033 | |
| Zcchc18 | zinc finger, CCHC domain containing 18 | 0.030 | |
| Cadps | Ca2+-dependent secretion activator | 0.030 | |
| Mll3 | myeloid/lymphoid or mixed-lineage leukemia 3 | 0.028 | |
| Rab1b | RAB1B, member RAS oncogene family | 0.027 | |
| Kif1b | kinesin family member 1B | 0.026 | |
| Dact1 | dapper homolog 1, antagonist of beta-catenin (xenopus) | 0.026 | |
| Ctnna1 | catenin (cadherin associated protein), alpha 1 | 0.025 | |
| Nsmce1 | non-SMC element 1 homolog (S. cerevisiae) | 0.024 | |
| Klf6 | Kruppel-like factor 6 | 0.024 | |
| Polr2i | polymerase (RNA) II (DNA directed) polypeptide I | 0.023 | |
| Htt | huntingtin | 0.022 | |
| Rab11a | RAB11a, member RAS oncogene family | 0.022 | |
| Itsn1 | intersectin 1 (SH3 domain protein 1A) | 0.020 | |
| Prkar1a | protein kinase, cAMP dependent regulatory, type I, alpha | 0.020 | |
| Nefl | neurofilament, light polypeptide | 0.020 | |
| Klf7 | Kruppel-like factor 7 (ubiquitous) | 0.019 | |
| Stmn2 | stathmin-like 2 | 0.019 | |
| Numb | numb gene homolog (Drosophila) | 0.018 | |
| Gsk3a | glycogen synthase kinase 3 alpha | 0.018 | |
| Mlf2 | myeloid leukemia factor 2 | 0.018 | |
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.017 | |
| Ptprr | protein tyrosine phosphatase, receptor type, R | 0.017 | |
| Nf2 | neurofibromatosis 2 | 0.017 | |
| Hist1h1c | histone cluster 1, H1c | 0.016 | |
| Pik3r2 | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) | 0.016 | |
| Tax1bp3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 0.015 | |
| Rab33a | RAB33A, member of RAS oncogene family | 0.014 | |
| Acd | adrenocortical dysplasia | 0.014 | |
| H2afv | H2A histone family, member V | 0.013 | |
| Stub1 | STIP1 homology and U-Box containing protein 1 | 0.013 | |
| Elavl4 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) | 0.013 | |
| Dennd1a | DENN/MADD domain containing 1A | 0.013 | |
| Med30 | mediator complex subunit 30 | 0.012 | |
| Rnf111 | ring finger 111 | 0.012 | |
| Mtmr7 | myotubularin related protein 7 | 0.012 | |
| Atp2b1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.012 | |
| Mef2a | myocyte enhancer factor 2A | 0.012 | |
| Scg5 | secretogranin V | 0.012 | |
| Mrpl23 | mitochondrial ribosomal protein L23 | 0.011 | |
| Celf4 | CUGBP, Elav-like family member 4 | 0.011 | |
| Resp18 | regulated endocrine-specific protein 18 | 0.011 | |
| Pfn2 | profilin 2 | 0.011 | |
| Epn1 | epsin 1 | 0.011 | |
| Dact2 | dapper homolog 2, antagonist of beta-catenin (xenopus) | 0.011 | |
| Aard | alanine and arginine rich domain containing protein | 0.011 | |
| Btbd2 | BTB (POZ) domain containing 2 | 0.011 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| BCL2L1 | BCL2-like 1 | 1.000 | |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 1.000 | |
| BCL2 | B-cell CLL/lymphoma 2 | 1.000 | |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.997 | |
| BAX | BCL2-associated X protein | 0.997 | |
| MCL1 | myeloid cell leukemia sequence 1 (BCL2-related) | 0.996 | |
| BAD | BCL2-associated agonist of cell death | 0.960 | |
| BECN1 | beclin 1, autophagy related | 0.941 | |
| BID | BH3 interacting domain death agonist | 0.916 | |
| BAK1 | BCL2-antagonist/killer 1 | 0.914 | |
| TP53BP2 | tumor protein p53 binding protein, 2 | 0.871 | |
| AXIN1 | axin 1 | 0.812 | |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.647 | |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | 0.624 | |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.613 | |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.553 | |
| NIN | ninein (GSK3B interacting protein) | 0.458 | |
| FKBP8 | FK506 binding protein 8, 38kDa | 0.405 | |
| AMBRA1 | autophagy/beclin-1 regulator 1 | 0.313 | |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.283 | |
| HUWE1 | HECT, UBA and WWE domain containing 1 | 0.240 | |
| BBC3 | BCL2 binding component 3 | 0.239 | |
| PRKACA | protein kinase, cAMP-dependent, catalytic, alpha | 0.193 | |
| PSEN1 | presenilin 1 | 0.181 | |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.167 | |
| ZHX1 | zinc fingers and homeoboxes 1 | 0.113 | |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.111 | |
| KIAA1191 | KIAA1191 | 0.095 | |
| MAPK8 | mitogen-activated protein kinase 8 | 0.085 | |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.079 | |
| MAPT | microtubule-associated protein tau | 0.069 | |
| DEAF1 | deformed epidermal autoregulatory factor 1 (Drosophila) | 0.069 | |
| GSK3B | glycogen synthase kinase 3 beta | 0.056 | |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.056 | |
| ZFPM1 | zinc finger protein, multitype 1 | 0.051 | |
| RPS6KA6 | ribosomal protein S6 kinase, 90kDa, polypeptide 6 | 0.042 | |
| PSEN2 | presenilin 2 (Alzheimer disease 4) | 0.042 | |
| TMEM44 | transmembrane protein 44 | 0.036 | |
| LMO4 | LIM domain only 4 | 0.030 | |
| APC | adenomatous polyposis coli | 0.028 | |
| MTOR | mechanistic target of rapamycin (serine/threonine kinase) | 0.028 | |
| ATXN3 | ataxin 3 | 0.028 | |
| ZNF746 | zinc finger protein 746 | 0.024 | |
| POLD1 | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 0.024 | |
| FKBP14 | FK506 binding protein 14, 22 kDa | 0.021 | |
| RSU1 | Ras suppressor protein 1 | 0.019 | |
| NAF1 | nuclear assembly factor 1 homolog (S. cerevisiae) | 0.019 | |
| SPNS1 | spinster homolog 1 (Drosophila) | 0.018 | |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.018 | |
| ING2 | inhibitor of growth family, member 2 | 0.017 | |
| KIAA1543 | KIAA1543 | 0.017 | |
| ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative) | 0.017 | |
| DCTN2 | dynactin 2 (p50) | 0.016 | |
| MZT2A | mitotic spindle organizing protein 2A | 0.016 | |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.016 | |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.016 | |
| MRPL23 | mitochondrial ribosomal protein L23 | 0.015 | |
| IER5 | immediate early response 5 | 0.014 | |
| C14orf129 | chromosome 14 open reading frame 129 | 0.014 | |
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | 0.014 | |
| HSPB1 | heat shock 27kDa protein 1 | 0.014 | |
| RXRA | retinoid X receptor, alpha | 0.013 | |
| CCDC85B | coiled-coil domain containing 85B | 0.013 | |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 0.012 | |
| PICK1 | protein interacting with PRKCA 1 | 0.012 | |
| SH3GLB2 | SH3-domain GRB2-like endophilin B2 | 0.012 | |
| NRBP1 | nuclear receptor binding protein 1 | 0.012 | |
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) | 0.012 | |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.011 | |
| HRK | harakiri, BCL2 interacting protein (contains only BH3 domain) | 0.011 | |
| PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 0.011 | |
| ADAP1 | ArfGAP with dual PH domains 1 | 0.011 | |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.010 |