The network for 'regulation of lamellipodium assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of lamellipodium assembly

Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.

Mus musculus
Name Description Probability Func Analog Organism
Vasp vasodilator-stimulated phosphoprotein 0.922
Rac1 RAS-related C3 botulinum substrate 1 0.920
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.904
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.885
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.779
Wdr1 WD repeat domain 1 0.774
Rhoa ras homolog gene family, member A 0.678
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.624
Arpc4 actin related protein 2/3 complex, subunit 4 0.596
Msn moesin 0.585
Evl Ena-vasodilator stimulated phosphoprotein 0.546
Lrrk2 leucine-rich repeat kinase 2 0.532
Mef2d myocyte enhancer factor 2D 0.457
Capzb capping protein (actin filament) muscle Z-line, beta 0.435
Arhgap1 Rho GTPase activating protein 1 0.380
Calm1 calmodulin 1 0.333
Tpm4 tropomyosin 4 0.323
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.319
Mapkap1 mitogen-activated protein kinase associated protein 1 0.262
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.244
Slit3 slit homolog 3 (Drosophila) 0.244
Robo1 roundabout homolog 1 (Drosophila) 0.213
Actg1 actin, gamma, cytoplasmic 1 0.182
9430031J16Rik RIKEN cDNA 9430031J16 gene 0.174
Necap2 NECAP endocytosis associated 2 0.166
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.147
Csrp1 cysteine and glycine-rich protein 1 0.146
Csk c-src tyrosine kinase 0.143
Sh3bgrl3 SH3 domain binding glutamic acid-rich protein-like 3 0.133
Bzw1 basic leucine zipper and W2 domains 1 0.128
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.120
Rptor regulatory associated protein of MTOR, complex 1 0.119
Rap1b RAS related protein 1b 0.118
Robo2 roundabout homolog 2 (Drosophila) 0.118
Abi1 abl-interactor 1 0.115
Bcl10 B-cell leukemia/lymphoma 10 0.115
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.115
Enah enabled homolog (Drosophila) 0.114
Rnd3 Rho family GTPase 3 0.114
Shisa5 shisa homolog 5 (Xenopus laevis) 0.114
Cttn cortactin 0.109
Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.104
Gnb1 guanine nucleotide binding protein (G protein), beta 1 0.100
Actb actin, beta 0.100
Actn1 actinin, alpha 1 0.098
Pfn2 profilin 2 0.096
Kctd10 potassium channel tetramerisation domain containing 10 0.093
Slit1 slit homolog 1 (Drosophila) 0.088
Plekho1 pleckstrin homology domain containing, family O member 1 0.088
Cotl1 coactosin-like 1 (Dictyostelium) 0.083
Cfl1 cofilin 1, non-muscle 0.082
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.081
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.079
Sdcbp syndecan binding protein 0.079
Morf4l2 mortality factor 4 like 2 0.078
Prr13 proline rich 13 0.078
Dazap2 DAZ associated protein 2 0.078
Ctnnb1 catenin (cadherin associated protein), beta 1 0.077
Vcl vinculin 0.074
Cltc clathrin, heavy polypeptide (Hc) 0.073
Hn1 hematological and neurological expressed sequence 1 0.072
Arf1 ADP-ribosylation factor 1 0.070
Pfn1 profilin 1 0.068
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.066
Capza1 capping protein (actin filament) muscle Z-line, alpha 1 0.065
Cdc42se1 CDC42 small effector 1 0.065
Arpc3 actin related protein 2/3 complex, subunit 3 0.064
Arf4 ADP-ribosylation factor 4 0.063
Crlf3 cytokine receptor-like factor 3 0.061
Pik3cb phosphatidylinositol 3-kinase, catalytic, beta polypeptide 0.060
2310014H01Rik RIKEN cDNA 2310014H01 gene 0.059
Lasp1 LIM and SH3 protein 1 0.057
Acot9 acyl-CoA thioesterase 9 0.056
Cnn2 calponin 2 0.053
Arpc2 actin related protein 2/3 complex, subunit 2 0.053
Pdlim5 PDZ and LIM domain 5 0.053
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.051
Mapkapk2 MAP kinase-activated protein kinase 2 0.051
Frmd8 FERM domain containing 8 0.050
Cald1 caldesmon 1 0.048
Tmod3 tropomodulin 3 0.047
Akt1 thymoma viral proto-oncogene 1 0.047
Dstn destrin 0.047
Zyx zyxin 0.046
Glipr2 GLI pathogenesis-related 2 0.046
Rap1gds1 RAP1, GTP-GDP dissociation stimulator 1 0.045
Gdi2 guanosine diphosphate (GDP) dissociation inhibitor 2 0.045
Efhd2 EF hand domain containing 2 0.045
Actr2 ARP2 actin-related protein 2 homolog (yeast) 0.045
Midn midnolin 0.043
Hspa8 heat shock protein 8 0.041
Gja1 gap junction protein, alpha 1 0.041
Marcksl1 MARCKS-like 1 0.041
Bmpr1a bone morphogenetic protein receptor, type 1A 0.040
Coro1a coronin, actin binding protein 1A 0.040
Abr active BCR-related gene 0.037
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.036
Mlst8 MTOR associated protein, LST8 homolog (S. cerevisiae) 0.035
Eed embryonic ectoderm development 0.035
Coro1c coronin, actin binding protein 1C 0.034
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
cdc-42 Protein CDC-42 0.747
vps-32.1 Protein VPS-32.1 0.414
fce-1 Protein FCE-1 0.213
goa-1 Protein GOA-1 0.173
gsp-1 Protein GSP-1 0.172
rab-1 Protein RAB-1 0.111
F38A5.2 Protein F38A5.2 0.090
sem-5 Protein SEM-5 0.087
F22D3.2 Protein F22D3.2 0.087
arx-1 Protein ARX-1 0.086
unc-60 Protein UNC-60 0.077
T19A6.1 Protein T19A6.1 0.073
set-16 Protein SET-16 0.068
mig-2 Protein MIG-2 0.058
cap-1 Protein CAP-1 0.044
scpl-2 Protein SCPL-2 0.044
hmg-1.2 Protein HMG-1.2 0.039
rab-5 Protein RAB-5 0.039
pph-4.1 Protein PPH-4.1 0.037
CELE_Y47G6A.18 Protein Y47G6A.18 0.036
pmp-3 Protein PMP-3 0.034
plc-4 Protein PLC-4 0.029
yif-1 Protein YIF-1 0.028
D2013.6 Protein D2013.6 0.027
lir-1 Protein LIR-1 0.027
D2085.5 Protein D2085.5 0.026
CELE_B0238.10 Protein B0238.10 0.025
kin-3 Protein KIN-3 0.025
gmeb-1 Protein GMEB-1 0.025
atf-7 Protein ATF-7 0.023
clic-1 Protein CLIC-1 0.023
rnf-121 Protein RNF-121 0.022
unc-50 Protein UNC-50 0.021
C18E9.2 Protein C18E9.2 0.021
unc-108 Protein UNC-108 0.021
hmgr-1 Protein HMGR-1 0.021
mlc-5 Protein MLC-5 0.020
Y18H1A.2 Protein Y18H1A.2 0.020
abts-1 Protein ABTS-1 0.020
paqr-2 Protein PAQR-2 0.019
eat-3 Protein EAT-3 0.019
sel-12 Protein SEL-12 0.019
tag-335 Protein TAG-335 0.019
Y22D7AL.7 Protein Y22D7AL.7 0.019
CELE_W05H12.1 Protein W05H12.1 0.019
helq-1 Protein HELQ-1 0.018
vps-36 Protein VPS-36 0.018
cam-1 Protein CAM-1 0.018
cnt-2 Protein CNT-2 0.018
C33H5.18 Protein C33H5.18 0.018
lin-28 Protein LIN-28 0.017
riok-3 Protein RIOK-3 0.017
rig-4 Protein RIG-4 0.017
smp-1 Protein SMP-1 0.017
dcn-1 Protein DCN-1 0.016
let-60 Protein LET-60 0.016
mig-38 Protein MIG-38 0.016
ced-10 Protein CED-10 0.016
unc-32 Protein UNC-32 0.016
T23F11.1 Protein T23F11.1 0.015
CELE_C30H7.2 Protein C30H7.2 0.015
Y48E1B.3 Protein Y48E1B.3 0.015
CELE_Y116A8C.26 Protein Y116A8C.26 0.014
rsy-1 Protein RSY-1 0.014
ttx-7 Protein TTX-7 0.014
C41H7.5 Protein C41H7.5 0.014
riok-1 Protein RIOK-1 0.014
unc-94 Protein UNC-94 0.014
unc-73 Protein UNC-73 0.013
ubc-3 Protein UBC-3 0.013
hipr-1 Protein HIPR-1 0.013
sars-1 Protein SARS-1 0.013
Y32H12A.8 Protein Y32H12A.8 0.013
nmy-1 Protein NMY-1 0.013
nkb-1 Protein NKB-1 0.013
rap-2 Protein RAP-2 0.013
wrk-1 Protein WRK-1 0.012
Y50C1A.1 Protein Y50C1A.1 0.012
F41H10.4 Protein F41H10.4 0.012
hut-1 Protein HUT-1 0.012
snf-1 Protein SNF-1 0.012
B0416.5 Protein B0416.5 0.012
afd-1 Protein AFD-1 0.012
K02B12.7 Protein K02B12.7 0.012
F45G2.4 Protein F45G2.4 0.012
CELE_F52C6.12 Protein F52C6.12 0.011
Y54G2A.2 Protein Y54G2A.2 0.011
pac-1 Protein PAC-1 0.011
snx-27 Protein SNX-27 0.011
nhr-49 Protein NHR-49 0.011
F54B11.5 Protein F54B11.5 0.011
lin-40 Protein LIN-40 0.011
CELE_F59B2.2 Protein F59B2.2 0.011
rilp-1 Protein RILP-1 0.011
clr-1 Protein CLR-1 0.011
unc-45 Protein UNC-45 0.011
tag-333 Protein TAG-333 0.011
iglr-2 Protein IGLR-2 0.011
C13F10.4 Protein C13F10.4 0.011
tbc-15 Protein TBC-15 0.011
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
chic chickadee 0.789
baz bazooka 0.781
Sop2 Suppressor of profilin 2 0.664
Rac1 CG2248 gene product from transcript CG2248-RA 0.652
Rho1 CG8416 gene product from transcript CG8416-RB 0.651
Cdc42 CG12530 gene product from transcript CG12530-RA 0.642
cpb capping protein beta 0.620
mbc myoblast city 0.507
Ephrin CG1862 gene product from transcript CG1862-RA 0.473
Vrp1 Verprolin 1 0.445
ena enabled 0.367
robo roundabout 0.350
flr flare 0.228
Dlic Dynein light intermediate chain 0.210
Rbsn-5 Rabenosyn-5 0.148
Rab11 Rab-protein 11 0.128
Syx1A Syntaxin 1A 0.125
Abl Abl tyrosine kinase 0.118
par-1 CG8201 gene product from transcript CG8201-RA 0.105
twf twinfilin 0.097
Rala Ras-related protein 0.090
Dhc64C Dynein heavy chain 64C 0.079
Arp66B Actin-related protein 66B 0.077
Akt1 CG4006 gene product from transcript CG4006-RA 0.075
sec6 CG5341 gene product from transcript CG5341-RA 0.072
cpa capping protein alpha 0.066
Hem HEM-protein 0.064
sds22 CG5851 gene product from transcript CG5851-RA 0.063
kuz kuzbanian 0.060
Rac2 CG8556 gene product from transcript CG8556-RA 0.051
Crag Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein 0.048
Khc Kinesin heavy chain 0.042
rok Rho-kinase 0.041
lea leak 0.039
Arp14D Actin-related protein 14D 0.036
gcm glial cells missing 0.033
ric8a CG15797 gene product from transcript CG15797-RA 0.031
pod1 CG4532 gene product from transcript CG4532-RF 0.030
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.030
egh egghead 0.028
Act5C Actin 5C 0.027
sn singed 0.026
RanBPM Ran-binding protein M 0.026
Src64B Src oncogene at 64B 0.026
rhea CG6831 gene product from transcript CG6831-RA 0.025
hkb huckebein 0.024
Rab5 Rab-protein 5 0.023
cta concertina 0.021
Arc-p34 CG10954 gene product from transcript CG10954-RA 0.020
S6k RPS6-p70-protein kinase 0.020
tai taiman 0.020
jing CG9397 gene product from transcript CG9397-RI 0.019
sqh spaghetti squash 0.019
Mtl Mig-2-like 0.019
lat latheo 0.019
usp ultraspiracle 0.018
phol pleiohomeotic like 0.018
CrebB-17A Cyclic-AMP response element binding protein B at 17A 0.017
HSPC300 CG30173 gene product from transcript CG30173-RA 0.017
Shc SHC-adaptor protein 0.017
p120ctn Adherens junction protein p120 0.016
lace CG4162 gene product from transcript CG4162-RA 0.016
kay kayak 0.016
scb scab 0.015
bnl branchless 0.015
alpha-Spec alpha Spectrin 0.015
G-oalpha47A G protein oalpha 47A 0.015
CG17082 CG17082 gene product from transcript CG17082-RD 0.014
sim single-minded 0.014
Lim3 CG10699 gene product from transcript CG10699-RB 0.014
mid midline 0.014
Mrtf Myocardin-related transcription factor 0.013
da daughterless 0.012
katanin-60 katanin 60 0.012
shd shade 0.012
kermit CG11546 gene product from transcript CG11546-RB 0.012
CG4511 CG4511 gene product from transcript CG4511-RA 0.011
tomosyn CG17762 gene product from transcript CG17762-RB 0.011
kon kon-tiki 0.011
zfh1 Zn finger homeodomain 1 0.011
stai stathmin 0.011
trc tricornered 0.011
Dscam Down syndrome cell adhesion molecule 0.010
zip zipper 0.010
Pten CG5671 gene product from transcript CG5671-RB 0.010
spdo sanpodo 0.010
Atx2 Ataxin-2 0.010
Ctr1A Copper transporter 1A 0.010
Upf1 CG1559 gene product from transcript CG1559-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.957
ZNF746 zinc finger protein 746 0.755
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.735
PRKCZ protein kinase C, zeta 0.436
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.410
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.377
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.288
BAIAP2 BAI1-associated protein 2 0.274
GAS7 growth arrest-specific 7 0.161
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.155
PFDN1 prefoldin subunit 1 0.132
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.129
TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila) 0.116
NCKAP1 NCK-associated protein 1 0.093
EFNA5 ephrin-A5 0.082
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.079
GRB7 growth factor receptor-bound protein 7 0.079
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.073
MEF2A myocyte enhancer factor 2A 0.065
NUMB numb homolog (Drosophila) 0.062
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.061
LDOC1 leucine zipper, down-regulated in cancer 1 0.056
ABI1 abl-interactor 1 0.054
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.053
PTOV1 prostate tumor overexpressed 1 0.053
MYL12B myosin, light chain 12B, regulatory 0.048
ILK integrin-linked kinase 0.043
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.043
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.040
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.035
LLGL1 lethal giant larvae homolog 1 (Drosophila) 0.034
SORBS3 sorbin and SH3 domain containing 3 0.031
CAPZB capping protein (actin filament) muscle Z-line, beta 0.029
FASLG Fas ligand (TNF superfamily, member 6) 0.026
ABI2 abl-interactor 2 0.026
SPRR2A small proline-rich protein 2A 0.026
CHRD chordin 0.025
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.023
SPTBN1 spectrin, beta, non-erythrocytic 1 0.023
SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 0.022
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.020
NCF2 neutrophil cytosolic factor 2 0.019
LRRK2 leucine-rich repeat kinase 2 0.019
EPHA8 EPH receptor A8 0.019
PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 0.018
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.018
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.018
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.018
PFN1 profilin 1 0.018
EPS8 epidermal growth factor receptor pathway substrate 8 0.018
COTL1 coactosin-like 1 (Dictyostelium) 0.017
EFHD2 EF-hand domain family, member D2 0.017
ZYX zyxin 0.016
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.015
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.014
PRKCI protein kinase C, iota 0.014
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.014
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.014
HOOK2 hook homolog 2 (Drosophila) 0.013
LRP6 low density lipoprotein receptor-related protein 6 0.013
VHL von Hippel-Lindau tumor suppressor 0.012
GOLGA2 golgin A2 0.012
ZNF71 zinc finger protein 71 0.012
NCK1 NCK adaptor protein 1 0.012
ZNF775 zinc finger protein 775 0.012
HCK hemopoietic cell kinase 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hspa8 heat shock protein 8 0.057
Arpc2 actin related protein 2/3 complex, subunit 2 0.022
Hspd1 heat shock protein 1 (chaperonin) 0.018
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism