The network for 'positive regulation of immune system process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

Rattus norvegicus
Name Description Probability Func Analog Organism
Cd37 CD37 molecule 0.926
Cp ceruloplasmin 0.829
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.755
Il1b interleukin 1 beta 0.683
Calcrl calcitonin receptor-like 0.653
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.636
Csf1 colony stimulating factor 1 (macrophage) 0.620
Ccr5 chemokine (C-C motif) receptor 5 0.619
Casp1 caspase 1 0.618
Il2rg interleukin 2 receptor, gamma 0.600
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 0.584
Cd38 CD38 molecule 0.571
Ccl4 chemokine (C-C motif) ligand 4 0.538
Il6 interleukin 6 0.513
RT1-Ba RT1 class II, locus Ba 0.510
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.462
Timp3 TIMP metallopeptidase inhibitor 3 0.452
Cd4 Cd4 molecule 0.451
Tgfbr2 transforming growth factor, beta receptor II 0.447
Plau plasminogen activator, urokinase 0.434
Cxcl10 chemokine (C-X-C motif) ligand 10 0.420
Cxcr4 chemokine (C-X-C motif) receptor 4 0.402
Ptafr platelet-activating factor receptor 0.365
RT1-EC2 RT1 class Ib, locus EC2 0.361
Cfb complement factor B 0.360
Cd14 CD14 molecule 0.354
LOC100360403 ATP-binding cassette, sub-family C, member 9-like 0.349
Ly86 lymphocyte antigen 86 0.344
Cybb cytochrome b-245, beta polypeptide 0.335
Cd5 Cd5 molecule 0.324
Prf1 perforin 1 (pore forming protein) 0.321
Sell selectin L 0.316
Irf5 interferon regulatory factor 5 0.309
Lst1 leukocyte specific transcript 1 0.305
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.304
Vav1 vav 1 guanine nucleotide exchange factor 0.292
Alox5ap arachidonate 5-lipoxygenase activating protein 0.276
Hck hemopoietic cell kinase 0.268
Dchs1 dachsous 1 (Drosophila) 0.260
Mmp12 matrix metallopeptidase 12 0.254
Cpa3 carboxypeptidase A3, mast cell 0.252
Dnase1l3 deoxyribonuclease 1-like 3 0.251
Ptprc protein tyrosine phosphatase, receptor type, C 0.250
Gzmk granzyme K 0.246
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.236
Vcam1 vascular cell adhesion molecule 1 0.223
Ciita class II, major histocompatibility complex, transactivator 0.220
Fgfr2 fibroblast growth factor receptor 2 0.219
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.214
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.212
Socs3 suppressor of cytokine signaling 3 0.202
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.200
Zcwpw1 zinc finger, CW-type with PWWP domain 1 0.198
Folr2 folate receptor 2 (fetal) 0.198
Prl prolactin 0.197
Cmklr1 chemokine-like receptor 1 0.194
Ccl3 chemokine (C-C motif) ligand 3 0.193
Cd247 Cd247 molecule 0.192
Cd68 Cd68 molecule 0.190
Clec9a C-type lectin domain family 9, member a 0.189
Ereg epiregulin 0.189
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.187
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.182
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.178
P2ry14 purinergic receptor P2Y, G-protein coupled, 14 0.177
Jak1 Janus kinase 1 0.175
Faslg Fas ligand (TNF superfamily, member 6) 0.175
RGD1559588 similar to cell surface receptor FDFACT 0.174
Il9r interleukin 9 receptor 0.174
RT1-Da RT1 class II, locus Da 0.173
Ar androgen receptor 0.172
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.172
Il7r interleukin 7 receptor 0.172
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.171
Mrgprf MAS-related GPR, member F 0.170
Icam1 intercellular adhesion molecule 1 0.168
S1pr2 sphingosine-1-phosphate receptor 2 0.167
Sirpa signal-regulatory protein alpha 0.161
RGD1559748 similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein) 0.158
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.157
Cd53 Cd53 molecule 0.155
Jak2 Janus kinase 2 0.152
Olfml2b olfactomedin-like 2B 0.152
Pecam1 platelet/endothelial cell adhesion molecule 1 0.151
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.149
Map3k1 mitogen activated protein kinase kinase kinase 1 0.149
Ctse cathepsin E 0.149
Il2rb interleukin 2 receptor, beta 0.147
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.146
Arhgap25 Rho GTPase activating protein 25 0.144
Ccl7 chemokine (C-C motif) ligand 7 0.143
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.142
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.141
Thbd thrombomodulin 0.141
Atf3 activating transcription factor 3 0.139
Mca32 mast cell antigen 32 0.138
Gja4 gap junction protein, alpha 4 0.138
Cd2 Cd2 molecule 0.138
Cxcr5 chemokine (C-X-C motif) receptor 5 0.137
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.136
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
mpx myeloid-specific peroxidase 0.941
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.651
c3b complement component c3b 0.597
tal1 T-cell acute lymphocytic leukemia 1 0.469
efnb2a ephrin B2a 0.456
shha sonic hedgehog a 0.405
gata1a GATA binding protein 1a 0.392
foxb1.2 forkhead box B1.2 0.364
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.238
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.214
epas1b endothelial PAS domain protein 1b 0.204
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.193
bmp2b bone morphogenetic protein 2b 0.192
nanos3 nanos homolog 3 0.168
fzd7a frizzled homolog 7a 0.156
fgfr3 fibroblast growth factor receptor 3 0.149
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.146
jun jun proto-oncogene 0.137
runx1 runt-related transcription factor 1 0.133
mmp9 matrix metalloproteinase 9 0.132
tgfb3 transforming growth factor, beta 3 0.125
socs3a suppressor of cytokine signaling 3a 0.121
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.117
LOC566708 FL cytokine receptor-like 0.117
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.110
kita kit receptor a 0.110
gpr126 G protein-coupled receptor 126 0.104
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.103
ip6k2 inositol hexaphosphate kinase 2 0.101
bmper BMP binding endothelial regulator 0.098
sfrp1a secreted frizzled-related protein 1a 0.096
tlr9 toll-like receptor 9 0.095
lyz lysozyme 0.095
grna granulin a 0.093
c1qc complement component 1, q subcomponent, C chain 0.093
acvr2a activin receptor IIa 0.091
rarga retinoic acid receptor gamma a 0.091
tnfsf10l2 tumor necrosis factor (ligand) superfamily, member 10 like 2 0.090
runx2a runt-related transcription factor 2a 0.089
col12a1 collagen, type XII, alpha 1 0.089
si:ch211-212m21.5 si:ch211-212m21.5 0.075
tlr3 toll-like receptor 3 0.074
ef1a elongation factor 1-alpha 0.074
timp2b tissue inhibitor of metalloproteinase 2b 0.074
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.074
pax5 paired box gene 5 0.074
zgc:64115 zgc:64115 0.072
cyp3a65 cytochrome P450, family 3, subfamily A, polypeptide 65 0.071
dlc deltaC 0.071
fcho2 FCH domain only 2 0.071
podxl podocalyxin-like 0.070
stc1l stanniocalcin 1, like 0.069
il6r interleukin 6 receptor 0.068
rhbg Rhesus blood group, B glycoprotein 0.066
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.065
mmp2 matrix metalloproteinase 2 0.065
stat5.1 signal transducer and activator of transcription 5.1 0.064
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.064
coro1a coronin, actin binding protein, 1A 0.063
nrg1 neuregulin 1 0.063
LOC100000934 hypothetical protein LOC100000934 0.062
fn1 fibronectin 1 0.061
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.060
stat1b signal transducer and activator of transcription 1b 0.057
pcdh18b protocadherin 18b 0.056
egr2b early growth response 2b 0.055
calcrla calcitonin receptor-like a 0.055
alk anaplastic lymphoma kinase (Ki-1) 0.054
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.054
entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.053
si:dkey-76b14.4 si:dkey-76b14.4 0.052
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.052
caspa caspase a 0.050
foxd3 forkhead box D3 0.049
kdrl kinase insert domain receptor like 0.049
nadl1.2 neural adhesion molecule L1.2 0.049
wnt8a wingless-type MMTV integration site family, member 8a 0.048
kpna3 karyopherin (importin) alpha 3 0.048
postn periostin, osteoblast specific factor 0.048
fzd7b frizzled homolog 7b 0.048
hbbe1.1 hemoglobin beta embryonic-1.1 0.047
c1qb complement component 1, q subcomponent, B chain 0.047
ripk2 receptor-interacting serine-threonine kinase 2 0.046
zgc:110340 zgc:110340 0.046
tnfb tumor necrosis factor b (TNF superfamily, member 2) 0.046
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.046
cx43 connexin 43 0.046
pdcd2 programmed cell death 2 0.045
dcn decorin 0.045
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.044
dll4 delta-like 4 (Drosophila) 0.044
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.044
alcama activated leukocyte cell adhesion molecule a 0.044
ifnphi1 interferon phi 1 0.044
scinlb scinderin like b 0.043
socs1 suppressor of cytokine signaling 1 0.043
smad9 MAD homolog 9 (Drosophila) 0.043
axin2 axin 2 (conductin, axil) 0.042
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.042
ptger4b prostaglandin E receptor 4 (subtype EP4) b 0.042
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Drosophila melanogaster
Name Description Probability Func Analog Organism
mbc myoblast city 0.883
AttA Attacin-A 0.830
PGRP-LC Peptidoglycan recognition protein LC 0.802
Rel Relish 0.785
DptB Diptericin B 0.779
hth homothorax 0.707
Spn27A Serpin 27A 0.606
rpr reaper 0.587
hep hemipterous 0.489
Mtk Metchnikowin 0.452
spz spatzle 0.400
drk downstream of receptor kinase 0.350
mys myospheroid 0.348
Mpk2 CG5475 gene product from transcript CG5475-RB 0.330
S6k RPS6-p70-protein kinase 0.310
Irc Immune-regulated catalase 0.297
PGRP-SA Peptidoglycan recognition protein SA 0.269
grass Gram-positive Specific Serine protease 0.264
Pvr PDGF- and VEGF-receptor related 0.245
spas spastin 0.242
kis kismet 0.242
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.224
SPE Spatzle-Processing Enzyme 0.224
stck steamer duck 0.201
key kenny 0.201
Cat Catalase 0.199
pnt pointed 0.197
JIL-1 CG6297 gene product from transcript CG6297-RA 0.185
Egfr Epidermal growth factor receptor 0.180
Mekk1 CG7717 gene product from transcript CG7717-RB 0.180
numb CG3779 gene product from transcript CG3779-RB 0.179
Dcr-2 Dicer-2 0.176
Rac2 CG8556 gene product from transcript CG8556-RA 0.175
CG6361 CG6361 gene product from transcript CG6361-RA 0.173
bnl branchless 0.168
norpA no receptor potential A 0.145
Snoo Sno oncogene 0.144
lok loki 0.143
Myo31DF Myosin 31DF 0.140
Myd88 CG2078 gene product from transcript CG2078-RA 0.134
dap dacapo 0.134
Chro Chromator 0.128
MP1 Melanization Protease 1 0.124
brat brain tumor 0.120
Idgf2 Imaginal disc growth factor 2 0.118
os outstretched 0.113
Sin3A CG8815 gene product from transcript CG8815-RC 0.112
p120ctn Adherens junction protein p120 0.111
Spn28D Serpin 28D 0.109
wun wunen 0.107
Sp7 Serine protease 7 0.105
CecC Cecropin C 0.105
Dredd Death related ced-3/Nedd2-like protein 0.104
NijA Ninjurin A 0.103
dome domeless 0.103
ird5 immune response deficient 5 0.101
babo baboon 0.101
rl rolled 0.097
Tab2 TAK1-associated binding protein 2 0.091
rev7 CG2948 gene product from transcript CG2948-RA 0.089
Timp Tissue inhibitor of metalloproteases 0.086
ci cubitus interruptus 0.085
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.084
modSP modular serine protease 0.084
cora coracle 0.083
Hcf Host cell factor 0.083
Ptp69D Protein tyrosine phosphatase 69D 0.081
nec necrotic 0.081
InR Insulin-like receptor 0.080
krz kurtz 0.080
Dad Daughters against dpp 0.079
mav maverick 0.078
E2f2 E2F transcription factor 2 0.077
Gyc76C Guanylyl cyclase at 76C 0.076
ird1 immune response deficient 1 0.076
Nrg Neuroglian 0.075
Dpt Diptericin 0.073
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.072
Dcp-1 Death caspase-1 0.071
bowl brother of odd with entrails limited 0.069
scrib scribbled 0.068
Hsf Heat shock factor 0.067
CG8155 CG8155 gene product from transcript CG8155-RA 0.066
Spn1 Serine protease inhibitor 1 0.066
ple pale 0.066
kay kayak 0.066
Toll-7 CG8595 gene product from transcript CG8595-RA 0.065
cact cactus 0.065
Tl Toll 0.065
CG18666 CG18666 gene product from transcript CG18666-RA 0.065
Krn Keren 0.063
Indy I'm not dead yet 0.062
Hr39 Hormone receptor-like in 39 0.062
CG15083 CG15083 gene product from transcript CG15083-RA 0.062
Duox Dual oxidase 0.062
CG4168 CG4168 gene product from transcript CG4168-RA 0.062
MTF-1 Metal response element-binding Transcription Factor-1 0.062
fon fondue 0.062
CG9631 CG9631 gene product from transcript CG9631-RA 0.061
Ephrin CG1862 gene product from transcript CG1862-RA 0.061
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Homo sapiens
Name Description Probability Func Analog Organism
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.000
GRB2 growth factor receptor-bound protein 2 1.000
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.998
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.998
BIRC3 baculoviral IAP repeat containing 3 0.997
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.996
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.995
LCK lymphocyte-specific protein tyrosine kinase 0.994
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.994
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.993
ESR1 estrogen receptor 1 0.988
CREBBP CREB binding protein 0.987
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.985
IRAK1 interleukin-1 receptor-associated kinase 1 0.985
TRAF6 TNF receptor-associated factor 6 0.985
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.985
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.984
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.981
CCR7 chemokine (C-C motif) receptor 7 0.977
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.973
HCK hemopoietic cell kinase 0.971
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.971
TRAF1 TNF receptor-associated factor 1 0.968
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.960
SOCS3 suppressor of cytokine signaling 3 0.954
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.953
STAT1 signal transducer and activator of transcription 1, 91kDa 0.950
EGFR epidermal growth factor receptor 0.947
CCR1 chemokine (C-C motif) receptor 1 0.946
ICAM1 intercellular adhesion molecule 1 0.943
CCR5 chemokine (C-C motif) receptor 5 0.943
IL1B interleukin 1, beta 0.942
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.940
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.938
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.935
TNIP2 TNFAIP3 interacting protein 2 0.935
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.934
SYK spleen tyrosine kinase 0.926
FASLG Fas ligand (TNF superfamily, member 6) 0.923
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.921
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.921
FGFR2 fibroblast growth factor receptor 2 0.918
XIAP X-linked inhibitor of apoptosis 0.906
PML promyelocytic leukemia 0.906
CD86 CD86 molecule 0.904
CXCL9 chemokine (C-X-C motif) ligand 9 0.903
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.900
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.897
IRF4 interferon regulatory factor 4 0.897
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.892
PTK2 PTK2 protein tyrosine kinase 2 0.891
CCL5 chemokine (C-C motif) ligand 5 0.886
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.886
IL2RB interleukin 2 receptor, beta 0.878
CCR2 chemokine (C-C motif) receptor 2 0.877
CXCL10 chemokine (C-X-C motif) ligand 10 0.873
MYD88 myeloid differentiation primary response gene (88) 0.869
CD80 CD80 molecule 0.867
JUN jun proto-oncogene 0.862
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.859
CARD11 caspase recruitment domain family, member 11 0.854
IL8 interleukin 8 0.851
B2M beta-2-microglobulin 0.849
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.847
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.847
HLA-DRA major histocompatibility complex, class II, DR alpha 0.846
PLCG1 phospholipase C, gamma 1 0.842
ABI1 abl-interactor 1 0.838
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.830
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.826
CD84 CD84 molecule 0.822
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.821
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) 0.819
CXCL2 chemokine (C-X-C motif) ligand 2 0.814
CCL22 chemokine (C-C motif) ligand 22 0.810
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.806
AXL AXL receptor tyrosine kinase 0.794
IL10 interleukin 10 0.793
IL4R interleukin 4 receptor 0.792
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.788
TEK TEK tyrosine kinase, endothelial 0.787
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.787
IL6 interleukin 6 (interferon, beta 2) 0.784
CCL2 chemokine (C-C motif) ligand 2 0.781
VCAM1 vascular cell adhesion molecule 1 0.781
BCL2 B-cell CLL/lymphoma 2 0.774
PTPRC protein tyrosine phosphatase, receptor type, C 0.771
SLAMF1 signaling lymphocytic activation molecule family member 1 0.767
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.763
IL10RA interleukin 10 receptor, alpha 0.760
FGA fibrinogen alpha chain 0.759
TNF tumor necrosis factor 0.752
DCN decorin 0.747
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.746
CAV1 caveolin 1, caveolae protein, 22kDa 0.745
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.745
CCL3 chemokine (C-C motif) ligand 3 0.745
VAV1 vav 1 guanine nucleotide exchange factor 0.743
IL1R1 interleukin 1 receptor, type I 0.742
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Mus musculus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism