The network for 'digestive system process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

digestive system process

A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

Danio rerio
Name Description Probability Func Analog Organism
fabp2 fatty acid binding protein 2, intestinal 0.632
aco1 aconitase 1, soluble 0.554
ireb2 iron-responsive element binding protein 2 0.539
anxa2a annexin A2a 0.448
fabp1b.1 fatty acid binding protein 1b, tandem duplicate 1 0.398
anxa1a annexin A1a 0.347
hbaa1 hemoglobin alpha adult-1 0.289
krt4 keratin 4 0.198
apoa1 apolipoprotein A-I 0.182
anxa1b annexin A1b 0.167
zgc:161979 zgc:161979 0.160
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.143
tpm3 tropomyosin 3 0.121
sox9b SRY-box containing gene 9b 0.110
cxcr4b chemokine (C-X-C motif), receptor 4b 0.106
adrb2a adrenergic receptor, beta 2a 0.104
zgc:194131 zgc:194131 0.103
oprd1b opioid receptor, delta 1b 0.096
zgc:91835 zgc:91835 0.077
pdzk1 PDZ domain containing 1 0.072
cntn1a contactin 1a 0.070
cdh17 cadherin 17, LI cadherin (liver-intestine) 0.066
apobl apolipoprotein B, like 0.058
apc adenomatosis polyposis coli 0.057
ptch1 patched 1 0.053
gmppb GDP-mannose pyrophosphorylase B 0.046
pkp1 plakophilin 1 0.046
zgc:92745 zgc:92745 0.046
pi4kb phosphatidylinositol 4-kinase, catalytic, beta 0.044
csrp1a cysteine and glycine-rich protein 1a 0.041
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.040
hand2 heart and neural crest derivatives expressed transcript 2 0.038
wu:fb18f06 wu:fb18f06 0.037
tax1bp3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.037
gdnf glial cell derived neurotrophic factor 0.036
fgf10a fibroblast growth factor 10a 0.035
evpl envoplakin 0.034
fev FEV (ETS oncogene family) 0.034
cpa4 carboxypeptidase A4 0.034
si:dkeyp-59a8.4 si:dkeyp-59a8.4 0.033
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.032
LOC100332193 growth hormone secretagogue receptor type 1-like 0.031
ext2 exostoses (multiple) 2 0.031
tp53 tumor protein p53 0.030
perp PERP, TP53 apoptosis effector 0.030
gata5 GATA-binding protein 5 0.029
cyp3a65 cytochrome P450, family 3, subfamily A, polypeptide 65 0.029
copb1 coatomer protein complex, subunit beta 1 0.029
gdf11 growth differentiation factor 11 0.028
smx5 smx5 0.027
pvalb9 parvalbumin 9 0.027
neurog1 neurogenin 1 0.027
sepp1b selenoprotein P, plasma, 1b 0.027
urod uroporphyrinogen decarboxylase 0.026
acsl5 acyl-CoA synthetase long-chain family member 5 0.026
fabp6 fatty acid binding protein 6, ileal (gastrotropin) 0.026
slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 0.025
pikfyve phosphoinositide kinase, FYVE finger containing 0.025
pla2g12b phospholipase A2, group XIIB 0.024
c6ast3 six-cysteine containing astacin protease 3 0.024
wls wntless homolog (Drosophila) 0.024
crhbp corticotropin releasing hormone binding protein 0.023
apoa4 apolipoprotein A-IV 0.023
rbp2a retinol binding protein 2a, cellular 0.023
nfe2l3 nuclear factor (erythroid-derived 2)-like 3 0.022
zgc:64040 zgc:64040 0.022
slc4a2a solute carrier family 4, anion exchanger, member 2a 0.022
LOC795916 mucolipin-1-like 0.021
slc4a4a solute carrier family 4, member 4a 0.021
zmat2 zinc finger, matrin type 2 0.021
otpa orthopedia homolog a 0.021
pparg peroxisome proliferator activated receptor gamma 0.021
ihha Indian hedgehog homolog a 0.020
cpox coproporphyrinogen oxidase 0.020
zgc:110409 zgc:110409 0.019
sept2 septin 2 0.019
neurod6a neurogenic differentiation 6a 0.018
edn1 endothelin 1 0.018
irx4b iroquois homeobox protein 4b 0.018
kal1b Kallmann syndrome 1b sequence 0.018
sgpl1 sphingosine-1-phosphate lyase 1 0.018
col6a2 collagen, type VI, alpha 2 0.017
mchr1a melanin-concentrating hormone receptor 1a 0.017
erf Ets2 repressor factor 0.017
si:dkey-14d8.6 si:dkey-14d8.6 0.017
ptch2 patched 2 0.017
ascl1a achaete-scute complex-like 1a (Drosophila) 0.016
wu:fd52f12 wu:fd52f12 0.016
dpysl2b dihydropyrimidinase-like 2b 0.016
hnf4a hepatocyte nuclear factor 4, alpha 0.016
cahz carbonic anhydrase 0.016
foxa1 forkhead box A1 0.016
ptp4a1 protein tyrosine phosphatase type IVA, member 1 0.016
abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.016
glulb glutamate-ammonia ligase (glutamine synthase) b 0.015
sf1 splicing factor 1 0.015
si:dkeyp-113d7.7 si:dkeyp-113d7.7 0.015
flot2a flotillin 2a 0.015
cacnb2a calcium channel, voltage-dependent, beta 2a 0.015
tlr3 toll-like receptor 3 0.014
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.999
FGF1 fibroblast growth factor 1 (acidic) 0.855
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.536
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.528
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.514
CRHR1 corticotropin releasing hormone receptor 1 0.505
TTR transthyretin 0.445
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 0.401
S100A10 S100 calcium binding protein A10 0.292
FGF10 fibroblast growth factor 10 0.289
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.263
COPG coatomer protein complex, subunit gamma 0.242
COPE coatomer protein complex, subunit epsilon 0.228
KLHL3 kelch-like 3 (Drosophila) 0.222
CD300LD CD300 molecule-like family member d 0.193
MYD88 myeloid differentiation primary response gene (88) 0.098
FGFR1 fibroblast growth factor receptor 1 0.095
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.089
RUNX1 runt-related transcription factor 1 0.082
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.076
TICAM2 toll-like receptor adaptor molecule 2 0.067
RXRA retinoid X receptor, alpha 0.067
CAV2 caveolin 2 0.052
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.051
GLIS2 GLIS family zinc finger 2 0.050
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.047
PSEN1 presenilin 1 0.046
RIPK2 receptor-interacting serine-threonine kinase 2 0.044
HR hairless homolog (mouse) 0.044
TXN thioredoxin 0.040
APOC3 apolipoprotein C-III 0.040
KCTD17 potassium channel tetramerisation domain containing 17 0.039
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.038
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.037
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.037
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.033
ADAMTSL4 ADAMTS-like 4 0.033
FRS2 fibroblast growth factor receptor substrate 2 0.032
IDI1 isopentenyl-diphosphate delta isomerase 1 0.032
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.032
FGF8 fibroblast growth factor 8 (androgen-induced) 0.031
PCSK9 proprotein convertase subtilisin/kexin type 9 0.030
FGF7 fibroblast growth factor 7 0.029
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.029
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 0.028
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.025
FCRL4 Fc receptor-like 4 0.025
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.024
LY96 lymphocyte antigen 96 0.023
SLC17A1 solute carrier family 17 (sodium phosphate), member 1 0.020
ANG angiogenin, ribonuclease, RNase A family, 5 0.019
OXSR1 oxidative-stress responsive 1 0.019
SLC34A1 solute carrier family 34 (sodium phosphate), member 1 0.019
LCAT lecithin-cholesterol acyltransferase 0.019
SLC9A3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 0.018
CTGF connective tissue growth factor 0.017
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 0.017
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 0.017
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.017
HIC1 hypermethylated in cancer 1 0.017
TAC1 tachykinin, precursor 1 0.016
DMC1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) 0.016
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.016
HP haptoglobin 0.016
PCBP1 poly(rC) binding protein 1 0.016
SNRPE small nuclear ribonucleoprotein polypeptide E 0.016
NCOA1 nuclear receptor coactivator 1 0.015
EDF1 endothelial differentiation-related factor 1 0.015
FGF2 fibroblast growth factor 2 (basic) 0.015
FGFR3 fibroblast growth factor receptor 3 0.015
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.014
TFF3 trefoil factor 3 (intestinal) 0.014
ALPI alkaline phosphatase, intestinal 0.014
SEC61G Sec61 gamma subunit 0.013
PYDC2 pyrin domain containing 2 0.013
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.013
MUC2 mucin 2, oligomeric mucus/gel-forming 0.013
PRODH2 proline dehydrogenase (oxidase) 2 0.013
TNIK TRAF2 and NCK interacting kinase 0.013
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.013
SIGLEC8 sialic acid binding Ig-like lectin 8 0.012
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.012
SYT9 synaptotagmin IX 0.012
MDFI MyoD family inhibitor 0.012
PYCARD PYD and CARD domain containing 0.012
HMGA1 high mobility group AT-hook 1 0.012
MT3 metallothionein 3 0.011
APOE apolipoprotein E 0.011
MSTO1 misato homolog 1 (Drosophila) 0.011
VIL1 villin 1 0.011
PTPRF protein tyrosine phosphatase, receptor type, F 0.011
FGFBP1 fibroblast growth factor binding protein 1 0.011
ADRA1D adrenergic, alpha-1D-, receptor 0.011
PTEN phosphatase and tensin homolog 0.011
GP2 glycoprotein 2 (zymogen granule membrane) 0.011
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 0.011
SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 0.011
TFF2 trefoil factor 2 0.010
APOC1 apolipoprotein C-I 0.010
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.120
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.109
Ncan neurocan 0.107
Cyss cystatin S 0.101
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.091
Ucn urocortin 0.080
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.077
Mag myelin-associated glycoprotein 0.075
Calcr calcitonin receptor 0.075
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.073
Fgfbp1 fibroblast growth factor binding protein 1 0.063
Teddm1 transmembrane epididymal protein 1 0.062
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.061
Pax6 paired box 6 0.055
Btc betacellulin 0.048
Cga glycoprotein hormones, alpha polypeptide 0.047
Il13 interleukin 13 0.047
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.044
Kl Klotho 0.043
Accn2 amiloride-sensitive cation channel 2, neuronal 0.043
Mep1a meprin 1 alpha 0.042
Slc9a4 solute carrier family 9 (sodium/hydrogen exchanger), member 4 0.042
Oprk1 opioid receptor, kappa 1 0.041
Ccbp2 chemokine binding protein 2 0.038
Aqp5 aquaporin 5 0.037
Smgb neonatal submandibular gland protein B 0.037
Insrr insulin receptor-related receptor 0.037
Mrgprf MAS-related GPR, member F 0.036
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.036
Vipr1 vasoactive intestinal peptide receptor 1 0.036
Cgm4 carcinoembryonic antigen gene family 4 0.035
Agtr1b angiotensin II receptor, type 1b 0.035
Hoxa2 homeo box A2 0.035
Aqp7 aquaporin 7 0.034
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.032
Avp arginine vasopressin 0.032
Sftpa1 surfactant protein A1 0.032
Prm3 protamine 3 0.032
Prss3 protease, serine, 3 0.032
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.032
Ppy pancreatic polypeptide 0.031
Cartpt CART prepropeptide 0.031
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.031
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.030
Prlr prolactin receptor 0.030
Upk3bl uroplakin 3B-like 0.030
Grifin galectin-related inter-fiber protein 0.029
Grk1 G protein-coupled receptor kinase 1 0.029
Aqp2 aquaporin 2 (collecting duct) 0.028
Fgf7 fibroblast growth factor 7 0.028
Mfrp membrane frizzled-related protein 0.027
Wfdc6a WAP four-disulfide core domain 6A 0.027
Il9r interleukin 9 receptor 0.027
Hnmt histamine N-methyltransferase 0.027
Rho rhodopsin 0.027
Ifna1 interferon-alpha 1 0.026
Hcrt hypocretin 0.026
Glp1r glucagon-like peptide 1 receptor 0.025
Trib1 tribbles homolog 1 (Drosophila) 0.025
Hrh2 histamine receptor H 2 0.025
Cnga1 cyclic nucleotide gated channel alpha 1 0.024
Rbp3 retinol binding protein 3, interstitial 0.024
Nlrp6 NLR family, pyrin domain containing 6 0.024
Gucy2d guanylate cyclase 2d 0.024
Sult1b1 sulfotransferase family, cytosolic, 1B, member 1 0.024
Fgf10 fibroblast growth factor 10 0.024
Gucy2f guanylate cyclase 2F 0.023
Gnrhr gonadotropin releasing hormone receptor 0.023
Mchr1 melanin-concentrating hormone receptor 1 0.023
Gpr88 G-protein coupled receptor 88 0.023
Hcrtr2 hypocretin (orexin) receptor 2 0.023
Olr1082 olfactory receptor 1082 0.023
Gabre gamma-aminobutyric acid (GABA) A receptor, epsilon 0.023
Slco1a1 solute carrier organic anion transporter family, member 1a1 0.022
Olr1496 olfactory receptor 1496 0.022
Pdyn prodynorphin 0.022
Fam38b family with sequence similarity 38, member B 0.022
Gcgr glucagon receptor 0.021
Notch3 Notch homolog 3 (Drosophila) 0.021
Kif6 kinesin family member 6 0.021
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.021
Nrl neural retina leucine zipper 0.021
Pnpla8 patatin-like phospholipase domain containing 8 0.021
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.021
Tff3 trefoil factor 3, intestinal 0.021
Pnliprp2 pancreatic lipase-related protein 2 0.020
Sag S-antigen; retina and pineal gland (arrestin) 0.020
Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 0.020
Cacng5 calcium channel, voltage-dependent, gamma subunit 5 0.020
Mamdc4 MAM domain containing 4 0.020
Gdnf glial cell derived neurotrophic factor 0.020
Pnlip pancreatic lipase 0.020
Casr calcium-sensing receptor 0.020
Pmfbp1 polyamine modulated factor 1 binding protein 1 0.020
Olr287 olfactory receptor 287 0.019
Bcan brevican 0.019
Cacng4 calcium channel, voltage-dependent, gamma subunit 4 0.019
Akr1c18 aldo-keto reductase family 1, member C18 0.019
Olr226 olfactory receptor 226 0.019
Zg16 zymogen granule protein 16 0.019
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism