The network for 'nose development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

nose development

The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).

Danio rerio
Name Description Probability Func Analog Organism
eya1 eyes absent homolog 1 0.703
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.458
sox2 SRY-box containing gene 2 0.369
six4a sine oculis homeobox homolog 4a 0.266
foxa3 forkhead box A3 0.184
sox10 SRY-box containing gene 10 0.181
otx1b orthodenticle homolog 1b 0.174
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.169
irx1b iroquois homeobox protein 1, b 0.162
tfe3b transcription factor binding to IGHM enhancer 3b 0.153
foxi3b forkhead box I3b 0.136
grem2 gremlin 2, cysteine knot superfamily 0.111
znf503 zinc finger protein 503 0.090
foxa2 forkhead box A2 0.082
fgf3 fibroblast growth factor 3 0.073
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.073
dlx4b distal-less homeobox gene 4b 0.064
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.064
tp63 tumor protein p63 0.059
foxi3a forkhead box I3a 0.053
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.053
sox19a SRY-box containing gene 19a 0.048
foxi1 forkhead box I1 0.046
grhl2b grainyhead-like 2b (Drosophila) 0.045
notch1a notch homolog 1a 0.044
sfrp1b secreted frizzled-related protein 1b 0.043
foxa1 forkhead box A1 0.041
six2a sine oculis-related homeobox 2a 0.041
six4b sine oculis homeobox homolog 4b 0.041
kif17 kinesin family member 17 0.040
fzd8a frizzled homolog 8a 0.037
zeb2a zinc finger E-box binding homeobox 2a 0.036
hoxb3a homeo box B3a 0.034
gbx2 gastrulation brain homeo box 2 0.032
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.032
cdc16 cell division cycle 16 homolog (S. cerevisiae) 0.032
smoc1 SPARC related modular calcium binding 1 0.032
foxd3 forkhead box D3 0.032
foxc1a forkhead box C1a 0.030
cldn5a claudin 5a 0.029
pou1f1 POU domain, class 1, transcription factor 1 0.029
gsc goosecoid 0.026
pdgfaa platelet-derived growth factor alpha a 0.023
flh floating head 0.022
foxg1a forkhead box G1a 0.022
otx2 orthodenticle homolog 2 0.021
shha sonic hedgehog a 0.021
cdx4 caudal type homeo box transcription factor 4 0.021
lypd6 LY6/PLAUR domain containing 6 0.020
hoxb8a homeo box B8a 0.020
ntn1a netrin 1a 0.020
barx2 BarH-like homeobox 2 0.020
pitx2 paired-like homeodomain transcription factor 2 0.020
hmx4 H6 family homeobox 4 0.019
fsta follistatin a 0.019
dlx3b distal-less homeobox gene 3b 0.018
vwf von Willebrand factor 0.018
nkx2.1b NK2 homeobox 1b 0.018
st8sia7.1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 7.1 0.017
nkx6.2 NK6 transcription factor related, locus 2 0.017
tcf12 transcription factor 12 0.017
bhlhe22 basic helix-loop-helix family, member e22 0.017
olfm1a olfactomedin 1a 0.017
dlc deltaC 0.016
zic6 zic family member 6 0.016
lmo3 LIM domain only 3 0.016
ints6 integrator complex subunit 6 0.016
jag1b jagged 1b 0.016
kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 0.016
emx2 empty spiracles homeobox 2 0.016
nkx2.3 NK2 transcription factor related 3 0.016
dao.2 D-amino-acid oxidase 2 0.015
slc4a1b solute carrier family 4, anion exchanger, member 1b 0.015
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.015
zgc:194131 zgc:194131 0.015
vasn vasorin 0.014
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.014
rorb RAR-related orphan receptor B 0.014
tfeb transcription factor EB 0.013
hs3st1l2 heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 2 0.013
smarcd3b SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b 0.013
ncf1 neutrophil cytosolic factor 1 0.013
frem3 Fras1 related extracellular matrix 3 0.013
gcm2 glial cells missing homolog 2 (Drosophila) 0.013
pcdh18a protocadherin 18a 0.013
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.013
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.013
atp1a1a.2 ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide 0.012
grhl1 grainyhead-like 1 (Drosophila) 0.012
acvr2b activin receptor IIb 0.011
dld deltaD 0.011
slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 0.011
bcl6a B-cell CLL/lymphoma 6a (zinc finger protein 51) 0.011
slc9a3.2 solute carrier family 9 (sodium/hydrogen exchanger), member 3.2 0.011
ildr1b immunoglobulin-like domain containing receptor 1b 0.010
LOC556647 GDNF family receptor alpha-4-like 0.010
si:ch211-207m11.1 si:ch211-207m11.1 0.010
flr fleer 0.010
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
ZFYVE9 zinc finger, FYVE domain containing 9 0.773
SMAD4 SMAD family member 4 0.627
CHD8 chromodomain helicase DNA binding protein 8 0.565
CHD7 chromodomain helicase DNA binding protein 7 0.539
SP1 Sp1 transcription factor 0.537
HCFC1 host cell factor C1 (VP16-accessory protein) 0.480
SMAD3 SMAD family member 3 0.236
PPARA peroxisome proliferator-activated receptor alpha 0.225
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.179
NCOR2 nuclear receptor corepressor 2 0.178
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.052
ATF7IP activating transcription factor 7 interacting protein 0.051
TCF4 transcription factor 4 0.036
NCOR1 nuclear receptor corepressor 1 0.034
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.033
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.026
CSNK1E casein kinase 1, epsilon 0.022
AXIN2 axin 2 0.022
MECP2 methyl CpG binding protein 2 (Rett syndrome) 0.020
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.020
SALL2 sal-like 2 (Drosophila) 0.020
KDM2A lysine (K)-specific demethylase 2A 0.015
FOXD3 forkhead box D3 0.014
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.013
EYA1 eyes absent homolog 1 (Drosophila) 0.011
PHF12 PHD finger protein 12 0.011
ZBTB17 zinc finger and BTB domain containing 17 0.010
GSK3B glycogen synthase kinase 3 beta 0.010
MAX MYC associated factor X 0.010
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Eya1 eyes absent 1 homolog (Drosophila) 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 0.994
Sox2 SRY-box containing gene 2 0.989
Pax3 paired box gene 3 0.989
Tcfap2a transcription factor AP-2, alpha 0.982
Isl1 ISL1 transcription factor, LIM/homeodomain 0.974
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.931
Pax6 paired box gene 6 0.883
Gbx2 gastrulation brain homeobox 2 0.856
Foxg1 forkhead box G1 0.827
Gli3 GLI-Kruppel family member GLI3 0.801
Chd7 chromodomain helicase DNA binding protein 7 0.789
Fgf8 fibroblast growth factor 8 0.764
Msx1 homeobox, msh-like 1 0.762
Pax2 paired box gene 2 0.730
Gsc goosecoid homeobox 0.705
Fgf3 fibroblast growth factor 3 0.582
Pitx2 paired-like homeodomain transcription factor 2 0.575
Dlx1 distal-less homeobox 1 0.551
Alx4 aristaless-like homeobox 4 0.535
Hes1 hairy and enhancer of split 1 (Drosophila) 0.522
Shh sonic hedgehog 0.517
Gata3 GATA binding protein 3 0.516
Fgf10 fibroblast growth factor 10 0.430
Tbx10 T-box 10 0.423
Prrx1 paired related homeobox 1 0.413
Sox11 SRY-box containing gene 11 0.407
Tbx1 T-box 1 0.388
Hand1 heart and neural crest derivatives expressed transcript 1 0.387
Hes5 hairy and enhancer of split 5 (Drosophila) 0.371
Fgfr1 fibroblast growth factor receptor 1 0.363
Dlx5 distal-less homeobox 5 0.361
Fgfr2 fibroblast growth factor receptor 2 0.348
Rarg retinoic acid receptor, gamma 0.331
Hoxa1 homeobox A1 0.304
Hand2 heart and neural crest derivatives expressed transcript 2 0.288
Lhx3 LIM homeobox protein 3 0.263
Sox3 SRY-box containing gene 3 0.258
Lmx1a LIM homeobox transcription factor 1 alpha 0.253
Msx2 homeobox, msh-like 2 0.228
Foxc2 forkhead box C2 0.224
Hoxa3 homeobox A3 0.202
Ednra endothelin receptor type A 0.198
Emx1 empty spiracles homolog 1 (Drosophila) 0.191
Nog noggin 0.182
Dlx2 distal-less homeobox 2 0.174
Emx2 empty spiracles homolog 2 (Drosophila) 0.160
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.137
Hoxd13 homeobox D13 0.131
Foxc1 forkhead box C1 0.116
Tcfap2c transcription factor AP-2, gamma 0.107
Nanog Nanog homeobox 0.107
Pbx1 pre B-cell leukemia transcription factor 1 0.085
Hoxa2 homeobox A2 0.084
Ece1 endothelin converting enzyme 1 0.079
Rarb retinoic acid receptor, beta 0.077
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.076
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.076
Hmx3 H6 homeobox 3 0.075
Phox2b paired-like homeobox 2b 0.075
Atoh7 atonal homolog 7 (Drosophila) 0.068
Alx3 aristaless-like homeobox 3 0.067
Prrx2 paired related homeobox 2 0.066
Zeb1 zinc finger E-box binding homeobox 1 0.062
Insm1 insulinoma-associated 1 0.061
Sall3 sal-like 3 (Drosophila) 0.060
Pax9 paired box gene 9 0.060
Neurod1 neurogenic differentiation 1 0.058
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.057
Vangl2 vang-like 2 (van gogh, Drosophila) 0.055
Bmp4 bone morphogenetic protein 4 0.049
Pml promyelocytic leukemia 0.048
Lef1 lymphoid enhancer binding factor 1 0.045
Neurog2 neurogenin 2 0.044
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.043
Jag1 jagged 1 0.043
Hesx1 homeobox gene expressed in ES cells 0.039
Bmp7 bone morphogenetic protein 7 0.038
Smo smoothened homolog (Drosophila) 0.037
Otx1 orthodenticle homolog 1 (Drosophila) 0.036
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.034
Atoh1 atonal homolog 1 (Drosophila) 0.034
Pou3f4 POU domain, class 3, transcription factor 4 0.034
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.033
Smad7 MAD homolog 7 (Drosophila) 0.031
Smad6 MAD homolog 6 (Drosophila) 0.031
Efnb2 ephrin B2 0.031
Meox2 mesenchyme homeobox 2 0.030
Sox1 SRY-box containing gene 1 0.030
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.028
Foxi3 forkhead box I3 0.028
Wnt6 wingless-related MMTV integration site 6 0.026
Foxd1 forkhead box D1 0.026
Ntf3 neurotrophin 3 0.026
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.024
She src homology 2 domain-containing transforming protein E 0.023
Foxb1 forkhead box B1 0.023
Hmx2 H6 homeobox 2 0.022
Bdnf brain derived neurotrophic factor 0.022
Gtf2ird1 general transcription factor II I repeat domain-containing 1 0.022
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism