The network for 'negative regulation of protein serine threonine kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein serine threonine kinase activity

Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.

Danio rerio
Name Description Probability Func Analog Organism
ntn2 netrin 2 0.312
dusp6 dual specificity phosphatase 6 0.291
rhoab ras homolog gene family, member Ab 0.280
fgf3 fibroblast growth factor 3 0.273
nrg2a neuregulin 2a 0.252
bmp2b bone morphogenetic protein 2b 0.191
prox1 prospero-related homeobox gene 1 0.186
efnb2a ephrin B2a 0.186
b3gat3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) and beta3-glucuronyltransferase 0.184
nf1a neurofibromin 1a 0.180
spry4 sprouty (Drosophila) homolog 4 0.168
egr1 early growth response 1 0.166
acvr2a activin receptor IIa 0.166
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.131
epha4a eph receptor A4a 0.125
fzd7b frizzled homolog 7b 0.125
adipoql adiponectin, C1Q and collagen domain containing, like 0.118
ahsa1l AHA1, activator of heat shock protein ATPase homolog 1, like 0.117
pea3 ETS-domain transcription factor pea3 0.113
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.108
mapk3 mitogen-activated protein kinase 3 0.106
sox3 SRY-box containing gene 3 0.104
gli3 GLI-Kruppel family member GLI3 0.101
myod1 myogenic differentiation 1 0.099
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.094
nf1b neurofibromin 1b 0.092
ficd FIC domain containing 0.090
phf23a PHD finger protein 23a 0.090
rarab retinoic acid receptor, alpha b 0.090
btg2 B-cell translocation gene 2 0.084
homez homeodomain leucine zipper gene 0.083
hoxa13a homeo box A13a 0.083
fam49ba family with sequence similarity 49, member Ba 0.083
mbtps1 membrane-bound transcription factor protease, site 1 0.080
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.077
notum3 notum 3 0.077
plk3 polo-like kinase 3 (Drosophila) 0.071
adipor2 adiponectin receptor 2 0.071
rab22a RAB22A, member RAS oncogene family 0.070
bcl2l1 bcl2-like 1 0.070
adipoql2 adiponectin, C1Q and collagen domain containing, like 2 0.069
sema3d semaphorin 3d 0.069
mcm6l MCM6 minichromosome maintenance deficient 6, like 0.068
stau2 staufen, RNA binding protein, homolog 2 (Drosophila) 0.068
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.066
rasl11b RAS-like, family 11, member B 0.065
slc25a25a solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a 0.063
vcana versican a 0.062
papolb poly(A) polymerase beta (testis specific) 0.062
tie2 endothelium-specific receptor tyrosine kinase 2 0.062
hoxc12b homeo box C12b 0.062
pfn1 profilin 1 0.062
ptpra protein tyrosine phosphatase, receptor type, A 0.061
etv5a ets variant 5a 0.061
ahcyl1 S-adenosylhomocysteine hydrolase-like 1 0.061
mapk6 mitogen-activated protein kinase 6 0.060
ctsba cathepsin B, a 0.060
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.060
wu:fi25h02 wu:fi25h02 0.060
sall1a sal-like 1a (Drosophila) 0.059
snai1a snail homolog 1a (Drosophila) 0.058
il17rd interleukin 17 receptor D 0.057
frem3 Fras1 related extracellular matrix 3 0.056
mapk7 mitogen-activated protein kinase 7 0.054
cps1 carbamoyl-phosphate synthase 1, mitochondrial 0.053
id1 inhibitor of DNA binding 1 0.053
slc4a1b solute carrier family 4, anion exchanger, member 1b 0.053
gsc goosecoid 0.053
mapk1 mitogen-activated protein kinase 1 0.052
zgc:92380 zgc:92380 0.052
nrarpa notch-regulated ankyrin repeat protein a 0.052
grnb granulin b 0.051
thy1 Thy-1 cell surface antigen 0.050
cdc25 cell division cycle 25 homolog 0.050
hspa5 heat shock protein 5 0.050
hspb11 heat shock protein, alpha-crystallin-related, b11 0.050
dennd5b DENN/MADD domain containing 5B 0.049
ppp6r3 protein phosphatase 6, regulatory subunit 3 0.049
efna2 ephrin A2 0.049
dnajb1a DnaJ (Hsp40) homolog, subfamily B, member 1a 0.048
dusp5 dual specificity phosphatase 5 0.048
wnt1 wingless-type MMTV integration site family, member 1 0.048
foxi3b forkhead box I3b 0.048
mapk12 mitogen-activated protein kinase 12 0.047
myog myogenin 0.047
arl5c ADP-ribosylation factor-like 5C 0.047
tnrc5 trinucleotide repeat containing 5 0.046
lass2 LAG1 homolog, ceramide synthase 2 (S. cerevisiae) 0.046
caspa caspase a 0.045
LOC555739 serine/threonine-protein kinase LMTK1-like 0.045
capns1a calpain, small subunit 1 a 0.044
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.044
ip6k2 inositol hexaphosphate kinase 2 0.043
cotl1 coactosin-like 1 (Dictyostelium) 0.043
si:ch73-60i13.2 si:ch73-60i13.2 0.043
atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.042
prkcq protein kinase C, theta 0.042
zgc:92851 zgc:92851 0.042
nrg2b neuregulin 2b 0.042
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.041
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
mec-2 Protein MEC-2 0.138
inx-12 Protein INX-12 0.042
ape-1 Protein APE-1 0.040
ajm-1 Protein AJM-1 0.039
unc-53 Protein UNC-53 0.030
vab-3 Protein VAB-3 0.027
R03H10.2 Protein R03H10.2 0.026
inx-13 Protein INX-13 0.020
inx-1 Protein INX-1 0.020
glr-5 Protein GLR-5 0.020
eat-4 Protein EAT-4 0.017
ger-1 Protein GER-1 0.015
CELE_F20D1.3 Protein F20D1.3 0.014
mel-26 Protein MEL-26 0.014
cnb-1 Protein CNB-1 0.012
CELE_M176.5 Protein M176.5 0.011
Y104H12D.2 Protein Y104H12D.2 0.011
pde-4 Protein PDE-4 0.011
C06G3.5 Protein C06G3.5 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
MAPK14 mitogen-activated protein kinase 14 1.000
MAPK1 mitogen-activated protein kinase 1 1.000
MAPK8 mitogen-activated protein kinase 8 0.998
ZNF43 zinc finger protein 43 0.986
SH3KBP1 SH3-domain kinase binding protein 1 0.971
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.967
FYN FYN oncogene related to SRC, FGR, YES 0.965
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.959
MAP2K4 mitogen-activated protein kinase kinase 4 0.957
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.956
GSK3B glycogen synthase kinase 3 beta 0.954
RB1 retinoblastoma 1 0.952
ZNF253 zinc finger protein 253 0.949
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.935
IRAK2 interleukin-1 receptor-associated kinase 2 0.934
EGFR epidermal growth factor receptor 0.925
DUSP1 dual specificity phosphatase 1 0.869
ZNF273 zinc finger protein 273 0.860
APP amyloid beta (A4) precursor protein 0.859
CCND1 cyclin D1 0.856
CDK6 cyclin-dependent kinase 6 0.845
CCND3 cyclin D3 0.840
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.836
MAPK3 mitogen-activated protein kinase 3 0.824
RARA retinoic acid receptor, alpha 0.823
ATF2 activating transcription factor 2 0.805
LARP7 La ribonucleoprotein domain family, member 7 0.799
PTK2 PTK2 protein tyrosine kinase 2 0.793
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.776
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.775
ARRB1 arrestin, beta 1 0.772
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.759
MAP2K1 mitogen-activated protein kinase kinase 1 0.756
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.718
JUN jun proto-oncogene 0.713
ZNF675 zinc finger protein 675 0.660
BMPR1A bone morphogenetic protein receptor, type IA 0.660
CREBBP CREB binding protein 0.659
XIAP X-linked inhibitor of apoptosis 0.621
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.620
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.619
A2M alpha-2-macroglobulin 0.603
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.555
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.552
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.541
IL1R1 interleukin 1 receptor, type I 0.513
AKAP1 A kinase (PRKA) anchor protein 1 0.503
MET met proto-oncogene (hepatocyte growth factor receptor) 0.498
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.493
LCK lymphocyte-specific protein tyrosine kinase 0.484
DUSP6 dual specificity phosphatase 6 0.473
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.472
TRAF6 TNF receptor-associated factor 6 0.439
NOXA1 NADPH oxidase activator 1 0.437
ARRB2 arrestin, beta 2 0.423
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.417
MYD88 myeloid differentiation primary response gene (88) 0.413
CDK4 cyclin-dependent kinase 4 0.406
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.404
ZNF430 zinc finger protein 430 0.384
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.384
ZNF254 zinc finger protein 254 0.380
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.370
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.341
HSPA8 heat shock 70kDa protein 8 0.334
PRKCZ protein kinase C, zeta 0.333
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.333
LAMP1 lysosomal-associated membrane protein 1 0.333
ZNF91 zinc finger protein 91 0.322
MAP2K7 mitogen-activated protein kinase kinase 7 0.311
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.306
AXIN1 axin 1 0.301
GHR growth hormone receptor 0.299
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.298
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.296
EGR2 early growth response 2 0.289
CHUK conserved helix-loop-helix ubiquitous kinase 0.288
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.283
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.274
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.266
ZNF85 zinc finger protein 85 0.258
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.251
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.249
PLCG1 phospholipase C, gamma 1 0.244
CTNND1 catenin (cadherin-associated protein), delta 1 0.237
NLRC4 NLR family, CARD domain containing 4 0.233
IRAK1 interleukin-1 receptor-associated kinase 1 0.233
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.223
IER2 immediate early response 2 0.217
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.212
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.208
RICTOR RPTOR independent companion of MTOR, complex 2 0.204
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.203
ZNF117 zinc finger protein 117 0.203
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.197
PKM2 pyruvate kinase, muscle 0.196
ZNF93 zinc finger protein 93 0.193
YAP1 Yes-associated protein 1 0.191
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.190
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 0.999
Rb1 retinoblastoma 1 0.989
Apc adenomatosis polyposis coli 0.986
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.985
Pten phosphatase and tensin homolog 0.978
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.928
Mdm2 transformed mouse 3T3 cell double minute 2 0.924
Igh immunoglobulin heavy chain complex 0.911
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.892
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.877
Prkce protein kinase C, epsilon 0.861
Traf6 TNF receptor-associated factor 6 0.848
Ikzf1 IKAROS family zinc finger 1 0.842
Blnk B-cell linker 0.819
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.781
Nf2 neurofibromatosis 2 0.772
Ghr growth hormone receptor 0.764
Ptch1 patched homolog 1 0.760
Fos FBJ osteosarcoma oncogene 0.741
C1qc complement component 1, q subcomponent, C chain 0.729
Ly86 lymphocyte antigen 86 0.726
Evl Ena-vasodilator stimulated phosphoprotein 0.698
Lyz2 lysozyme 2 0.688
Dok1 docking protein 1 0.687
Plcg2 phospholipase C, gamma 2 0.671
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.663
Tnf tumor necrosis factor 0.661
Nf1 neurofibromatosis 1 0.659
Cbl Casitas B-lineage lymphoma 0.617
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.609
Il1b interleukin 1 beta 0.603
Axin1 axin 1 0.602
Cdh5 cadherin 5 0.600
Egr1 early growth response 1 0.586
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.571
Mapk14 mitogen-activated protein kinase 14 0.562
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.551
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.550
Ptprc protein tyrosine phosphatase, receptor type, C 0.531
Jun Jun oncogene 0.516
Gsk3b glycogen synthase kinase 3 beta 0.515
Tsc1 tuberous sclerosis 1 0.494
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.460
Cd40 CD40 antigen 0.438
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.423
Grb2 growth factor receptor bound protein 2 0.404
Casp1 caspase 1 0.395
Nsf N-ethylmaleimide sensitive fusion protein 0.394
Clock circadian locomotor output cycles kaput 0.378
Bmp4 bone morphogenetic protein 4 0.374
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.368
Prkaca protein kinase, cAMP dependent, catalytic, alpha 0.362
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.356
Fgfr1 fibroblast growth factor receptor 1 0.331
Aif1 allograft inflammatory factor 1 0.329
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.313
Pparg peroxisome proliferator activated receptor gamma 0.312
Braf Braf transforming gene 0.309
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.301
Aim2 absent in melanoma 2 0.300
Irf8 interferon regulatory factor 8 0.298
Enah enabled homolog (Drosophila) 0.296
Mdm4 transformed mouse 3T3 cell double minute 4 0.289
Vangl2 vang-like 2 (van gogh, Drosophila) 0.288
Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 0.285
Prkcb protein kinase C, beta 0.276
Btk Bruton agammaglobulinemia tyrosine kinase 0.268
Lepr leptin receptor 0.267
Cd22 CD22 antigen 0.267
Skil SKI-like 0.266
Ret ret proto-oncogene 0.265
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.258
Spry2 sprouty homolog 2 (Drosophila) 0.256
Src Rous sarcoma oncogene 0.256
Sirpa signal-regulatory protein alpha 0.256
Gbp5 guanylate binding protein 5 0.246
Stk4 serine/threonine kinase 4 0.244
Hsph1 heat shock 105kDa/110kDa protein 1 0.244
Dnajb4 DnaJ (Hsp40) homolog, subfamily B, member 4 0.241
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.230
Msh2 mutS homolog 2 (E. coli) 0.224
Ldb3 LIM domain binding 3 0.217
Rel reticuloendotheliosis oncogene 0.216
Esr1 estrogen receptor 1 (alpha) 0.214
Ccnd1 cyclin D1 0.214
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.213
Yap1 yes-associated protein 1 0.212
Irak4 interleukin-1 receptor-associated kinase 4 0.210
Rxra retinoid X receptor alpha 0.208
Junb Jun-B oncogene 0.207
Lrp6 low density lipoprotein receptor-related protein 6 0.205
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.205
Mapk8 mitogen-activated protein kinase 8 0.204
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.203
E2f1 E2F transcription factor 1 0.198
Grm1 glutamate receptor, metabotropic 1 0.192
Tyrobp TYRO protein tyrosine kinase binding protein 0.190
Itgb2 integrin beta 2 0.189
Sykb spleen tyrosine kinase 0.188
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RLM1 Rlm1p 0.047
BOI1 Boi1p 0.034
LHS1 Lhs1p 0.028
NBP2 Nbp2p 0.025
MSG5 Msg5p 0.019
BCK1 Bck1p 0.012
STE5 Ste5p 0.012
KSS1 Kss1p 0.011
PBS2 Pbs2p 0.011
GAL83 Gal83p 0.011
STE7 Ste7p 0.011
GYL1 Gyl1p 0.010
SSK1 Ssk1p 0.010