IMP

Process View

Homo sapiens

15 genes annotated in human

foam cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "foam cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "foam cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.999
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.867
ENG	endoglin	0.756
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.661
CXCL2	chemokine (C-X-C motif) ligand 2	0.644
FHL2	four and a half LIM domains 2	0.569
ATF2	activating transcription factor 2	0.487
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.477
C1QA	complement component 1, q subcomponent, A chain	0.466	Human
MAP2K4	mitogen-activated protein kinase kinase 4	0.434
C1QC	complement component 1, q subcomponent, C chain	0.419	Human
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.303	Human
TLN1	talin 1	0.298
NCOR2	nuclear receptor corepressor 2	0.297
PXN	paxillin	0.281
JUN	jun proto-oncogene	0.270
VCAM1	vascular cell adhesion molecule 1	0.249
COTL1	coactosin-like 1 (Dictyostelium)	0.244
MAPK14	mitogen-activated protein kinase 14	0.236	Human
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.218
FN1	fibronectin 1	0.211
MAPK1	mitogen-activated protein kinase 1	0.197
DPP4	dipeptidyl-peptidase 4	0.146
CXCL10	chemokine (C-X-C motif) ligand 10	0.136	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.133	Human
CXCL5	chemokine (C-X-C motif) ligand 5	0.129	Human
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.124
MAPK8	mitogen-activated protein kinase 8	0.124	Human
PDIA3	protein disulfide isomerase family A, member 3	0.112
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.107	Human
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.102	Human
DUSP1	dual specificity phosphatase 1	0.090
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.089
ITGB4	integrin, beta 4	0.088
IL8	interleukin 8	0.074
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.074
FLNA	filamin A, alpha	0.070
CCL8	chemokine (C-C motif) ligand 8	0.059
ATF3	activating transcription factor 3	0.058
RXRA	retinoid X receptor, alpha	0.052
CXCL3	chemokine (C-X-C motif) ligand 3	0.045	Human
ARRB2	arrestin, beta 2	0.043
IL1B	interleukin 1, beta	0.043
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.042
UBD	ubiquitin D	0.041
CREBBP	CREB binding protein	0.040
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.037
CCL20	chemokine (C-C motif) ligand 20	0.035
CXCL9	chemokine (C-X-C motif) ligand 9	0.035	Human
SOCS3	suppressor of cytokine signaling 3	0.033
MAPK3	mitogen-activated protein kinase 3	0.033
THBS1	thrombospondin 1	0.032
CCL2	chemokine (C-C motif) ligand 2	0.032
HDAC3	histone deacetylase 3	0.031
ARRB1	arrestin, beta 1	0.030
PF4	platelet factor 4	0.029
MAPK9	mitogen-activated protein kinase 9	0.024
C1QB	complement component 1, q subcomponent, B chain	0.023	Human
SETD7	SET domain containing (lysine methyltransferase) 7	0.022
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.022
DUSP9	dual specificity phosphatase 9	0.022
RARA	retinoic acid receptor, alpha	0.021
CPNE6	copine VI (neuronal)	0.021
XPO7	exportin 7	0.021
S100A12	S100 calcium binding protein A12	0.020
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.019
HR	hairless homolog (mouse)	0.019
MED25	mediator complex subunit 25	0.019
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.018
CXCL13	chemokine (C-X-C motif) ligand 13	0.017
IL6	interleukin 6 (interferon, beta 2)	0.017
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.016
HBB	hemoglobin, beta	0.016
PF4V1	platelet factor 4 variant 1	0.015	Human
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.015
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.015	Human
SOCS1	suppressor of cytokine signaling 1	0.015
MARCO	macrophage receptor with collagenous structure	0.015
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.014
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.014
CCL7	chemokine (C-C motif) ligand 7	0.013
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.013
HNF4A	hepatocyte nuclear factor 4, alpha	0.013
DUSP7	dual specificity phosphatase 7	0.013
KRT5	keratin 5	0.013
ALB	albumin	0.012
CCL13	chemokine (C-C motif) ligand 13	0.012
SAA4	serum amyloid A4, constitutive	0.012
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.012
SLAMF8	SLAM family member 8	0.012
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.012
BCL2A1	BCL2-related protein A1	0.012
SELE	selectin E	0.011
APOC1	apolipoprotein C-I	0.011
MAPK11	mitogen-activated protein kinase 11	0.011	Human
ITGA7	integrin, alpha 7	0.011
CCL19	chemokine (C-C motif) ligand 19	0.011
LAMC3	laminin, gamma 3	0.011
SIRT6	sirtuin 6	0.011
PPARA	peroxisome proliferator-activated receptor alpha	0.010
KYNU	kynureninase	0.010