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Homo sapiens

25 genes annotated in human

Multi-species View

megakaryocyte differentiation

GO:0030219

The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "megakaryocyte differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "megakaryocyte differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
HIST1H3D	histone cluster 1, H3d	0.998	Human
TAL1	T-cell acute lymphocytic leukemia 1	0.983
HIST1H2BD	histone cluster 1, H2bd	0.982
HIST1H2AE	histone cluster 1, H2ae	0.968	Human
HIST1H2BG	histone cluster 1, H2bg	0.938
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.860	Mouse
HIST2H2BE	histone cluster 2, H2be	0.845
HIST1H2AC	histone cluster 1, H2ac	0.833	Human
HIST1H2AM	histone cluster 1, H2am	0.829
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.779	Human
HIST1H1C	histone cluster 1, H1c	0.774
HIST1H4B	histone cluster 1, H4b	0.754
HIST1H2AI	histone cluster 1, H2ai	0.742	Human
CXCL2	chemokine (C-X-C motif) ligand 2	0.725
SP1	Sp1 transcription factor	0.685	Mouse
PBX1	pre-B-cell leukemia homeobox 1	0.640
HIST1H3A	histone cluster 1, H3a	0.639
HIST1H2AJ	histone cluster 1, H2aj	0.637	Human
HIST1H3B	histone cluster 1, H3b	0.626
HIST1H4D	histone cluster 1, H4d	0.589
HIST1H2BI	histone cluster 1, H2bi	0.547
HIST1H2AB	histone cluster 1, H2ab	0.523	Human
HDAC3	histone deacetylase 3	0.518
HIST1H4A	histone cluster 1, H4a	0.501
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.498
HIST1H1E	histone cluster 1, H1e	0.497
HIST1H2BJ	histone cluster 1, H2bj	0.416
HIST1H4E	histone cluster 1, H4e	0.415
HIST1H4F	histone cluster 1, H4f	0.405
SETD8	SET domain containing (lysine methyltransferase) 8	0.356
HIST1H4H	histone cluster 1, H4h	0.354
EP300	E1A binding protein p300	0.338
HIST1H2BC	histone cluster 1, H2bc	0.312
GATA2	GATA binding protein 2	0.308	Human Mouse
HIST1H2AL	histone cluster 1, H2al	0.281	Human
HIST1H2BE	histone cluster 1, H2be	0.277
HIST1H4J	histone cluster 1, H4j	0.275
HIST1H3G	histone cluster 1, H3g	0.269
IL8	interleukin 8	0.263
HIST1H2BF	histone cluster 1, H2bf	0.235
HIST1H2BM	histone cluster 1, H2bm	0.211
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.205
DPP4	dipeptidyl-peptidase 4	0.202
HIST1H2BB	histone cluster 1, H2bb	0.185
CXCL5	chemokine (C-X-C motif) ligand 5	0.174	Human
PSEN2	presenilin 2 (Alzheimer disease 4)	0.166
HIST2H4A	histone cluster 2, H4a	0.156
HIST1H2AG	histone cluster 1, H2ag	0.149	Human
SP3	Sp3 transcription factor	0.147	Mouse
CXCL10	chemokine (C-X-C motif) ligand 10	0.131	Human
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.129
CXCL11	chemokine (C-X-C motif) ligand 11	0.123	Human
HIST1H4I	histone cluster 1, H4i	0.095
MKL1	megakaryoblastic leukemia (translocation) 1	0.090
KDM1A	lysine (K)-specific demethylase 1A	0.087	Mouse
NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.084
MYOD1	myogenic differentiation 1	0.084
HIST1H2AK	histone cluster 1, H2ak	0.077	Human
HIST1H2BH	histone cluster 1, H2bh	0.075
PTMA	prothymosin, alpha	0.072
HIST1H2BO	histone cluster 1, H2bo	0.070
RUNX1	runt-related transcription factor 1	0.064
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.064	Human
HIST1H4L	histone cluster 1, H4l	0.062
CCL20	chemokine (C-C motif) ligand 20	0.061
HMG20A	high mobility group 20A	0.059
TP53BP1	tumor protein p53 binding protein 1	0.057
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.056
HIST1H1D	histone cluster 1, H1d	0.056
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.056
HIST1H2BN	histone cluster 1, H2bn	0.053
GAB1	GRB2-associated binding protein 1	0.052
HIST1H3H	histone cluster 1, H3h	0.051
HIST1H4C	histone cluster 1, H4c	0.050
KITLG	KIT ligand	0.047
HMGA1	high mobility group AT-hook 1	0.047
HIST2H2AC	histone cluster 2, H2ac	0.044	Human
GATA4	GATA binding protein 4	0.044	Human
HIST1H3F	histone cluster 1, H3f	0.042
CXCL3	chemokine (C-X-C motif) ligand 3	0.041	Human
MYOCD	myocardin	0.040
SOS1	son of sevenless homolog 1 (Drosophila)	0.039
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.039
HIST2H4B	histone cluster 2, H4b	0.036
HIST1H3I	histone cluster 1, H3i	0.035
DAXX	death-domain associated protein	0.035
CCL2	chemokine (C-C motif) ligand 2	0.035
MYOG	myogenin (myogenic factor 4)	0.034
PHF10	PHD finger protein 10	0.034
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.033
HIST2H2AA4	histone cluster 2, H2aa4	0.033	Human
HIST2H2AA3	histone cluster 2, H2aa3	0.033	Human
HIST1H3C	histone cluster 1, H3c	0.032
HAND2	heart and neural crest derivatives expressed 2	0.031	Human
UBD	ubiquitin D	0.031
LMO2	LIM domain only 2 (rhombotin-like 1)	0.030
H3F3A	H3 histone, family 3A	0.027
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.027
NCOR2	nuclear receptor corepressor 2	0.026
POU2F1	POU class 2 homeobox 1	0.025
CCL8	chemokine (C-C motif) ligand 8	0.025
NFYA	nuclear transcription factor Y, alpha	0.024
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.024	Human
WASL	Wiskott-Aldrich syndrome-like	0.024
IL1B	interleukin 1, beta	0.024
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.023
RB1	retinoblastoma 1	0.022
KDM4A	lysine (K)-specific demethylase 4A	0.021
HIST1H2BL	histone cluster 1, H2bl	0.021
NCKAP1	NCK-associated protein 1	0.020
HDAC2	histone deacetylase 2	0.020
PF4	platelet factor 4	0.019
LAT	linker for activation of T cells	0.019
NRIP1	nuclear receptor interacting protein 1	0.019
HIST1H1B	histone cluster 1, H1b	0.019
KLF13	Kruppel-like factor 13	0.018
IL6	interleukin 6 (interferon, beta 2)	0.018
HIST1H3J	histone cluster 1, H3j	0.018
VCAM1	vascular cell adhesion molecule 1	0.017
HOXA9	homeobox A9	0.017
SNAI1	snail homolog 1 (Drosophila)	0.017
HIST1H2AH	histone cluster 1, H2ah	0.016	Human
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.016
SFRP5	secreted frizzled-related protein 5	0.015
YY1	YY1 transcription factor	0.014
TEX11	testis expressed 11	0.014
MKL2	MKL/myocardin-like 2	0.014
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.014
LHX5	LIM homeobox 5	0.014
ESR1	estrogen receptor 1	0.014
HDAC4	histone deacetylase 4	0.014
RHAG	Rh-associated glycoprotein	0.013
HIST1H3E	histone cluster 1, H3e	0.013
MED4	mediator complex subunit 4	0.013
HDAC9	histone deacetylase 9	0.013
SLC9A1	solute carrier family 9 (sodium/hydrogen exchanger), member 1	0.013
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.013
HBB	hemoglobin, beta	0.012
MED13	mediator complex subunit 13	0.012
HIST3H3	histone cluster 3, H3	0.012
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.012
EIF4A3	eukaryotic translation initiation factor 4A3	0.012
IDO1	indoleamine 2,3-dioxygenase 1	0.012
CXCL9	chemokine (C-X-C motif) ligand 9	0.012	Human
CH25H	cholesterol 25-hydroxylase	0.012
PHF20	PHD finger protein 20	0.011
CREB1	cAMP responsive element binding protein 1	0.011
KLF1	Kruppel-like factor 1 (erythroid)	0.011
ZNF217	zinc finger protein 217	0.011
CSNK1A1	casein kinase 1, alpha 1	0.010
ETV7	ets variant 7	0.010
HIST3H2A	histone cluster 3, H2a	0.010	Human
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.010
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.010
NFE2	nuclear factor (erythroid-derived 2), 45kDa	0.010