IMP

Process View

Homo sapiens

22 genes annotated in human

Multi-species View

negative regulation of hemostasis

GO:1900047

Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of hemostasis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of hemostasis" (in gray)

Name	Description	Probability	Func Analog Organism
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	1.000
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.998	Human
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.994
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.980	Human
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.971
NRP1	neuropilin 1	0.968
C1QA	complement component 1, q subcomponent, A chain	0.967	Human
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.898	Human
PLAU	plasminogen activator, urokinase	0.889	Human Mouse
PLG	plasminogen	0.834
CDH5	cadherin 5, type 2 (vascular endothelium)	0.755
C1QC	complement component 1, q subcomponent, C chain	0.744	Human
FGB	fibrinogen beta chain	0.721
ALB	albumin	0.645
HP	haptoglobin	0.645
VEGFA	vascular endothelial growth factor A	0.630	Human
PLCG1	phospholipase C, gamma 1	0.608
PLAT	plasminogen activator, tissue	0.541	Human
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.510
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.483
PDGFA	platelet-derived growth factor alpha polypeptide	0.477
PDGFC	platelet derived growth factor C	0.474
C1S	complement component 1, s subcomponent	0.372
PTPRB	protein tyrosine phosphatase, receptor type, B	0.320
FGA	fibrinogen alpha chain	0.315
S100A10	S100 calcium binding protein A10	0.304
C3	complement component 3	0.269
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.261
A2M	alpha-2-macroglobulin	0.260
PGF	placental growth factor	0.254	Human
C1R	complement component 1, r subcomponent	0.250
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.244
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.243
APOA2	apolipoprotein A-II	0.240
APOC1	apolipoprotein C-I	0.234
COL4A1	collagen, type IV, alpha 1	0.209
KNG1	kininogen 1	0.196
FN1	fibronectin 1	0.181
MASP2	mannan-binding lectin serine peptidase 2	0.179
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.176
AXL	AXL receptor tyrosine kinase	0.157
LDLR	low density lipoprotein receptor	0.144
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.133
ANXA1	annexin A1	0.131
SPINT1	serine peptidase inhibitor, Kunitz type 1	0.130
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.111
CDCP1	CUB domain containing protein 1	0.109
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.109
FLT4	fms-related tyrosine kinase 4	0.105	Human
HRG	histidine-rich glycoprotein	0.096	Mouse
F11	coagulation factor XI	0.090
C1QB	complement component 1, q subcomponent, B chain	0.084	Human
LCAT	lecithin-cholesterol acyltransferase	0.082
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.078
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.078	Human
C2	complement component 2	0.078
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.077
APOC3	apolipoprotein C-III	0.075
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.072
AHSG	alpha-2-HS-glycoprotein	0.068
C8A	complement component 8, alpha polypeptide	0.059
VTN	vitronectin	0.058
ORM1	orosomucoid 1	0.057
LPA	lipoprotein, Lp(a)	0.054	Human
C8B	complement component 8, beta polypeptide	0.053
VWF	von Willebrand factor	0.051
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.049
SLC38A3	solute carrier family 38, member 3	0.048
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.048
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.047
DCN	decorin	0.047
EGFR	epidermal growth factor receptor	0.047
APOB	apolipoprotein B (including Ag(x) antigen)	0.047
APOE	apolipoprotein E	0.046
SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0.046
KITLG	KIT ligand	0.043
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.040
C6	complement component 6	0.039
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.039
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.038
VEGFC	vascular endothelial growth factor C	0.037	Human
STAB1	stabilin 1	0.036
CYP2A7	cytochrome P450, family 2, subfamily A, polypeptide 7	0.036
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.035
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.035
HPN	hepsin	0.034
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.034
ADH6	alcohol dehydrogenase 6 (class V)	0.033
LIPC	lipase, hepatic	0.032
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.032
F2	coagulation factor II (thrombin)	0.032
NNMT	nicotinamide N-methyltransferase	0.032
F3	coagulation factor III (thromboplastin, tissue factor)	0.031
GAB1	GRB2-associated binding protein 1	0.031
PRODH2	proline dehydrogenase (oxidase) 2	0.030
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.030
LAT	linker for activation of T cells	0.029
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.028
F10	coagulation factor X	0.028	Human
GAB2	GRB2-associated binding protein 2	0.028
COL1A1	collagen, type I, alpha 1	0.027
APOC2	apolipoprotein C-II	0.026
PLTP	phospholipid transfer protein	0.026
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.026
COL2A1	collagen, type II, alpha 1	0.026
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.025
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.025
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.024
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.024
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.024
OSMR	oncostatin M receptor	0.023
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.023
ASGR2	asialoglycoprotein receptor 2	0.023
MARCO	macrophage receptor with collagenous structure	0.023
ITIH1	inter-alpha (globulin) inhibitor H1	0.023
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.023
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.023
LRP1	low density lipoprotein receptor-related protein 1	0.023
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.022
AFM	afamin	0.022
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.021	Human Mouse
TGFBI	transforming growth factor, beta-induced, 68kDa	0.021
PTEN	phosphatase and tensin homolog	0.021
CPB2	carboxypeptidase B2 (plasma)	0.021	Rat
F9	coagulation factor IX	0.021	Human
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.020
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.019
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.019
SOS1	son of sevenless homolog 1 (Drosophila)	0.019
ITIH2	inter-alpha (globulin) inhibitor H2	0.018
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.018
SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	0.018
APCS	amyloid P component, serum	0.018
CPN2	carboxypeptidase N, polypeptide 2	0.018
DPYS	dihydropyrimidinase	0.017
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.017	Human
ITIH3	inter-alpha (globulin) inhibitor H3	0.017
C4B	complement component 4B (Chido blood group)	0.017
TEK	TEK tyrosine kinase, endothelial	0.017
FTCD	formiminotransferase cyclodeaminase	0.016
WNT2	wingless-type MMTV integration site family member 2	0.016
SPP2	secreted phosphoprotein 2, 24kDa	0.016
LBP	lipopolysaccharide binding protein	0.016
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.016	Human
DAO	D-amino-acid oxidase	0.016
HABP2	hyaluronan binding protein 2	0.016	Human
PTPRA	protein tyrosine phosphatase, receptor type, A	0.016
HPX	hemopexin	0.016
CPN1	carboxypeptidase N, polypeptide 1	0.016
NCF1	neutrophil cytosolic factor 1	0.016
C4BPB	complement component 4 binding protein, beta	0.015
SAA4	serum amyloid A4, constitutive	0.015
F7	coagulation factor VII (serum prothrombin conversion accelerator)	0.015	Human
ANGPT2	angiopoietin 2	0.015
C4BPA	complement component 4 binding protein, alpha	0.015
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.015
MAPT	microtubule-associated protein tau	0.015
IGFBP1	insulin-like growth factor binding protein 1	0.014
COMP	cartilage oligomeric matrix protein	0.014	Human
CFH	complement factor H	0.014
STC1	stanniocalcin 1	0.014
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.014
RDH16	retinol dehydrogenase 16 (all-trans)	0.014
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.014
COL6A1	collagen, type VI, alpha 1	0.014
COL5A1	collagen, type V, alpha 1	0.014
TMSB4X	thymosin beta 4, X-linked	0.014
LMNA	lamin A/C	0.014
TMEM176A	transmembrane protein 176A	0.013
PON1	paraoxonase 1	0.013
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.013
TTR	transthyretin	0.013
MMP19	matrix metallopeptidase 19	0.013
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.013
ECM1	extracellular matrix protein 1	0.013
TIMP3	TIMP metallopeptidase inhibitor 3	0.013
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.013
VSIG4	V-set and immunoglobulin domain containing 4	0.013
ARG1	arginase, liver	0.013
HGFAC	HGF activator	0.013	Human
ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif, 12	0.012	Human
CLEC4G	C-type lectin domain family 4, member G	0.012
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.012
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.012
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.012
AMT	aminomethyltransferase	0.012
KLKB1	kallikrein B, plasma (Fletcher factor) 1	0.012
HSPG2	heparan sulfate proteoglycan 2	0.012
MRVI1	murine retrovirus integration site 1 homolog	0.012
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.012
KRT5	keratin 5	0.012
DDIT4	DNA-damage-inducible transcript 4	0.012
ITGB5	integrin, beta 5	0.012
AMBP	alpha-1-microglobulin/bikunin precursor	0.012
PROZ	protein Z, vitamin K-dependent plasma glycoprotein	0.012	Human
AGXT	alanine-glyoxylate aminotransferase	0.012
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.012
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.012
CYBA	cytochrome b-245, alpha polypeptide	0.012
RARRES1	retinoic acid receptor responder (tazarotene induced) 1	0.012
PLAUR	plasminogen activator, urokinase receptor	0.012
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.012
HAS2	hyaluronan synthase 2	0.012
GGT5	gamma-glutamyltransferase 5	0.012
PKLR	pyruvate kinase, liver and RBC	0.012
ALDOB	aldolase B, fructose-bisphosphate	0.011
FETUB	fetuin B	0.011
GJB1	gap junction protein, beta 1, 32kDa	0.011
APOC4	apolipoprotein C-IV	0.011
MAP2	microtubule-associated protein 2	0.011
SLC25A47	solute carrier family 25, member 47	0.011
CFHR2	complement factor H-related 2	0.011
CFB	complement factor B	0.011
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.011
SARDH	sarcosine dehydrogenase	0.011
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.011
APOA1	apolipoprotein A-I	0.011	Human
LOXL2	lysyl oxidase-like 2	0.011
GP1BA	glycoprotein Ib (platelet), alpha polypeptide	0.011
STAB2	stabilin 2	0.011
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.011
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.011
APOF	apolipoprotein F	0.011
CFHR4	complement factor H-related 4	0.011
GPX3	glutathione peroxidase 3 (plasma)	0.011
CA5A	carbonic anhydrase VA, mitochondrial	0.011
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.011
LGALS1	lectin, galactoside-binding, soluble, 1	0.011
ACTG1	actin, gamma 1	0.010
AADAC	arylacetamide deacetylase (esterase)	0.010
CORO1C	coronin, actin binding protein, 1C	0.010
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.010
MSN	moesin	0.010
PON3	paraoxonase 3	0.010
GCKR	glucokinase (hexokinase 4) regulator	0.010
BHMT	betaine--homocysteine S-methyltransferase	0.010
CDKL5	cyclin-dependent kinase-like 5	0.010