IMP
Process View
chemokine biosynthetic process
The chemical reactions and pathways resulting in the formation of chemokines, any member of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "chemokine biosynthetic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| TIRAP | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 0.993 | ||
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.903 | ||
| IL1R1 | interleukin 1 receptor, type I | 0.869 | ||
| IL4R | interleukin 4 receptor | 0.682 | ||
| TLR4 | toll-like receptor 4 | 0.636 | ||
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.469 | ||
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.411 | ||
| IL8 | interleukin 8 | 0.356 | ||
| TLR2 | toll-like receptor 2 | 0.316 | ||
| IL1RAP | interleukin 1 receptor accessory protein | 0.187 | ||
| TICAM2 | toll-like receptor adaptor molecule 2 | 0.155 | ||
| IL6R | interleukin 6 receptor | 0.141 | ||
| IL1RN | interleukin 1 receptor antagonist | 0.137 | ||
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.123 | ||
| FZD1 | frizzled homolog 1 (Drosophila) | 0.122 | ||
| TRAF1 | TNF receptor-associated factor 1 | 0.121 | ||
| ZC3H12A | zinc finger CCCH-type containing 12A | 0.116 | ||
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.111 | ||
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.108 | ||
| IRAK4 | interleukin-1 receptor-associated kinase 4 | 0.100 | ||
| SPOP | speckle-type POZ protein | 0.089 | ||
| ENO2 | enolase 2 (gamma, neuronal) | 0.066 | ||
| CCL20 | chemokine (C-C motif) ligand 20 | 0.060 | ||
| MPO | myeloperoxidase | 0.054 | ||
| IL1B | interleukin 1, beta | 0.047 | Mouse | |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.047 | ||
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.034 | ||
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.032 | ||
| TNFRSF1B | tumor necrosis factor receptor superfamily, member 1B | 0.031 | ||
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.030 | ||
| ELANE | elastase, neutrophil expressed | 0.027 | ||
| RNASE3 | ribonuclease, RNase A family, 3 | 0.026 | ||
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.023 | ||
| STAP2 | signal transducing adaptor family member 2 | 0.022 | ||
| CTSG | cathepsin G | 0.022 | ||
| SAMHD1 | SAM domain and HD domain 1 | 0.020 | ||
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 0.019 | ||
| FADD | Fas (TNFRSF6)-associated via death domain | 0.018 | ||
| PIAS4 | protein inhibitor of activated STAT, 4 | 0.018 | ||
| ARAF | v-raf murine sarcoma 3611 viral oncogene homolog | 0.016 | ||
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.015 | ||
| DOCK8 | dedicator of cytokinesis 8 | 0.014 | ||
| IFNB1 | interferon, beta 1, fibroblast | 0.013 | ||
| BPI | bactericidal/permeability-increasing protein | 0.013 | ||
| ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | 0.013 | ||
| CCL4 | chemokine (C-C motif) ligand 4 | 0.013 | ||
| CD83 | CD83 molecule | 0.013 | ||
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.012 | ||
| TNIP1 | TNFAIP3 interacting protein 1 | 0.012 | ||
| DEFA4 | defensin, alpha 4, corticostatin | 0.012 | ||
| CAMP | cathelicidin antimicrobial peptide | 0.012 | ||
| TXN | thioredoxin | 0.011 | ||
| FZD8 | frizzled homolog 8 (Drosophila) | 0.011 | ||
| S100A12 | S100 calcium binding protein A12 | 0.011 | ||
| CLEC4G | C-type lectin domain family 4, member G | 0.011 | ||
| CXCL6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | 0.010 | ||
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.010 | ||
| AZU1 | azurocidin 1 | 0.010 |