IMP

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Homo sapiens

2 genes annotated in human

cannabinoid signaling pathway

The series of molecular signals generated as a consequence of a cannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids.

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
TP63	tumor protein p63	0.372
ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	0.218
POU2F2	POU class 2 homeobox 2	0.203
GFRA4	GDNF family receptor alpha 4	0.191
TSPAN32	tetraspanin 32	0.134
CD5	CD5 molecule	0.105
TCL1A	T-cell leukemia/lymphoma 1A	0.093
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.085
HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.085
CRHR2	corticotropin releasing hormone receptor 2	0.072
NEUROD2	neurogenic differentiation 2	0.069
DENND1C	DENN/MADD domain containing 1C	0.067
ACAP1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.060
GMIP	GEM interacting protein	0.059
NCR2	natural cytotoxicity triggering receptor 2	0.059
CD6	CD6 molecule	0.058
LYL1	lymphoblastic leukemia derived sequence 1	0.058
RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	0.055
SIT1	signaling threshold regulating transmembrane adaptor 1	0.054
TRPM2	transient receptor potential cation channel, subfamily M, member 2	0.054
CTRL	chymotrypsin-like	0.051
RGS14	regulator of G-protein signaling 14	0.051
DRD2	dopamine receptor D2	0.050
IL19	interleukin 19	0.050
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.050
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.048
MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.044
PNOC	prepronociceptin	0.043
ZNF835	zinc finger protein 835	0.042
HRH3	histamine receptor H3	0.042
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.042
CHIA	chitinase, acidic	0.042
GPR12	G protein-coupled receptor 12	0.041	Human
P2RX1	purinergic receptor P2X, ligand-gated ion channel, 1	0.040
FOXN1	forkhead box N1	0.039
GPR97	G protein-coupled receptor 97	0.039
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.038
PDE6G	phosphodiesterase 6G, cGMP-specific, rod, gamma	0.037
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.036
WNT1	wingless-type MMTV integration site family, member 1	0.035
FCHO1	FCH domain only 1	0.035
OLIG2	oligodendrocyte lineage transcription factor 2	0.033
CD79A	CD79a molecule, immunoglobulin-associated alpha	0.032
GPR15	G protein-coupled receptor 15	0.032
CD22	CD22 molecule	0.031
C11orf21	chromosome 11 open reading frame 21	0.031
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.031
FLT3	fms-related tyrosine kinase 3	0.031
AVPR1B	arginine vasopressin receptor 1B	0.031
UBASH3A	ubiquitin associated and SH3 domain containing A	0.030
ACTL7A	actin-like 7A	0.030
KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.030
GP1BA	glycoprotein Ib (platelet), alpha polypeptide	0.029
WNT10B	wingless-type MMTV integration site family, member 10B	0.028
CHIT1	chitinase 1 (chitotriosidase)	0.028
EMILIN2	elastin microfibril interfacer 2	0.028
KRT5	keratin 5	0.027
SH2D3C	SH2 domain containing 3C	0.027
SIGLEC6	sialic acid binding Ig-like lectin 6	0.027
FGF4	fibroblast growth factor 4	0.027
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.025
SH2D2A	SH2 domain containing 2A	0.025
LY9	lymphocyte antigen 9	0.025
GRAP	GRB2-related adaptor protein	0.025
CLC	Charcot-Leyden crystal protein	0.024
MLN	motilin	0.024
ICOSLG	inducible T-cell co-stimulator ligand	0.024
GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	0.023
SLC7A4	solute carrier family 7 (cationic amino acid transporter, y+ system), member 4	0.023
B3GNT4	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4	0.023
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.023
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	0.023
CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	0.022
RAB33A	RAB33A, member RAS oncogene family	0.022
LAIR2	leukocyte-associated immunoglobulin-like receptor 2	0.022
GRM6	glutamate receptor, metabotropic 6	0.022
GFRA3	GDNF family receptor alpha 3	0.022
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.021
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.021
KRT75	keratin 75	0.021
SLC22A14	solute carrier family 22, member 14	0.021
SH2B2	SH2B adaptor protein 2	0.021
PLA2G2D	phospholipase A2, group IID	0.021
EPB42	erythrocyte membrane protein band 4.2	0.021
CXCR1	chemokine (C-X-C motif) receptor 1	0.020
GH1	growth hormone 1	0.020
GRIA4	glutamate receptor, ionotrophic, AMPA 4	0.020
MC4R	melanocortin 4 receptor	0.020
BLK	B lymphoid tyrosine kinase	0.020
KIF21B	kinesin family member 21B	0.020
TCL1B	T-cell leukemia/lymphoma 1B	0.020
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.020
GH2	growth hormone 2	0.020
ITGB7	integrin, beta 7	0.019
ARHGAP4	Rho GTPase activating protein 4	0.019
MAL	mal, T-cell differentiation protein	0.019
CD300C	CD300c molecule	0.019
ABLIM3	actin binding LIM protein family, member 3	0.019
PDZK1	PDZ domain containing 1	0.019
LDHAL6B	lactate dehydrogenase A-like 6B	0.019
TAC3	tachykinin 3	0.018
FOLR3	folate receptor 3 (gamma)	0.018
ADORA2A	adenosine A2a receptor	0.018
KCND1	potassium voltage-gated channel, Shal-related subfamily, member 1	0.018
JAK3	Janus kinase 3	0.018
PITPNM3	PITPNM family member 3	0.018
LHX3	LIM homeobox 3	0.018
RTDR1	rhabdoid tumor deletion region gene 1	0.018
GPR27	G protein-coupled receptor 27	0.018
KCTD12	potassium channel tetramerisation domain containing 12	0.018
TBX21	T-box 21	0.018
TREML2	triggering receptor expressed on myeloid cells-like 2	0.018
CD19	CD19 molecule	0.018
PTPRCAP	protein tyrosine phosphatase, receptor type, C-associated protein	0.017
GP6	glycoprotein VI (platelet)	0.017
AIPL1	aryl hydrocarbon receptor interacting protein-like 1	0.017
MZB1	marginal zone B and B1 cell-specific protein	0.017
CXCR5	chemokine (C-X-C motif) receptor 5	0.017
SSTR3	somatostatin receptor 3	0.017
KCNJ9	potassium inwardly-rectifying channel, subfamily J, member 9	0.017
COLEC12	collectin sub-family member 12	0.017
OPRL1	opiate receptor-like 1	0.017
NXPH4	neurexophilin 4	0.017
DAB1	disabled homolog 1 (Drosophila)	0.017
C7orf16	chromosome 7 open reading frame 16	0.017
GFI1	growth factor independent 1 transcription repressor	0.017
AICDA	activation-induced cytidine deaminase	0.017
GPX5	glutathione peroxidase 5 (epididymal androgen-related protein)	0.016
FUT1	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	0.016
ALOX12	arachidonate 12-lipoxygenase	0.016
OR2C1	olfactory receptor, family 2, subfamily C, member 1	0.016
DGKG	diacylglycerol kinase, gamma 90kDa	0.016
LILRA4	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	0.016
IL18BP	interleukin 18 binding protein	0.016
PPAP2B	phosphatidic acid phosphatase type 2B	0.016
NECAB2	N-terminal EF-hand calcium binding protein 2	0.016
KLF2	Kruppel-like factor 2 (lung)	0.016
GJD2	gap junction protein, delta 2, 36kDa	0.016
KLRG1	killer cell lectin-like receptor subfamily G, member 1	0.016
OPN1SW	opsin 1 (cone pigments), short-wave-sensitive	0.016
SPN	sialophorin	0.016
NPY	neuropeptide Y	0.016
IL12RB1	interleukin 12 receptor, beta 1	0.015
CETP	cholesteryl ester transfer protein, plasma	0.015
HBQ1	hemoglobin, theta 1	0.015
GPR31	G protein-coupled receptor 31	0.015
CXCR3	chemokine (C-X-C motif) receptor 3	0.015
RASL10A	RAS-like, family 10, member A	0.015
GIMAP7	GTPase, IMAP family member 7	0.015
EDAR	ectodysplasin A receptor	0.015
SLC17A9	solute carrier family 17, member 9	0.015
KCNE1	potassium voltage-gated channel, Isk-related family, member 1	0.015
AZU1	azurocidin 1	0.015
FOXI1	forkhead box I1	0.015
CCR4	chemokine (C-C motif) receptor 4	0.015
GLRA1	glycine receptor, alpha 1	0.015
AANAT	aralkylamine N-acetyltransferase	0.015
DEF6	differentially expressed in FDCP 6 homolog (mouse)	0.015
CFP	complement factor properdin	0.015
ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	0.015
MCHR1	melanin-concentrating hormone receptor 1	0.015
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.015
CD101	CD101 molecule	0.015
GDF3	growth differentiation factor 3	0.015
GPA33	glycoprotein A33 (transmembrane)	0.015
VPREB3	pre-B lymphocyte 3	0.014
DTX1	deltex homolog 1 (Drosophila)	0.014
C15orf2	chromosome 15 open reading frame 2	0.014
GNRH2	gonadotropin-releasing hormone 2	0.014
VSTM2A	V-set and transmembrane domain containing 2A	0.014
ABCD2	ATP-binding cassette, sub-family D (ALD), member 2	0.014
ADAM11	ADAM metallopeptidase domain 11	0.014
RENBP	renin binding protein	0.014
KIR2DL3	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3	0.014
STMN4	stathmin-like 4	0.014
PF4	platelet factor 4	0.014
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.014
HS3ST3B1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	0.014
RNF122	ring finger protein 122	0.014
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.013
CHST4	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4	0.013
SOX21	SRY (sex determining region Y)-box 21	0.013
C8G	complement component 8, gamma polypeptide	0.013
NCR3	natural cytotoxicity triggering receptor 3	0.013
GPR132	G protein-coupled receptor 132	0.013
CA10	carbonic anhydrase X	0.013
SCN3B	sodium channel, voltage-gated, type III, beta	0.013
DGKQ	diacylglycerol kinase, theta 110kDa	0.013
ABCA7	ATP-binding cassette, sub-family A (ABC1), member 7	0.013
POU3F1	POU class 3 homeobox 1	0.013
GPR68	G protein-coupled receptor 68	0.013
HTR3A	5-hydroxytryptamine (serotonin) receptor 3A	0.013
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.013
TPST1	tyrosylprotein sulfotransferase 1	0.013
RFPL3	ret finger protein-like 3	0.013
AOC2	amine oxidase, copper containing 2 (retina-specific)	0.013
PAPSS2	3'-phosphoadenosine 5'-phosphosulfate synthase 2	0.013
PRSS21	protease, serine, 21 (testisin)	0.013
CDK3	cyclin-dependent kinase 3	0.013
ATP2A3	ATPase, Ca++ transporting, ubiquitous	0.013
DSC1	desmocollin 1	0.013
CD27	CD27 molecule	0.013
LAX1	lymphocyte transmembrane adaptor 1	0.013
BPI	bactericidal/permeability-increasing protein	0.013
KIF17	kinesin family member 17	0.013
PRKCG	protein kinase C, gamma	0.013
MEF2B	myocyte enhancer factor 2B	0.013
C1orf61	chromosome 1 open reading frame 61	0.013
MOS	v-mos Moloney murine sarcoma viral oncogene homolog	0.013
FGFBP1	fibroblast growth factor binding protein 1	0.013
IL18RAP	interleukin 18 receptor accessory protein	0.013
CYBRD1	cytochrome b reductase 1	0.013
PTPRM	protein tyrosine phosphatase, receptor type, M	0.013
ALX4	ALX homeobox 4	0.013
COL9A2	collagen, type IX, alpha 2	0.013
TBC1D10C	TBC1 domain family, member 10C	0.012
CHRNA6	cholinergic receptor, nicotinic, alpha 6	0.012
AHSP	alpha hemoglobin stabilizing protein	0.012
RIC3	resistance to inhibitors of cholinesterase 3 homolog (C. elegans)	0.012
CABP5	calcium binding protein 5	0.012
HK3	hexokinase 3 (white cell)	0.012
KRT37	keratin 37	0.012
PRODH2	proline dehydrogenase (oxidase) 2	0.012
LAG3	lymphocyte-activation gene 3	0.012
ACRV1	acrosomal vesicle protein 1	0.012
CA7	carbonic anhydrase VII	0.012
SH3BP1	SH3-domain binding protein 1	0.012
CAMK4	calcium/calmodulin-dependent protein kinase IV	0.012
TRPM8	transient receptor potential cation channel, subfamily M, member 8	0.012
ALAS2	aminolevulinate, delta-, synthase 2	0.012
GALR3	galanin receptor 3	0.012
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.012
JAM2	junctional adhesion molecule 2	0.012
NDP	Norrie disease (pseudoglioma)	0.012
KCNK13	potassium channel, subfamily K, member 13	0.012
TMC6	transmembrane channel-like 6	0.012
MEFV	Mediterranean fever	0.012
LPAR3	lysophosphatidic acid receptor 3	0.012	Human
S1PR5	sphingosine-1-phosphate receptor 5	0.012	Human
CA6	carbonic anhydrase VI	0.012
TXNDC3	thioredoxin domain containing 3 (spermatozoa)	0.012
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.012
CACNG2	calcium channel, voltage-dependent, gamma subunit 2	0.012
MAPK11	mitogen-activated protein kinase 11	0.012
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.012
AJAP1	adherens junctions associated protein 1	0.012
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.012
NT5E	5'-nucleotidase, ecto (CD73)	0.012
CDH7	cadherin 7, type 2	0.012
ARR3	arrestin 3, retinal (X-arrestin)	0.011
GCM1	glial cells missing homolog 1 (Drosophila)	0.011
BTG4	B-cell translocation gene 4	0.011
KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	0.011
EPHB6	EPH receptor B6	0.011
GNMT	glycine N-methyltransferase	0.011
KRT84	keratin 84	0.011
IL12RB2	interleukin 12 receptor, beta 2	0.011
HSD17B3	hydroxysteroid (17-beta) dehydrogenase 3	0.011
TKTL1	transketolase-like 1	0.011
PGC	progastricsin (pepsinogen C)	0.011
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.011
PTGDR	prostaglandin D2 receptor (DP)	0.011
CHRNA3	cholinergic receptor, nicotinic, alpha 3	0.011
DLX6	distal-less homeobox 6	0.011
C22orf43	chromosome 22 open reading frame 43	0.011
SPINK2	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)	0.011
GPR35	G protein-coupled receptor 35	0.011
ZMAT4	zinc finger, matrin-type 4	0.011
C19orf22	chromosome 19 open reading frame 22	0.011
DCHS2	dachsous 2 (Drosophila)	0.011
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.011
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.011
GDPD4	glycerophosphodiester phosphodiesterase domain containing 4	0.011
CABLES1	Cdk5 and Abl enzyme substrate 1	0.011
ETV3	ets variant 3	0.011
ASGR2	asialoglycoprotein receptor 2	0.011
D4S234E	DNA segment on chromosome 4 (unique) 234 expressed sequence	0.011
CD28	CD28 molecule	0.011
KIAA0748	KIAA0748	0.011
CCIN	calicin	0.011
SIGLEC5	sialic acid binding Ig-like lectin 5	0.011
CNTN2	contactin 2 (axonal)	0.011
HTR4	5-hydroxytryptamine (serotonin) receptor 4	0.011
POU3F3	POU class 3 homeobox 3	0.011
CD244	CD244 molecule, natural killer cell receptor 2B4	0.011
FBXO41	F-box protein 41	0.011
TRIM46	tripartite motif containing 46	0.011
PSD4	pleckstrin and Sec7 domain containing 4	0.011
KLK5	kallikrein-related peptidase 5	0.011
ZNF8	zinc finger protein 8	0.011
FAM163A	family with sequence similarity 163, member A	0.011
STAG3	stromal antigen 3	0.011
KCNK12	potassium channel, subfamily K, member 12	0.011
BMX	BMX non-receptor tyrosine kinase	0.011
GRAP2	GRB2-related adaptor protein 2	0.011
C7orf43	chromosome 7 open reading frame 43	0.010
KLHL25	kelch-like 25 (Drosophila)	0.010
PYHIN1	pyrin and HIN domain family, member 1	0.010
CUBN	cubilin (intrinsic factor-cobalamin receptor)	0.010
KCNA2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.010
VWCE	von Willebrand factor C and EGF domains	0.010
SASH1	SAM and SH3 domain containing 1	0.010
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.010
KLK7	kallikrein-related peptidase 7	0.010
GZMM	granzyme M (lymphocyte met-ase 1)	0.010
CAMK1G	calcium/calmodulin-dependent protein kinase IG	0.010
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.010
MPO	myeloperoxidase	0.010
GUCA1A	guanylate cyclase activator 1A (retina)	0.010
BEGAIN	brain-enriched guanylate kinase-associated homolog (rat)	0.010
AATK	apoptosis-associated tyrosine kinase	0.010
DLX5	distal-less homeobox 5	0.010
SOCS7	suppressor of cytokine signaling 7	0.010
DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	0.010
ITGAD	integrin, alpha D	0.010
TM7SF4	transmembrane 7 superfamily member 4	0.010
PVRIG	poliovirus receptor related immunoglobulin domain containing	0.010
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.010
RXFP3	relaxin/insulin-like family peptide receptor 3	0.010
NPFFR1	neuropeptide FF receptor 1	0.010
N4BP3	NEDD4 binding protein 3	0.010
ZNF804A	zinc finger protein 804A	0.010
JAM3	junctional adhesion molecule 3	0.010
AGRP	agouti related protein homolog (mouse)	0.010
CLSTN2	calsyntenin 2	0.010
TERT	telomerase reverse transcriptase	0.010
MPZ	myelin protein zero	0.010