IMP

Process View

Homo sapiens

2 genes annotated in human

positive regulation of transcription from rna polymerase ii promoter in response to hypoxia

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of transcription from rna polymerase ii promoter in response to hypoxia"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of transcription from rna polymerase ii promoter in response to hypoxia" (in gray)

Name	Description	Probability	Func Analog Organism
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	1.000
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	1.000
VEGFA	vascular endothelial growth factor A	1.000
NRP1	neuropilin 1	1.000
JAG1	jagged 1	0.999
EGLN1	egl nine homolog 1 (C. elegans)	0.998
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.993
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.988
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.988
SP1	Sp1 transcription factor	0.986
EGLN3	egl nine homolog 3 (C. elegans)	0.981
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.979	Human
VHL	von Hippel-Lindau tumor suppressor	0.977
EP300	E1A binding protein p300	0.977
SMAD3	SMAD family member 3	0.977
ARNT	aryl hydrocarbon receptor nuclear translocator	0.961
NOTCH3	notch 3	0.925
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.890
PGF	placental growth factor	0.872	Human
MAML1	mastermind-like 1 (Drosophila)	0.809
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.580
KAT2B	K(lysine) acetyltransferase 2B	0.570
HIPK2	homeodomain interacting protein kinase 2	0.511
CREBBP	CREB binding protein	0.487
LDLR	low density lipoprotein receptor	0.453
EPAS1	endothelial PAS domain protein 1	0.425	Human
XIAP	X-linked inhibitor of apoptosis	0.353
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.327
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.309
NCOA6	nuclear receptor coactivator 6	0.304
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.283
RUNX1	runt-related transcription factor 1	0.257
BHLHE40	basic helix-loop-helix family, member e40	0.247
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.242
PTPRB	protein tyrosine phosphatase, receptor type, B	0.237
HTT	huntingtin	0.233
PLCG1	phospholipase C, gamma 1	0.230
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.208
NCOA1	nuclear receptor coactivator 1	0.197
ESR1	estrogen receptor 1	0.183
STC1	stanniocalcin 1	0.149
COL4A1	collagen, type IV, alpha 1	0.149
SREBF2	sterol regulatory element binding transcription factor 2	0.131
DLL1	delta-like 1 (Drosophila)	0.119
NCOR2	nuclear receptor corepressor 2	0.118
AHR	aryl hydrocarbon receptor	0.107
FOXO3	forkhead box O3	0.106
PKM2	pyruvate kinase, muscle	0.098
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.091
JAG2	jagged 2	0.086
NFIL3	nuclear factor, interleukin 3 regulated	0.085
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.084
NCOA3	nuclear receptor coactivator 3	0.083
PDGFA	platelet-derived growth factor alpha polypeptide	0.082	Human
NCOA2	nuclear receptor coactivator 2	0.078
NOTCH2	notch 2	0.073
AR	androgen receptor	0.069
MEF2C	myocyte enhancer factor 2C	0.068
COL2A1	collagen, type II, alpha 1	0.064
DDIT4	DNA-damage-inducible transcript 4	0.064
CXXC5	CXXC finger protein 5	0.063
POU2F1	POU class 2 homeobox 1	0.061
HDAC1	histone deacetylase 1	0.058
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.058
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.057
DDIT3	DNA-damage-inducible transcript 3	0.055
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.053
FLT4	fms-related tyrosine kinase 4	0.050
JUN	jun proto-oncogene	0.045
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.044
TP53	tumor protein p53	0.044
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.041
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.040
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.038
PDGFC	platelet derived growth factor C	0.036
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.036
ZFYVE9	zinc finger, FYVE domain containing 9	0.036
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.035
FOXO1	forkhead box O1	0.032
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.032
MTA1	metastasis associated 1	0.031
HMGA1	high mobility group AT-hook 1	0.030
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.027
NDRG1	N-myc downstream regulated 1	0.027
BCL3	B-cell CLL/lymphoma 3	0.027
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.026
FOSL2	FOS-like antigen 2	0.026
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.025
STC2	stanniocalcin 2	0.025
SSX4	synovial sarcoma, X breakpoint 4	0.023
ATXN1L	ataxin 1-like	0.023
EGR1	early growth response 1	0.023
MED15	mediator complex subunit 15	0.021
DEDD	death effector domain containing	0.020
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.019
EGFL7	EGF-like-domain, multiple 7	0.019
G0S2	G0/G1switch 2	0.018
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.018
ZC3H12A	zinc finger CCCH-type containing 12A	0.017
ADM	adrenomedullin	0.017
ATF3	activating transcription factor 3	0.017
CNOT4	CCR4-NOT transcription complex, subunit 4	0.016
YY1	YY1 transcription factor	0.016
CUX1	cut-like homeobox 1	0.016
EGLN2	egl nine homolog 2 (C. elegans)	0.016
IER2	immediate early response 2	0.016
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.015
BCL6	B-cell CLL/lymphoma 6	0.015
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.015
EFNB2	ephrin-B2	0.014
SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	0.014
PRDM4	PR domain containing 4	0.014
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.014
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.014
MDFI	MyoD family inhibitor	0.014
TGIF1	TGFB-induced factor homeobox 1	0.014
GLI1	GLI family zinc finger 1	0.014
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.013
IER3	immediate early response 3	0.013
SRCAP	Snf2-related CREBBP activator protein	0.013
KLF13	Kruppel-like factor 13	0.013
FKBP5	FK506 binding protein 5	0.013
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.012
ZNF358	zinc finger protein 358	0.012
EFNA1	ephrin-A1	0.012
NAMPT	nicotinamide phosphoribosyltransferase	0.012
KLF4	Kruppel-like factor 4 (gut)	0.012
VLDLR	very low density lipoprotein receptor	0.012
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.011
KDM2A	lysine (K)-specific demethylase 2A	0.010
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.010
HOXB7	homeobox B7	0.010
C7orf68	chromosome 7 open reading frame 68	0.010