IMP

Process View

Homo sapiens

4 genes annotated in human

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regulation of mesoderm development

GO:2000380

Any process that modulates the frequency, rate or extent of mesoderm development.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of mesoderm development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of mesoderm development" (in gray)

Name	Description	Probability	Func Analog Organism
SMAD1	SMAD family member 1	1.000	Human
SMAD2	SMAD family member 2	1.000
SMAD3	SMAD family member 3	0.998	Human
SMAD7	SMAD family member 7	0.957	Human
BMP2	bone morphogenetic protein 2	0.863
SMAD5	SMAD family member 5	0.546	Human
LRP6	low density lipoprotein receptor-related protein 6	0.471
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.439
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.394
FZD1	frizzled homolog 1 (Drosophila)	0.344
PLCG1	phospholipase C, gamma 1	0.332
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.258
SMAD6	SMAD family member 6	0.232	Human
FGF2	fibroblast growth factor 2 (basic)	0.216
JAG1	jagged 1	0.204
RNF11	ring finger protein 11	0.191
CABLES1	Cdk5 and Abl enzyme substrate 1	0.170
KRT5	keratin 5	0.138
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.131
NOSTRIN	nitric oxide synthase trafficker	0.119
SATB2	SATB homeobox 2	0.111
MAML1	mastermind-like 1 (Drosophila)	0.095
FGF1	fibroblast growth factor 1 (acidic)	0.093
C10orf116	chromosome 10 open reading frame 116	0.092
NOTCH3	notch 3	0.077
FRS2	fibroblast growth factor receptor substrate 2	0.076
C19orf46	chromosome 19 open reading frame 46	0.066
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.058
SOX7	SRY (sex determining region Y)-box 7	0.052
YAP1	Yes-associated protein 1	0.052
TRAF4	TNF receptor-associated factor 4	0.049
FBXL15	F-box and leucine-rich repeat protein 15	0.049
DCP1B	DCP1 decapping enzyme homolog B (S. cerevisiae)	0.048
FZD5	frizzled homolog 5 (Drosophila)	0.041
KRT6C	keratin 6C	0.040
FGFR2	fibroblast growth factor receptor 2	0.035
ZMYM2	zinc finger, MYM-type 2	0.035
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.031
AR	androgen receptor	0.031
TFPI2	tissue factor pathway inhibitor 2	0.031
HNRNPCL1	heterogeneous nuclear ribonucleoprotein C-like 1	0.030
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.029
SPTBN4	spectrin, beta, non-erythrocytic 4	0.028
HTT	huntingtin	0.028
MKL2	MKL/myocardin-like 2	0.027
NCOR1	nuclear receptor corepressor 1	0.027
TGFBR1	transforming growth factor, beta receptor 1	0.024
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.023
FOXO3	forkhead box O3	0.023
ZBED5	zinc finger, BED-type containing 5	0.022
ACBD3	acyl-CoA binding domain containing 3	0.022
NOTCH2	notch 2	0.022
HOXC8	homeobox C8	0.021
MPP1	membrane protein, palmitoylated 1, 55kDa	0.020
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.020
S1PR5	sphingosine-1-phosphate receptor 5	0.020
FBN3	fibrillin 3	0.019
DHX34	DEAH (Asp-Glu-Ala-His) box polypeptide 34	0.019
NIPSNAP3A	nipsnap homolog 3A (C. elegans)	0.018
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.018
FOXO1	forkhead box O1	0.017
FZD8	frizzled homolog 8 (Drosophila)	0.017
BMP4	bone morphogenetic protein 4	0.017
FSTL1	follistatin-like 1	0.016
DLL1	delta-like 1 (Drosophila)	0.016
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.016
AMOTL1	angiomotin like 1	0.016
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.016
CXXC5	CXXC finger protein 5	0.016
SMAD9	SMAD family member 9	0.016
ARHGAP5	Rho GTPase activating protein 5	0.016
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.015
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.015
DACH1	dachshund homolog 1 (Drosophila)	0.014
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.014
PIAS1	protein inhibitor of activated STAT, 1	0.014
ATF7IP	activating transcription factor 7 interacting protein	0.014
SNIP1	Smad nuclear interacting protein 1	0.014
YY1	YY1 transcription factor	0.014
AMOTL2	angiomotin like 2	0.014
NCOA6	nuclear receptor coactivator 6	0.014
RHOB	ras homolog gene family, member B	0.013
KAT2B	K(lysine) acetyltransferase 2B	0.013
ZMYND11	zinc finger, MYND-type containing 11	0.013
CLEC3B	C-type lectin domain family 3, member B	0.013
PIAS4	protein inhibitor of activated STAT, 4	0.013
UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	0.012
ZNF676	zinc finger protein 676	0.012
MAST4	microtubule associated serine/threonine kinase family member 4	0.012
PDX1	pancreatic and duodenal homeobox 1	0.012
TP73	tumor protein p73	0.012
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.012
GMEB1	glucocorticoid modulatory element binding protein 1	0.012
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.012
TRAF5	TNF receptor-associated factor 5	0.012
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.011
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.011
TMEM139	transmembrane protein 139	0.011
ZNF746	zinc finger protein 746	0.011
FZD2	frizzled homolog 2 (Drosophila)	0.011
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.011
ICK	intestinal cell (MAK-like) kinase	0.011
HOXB7	homeobox B7	0.011
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.011
HOXD9	homeobox D9	0.011
RNF111	ring finger protein 111	0.011
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.011
ZNF227	zinc finger protein 227	0.010
GATA2	GATA binding protein 2	0.010
RMND5B	required for meiotic nuclear division 5 homolog B (S. cerevisiae)	0.010
NOG	noggin	0.010
CUEDC1	CUE domain containing 1	0.010
WNT10A	wingless-type MMTV integration site family, member 10A	0.010
SYK	spleen tyrosine kinase	0.010
NCOA1	nuclear receptor coactivator 1	0.010