IMP

Process View

Homo sapiens

24 genes annotated in human

Multi-species View

negative regulation of coagulation

GO:0050819

Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of coagulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of coagulation" (in gray)

Name	Description	Probability	Func Analog Organism
VEGFA	vascular endothelial growth factor A	0.998	Human
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.995
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.994	Human
C1QA	complement component 1, q subcomponent, A chain	0.993	Human
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.971	Human
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.967	Human
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.950
NRP1	neuropilin 1	0.943
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.756
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.756
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.606
C1QC	complement component 1, q subcomponent, C chain	0.575	Human
SYK	spleen tyrosine kinase	0.555
S100A10	S100 calcium binding protein A10	0.505
PLAU	plasminogen activator, urokinase	0.498	Human Mouse
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.450
PLG	plasminogen	0.431
PLAT	plasminogen activator, tissue	0.421	Human
FGA	fibrinogen alpha chain	0.400
EGFR	epidermal growth factor receptor	0.380
PGF	placental growth factor	0.290	Human
PDGFC	platelet derived growth factor C	0.277
PLAUR	plasminogen activator, urokinase receptor	0.276
APOC1	apolipoprotein C-I	0.261
PLCG1	phospholipase C, gamma 1	0.249
KNG1	kininogen 1	0.216
C1QB	complement component 1, q subcomponent, B chain	0.195	Human
PDGFA	platelet-derived growth factor alpha polypeptide	0.181
HP	haptoglobin	0.176
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.108
C1S	complement component 1, s subcomponent	0.104
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.101
FN1	fibronectin 1	0.100
ALB	albumin	0.099
CDCP1	CUB domain containing protein 1	0.098
ACTB	actin, beta	0.093
PTPRB	protein tyrosine phosphatase, receptor type, B	0.086
F11	coagulation factor XI	0.078
LAT	linker for activation of T cells	0.074
SPINT1	serine peptidase inhibitor, Kunitz type 1	0.071
APOA2	apolipoprotein A-II	0.069
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.068
C1R	complement component 1, r subcomponent	0.064
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.064
APOC3	apolipoprotein C-III	0.063
CDH5	cadherin 5, type 2 (vascular endothelium)	0.062
AXL	AXL receptor tyrosine kinase	0.062
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.061
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.061
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.058
KITLG	KIT ligand	0.055
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.055
GAB1	GRB2-associated binding protein 1	0.049
NCF1	neutrophil cytosolic factor 1	0.048
FLT4	fms-related tyrosine kinase 4	0.046	Human
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.042
CAV1	caveolin 1, caveolae protein, 22kDa	0.041
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.041
MASP2	mannan-binding lectin serine peptidase 2	0.038
APOB	apolipoprotein B (including Ag(x) antigen)	0.038
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.037
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.035
C8A	complement component 8, alpha polypeptide	0.035
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.032
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.032
SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0.031
LPA	lipoprotein, Lp(a)	0.031	Human
HRG	histidine-rich glycoprotein	0.030	Mouse
C8B	complement component 8, beta polypeptide	0.029
GAB2	GRB2-associated binding protein 2	0.029
ARRDC3	arrestin domain containing 3	0.029
ANGPTL2	angiopoietin-like 2	0.029
SLC38A3	solute carrier family 38, member 3	0.029
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.029
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.028
COL4A1	collagen, type IV, alpha 1	0.027
LDLR	low density lipoprotein receptor	0.027
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.026
ANXA1	annexin A1	0.025
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.025
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.024
LCAT	lecithin-cholesterol acyltransferase	0.024
STAB1	stabilin 1	0.024
F3	coagulation factor III (thromboplastin, tissue factor)	0.023
FGFR1	fibroblast growth factor receptor 1	0.023
VTN	vitronectin	0.023
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.022	Human
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.022
C6	complement component 6	0.021
DCN	decorin	0.021
PLTP	phospholipid transfer protein	0.020
ORM1	orosomucoid 1	0.018
TGFBI	transforming growth factor, beta-induced, 68kDa	0.018
SOS1	son of sevenless homolog 1 (Drosophila)	0.018
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.018
F10	coagulation factor X	0.017	Human
CYBA	cytochrome b-245, alpha polypeptide	0.017
MARCO	macrophage receptor with collagenous structure	0.017
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.017
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.017
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.016
VEGFC	vascular endothelial growth factor C	0.016	Human
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.016
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.016
AHSG	alpha-2-HS-glycoprotein	0.015
S100A11	S100 calcium binding protein A11	0.015
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.015
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.015
CRP	C-reactive protein, pentraxin-related	0.015
SPP2	secreted phosphoprotein 2, 24kDa	0.015
PTH1R	parathyroid hormone 1 receptor	0.015
VWF	von Willebrand factor	0.014
LGALS1	lectin, galactoside-binding, soluble, 1	0.014
PRKCB	protein kinase C, beta	0.014
RDH16	retinol dehydrogenase 16 (all-trans)	0.014
F9	coagulation factor IX	0.013	Human
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.013
GJB1	gap junction protein, beta 1, 32kDa	0.013
TRIM9	tripartite motif containing 9	0.013
ITIH1	inter-alpha (globulin) inhibitor H1	0.013
STC1	stanniocalcin 1	0.013
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.013
TEK	TEK tyrosine kinase, endothelial	0.013
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.013
AFM	afamin	0.013
C2	complement component 2	0.012
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.012
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.012
APCS	amyloid P component, serum	0.012
APOC4	apolipoprotein C-IV	0.012
MRVI1	murine retrovirus integration site 1 homolog	0.012
TIMP3	TIMP metallopeptidase inhibitor 3	0.012
WNT2	wingless-type MMTV integration site family member 2	0.012
CLEC4G	C-type lectin domain family 4, member G	0.012
MRC1	mannose receptor, C type 1	0.012
GP1BA	glycoprotein Ib (platelet), alpha polypeptide	0.012
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.012
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.012
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.012
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.012
COL2A1	collagen, type II, alpha 1	0.012
CFHR2	complement factor H-related 2	0.012
APOF	apolipoprotein F	0.011
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.011
MYO1D	myosin ID	0.011
PTEN	phosphatase and tensin homolog	0.011
ITGB5	integrin, beta 5	0.011
SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	0.011
ASGR2	asialoglycoprotein receptor 2	0.011
MSN	moesin	0.011
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.011
HPN	hepsin	0.011
C4BPB	complement component 4 binding protein, beta	0.011
DDIT4	DNA-damage-inducible transcript 4	0.011
SAA4	serum amyloid A4, constitutive	0.011
TUBB6	tubulin, beta 6	0.011
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.011
ITIH3	inter-alpha (globulin) inhibitor H3	0.011
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.010	Human
PRODH2	proline dehydrogenase (oxidase) 2	0.010
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.010
AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.010
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.010
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.010
F7	coagulation factor VII (serum prothrombin conversion accelerator)	0.010	Human
FAM83C	family with sequence similarity 83, member C	0.010
COL5A1	collagen, type V, alpha 1	0.010
NNMT	nicotinamide N-methyltransferase	0.010
SOS2	son of sevenless homolog 2 (Drosophila)	0.010
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.010