IMP
Process View
protein k11 linked ubiquitination
A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.
Loading network...
In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "protein k11 linked ubiquitination"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | 1.000 | Human | |
| ANAPC4 | anaphase promoting complex subunit 4 | 1.000 | ||
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 1.000 | ||
| CDC20 | cell division cycle 20 homolog (S. cerevisiae) | 1.000 | ||
| CDC16 | cell division cycle 16 homolog (S. cerevisiae) | 1.000 | ||
| CDC27 | cell division cycle 27 homolog (S. cerevisiae) | 1.000 | ||
| ANAPC1 | anaphase promoting complex subunit 1 | 1.000 | ||
| ANAPC5 | anaphase promoting complex subunit 5 | 1.000 | ||
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) | 1.000 | Human | |
| ANAPC7 | anaphase promoting complex subunit 7 | 1.000 | ||
| CDC26 | cell division cycle 26 homolog (S. cerevisiae) | 0.998 | ||
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | 0.983 | ||
| RNF5 | ring finger protein 5 | 0.978 | ||
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) | 0.888 | Human | |
| ANAPC11 | anaphase promoting complex subunit 11 | 0.840 | ||
| BUB1B | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 0.828 | ||
| CDC23 | cell division cycle 23 homolog (S. cerevisiae) | 0.817 | ||
| PTTG1 | pituitary tumor-transforming 1 | 0.788 | ||
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast) | 0.754 | ||
| CCNB1 | cyclin B1 | 0.681 | ||
| RNF144B | ring finger protein 144B | 0.652 | ||
| MAD2L2 | MAD2 mitotic arrest deficient-like 2 (yeast) | 0.497 | ||
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.443 | ||
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) | 0.441 | ||
| ANAPC13 | anaphase promoting complex subunit 13 | 0.407 | ||
| ARIH2 | ariadne homolog 2 (Drosophila) | 0.362 | ||
| RAD18 | RAD18 homolog (S. cerevisiae) | 0.326 | ||
| ZNRF1 | zinc and ring finger 1 | 0.302 | ||
| UBA1 | ubiquitin-like modifier activating enzyme 1 | 0.269 | ||
| UBE2I | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 0.219 | ||
| TRIM39 | tripartite motif containing 39 | 0.206 | ||
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.188 | ||
| FBXO5 | F-box protein 5 | 0.174 | ||
| UBE2S | ubiquitin-conjugating enzyme E2S | 0.169 | ||
| ANAPC16 | anaphase promoting complex subunit 16 | 0.155 | ||
| RNF14 | ring finger protein 14 | 0.147 | ||
| PLK1 | polo-like kinase 1 | 0.119 | ||
| BUB3 | budding uninhibited by benzimidazoles 3 homolog (yeast) | 0.109 | ||
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.086 | ||
| PTEN | phosphatase and tensin homolog | 0.084 | ||
| UBQLN2 | ubiquilin 2 | 0.077 | ||
| RNF114 | ring finger protein 114 | 0.073 | ||
| BST2 | bone marrow stromal cell antigen 2 | 0.069 | ||
| DZIP3 | DAZ interacting protein 3, zinc finger | 0.068 | ||
| CKS1B | CDC28 protein kinase regulatory subunit 1B | 0.066 | ||
| RLIM | ring finger protein, LIM domain interacting | 0.065 | ||
| HN1 | hematological and neurological expressed 1 | 0.062 | ||
| RNF11 | ring finger protein 11 | 0.061 | ||
| TRIM27 | tripartite motif containing 27 | 0.055 | ||
| TRIM23 | tripartite motif containing 23 | 0.054 | ||
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.049 | ||
| DTX2 | deltex homolog 2 (Drosophila) | 0.044 | ||
| RNF130 | ring finger protein 130 | 0.043 | ||
| ITCH | itchy E3 ubiquitin protein ligase homolog (mouse) | 0.042 | ||
| DTX3L | deltex 3-like (Drosophila) | 0.039 | ||
| RNF38 | ring finger protein 38 | 0.034 | ||
| RNF20 | ring finger protein 20 | 0.033 | ||
| UBE2A | ubiquitin-conjugating enzyme E2A (RAD6 homolog) | 0.032 | ||
| RNF10 | ring finger protein 10 | 0.032 | ||
| RANGAP1 | Ran GTPase activating protein 1 | 0.031 | ||
| ABHD16A | abhydrolase domain containing 16A | 0.028 | ||
| SNRNP27 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5) | 0.027 | ||
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.026 | ||
| RNF181 | ring finger protein 181 | 0.025 | ||
| RNF103 | ring finger protein 103 | 0.025 | ||
| UBE2M | ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) | 0.024 | ||
| PIAS3 | protein inhibitor of activated STAT, 3 | 0.023 | ||
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.023 | ||
| TRPS1 | trichorhinophalangeal syndrome I | 0.023 | ||
| RNF31 | ring finger protein 31 | 0.021 | ||
| RMND5B | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | 0.021 | ||
| TOMM22 | translocase of outer mitochondrial membrane 22 homolog (yeast) | 0.021 | ||
| FHOD1 | formin homology 2 domain containing 1 | 0.019 | ||
| RNF115 | ring finger protein 115 | 0.019 | ||
| LAMTOR3 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 | 0.019 | ||
| ENSA | endosulfine alpha | 0.018 | ||
| OAS1 | 2',5'-oligoadenylate synthetase 1, 40/46kDa | 0.018 | ||
| TUBB2C | tubulin, beta 2C | 0.018 | ||
| UBE2B | ubiquitin-conjugating enzyme E2B (RAD6 homolog) | 0.018 | ||
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.017 | ||
| RNF4 | ring finger protein 4 | 0.017 | Rat | |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.017 | ||
| BFAR | bifunctional apoptosis regulator | 0.017 | ||
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.015 | ||
| PSRC1 | proline/serine-rich coiled-coil 1 | 0.015 | ||
| AURKB | aurora kinase B | 0.015 | ||
| TRIM2 | tripartite motif containing 2 | 0.015 | ||
| RNF111 | ring finger protein 111 | 0.015 | ||
| RNF166 | ring finger protein 166 | 0.014 | ||
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) | 0.014 | ||
| UBOX5 | U-box domain containing 5 | 0.013 | ||
| CHFR | checkpoint with forkhead and ring finger domains | 0.013 | ||
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.013 | ||
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.013 | ||
| RNF146 | ring finger protein 146 | 0.013 | ||
| THOC4 | THO complex 4 | 0.012 | ||
| MUL1 | mitochondrial E3 ubiquitin protein ligase 1 | 0.012 | ||
| RNF165 | ring finger protein 165 | 0.012 | ||
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.012 | ||
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4 | 0.012 | ||
| ACOT7 | acyl-CoA thioesterase 7 | 0.012 | ||
| C16orf61 | chromosome 16 open reading frame 61 | 0.012 | ||
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.012 | ||
| RNF7 | ring finger protein 7 | 0.012 | ||
| MID1 | midline 1 (Opitz/BBB syndrome) | 0.012 | ||
| ARL15 | ADP-ribosylation factor-like 15 | 0.011 | ||
| STIP1 | stress-induced-phosphoprotein 1 | 0.011 | ||
| UBE2D4 | ubiquitin-conjugating enzyme E2D 4 (putative) | 0.011 | ||
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.011 | ||
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.011 | ||
| FAM64A | family with sequence similarity 64, member A | 0.010 | ||
| FANCD2 | Fanconi anemia, complementation group D2 | 0.010 | ||
| AMFR | autocrine motility factor receptor | 0.010 |