IMP

Process View

Homo sapiens

10 genes annotated in human

regulation of smad protein import into nucleus

Any process that modulates the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of smad protein import into nucleus"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of smad protein import into nucleus" (in gray)

Name	Description	Probability	Func Analog Organism
TGFB1	transforming growth factor, beta 1	1.000
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	1.000	Human
BMPR1A	bone morphogenetic protein receptor, type IA	0.999
SMAD7	SMAD family member 7	0.997
SMAD2	SMAD family member 2	0.984
BMP2	bone morphogenetic protein 2	0.979	Human
FSTL1	follistatin-like 1	0.976
ENG	endoglin	0.971
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.969	Human
FKBP1A	FK506 binding protein 1A, 12kDa	0.948
TGFBR1	transforming growth factor, beta receptor 1	0.938
TGFB3	transforming growth factor, beta 3	0.899	Mouse
SP1	Sp1 transcription factor	0.895
SMAD3	SMAD family member 3	0.886
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.869
BMPR1B	bone morphogenetic protein receptor, type IB	0.843	Human
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.824
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.823
PAX3	paired box 3	0.673
GDF5	growth differentiation factor 5	0.643	Human
SOX10	SRY (sex determining region Y)-box 10	0.628
FOXD3	forkhead box D3	0.587
NRP1	neuropilin 1	0.426
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.319
ACVR1	activin A receptor, type I	0.246	Human
SOX2	SRY (sex determining region Y)-box 2	0.178
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.170
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.166
ZFYVE9	zinc finger, FYVE domain containing 9	0.144
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.130
SMAD1	SMAD family member 1	0.122
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.107
HCFC1	host cell factor C1 (VP16-accessory protein)	0.107
NOG	noggin	0.100
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.095
SMAD4	SMAD family member 4	0.073	Mouse
PRKG1	protein kinase, cGMP-dependent, type I	0.068
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.054
BMP4	bone morphogenetic protein 4	0.054
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.048
SMAD6	SMAD family member 6	0.046
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.044
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.043
TJP1	tight junction protein 1 (zona occludens 1)	0.038
ACVR2B	activin A receptor, type IIB	0.036
RXRA	retinoid X receptor, alpha	0.035
AMOTL1	angiomotin like 1	0.033
TGFBR3	transforming growth factor, beta receptor III	0.029
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.027
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.026
ZEB2	zinc finger E-box binding homeobox 2	0.026
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.025
PDLIM4	PDZ and LIM domain 4	0.025
THBS1	thrombospondin 1	0.024
PIAS4	protein inhibitor of activated STAT, 4	0.024
HMGA1	high mobility group AT-hook 1	0.022
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.022
TJP2	tight junction protein 2 (zona occludens 2)	0.021
TEAD4	TEA domain family member 4	0.020
HTT	huntingtin	0.019
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.018
MEOX2	mesenchyme homeobox 2	0.018
SMAD5	SMAD family member 5	0.017
QKI	quaking homolog, KH domain RNA binding (mouse)	0.016
MYO6	myosin VI	0.016
SOX21	SRY (sex determining region Y)-box 21	0.015
EYA2	eyes absent homolog 2 (Drosophila)	0.015
NCOR1	nuclear receptor corepressor 1	0.015
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.014
ZMYND11	zinc finger, MYND-type containing 11	0.013
SOX1	SRY (sex determining region Y)-box 1	0.013
EP300	E1A binding protein p300	0.013
AMOT	angiomotin	0.012
KLF5	Kruppel-like factor 5 (intestinal)	0.012
ATXN1	ataxin 1	0.012
CXXC5	CXXC finger protein 5	0.011
ATF7IP	activating transcription factor 7 interacting protein	0.011
AMOTL2	angiomotin like 2	0.011
SOX11	SRY (sex determining region Y)-box 11	0.011
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.011
TGFB2	transforming growth factor, beta 2	0.011	Human
C9orf100	chromosome 9 open reading frame 100	0.010