IMP

Process View

Homo sapiens

18 genes annotated in human

ruffle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ruffle organization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "ruffle organization" (in gray)

Name	Description	Probability	Func Analog Organism
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.777
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.776	Human
MPDZ	multiple PDZ domain protein	0.440
TPM4	tropomyosin 4	0.320
ARFIP2	ADP-ribosylation factor interacting protein 2	0.314
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.281
ACTB	actin, beta	0.279
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.203
ZYX	zyxin	0.133
EMP3	epithelial membrane protein 3	0.127
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.118
RAB1A	RAB1A, member RAS oncogene family	0.110
NCOA1	nuclear receptor coactivator 1	0.110
MSN	moesin	0.102
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.099
PFN1	profilin 1	0.092
CFL1	cofilin 1 (non-muscle)	0.085
NCF4	neutrophil cytosolic factor 4, 40kDa	0.082
RHOG	ras homolog gene family, member G (rho G)	0.076	Human Mouse
SOS1	son of sevenless homolog 1 (Drosophila)	0.068
FKBP1A	FK506 binding protein 1A, 12kDa	0.063
NCF1	neutrophil cytosolic factor 1	0.057
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.056
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.055
RHOA	ras homolog gene family, member A	0.053
SPAG9	sperm associated antigen 9	0.048
RAB6A	RAB6A, member RAS oncogene family	0.046
RAB1B	RAB1B, member RAS oncogene family	0.045
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.045
COTL1	coactosin-like 1 (Dictyostelium)	0.044
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.044
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.039
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.039
RALBP1	ralA binding protein 1	0.038
CAPNS1	calpain, small subunit 1	0.038
BAIAP2	BAI1-associated protein 2	0.034
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.030
LST1	leukocyte specific transcript 1	0.030
PNPLA6	patatin-like phospholipase domain containing 6	0.029
WASF2	WAS protein family, member 2	0.029
PTK2	PTK2 protein tyrosine kinase 2	0.028
ACTG1	actin, gamma 1	0.028
VASP	vasodilator-stimulated phosphoprotein	0.028	Human
LCP1	lymphocyte cytosolic protein 1 (L-plastin)	0.028
FAT1	FAT tumor suppressor homolog 1 (Drosophila)	0.027
CD44	CD44 molecule (Indian blood group)	0.026
AP2A2	adaptor-related protein complex 2, alpha 2 subunit	0.025
PEBP4	phosphatidylethanolamine-binding protein 4	0.025
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.025
GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.024
SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	0.024
HTT	huntingtin	0.023
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.023
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.023
ARF6	ADP-ribosylation factor 6	0.023
LASP1	LIM and SH3 protein 1	0.022
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.022
NCF2	neutrophil cytosolic factor 2	0.022
NDUFB8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	0.021
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.021
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.021
TSC22D1	TSC22 domain family, member 1	0.021
RHEB	Ras homolog enriched in brain	0.021
CLTB	clathrin, light chain B	0.020
RAB8A	RAB8A, member RAS oncogene family	0.020
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.020
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.020
FYN	FYN oncogene related to SRC, FGR, YES	0.019
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.019
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.018
RALGDS	ral guanine nucleotide dissociation stimulator	0.018
DEF6	differentially expressed in FDCP 6 homolog (mouse)	0.017
PICALM	phosphatidylinositol binding clathrin assembly protein	0.017
RARA	retinoic acid receptor, alpha	0.017
WASF1	WAS protein family, member 1	0.017
TMOD3	tropomodulin 3 (ubiquitous)	0.017
DLG5	discs, large homolog 5 (Drosophila)	0.016
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.016	Human
RGS19	regulator of G-protein signaling 19	0.016
CDV3	CDV3 homolog (mouse)	0.016
PLAUR	plasminogen activator, urokinase receptor	0.016
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.016
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.016
RIN1	Ras and Rab interactor 1	0.016
FMNL1	formin-like 1	0.016
HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.015
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.015
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.015
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.015
FAM89B	family with sequence similarity 89, member B	0.015
SFN	stratifin	0.014
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.014
DLG4	discs, large homolog 4 (Drosophila)	0.014
XIRP1	xin actin-binding repeat containing 1	0.014
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.014
MAP2K1	mitogen-activated protein kinase kinase 1	0.014
CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	0.013
RHOC	ras homolog gene family, member C	0.013
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.013
HIP1	huntingtin interacting protein 1	0.013
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.013
UNC119	unc-119 homolog (C. elegans)	0.013
EHD1	EH-domain containing 1	0.013
CLIC4	chloride intracellular channel 4	0.013
TJP1	tight junction protein 1 (zona occludens 1)	0.013
CLDN7	claudin 7	0.013
CLTC	clathrin, heavy chain (Hc)	0.012
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.012
BCL3	B-cell CLL/lymphoma 3	0.012
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.012
CYTH2	cytohesin 2	0.012
SORBS1	sorbin and SH3 domain containing 1	0.012
IQGAP1	IQ motif containing GTPase activating protein 1	0.012
ITGB5	integrin, beta 5	0.012
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.012
EZR	ezrin	0.012
FKBP8	FK506 binding protein 8, 38kDa	0.012
ATN1	atrophin 1	0.012
RXRA	retinoid X receptor, alpha	0.012
EFHD2	EF-hand domain family, member D2	0.012
RAP1B	RAP1B, member of RAS oncogene family	0.012
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.011
TAGLN2	transgelin 2	0.011
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.011
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.011	Human
LGALS1	lectin, galactoside-binding, soluble, 1	0.011
OSGEP	O-sialoglycoprotein endopeptidase	0.011
GMFB	glia maturation factor, beta	0.011
ZDHHC24	zinc finger, DHHC-type containing 24	0.011
CLDN4	claudin 4	0.011
LAPTM5	lysosomal protein transmembrane 5	0.010
FERMT3	fermitin family member 3	0.010
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.010
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.010
ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	0.010
NCKIPSD	NCK interacting protein with SH3 domain	0.010