IMP

Process View

Homo sapiens

14 genes annotated in human

regulation of macrophage derived foam cell differentiation

Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of macrophage derived foam cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of macrophage derived foam cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	1.000
C1QA	complement component 1, q subcomponent, A chain	0.994	Human
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.901
CXCL2	chemokine (C-X-C motif) ligand 2	0.754
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.699	Human
FHL2	four and a half LIM domains 2	0.675
C1QC	complement component 1, q subcomponent, C chain	0.675	Human
COTL1	coactosin-like 1 (Dictyostelium)	0.581
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.549
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.544
IL8	interleukin 8	0.522
TLN1	talin 1	0.481
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.445
FN1	fibronectin 1	0.405
RARA	retinoic acid receptor, alpha	0.346
CXCL3	chemokine (C-X-C motif) ligand 3	0.342	Human
ENG	endoglin	0.313
ATF2	activating transcription factor 2	0.302
C1QB	complement component 1, q subcomponent, B chain	0.267	Human
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.261
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.207
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.203	Human
MAP2K4	mitogen-activated protein kinase kinase 4	0.170
CXCL5	chemokine (C-X-C motif) ligand 5	0.166	Human
CXCL10	chemokine (C-X-C motif) ligand 10	0.149	Human
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.144
NCOR2	nuclear receptor corepressor 2	0.135
CCL8	chemokine (C-C motif) ligand 8	0.133
CCL20	chemokine (C-C motif) ligand 20	0.129
SOCS3	suppressor of cytokine signaling 3	0.127
PDIA3	protein disulfide isomerase family A, member 3	0.123
CXCL11	chemokine (C-X-C motif) ligand 11	0.114	Human
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.086
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.075	Human
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.073
HR	hairless homolog (mouse)	0.071
ICAM1	intercellular adhesion molecule 1	0.068
CXCL9	chemokine (C-X-C motif) ligand 9	0.067	Human
IL6	interleukin 6 (interferon, beta 2)	0.064
THBS1	thrombospondin 1	0.062
DPP4	dipeptidyl-peptidase 4	0.061
VCAM1	vascular cell adhesion molecule 1	0.060
MAPK14	mitogen-activated protein kinase 14	0.057	Human
JUN	jun proto-oncogene	0.052
CHUK	conserved helix-loop-helix ubiquitous kinase	0.048
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.046
CCL2	chemokine (C-C motif) ligand 2	0.043
DUSP1	dual specificity phosphatase 1	0.042
CREBBP	CREB binding protein	0.042
PF4	platelet factor 4	0.041
SETD7	SET domain containing (lysine methyltransferase) 7	0.040
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.037
ADAM9	ADAM metallopeptidase domain 9	0.037
CD63	CD63 molecule	0.034
PXN	paxillin	0.034
BCL3	B-cell CLL/lymphoma 3	0.033	Human
IL1B	interleukin 1, beta	0.031
CHD9	chromodomain helicase DNA binding protein 9	0.028
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.028
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.027
CD9	CD9 molecule	0.024
ATF3	activating transcription factor 3	0.024
EP300	E1A binding protein p300	0.023
CPNE6	copine VI (neuronal)	0.023
HDAC3	histone deacetylase 3	0.023
UBD	ubiquitin D	0.022
MARCO	macrophage receptor with collagenous structure	0.021
RXRA	retinoid X receptor, alpha	0.020
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.019	Human
ITGB4	integrin, beta 4	0.019
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.019
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.019
KRT5	keratin 5	0.018
FOSL1	FOS-like antigen 1	0.018
ITGB5	integrin, beta 5	0.018
PF4V1	platelet factor 4 variant 1	0.017	Human
FLNA	filamin A, alpha	0.017
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.017	Human
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.017
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.016	Human
HIPK2	homeodomain interacting protein kinase 2	0.015
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.015
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.015
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.015
PPARA	peroxisome proliferator-activated receptor alpha	0.015
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.014
ALOXE3	arachidonate lipoxygenase 3	0.014	Human
SLAMF8	SLAM family member 8	0.013
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.013
CUL7	cullin 7	0.013
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.012
SOCS1	suppressor of cytokine signaling 1	0.012
APOC1	apolipoprotein C-I	0.012
TP53BP2	tumor protein p53 binding protein, 2	0.012
CCL7	chemokine (C-C motif) ligand 7	0.012
SIRT6	sirtuin 6	0.012
MAPK3	mitogen-activated protein kinase 3	0.011
ITGA6	integrin, alpha 6	0.011	Human
ALOX12B	arachidonate 12-lipoxygenase, 12R type	0.010	Human
RUNX1	runt-related transcription factor 1	0.010
TLR7	toll-like receptor 7	0.010
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.010