IMP

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Homo sapiens

1 genes annotated in human

cd8 positive alpha beta t cell differentiation involved in immune response

The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cd8 positive alpha beta t cell differentiation involved in immune response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cd8 positive alpha beta t cell differentiation involved in immune response" (in gray)

Name	Description	Probability	Func Analog Organism
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	1.000
GATA4	GATA binding protein 4	0.999
TBX5	T-box 5	0.953	Human
SOX18	SRY (sex determining region Y)-box 18	0.498
GATA5	GATA binding protein 5	0.409
TBX1	T-box 1	0.368	Human
LBX1	ladybird homeobox 1	0.300
MSX1	msh homeobox 1	0.247
PYY	peptide YY	0.225
KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	0.146
HOXC11	homeobox C11	0.116
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.105
TBX2	T-box 2	0.099	Human
MYH6	myosin, heavy chain 6, cardiac muscle, alpha	0.096
LTK	leukocyte receptor tyrosine kinase	0.081
FOXF1	forkhead box F1	0.079
ACAN	aggrecan	0.078
HOXB13	homeobox B13	0.076
HOXD12	homeobox D12	0.076
WNT1	wingless-type MMTV integration site family, member 1	0.076
COL2A1	collagen, type II, alpha 1	0.074
FGF3	fibroblast growth factor 3	0.072
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.071
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.069
DLL4	delta-like 4 (Drosophila)	0.066
IRX5	iroquois homeobox 5	0.058
HOXD9	homeobox D9	0.056
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.056
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.052
GNAT1	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	0.052
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.050
HOXD11	homeobox D11	0.049
POU4F2	POU class 4 homeobox 2	0.049
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.049
GATA3	GATA binding protein 3	0.048
FOXD2	forkhead box D2	0.048
MPPED1	metallophosphoesterase domain containing 1	0.047
DLX4	distal-less homeobox 4	0.046
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.045
SIX2	SIX homeobox 2	0.045
TBX21	T-box 21	0.044	Human
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.044
DCC	deleted in colorectal carcinoma	0.043
MYF6	myogenic factor 6 (herculin)	0.041
CXCR6	chemokine (C-X-C motif) receptor 6	0.041
NOVA2	neuro-oncological ventral antigen 2	0.039
KLHL35	kelch-like 35 (Drosophila)	0.038
TLX1	T-cell leukemia homeobox 1	0.037
PAX9	paired box 9	0.037
SCN5A	sodium channel, voltage-gated, type V, alpha subunit	0.036
MAPK7	mitogen-activated protein kinase 7	0.034
IRX4	iroquois homeobox 4	0.034
FLT4	fms-related tyrosine kinase 4	0.034
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.034
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.033
SOX1	SRY (sex determining region Y)-box 1	0.031
OTOP2	otopetrin 2	0.030
CD7	CD7 molecule	0.030
CXCR3	chemokine (C-X-C motif) receptor 3	0.029
NKX2-8	NK2 homeobox 8	0.029
HOXA11	homeobox A11	0.029
UBASH3A	ubiquitin associated and SH3 domain containing A	0.029
HCRTR1	hypocretin (orexin) receptor 1	0.028
BGLAP	bone gamma-carboxyglutamate (gla) protein	0.028
GRM8	glutamate receptor, metabotropic 8	0.028
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.028
BFSP2	beaded filament structural protein 2, phakinin	0.027
GJC2	gap junction protein, gamma 2, 47kDa	0.027
COL13A1	collagen, type XIII, alpha 1	0.027
HOXD13	homeobox D13	0.027
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.027
HOXD3	homeobox D3	0.026
LDB3	LIM domain binding 3	0.026
ATP8B3	ATPase, aminophospholipid transporter, class I, type 8B, member 3	0.026
FOXF2	forkhead box F2	0.026
SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	0.026
KCNIP2	Kv channel interacting protein 2	0.026
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.025
SIM2	single-minded homolog 2 (Drosophila)	0.025
SFTPC	surfactant protein C	0.025
EBF4	early B-cell factor 4	0.024
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.024
CD160	CD160 molecule	0.024
PTGDR	prostaglandin D2 receptor (DP)	0.024
NPTX1	neuronal pentraxin I	0.024
EVX1	even-skipped homeobox 1	0.024
IHH	Indian hedgehog	0.023
HBZ	hemoglobin, zeta	0.023
FAM46A	family with sequence similarity 46, member A	0.023
SIX3	SIX homeobox 3	0.023
SPTB	spectrin, beta, erythrocytic	0.022
PAX2	paired box 2	0.022
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.022
NKX2-1	NK2 homeobox 1	0.021
POU3F1	POU class 3 homeobox 1	0.021
REM1	RAS (RAD and GEM)-like GTP-binding 1	0.021
LAIR2	leukocyte-associated immunoglobulin-like receptor 2	0.021
LMO1	LIM domain only 1 (rhombotin 1)	0.021
KRT31	keratin 31	0.021
KLF14	Kruppel-like factor 14	0.021
HOXC8	homeobox C8	0.020
KCNE4	potassium voltage-gated channel, Isk-related family, member 4	0.020
TRPC6	transient receptor potential cation channel, subfamily C, member 6	0.020
DIO3	deiodinase, iodothyronine, type III	0.020
WNT10A	wingless-type MMTV integration site family, member 10A	0.020
SOX14	SRY (sex determining region Y)-box 14	0.020
TLL2	tolloid-like 2	0.019
BNC1	basonuclin 1	0.019
HOXC5	homeobox C5	0.019
HOXA3	homeobox A3	0.019
PRDM12	PR domain containing 12	0.019
HOXC10	homeobox C10	0.019
CMA1	chymase 1, mast cell	0.019
KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.019
SMAD6	SMAD family member 6	0.019
CHRNG	cholinergic receptor, nicotinic, gamma	0.019
FOXL1	forkhead box L1	0.019
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.019
KIF21B	kinesin family member 21B	0.018
NKX3-2	NK3 homeobox 2	0.018
FGF6	fibroblast growth factor 6	0.018
LMX1A	LIM homeobox transcription factor 1, alpha	0.018
ZNF80	zinc finger protein 80	0.018
NT5C1A	5'-nucleotidase, cytosolic IA	0.018
PPP1R12C	protein phosphatase 1, regulatory (inhibitor) subunit 12C	0.018
ADRA2C	adrenergic, alpha-2C-, receptor	0.018
DOC2B	double C2-like domains, beta	0.018
TNNT3	troponin T type 3 (skeletal, fast)	0.018
GNGT2	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2	0.017
HOXB5	homeobox B5	0.017
ADRA2B	adrenergic, alpha-2B-, receptor	0.017
EN2	engrailed homeobox 2	0.017
BANP	BTG3 associated nuclear protein	0.017
SRPK3	SRSF protein kinase 3	0.017
ZBTB7B	zinc finger and BTB domain containing 7B	0.017
SCUBE3	signal peptide, CUB domain, EGF-like 3	0.017
HOXA7	homeobox A7	0.017
PRSS21	protease, serine, 21 (testisin)	0.016
PAX7	paired box 7	0.016
WNT3	wingless-type MMTV integration site family, member 3	0.016
VAX2	ventral anterior homeobox 2	0.016
C10orf72	chromosome 10 open reading frame 72	0.016
GATA2	GATA binding protein 2	0.016
TBX20	T-box 20	0.016	Human
TRPC3	transient receptor potential cation channel, subfamily C, member 3	0.016
FOXD1	forkhead box D1	0.016
BHLHE23	basic helix-loop-helix family, member e23	0.016
TGM5	transglutaminase 5	0.016
FOXL2	forkhead box L2	0.016
PRMT8	protein arginine methyltransferase 8	0.016
FOXA2	forkhead box A2	0.015
B4GALNT1	beta-1,4-N-acetyl-galactosaminyl transferase 1	0.015
ZACN	zinc activated ligand-gated ion channel	0.015
HOXC6	homeobox C6	0.015
FGF4	fibroblast growth factor 4	0.015
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.015
CHRDL2	chordin-like 2	0.015
MYH8	myosin, heavy chain 8, skeletal muscle, perinatal	0.015
GSC2	goosecoid homeobox 2	0.015
TBX4	T-box 4	0.015	Human
GCM2	glial cells missing homolog 2 (Drosophila)	0.015
ADRA1D	adrenergic, alpha-1D-, receptor	0.015
COMP	cartilage oligomeric matrix protein	0.015
NGFR	nerve growth factor receptor	0.015
HOXD8	homeobox D8	0.015
MAPK4	mitogen-activated protein kinase 4	0.015
HOXB8	homeobox B8	0.015
GPR1	G protein-coupled receptor 1	0.015
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.015
SCARF2	scavenger receptor class F, member 2	0.014
SIX1	SIX homeobox 1	0.014
GRIK1	glutamate receptor, ionotropic, kainate 1	0.014
HOXC9	homeobox C9	0.014
FKBP6	FK506 binding protein 6, 36kDa	0.014
RGS9	regulator of G-protein signaling 9	0.014
HOXB3	homeobox B3	0.014
EOMES	eomesodermin	0.014
CRLF1	cytokine receptor-like factor 1	0.014
LILRA4	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	0.014
PFDN1	prefoldin subunit 1	0.014
NKPD1	NTPase, KAP family P-loop domain containing 1	0.014
PVRIG	poliovirus receptor related immunoglobulin domain containing	0.014
FGF18	fibroblast growth factor 18	0.014
PRICKLE3	prickle homolog 3 (Drosophila)	0.014
SIM1	single-minded homolog 1 (Drosophila)	0.014
NTN1	netrin 1	0.014
PDE3A	phosphodiesterase 3A, cGMP-inhibited	0.014
PHOX2A	paired-like homeobox 2a	0.014
EMX1	empty spiracles homeobox 1	0.014
GP1BA	glycoprotein Ib (platelet), alpha polypeptide	0.014
FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	0.014
HTR1E	5-hydroxytryptamine (serotonin) receptor 1E	0.014
HBE1	hemoglobin, epsilon 1	0.014
IL11	interleukin 11	0.014
MEOX2	mesenchyme homeobox 2	0.014
HOXA13	homeobox A13	0.014
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.014
GSTT1	glutathione S-transferase theta 1	0.014
COL5A3	collagen, type V, alpha 3	0.013
UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	0.013
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.013
PAX3	paired box 3	0.013
SHH	sonic hedgehog	0.013
MCOLN2	mucolipin 2	0.013
ERN2	endoplasmic reticulum to nucleus signaling 2	0.013
PITX2	paired-like homeodomain 2	0.013
GUCA1B	guanylate cyclase activator 1B (retina)	0.013
GALR2	galanin receptor 2	0.013
PHOX2B	paired-like homeobox 2b	0.013
KDM5D	lysine (K)-specific demethylase 5D	0.013
ZNF155	zinc finger protein 155	0.013
TMSB4Y	thymosin beta 4, Y-linked	0.013
NDUFA4L2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2	0.013
CTAG2	cancer/testis antigen 2	0.013
IGHMBP2	immunoglobulin mu binding protein 2	0.013
IL24	interleukin 24	0.013
SAMD11	sterile alpha motif domain containing 11	0.013
SHOX2	short stature homeobox 2	0.013
LIM2	lens intrinsic membrane protein 2, 19kDa	0.013
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.013
PRAC	prostate cancer susceptibility candidate	0.013
CHRNB3	cholinergic receptor, nicotinic, beta 3	0.013
FAM5C	family with sequence similarity 5, member C	0.012
INSM2	insulinoma-associated 2	0.012
FEZF2	FEZ family zinc finger 2	0.012
CD70	CD70 molecule	0.012
ZNF8	zinc finger protein 8	0.012
FOXS1	forkhead box S1	0.012
WNT7A	wingless-type MMTV integration site family, member 7A	0.012
DMBX1	diencephalon/mesencephalon homeobox 1	0.012
ATOH8	atonal homolog 8 (Drosophila)	0.012
TCF21	transcription factor 21	0.012
KRT9	keratin 9	0.012
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.012
KCNK13	potassium channel, subfamily K, member 13	0.012
GABRB2	gamma-aminobutyric acid (GABA) A receptor, beta 2	0.012
LDHC	lactate dehydrogenase C	0.012
HOXB4	homeobox B4	0.012
PKNOX2	PBX/knotted 1 homeobox 2	0.012
RAB11FIP3	RAB11 family interacting protein 3 (class II)	0.012
TIGIT	T cell immunoreceptor with Ig and ITIM domains	0.012
CASS4	Cas scaffolding protein family member 4	0.012
SOX3	SRY (sex determining region Y)-box 3	0.012
CDKL1	cyclin-dependent kinase-like 1 (CDC2-related kinase)	0.012
EXOC3L2	exocyst complex component 3-like 2	0.012
FIBCD1	fibrinogen C domain containing 1	0.012
TBX15	T-box 15	0.012	Human
C3orf54	chromosome 3 open reading frame 54	0.012
PRPH	peripherin	0.012
C22orf43	chromosome 22 open reading frame 43	0.012
NKD2	naked cuticle homolog 2 (Drosophila)	0.012
PNMT	phenylethanolamine N-methyltransferase	0.012
RPS4Y1	ribosomal protein S4, Y-linked 1	0.012
KAZALD1	Kazal-type serine peptidase inhibitor domain 1	0.012
MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	0.012
KCNC4	potassium voltage-gated channel, Shaw-related subfamily, member 4	0.012
PHOSPHO1	phosphatase, orphan 1	0.012
BMP6	bone morphogenetic protein 6	0.012
CACNA1S	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.012
NES	nestin	0.012
HMX2	H6 family homeobox 2	0.011
ALOX15	arachidonate 15-lipoxygenase	0.011
SLC46A2	solute carrier family 46, member 2	0.011
C1orf187	chromosome 1 open reading frame 187	0.011
ABI3	ABI family, member 3	0.011
FAM70B	family with sequence similarity 70, member B	0.011
LIN7A	lin-7 homolog A (C. elegans)	0.011
NRG2	neuregulin 2	0.011
TBX3	T-box 3	0.011	Human
NTF3	neurotrophin 3	0.011
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.011
PDE6G	phosphodiesterase 6G, cGMP-specific, rod, gamma	0.011
SLC25A42	solute carrier family 25, member 42	0.011
PAX5	paired box 5	0.011
RGS9BP	regulator of G protein signaling 9 binding protein	0.011
TACR1	tachykinin receptor 1	0.011
TXK	TXK tyrosine kinase	0.011
P2RY1	purinergic receptor P2Y, G-protein coupled, 1	0.011
DGKG	diacylglycerol kinase, gamma 90kDa	0.011
MAB21L2	mab-21-like 2 (C. elegans)	0.011
RAB3IL1	RAB3A interacting protein (rabin3)-like 1	0.011
DMRT3	doublesex and mab-3 related transcription factor 3	0.011
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.011
DLX3	distal-less homeobox 3	0.011
VRTN	vertebrae development homolog (pig)	0.011
ESPN	espin	0.011
DSPP	dentin sialophosphoprotein	0.011
KLK2	kallikrein-related peptidase 2	0.011
LRP5L	low density lipoprotein receptor-related protein 5-like	0.011
MMD2	monocyte to macrophage differentiation-associated 2	0.011
FOXJ1	forkhead box J1	0.011
PATL2	protein associated with topoisomerase II homolog 2 (yeast)	0.011
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.011
GHSR	growth hormone secretagogue receptor	0.011
NR2F1	nuclear receptor subfamily 2, group F, member 1	0.011
TEX19	testis expressed 19	0.011
ONECUT2	one cut homeobox 2	0.011
TCAP	titin-cap (telethonin)	0.011
GRAP2	GRB2-related adaptor protein 2	0.011
ZNF831	zinc finger protein 831	0.011
KCNA7	potassium voltage-gated channel, shaker-related subfamily, member 7	0.011
GFI1	growth factor independent 1 transcription repressor	0.011
HTR6	5-hydroxytryptamine (serotonin) receptor 6	0.011
HOXA2	homeobox A2	0.011
GPR171	G protein-coupled receptor 171	0.011
BCL2L10	BCL2-like 10 (apoptosis facilitator)	0.011
NTNG2	netrin G2	0.011
XCL2	chemokine (C motif) ligand 2	0.011
NGF	nerve growth factor (beta polypeptide)	0.010
COL25A1	collagen, type XXV, alpha 1	0.010
GLP1R	glucagon-like peptide 1 receptor	0.010
HAPLN1	hyaluronan and proteoglycan link protein 1	0.010
PRDM8	PR domain containing 8	0.010
DGKQ	diacylglycerol kinase, theta 110kDa	0.010
HOXD1	homeobox D1	0.010
ITIH3	inter-alpha (globulin) inhibitor H3	0.010
PODNL1	podocan-like 1	0.010
SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.010
ELOVL3	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	0.010
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.010
CAMK2N2	calcium/calmodulin-dependent protein kinase II inhibitor 2	0.010
CLDN6	claudin 6	0.010
IRX3	iroquois homeobox 3	0.010
L1TD1	LINE-1 type transposase domain containing 1	0.010
ZFHX3	zinc finger homeobox 3	0.010
KLRC4	killer cell lectin-like receptor subfamily C, member 4	0.010
GRASP	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	0.010
MYOD1	myogenic differentiation 1	0.010
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.010