IMP

Process View

Mus musculus

8 genes annotated in mouse

serotonin metabolic process

The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "serotonin metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "serotonin metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	1.000
Adrb1	adrenergic receptor, beta 1	0.880	Mouse
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.815
Dlg4	discs, large homolog 4 (Drosophila)	0.615
Sstr4	somatostatin receptor 4	0.516
Shc3	src homology 2 domain-containing transforming protein C3	0.436
Pnpla2	patatin-like phospholipase domain containing 2	0.433
Pparg	peroxisome proliferator activated receptor gamma	0.284
Grid1	glutamate receptor, ionotropic, delta 1	0.271
Drd2	dopamine receptor D2	0.262
Nos1	nitric oxide synthase 1, neuronal	0.208
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.202
Kl	klotho	0.194
Kifc2	kinesin family member C2	0.148
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.142
Cckbr	cholecystokinin B receptor	0.124
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.119
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.100
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.090
Epha6	Eph receptor A6	0.086
Prkcc	protein kinase C, gamma	0.083
Plcg1	phospholipase C, gamma 1	0.068
Cnr1	cannabinoid receptor 1 (brain)	0.062
Tff1	trefoil factor 1	0.061
Syn2	synapsin II	0.056
Mas1	MAS1 oncogene	0.055
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.054
Slc12a5	solute carrier family 12, member 5	0.053
Rasgrp1	RAS guanyl releasing protein 1	0.052
Sstr1	somatostatin receptor 1	0.051
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.051
Sstr3	somatostatin receptor 3	0.048
Slc31a1	solute carrier family 31, member 1	0.047
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.047
Acr	acrosin prepropeptide	0.047
Hsf4	heat shock transcription factor 4	0.045
Galr2	galanin receptor 2	0.040
Cux2	cut-like homeobox 2	0.039
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.039
Mog	myelin oligodendrocyte glycoprotein	0.038
Gpr83	G protein-coupled receptor 83	0.037
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.035
Foxg1	forkhead box G1	0.034
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.032
Grm1	glutamate receptor, metabotropic 1	0.032
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, subunit beta 2	0.031
Lhx6	LIM homeobox protein 6	0.030
Il16	interleukin 16	0.029
Slc1a2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.029
Thrb	thyroid hormone receptor beta	0.029
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.028
Ccr1l1	chemokine (C-C motif) receptor 1-like 1	0.028
ND6	NADH dehydrogenase subunit 6	0.028
Mobp	myelin-associated oligodendrocytic basic protein	0.028
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.027
Sebox	SEBOX homeobox	0.027
Npy2r	neuropeptide Y receptor Y2	0.026
Cdh6	cadherin 6	0.025
Slc39a4	solute carrier family 39 (zinc transporter), member 4	0.025
Crhr1	corticotropin releasing hormone receptor 1	0.025
Gast	gastrin	0.024
Steap3	STEAP family member 3	0.024
Cdh23	cadherin 23 (otocadherin)	0.024
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.024	Mouse
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.023
Gpr27	G protein-coupled receptor 27	0.023
Kcnk3	potassium channel, subfamily K, member 3	0.023
Matk	megakaryocyte-associated tyrosine kinase	0.022
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.022
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.021
Grm2	glutamate receptor, metabotropic 2	0.021
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.021
Inadl	InaD-like (Drosophila)	0.020
Hrh1	histamine receptor H1	0.020
Cplx1	complexin 1	0.020
Cdh10	cadherin 10	0.020
Lag3	lymphocyte-activation gene 3	0.019
Gad2	glutamic acid decarboxylase 2	0.019
Trh	thyrotropin releasing hormone	0.019
Galnt6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6	0.019
Tgfbr1	transforming growth factor, beta receptor I	0.019
Shank2	SH3/ankyrin domain gene 2	0.018
Galr1	galanin receptor 1	0.018
Kcna3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.018
Npy1r	neuropeptide Y receptor Y1	0.018
Prkaca	protein kinase, cAMP dependent, catalytic, alpha	0.018
Gsg1	germ cell-specific gene 1	0.018
Gpr3	G-protein coupled receptor 3	0.018
Zswim6	zinc finger, SWIM domain containing 6	0.018
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.017	Mouse
Cntnap1	contactin associated protein-like 1	0.017
Nos3	nitric oxide synthase 3, endothelial cell	0.017
Ncam2	neural cell adhesion molecule 2	0.017
Npy5r	neuropeptide Y receptor Y5	0.017
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.016
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.016	Mouse
Itga2	integrin alpha 2	0.016
Prox1	prospero-related homeobox 1	0.016
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.016
Nmbr	neuromedin B receptor	0.016
Dlg2	discs, large homolog 2 (Drosophila)	0.016
Gabra6	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	0.016
Atxn1	ataxin 1	0.015
Npy6r	neuropeptide Y receptor Y6	0.015
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.015
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.015
Kcnc1	potassium voltage gated channel, Shaw-related subfamily, member 1	0.015
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3	0.015
Slc30a3	solute carrier family 30 (zinc transporter), member 3	0.015
Adrb2	adrenergic receptor, beta 2	0.015	Mouse
S1pr2	sphingosine-1-phosphate receptor 2	0.015
Slc12a2	solute carrier family 12, member 2	0.015
Sst	somatostatin	0.015
Elf4	E74-like factor 4 (ets domain transcription factor)	0.015
Gpr33	G protein-coupled receptor 33	0.015
Rasgrf2	RAS protein-specific guanine nucleotide-releasing factor 2	0.014
Rgs9	regulator of G-protein signaling 9	0.014
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.014
Clip2	CAP-GLY domain containing linker protein 2	0.014
Dmkn	dermokine	0.014
Cntn3	contactin 3	0.014
Cfh	complement component factor h	0.014
Gpr12	G-protein coupled receptor 12	0.014
Ros1	Ros1 proto-oncogene	0.014
Cbx7	chromobox homolog 7	0.014
S100a5	S100 calcium binding protein A5	0.013
Wnt7a	wingless-related MMTV integration site 7A	0.013
Glra1	glycine receptor, alpha 1 subunit	0.013
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.013
Adrb3	adrenergic receptor, beta 3	0.013	Mouse
Slc22a6	solute carrier family 22 (organic anion transporter), member 6	0.013
Pspn	persephin	0.013
Limk1	LIM-domain containing, protein kinase	0.013
Bdkrb2	bradykinin receptor, beta 2	0.013
Kcnab2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	0.013
Mc2r	melanocortin 2 receptor	0.013
Fgf10	fibroblast growth factor 10	0.013
Krt86	keratin 86	0.013
Inpp5j	inositol polyphosphate 5-phosphatase J	0.012
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.012
Chia	chitinase, acidic	0.012
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.012
Atp4b	ATPase, H+/K+ exchanging, beta polypeptide	0.012
Oprd1	opioid receptor, delta 1	0.012
Bsn	bassoon	0.012
Rasal1	RAS protein activator like 1 (GAP1 like)	0.012
Clcnka	chloride channel Ka	0.012
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.012
Rasgrp2	RAS, guanyl releasing protein 2	0.012
Sncb	synuclein, beta	0.012
Lin7b	lin-7 homolog B (C. elegans)	0.012
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.012	Mouse
Adra2a	adrenergic receptor, alpha 2a	0.012	Mouse
Hapln2	hyaluronan and proteoglycan link protein 2	0.011
Ryr3	ryanodine receptor 3	0.011
Vip	vasoactive intestinal polypeptide	0.011
Syt6	synaptotagmin VI	0.011
Ntsr2	neurotensin receptor 2	0.011
Fut8	fucosyltransferase 8	0.011
Elk4	ELK4, member of ETS oncogene family	0.011
Grm5	glutamate receptor, metabotropic 5	0.011
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.011
Lct	lactase	0.011
Gm14743	predicted gene 14743	0.011
Mag	myelin-associated glycoprotein	0.011
Fmnl1	formin-like 1	0.011
Fam164c	family with sequence similarity 164, member C	0.011
Sema6b	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	0.011
Dhrs4	dehydrogenase/reductase (SDR family) member 4	0.010
Syt5	synaptotagmin V	0.010
Muc13	mucin 13, epithelial transmembrane	0.010
Iyd	iodotyrosine deiodinase	0.010
Hpca	hippocalcin	0.010
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.010
Hivep3	human immunodeficiency virus type I enhancer binding protein 3	0.010
Scn10a	sodium channel, voltage-gated, type X, alpha	0.010
Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	0.010
Upp2	uridine phosphorylase 2	0.010