IMP

Process View

Mus musculus

0 genes annotated in mouse

agammaglobulinemia

DOID:2583

A B cell deficiency that is caused by a reduction in all types of gamma globulins.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "agammaglobulinemia" (in gray)

Name	Description	Probability	Func Analog Organism
Igh	immunoglobulin heavy chain complex	1.000
Cd19	CD19 antigen	1.000	Human
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	1.000	Human
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.860	Human
Blnk	B-cell linker	0.805	Human
Fas	Fas (TNF receptor superfamily member 6)	0.750
Pou2af1	POU domain, class 2, associating factor 1	0.712
Ikzf1	IKAROS family zinc finger 1	0.580
Btk	Bruton agammaglobulinemia tyrosine kinase	0.492	Human
Cd22	CD22 antigen	0.401
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.298
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.297
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.291
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.221
Tnf	tumor necrosis factor	0.201
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.171
Cd79b	CD79B antigen	0.145	Human
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.124
Plcg2	phospholipase C, gamma 2	0.119
Rag1	recombination activating gene 1	0.100
Prkcd	protein kinase C, delta	0.092	Human
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.091
Bcl6	B-cell leukemia/lymphoma 6	0.073
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.071
Sykb	spleen tyrosine kinase	0.068
Trp53	transformation related protein 53	0.068
Igk	immunoglobulin kappa chain complex	0.067
Card11	caspase recruitment domain family, member 11	0.062
Cd40	CD40 antigen	0.055
Ltb	lymphotoxin B	0.053
Traf3ip2	TRAF3 interacting protein 2	0.052
Tcrd	T-cell receptor delta chain	0.048
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.042
Tnip1	TNFAIP3 interacting protein 1	0.042
Ikzf3	IKAROS family zinc finger 3	0.039
Irf4	interferon regulatory factor 4	0.038
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.036
Ifng	interferon gamma	0.032
Rag2	recombination activating gene 2	0.030
Ltbr	lymphotoxin B receptor	0.029
Grb2	growth factor receptor bound protein 2	0.028
Foxp3	forkhead box P3	0.027
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.026
Bcl3	B-cell leukemia/lymphoma 3	0.026
Sh3kbp1	SH3-domain kinase binding protein 1	0.024
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.023
H2-Ob	histocompatibility 2, O region beta locus	0.022
Tcrb	T-cell receptor beta chain	0.020
Ebf1	early B-cell factor 1	0.020
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.020
Ccr6	chemokine (C-C motif) receptor 6	0.020
Lat	linker for activation of T cells	0.019
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.019
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.017
Cxcr5	chemokine (C-X-C motif) receptor 5	0.017
Map4k1	mitogen-activated protein kinase kinase kinase kinase 1	0.014
Pten	phosphatase and tensin homolog	0.014
Inpp5d	inositol polyphosphate-5-phosphatase D	0.013
Col4a2	collagen, type IV, alpha 2	0.013
Vav2	vav 2 oncogene	0.012
Lta	lymphotoxin A	0.011
Icos	inducible T-cell co-stimulator	0.011
Blk	B lymphoid kinase	0.010