IMP

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Mus musculus

1 genes annotated in mouse

maintenance of presynaptic active zone structure

The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "maintenance of presynaptic active zone structure"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "maintenance of presynaptic active zone structure" (in gray)

Name	Description	Probability	Func Analog Organism
Dlg4	discs, large homolog 4 (Drosophila)	0.599
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.263
Auts2	autism susceptibility candidate 2	0.242
Rph3a	rabphilin 3A	0.210
Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.179
Astn1	astrotactin 1	0.178
Ina	internexin neuronal intermediate filament protein, alpha	0.153
Wnk2	WNK lysine deficient protein kinase 2	0.147
Ncam1	neural cell adhesion molecule 1	0.138
Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	0.137
Mark1	MAP/microtubule affinity-regulating kinase 1	0.130
Peg3	paternally expressed 3	0.120
Myt1l	myelin transcription factor 1-like	0.118
Ptprz1	protein tyrosine phosphatase, receptor type Z, polypeptide 1	0.106
Myo6	myosin VI	0.097
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.097
Ccdc64b	coiled-coil domain containing 64B	0.094
Epb4.1l1	erythrocyte protein band 4.1-like 1	0.093
Pcsk1n	proprotein convertase subtilisin/kexin type 1 inhibitor	0.090
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.087
Resp18	regulated endocrine-specific protein 18	0.076
Grik5	glutamate receptor, ionotropic, kainate 5 (gamma 2)	0.076
Pbx1	pre B-cell leukemia transcription factor 1	0.075
Tro	trophinin	0.075
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.072
Scg3	secretogranin III	0.066
Nnat	neuronatin	0.063
Scn8a	sodium channel, voltage-gated, type VIII, alpha	0.057
Pcsk2	proprotein convertase subtilisin/kexin type 2	0.057
Ptprd	protein tyrosine phosphatase, receptor type, D	0.056
Cdh8	cadherin 8	0.054
Dab1	disabled homolog 1 (Drosophila)	0.054
Ephb2	Eph receptor B2	0.054
Syt1	synaptotagmin I	0.052
Dpysl4	dihydropyrimidinase-like 4	0.052
Sox12	SRY-box containing gene 12	0.050
Tnks1bp1	tankyrase 1 binding protein 1	0.049
Cnih2	cornichon homolog 2 (Drosophila)	0.048
Pak3	p21 protein (Cdc42/Rac)-activated kinase 3	0.047
Fam19a5	family with sequence similarity 19, member A5	0.047
Mtap1b	microtubule-associated protein 1B	0.046
Gnao1	guanine nucleotide binding protein, alpha O	0.045
Aplp1	amyloid beta (A4) precursor-like protein 1	0.045
Ppp2r2b	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform	0.044
Sh3gl2	SH3-domain GRB2-like 2	0.044
Plxna2	plexin A2	0.043
Mmp17	matrix metallopeptidase 17	0.043
Celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.042
Odz4	odd Oz/ten-m homolog 4 (Drosophila)	0.041	Fly
Elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.040
Meis2	Meis homeobox 2	0.039
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.039
Gdpd5	glycerophosphodiester phosphodiesterase domain containing 5	0.038
Shd	src homology 2 domain-containing transforming protein D	0.036
Ntm	neurotrimin	0.036
Asxl3	additional sex combs like 3 (Drosophila)	0.035
BC018242	cDNA sequence BC018242	0.035
Cit	citron	0.035
Syt5	synaptotagmin V	0.035
Ache	acetylcholinesterase	0.035
Fgd1	FYVE, RhoGEF and PH domain containing 1	0.034
Rac3	RAS-related C3 botulinum substrate 3	0.033
Stmn3	stathmin-like 3	0.033
Epha5	Eph receptor A5	0.033
Cacna1g	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.032
Fzd2	frizzled homolog 2 (Drosophila)	0.032
Nefl	neurofilament, light polypeptide	0.032
Tagln3	transgelin 3	0.032
Gnaz	guanine nucleotide binding protein, alpha z subunit	0.032
B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.032
Nefm	neurofilament, medium polypeptide	0.031
Crmp1	collapsin response mediator protein 1	0.030
Prkar1b	protein kinase, cAMP dependent regulatory, type I beta	0.029
Kif1a	kinesin family member 1A	0.029
Fez1	fasciculation and elongation protein zeta 1 (zygin I)	0.029
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.029
Cplx2	complexin 2	0.029
Atp6v1b2	ATPase, H+ transporting, lysosomal V1 subunit B2	0.029
Fgf12	fibroblast growth factor 12	0.029
Irs1	insulin receptor substrate 1	0.028
Chga	chromogranin A	0.028
Ppp1r1a	protein phosphatase 1, regulatory (inhibitor) subunit 1A	0.027
Slc22a17	solute carrier family 22 (organic cation transporter), member 17	0.027
L1cam	L1 cell adhesion molecule	0.027
Cadps	Ca2+-dependent secretion activator	0.027
Accn1	amiloride-sensitive cation channel 1, neuronal (degenerin)	0.027
Mark4	MAP/microtubule affinity-regulating kinase 4	0.027
Numbl	numb-like	0.026
Tshz2	teashirt zinc finger family member 2	0.025
Sept3	septin 3	0.025
Zfp423	zinc finger protein 423	0.025
Nrg3	neuregulin 3	0.025
Msi1	Musashi homolog 1(Drosophila)	0.024
Fmn2	formin 2	0.024
Tubb4	tubulin, beta 4	0.024
Ptn	pleiotrophin	0.024
Hpca	hippocalcin	0.024
Ephb3	Eph receptor B3	0.024
Nxph1	neurexophilin 1	0.024
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.024
Snap25	synaptosomal-associated protein 25	0.023
Gng3	guanine nucleotide binding protein (G protein), gamma 3	0.023
Celf4	CUGBP, Elav-like family member 4	0.023
Lin7b	lin-7 homolog B (C. elegans)	0.023
Actl6b	actin-like 6B	0.023
Sobp	sine oculis-binding protein homolog (Drosophila)	0.023
Pcgf2	polycomb group ring finger 2	0.023
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.023
Lrrtm1	leucine rich repeat transmembrane neuronal 1	0.022
Cachd1	cache domain containing 1	0.022
Odz2	odd Oz/ten-m homolog 2 (Drosophila)	0.022	Fly
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.021
Mapt	microtubule-associated protein tau	0.021
Tcfap2b	transcription factor AP-2 beta	0.021
Atp1b2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.021
Scg2	secretogranin II	0.021
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.020
Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	0.020
Cux2	cut-like homeobox 2	0.020
Syp	synaptophysin	0.020
Kalrn	kalirin, RhoGEF kinase	0.020
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.019
Hspa12a	heat shock protein 12A	0.019
Kif5c	kinesin family member 5C	0.019
Sema4g	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	0.019
Fjx1	four jointed box 1 (Drosophila)	0.019
Dpysl3	dihydropyrimidinase-like 3	0.019
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	0.019
Fbn2	fibrillin 2	0.019
Wdr7	WD repeat domain 7	0.019
Zfp618	zinc fingerprotein 618	0.019
Ebf3	early B-cell factor 3	0.019
Kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.019
Arhgef5	Rho guanine nucleotide exchange factor (GEF) 5	0.019
Zfp358	zinc finger protein 358	0.018
Pcdh8	protocadherin 8	0.018
Dlg2	discs, large homolog 2 (Drosophila)	0.018
B930041F14Rik	RIKEN cDNA B930041F14 gene	0.018
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.018
Vsnl1	visinin-like 1	0.018
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.018
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.018
Slit2	slit homolog 2 (Drosophila)	0.018
Cxxc4	CXXC finger 4	0.017
Rap1gap	Rap1 GTPase-activating protein	0.017
Lrrn1	leucine rich repeat protein 1, neuronal	0.017
Lingo1	leucine rich repeat and Ig domain containing 1	0.017
Nrcam	neuron-glia-CAM-related cell adhesion molecule	0.017
St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.017
Inha	inhibin alpha	0.017
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.017
Mfsd4	major facilitator superfamily domain containing 4	0.017
Pnck	pregnancy upregulated non-ubiquitously expressed CaM kinase	0.017
Pcdh10	protocadherin 10	0.016
Mbp	myelin basic protein	0.016
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.016
Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B	0.016
Dnm1	dynamin 1	0.016
Gng4	guanine nucleotide binding protein (G protein), gamma 4	0.016
Efna5	ephrin A5	0.016
Gabra3	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3	0.016
Eef2k	eukaryotic elongation factor-2 kinase	0.016
Csdc2	cold shock domain containing C2, RNA binding	0.016
St6galnac5	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	0.016
Zfhx3	zinc finger homeobox 3	0.016
Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	0.016
Mmp16	matrix metallopeptidase 16	0.016
Dbc1	deleted in bladder cancer 1 (human)	0.016
C77370	expressed sequence C77370	0.015
Efnb3	ephrin B3	0.015
Phyhip	phytanoyl-CoA hydroxylase interacting protein	0.015
Cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.015
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.015
9030425E11Rik	RIKEN cDNA 9030425E11 gene	0.015
Plxna3	plexin A3	0.015
Cadm2	cell adhesion molecule 2	0.015
Ly6h	lymphocyte antigen 6 complex, locus H	0.015
Clstn2	calsyntenin 2	0.014
Slc27a1	solute carrier family 27 (fatty acid transporter), member 1	0.014
Maneal	mannosidase, endo-alpha-like	0.014
Robo1	roundabout homolog 1 (Drosophila)	0.014
Phactr1	phosphatase and actin regulator 1	0.014
Slc35f1	solute carrier family 35, member F1	0.014
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.014
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.014
Syn2	synapsin II	0.014
Rusc1	RUN and SH3 domain containing 1	0.014
Cuedc1	CUE domain containing 1	0.014
Ttl	tubulin tyrosine ligase	0.014
Lgi1	leucine-rich repeat LGI family, member 1	0.014
Pou3f3	POU domain, class 3, transcription factor 3	0.014
Sorcs2	sortilin-related VPS10 domain containing receptor 2	0.014
Prkce	protein kinase C, epsilon	0.014
Acvr2b	activin receptor IIB	0.014
Sema4b	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B	0.014
Doc2b	double C2, beta	0.013
Ank3	ankyrin 3, epithelial	0.013
Scn2a1	sodium channel, voltage-gated, type II, alpha 1	0.013
Elk1	ELK1, member of ETS oncogene family	0.013
Sfrp2	secreted frizzled-related protein 2	0.013
Tpbg	trophoblast glycoprotein	0.013
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.013
Pcdh19	protocadherin 19	0.013
Efna3	ephrin A3	0.013
Ddx25	DEAD (Asp-Glu-Ala-Asp) box polypeptide 25	0.013
Mink1	misshapen-like kinase 1 (zebrafish)	0.013
Sv2a	synaptic vesicle glycoprotein 2 a	0.013
Atcay	ataxia, cerebellar, Cayman type homolog (human)	0.013
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.013
Notch3	Notch gene homolog 3 (Drosophila)	0.013
Cntfr	ciliary neurotrophic factor receptor	0.013
Cntnap2	contactin associated protein-like 2	0.012
Gas1	growth arrest specific 1	0.012
Flrt2	fibronectin leucine rich transmembrane protein 2	0.012
Gpr37	G protein-coupled receptor 37	0.012
Ckmt1	creatine kinase, mitochondrial 1, ubiquitous	0.012
Zfhx4	zinc finger homeodomain 4	0.012
Unc13a	unc-13 homolog A (C. elegans)	0.012
Rundc3a	RUN domain containing 3A	0.012
Fabp7	fatty acid binding protein 7, brain	0.012
Gnal	guanine nucleotide binding protein, alpha stimulating, olfactory type	0.012
Enah	enabled homolog (Drosophila)	0.012
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.012
Fhod3	formin homology 2 domain containing 3	0.012
Camk1g	calcium/calmodulin-dependent protein kinase I gamma	0.012
Foxp4	forkhead box P4	0.012
Zfp651	zinc finger protein 651	0.012
Cdh10	cadherin 10	0.012
Slc48a1	solute carrier family 48 (heme transporter), member 1	0.012
Scg5	secretogranin V	0.012
Sox11	SRY-box containing gene 11	0.012
Gap43	growth associated protein 43	0.012
Gdap1l1	ganglioside-induced differentiation-associated protein 1-like 1	0.012
Ctsd	cathepsin D	0.012
Dync1i1	dynein cytoplasmic 1 intermediate chain 1	0.011
Lmo1	LIM domain only 1	0.011
Gpr85	G protein-coupled receptor 85	0.011
Ephb4	Eph receptor B4	0.011
Shank2	SH3/ankyrin domain gene 2	0.011
Mpped2	metallophosphoesterase domain containing 2	0.011
Clip3	CAP-GLY domain containing linker protein 3	0.011
Osbpl6	oxysterol binding protein-like 6	0.011
Pcp2	Purkinje cell protein 2 (L7)	0.011
Purb	purine rich element binding protein B	0.011
Ank2	ankyrin 2, brain	0.011
Elovl4	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	0.011
Clip2	CAP-GLY domain containing linker protein 2	0.011
Robo2	roundabout homolog 2 (Drosophila)	0.011
Wwc1	WW, C2 and coiled-coil domain containing 1	0.011
H1fx	H1 histone family, member X	0.011
Epha3	Eph receptor A3	0.011
Dcc	deleted in colorectal carcinoma	0.011
Bmp2	bone morphogenetic protein 2	0.011
Jag2	jagged 2	0.011
Sept5	septin 5	0.011
Nsf	N-ethylmaleimide sensitive fusion protein	0.011
Tmod2	tropomodulin 2	0.011
Apbb1	amyloid beta (A4) precursor protein-binding, family B, member 1	0.011
Fxyd7	FXYD domain-containing ion transport regulator 7	0.011
Palm	paralemmin	0.011
Klc2	kinesin light chain 2	0.011
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.011
Bace1	beta-site APP cleaving enzyme 1	0.011
Atp9a	ATPase, class II, type 9A	0.011
Uchl1	ubiquitin carboxy-terminal hydrolase L1	0.011
Dok5	docking protein 5	0.011
Negr1	neuronal growth regulator 1	0.010
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.010
Npas3	neuronal PAS domain protein 3	0.010
Dtx3	deltex 3 homolog (Drosophila)	0.010
Rgs4	regulator of G-protein signaling 4	0.010
Zcchc18	zinc finger, CCHC domain containing 18	0.010
Rab15	RAB15, member RAS oncogene family	0.010
Chodl	chondrolectin	0.010
Rnf208	ring finger protein 208	0.010
Ptprf	protein tyrosine phosphatase, receptor type, F	0.010
Foxp2	forkhead box P2	0.010
Lzts2	leucine zipper, putative tumor suppressor 2	0.010
Nudt11	nudix (nucleoside diphosphate linked moiety X)-type motif 11	0.010