IMP
Process View
chondroitin sulfate metabolic process
The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
Loading network...
In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "chondroitin sulfate metabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Bgn | biglycan | 0.958 | ||
| Lum | lumican | 0.924 | Mouse | |
| Dcn | decorin | 0.863 | ||
| H2-Aa | histocompatibility 2, class II antigen A, alpha | 0.491 | ||
| H2-DMa | histocompatibility 2, class II, locus DMa | 0.334 | ||
| Fmod | fibromodulin | 0.321 | Mouse | |
| H2-Eb1 | histocompatibility 2, class II antigen E beta | 0.204 | ||
| Ogn | osteoglycin | 0.165 | ||
| H2-Ab1 | histocompatibility 2, class II antigen A, beta 1 | 0.107 | ||
| Dpt | dermatopontin | 0.099 | ||
| Col1a2 | collagen, type I, alpha 2 | 0.071 | ||
| Ltbp4 | latent transforming growth factor beta binding protein 4 | 0.068 | ||
| Dag1 | dystroglycan 1 | 0.066 | ||
| Serping1 | serine (or cysteine) peptidase inhibitor, clade G, member 1 | 0.066 | ||
| Islr | immunoglobulin superfamily containing leucine-rich repeat | 0.064 | ||
| Postn | periostin, osteoblast specific factor | 0.062 | ||
| Abi3bp | ABI gene family, member 3 (NESH) binding protein | 0.060 | ||
| Cfh | complement component factor h | 0.057 | ||
| Sod3 | superoxide dismutase 3, extracellular | 0.050 | ||
| Prelp | proline arginine-rich end leucine-rich repeat | 0.045 | ||
| Ctrb1 | chymotrypsinogen B1 | 0.045 | ||
| Npdc1 | neural proliferation, differentiation and control gene 1 | 0.041 | ||
| Pkd1 | polycystic kidney disease 1 homolog | 0.034 | ||
| Krt4 | keratin 4 | 0.033 | ||
| Igfbp6 | insulin-like growth factor binding protein 6 | 0.032 | ||
| Colec12 | collectin sub-family member 12 | 0.032 | ||
| Tnxb | tenascin XB | 0.032 | ||
| Gas1 | growth arrest specific 1 | 0.028 | ||
| Amhr2 | anti-Mullerian hormone type 2 receptor | 0.028 | ||
| Mgp | matrix Gla protein | 0.028 | ||
| Htr5b | 5-hydroxytryptamine (serotonin) receptor 5B | 0.028 | ||
| Pcolce | procollagen C-endopeptidase enhancer protein | 0.028 | ||
| Col2a1 | collagen, type II, alpha 1 | 0.027 | ||
| C1s | complement component 1, s subcomponent | 0.026 | ||
| Reg4 | regenerating islet-derived family, member 4 | 0.025 | ||
| Col3a1 | collagen, type III, alpha 1 | 0.022 | ||
| Nbl1 | neuroblastoma, suppression of tumorigenicity 1 | 0.022 | ||
| Prl2a1 | prolactin family 2, subfamily a, member 1 | 0.022 | ||
| Col6a2 | collagen, type VI, alpha 2 | 0.021 | ||
| Serpinf1 | serine (or cysteine) peptidase inhibitor, clade F, member 1 | 0.020 | ||
| 2010003K11Rik | RIKEN cDNA 2010003K11 gene | 0.019 | ||
| Gpa33 | glycoprotein A33 (transmembrane) | 0.019 | ||
| Defa-rs10 | defensin, alpha, related sequence 10 | 0.019 | ||
| Aebp1 | AE binding protein 1 | 0.019 | ||
| Pklr | pyruvate kinase liver and red blood cell | 0.018 | ||
| Mmp20 | matrix metallopeptidase 20 (enamelysin) | 0.018 | ||
| Dchs1 | dachsous 1 (Drosophila) | 0.017 | ||
| Bicc1 | bicaudal C homolog 1 (Drosophila) | 0.017 | ||
| Col6a1 | collagen, type VI, alpha 1 | 0.017 | ||
| Dnahc1 | dynein, axonemal, heavy chain 1 | 0.017 | ||
| Dlx4 | distal-less homeobox 4 | 0.017 | ||
| Tenc1 | tensin like C1 domain-containing phosphatase | 0.017 | ||
| Slc45a2 | solute carrier family 45, member 2 | 0.017 | ||
| Lypd3 | Ly6/Plaur domain containing 3 | 0.017 | ||
| 1700080E11Rik | RIKEN cDNA 1700080E11 gene | 0.016 | ||
| Naalad2 | N-acetylated alpha-linked acidic dipeptidase 2 | 0.016 | ||
| B4galt2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | 0.016 | ||
| Slc14a2 | solute carrier family 14 (urea transporter), member 2 | 0.016 | ||
| Psca | prostate stem cell antigen | 0.016 | ||
| Fgfr4 | fibroblast growth factor receptor 4 | 0.015 | ||
| Actl7a | actin-like 7a | 0.015 | ||
| 2210010C04Rik | RIKEN cDNA 2210010C04 gene | 0.015 | ||
| Tubb4 | tubulin, beta 4 | 0.015 | ||
| Fbln5 | fibulin 5 | 0.015 | ||
| Gdf10 | growth differentiation factor 10 | 0.015 | ||
| Chst4 | carbohydrate (chondroitin 6/keratan) sulfotransferase 4 | 0.014 | Mouse | |
| Sdpr | serum deprivation response | 0.014 | ||
| Pkd2 | polycystic kidney disease 2 | 0.014 | ||
| Cldn13 | claudin 13 | 0.014 | ||
| Upk2 | uroplakin 2 | 0.014 | ||
| Ccdc92 | coiled-coil domain containing 92 | 0.014 | ||
| Clec14a | C-type lectin domain family 14, member a | 0.014 | ||
| Cel | carboxyl ester lipase | 0.014 | ||
| Ttc16 | tetratricopeptide repeat domain 16 | 0.013 | ||
| 1700016M24Rik | RIKEN cDNA 1700016M24 gene | 0.013 | ||
| P2ry4 | pyrimidinergic receptor P2Y, G-protein coupled, 4 | 0.013 | ||
| 1700011A15Rik | RIKEN cDNA 1700011A15 gene | 0.013 | ||
| Kdelc2 | KDEL (Lys-Asp-Glu-Leu) containing 2 | 0.013 | ||
| Cacng4 | calcium channel, voltage-dependent, gamma subunit 4 | 0.013 | ||
| Olfml3 | olfactomedin-like 3 | 0.013 | ||
| Rpe65 | retinal pigment epithelium 65 | 0.013 | ||
| Cela3b | chymotrypsin-like elastase family, member 3B | 0.013 | ||
| Vax2 | ventral anterior homeobox containing gene 2 | 0.013 | ||
| Spink4 | serine peptidase inhibitor, Kazal type 4 | 0.013 | ||
| Gkn2 | gastrokine 2 | 0.013 | ||
| Foxo3 | forkhead box O3 | 0.013 | ||
| Fkbp6 | FK506 binding protein 6 | 0.013 | ||
| Trex2 | three prime repair exonuclease 2 | 0.012 | ||
| Mfap5 | microfibrillar associated protein 5 | 0.012 | ||
| Sprr2a2 | small proline-rich protein 2A2 | 0.012 | ||
| Odf3 | outer dense fiber of sperm tails 3 | 0.012 | ||
| Butr1 | butyrophilin related 1 | 0.012 | ||
| Stra8 | stimulated by retinoic acid gene 8 | 0.012 | ||
| Rnase4 | ribonuclease, RNase A family 4 | 0.012 | ||
| Sorcs1 | VPS10 domain receptor protein SORCS 1 | 0.012 | ||
| Ces2a | carboxylesterase 2A | 0.012 | ||
| Sparc | secreted acidic cysteine rich glycoprotein | 0.012 | ||
| Gdf3 | growth differentiation factor 3 | 0.012 | ||
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.012 | ||
| Kif12 | kinesin family member 12 | 0.012 | ||
| Treml1 | triggering receptor expressed on myeloid cells-like 1 | 0.012 | ||
| Strc | stereocilin | 0.012 | ||
| Mxra8 | matrix-remodelling associated 8 | 0.012 | ||
| Hapln3 | hyaluronan and proteoglycan link protein 3 | 0.011 | ||
| Gjd4 | gap junction protein, delta 4 | 0.011 | ||
| Sparcl1 | SPARC-like 1 | 0.011 | ||
| Trim10 | tripartite motif-containing 10 | 0.011 | ||
| Add2 | adducin 2 (beta) | 0.011 | ||
| Cxcl17 | chemokine (C-X-C motif) ligand 17 | 0.011 | ||
| Scara3 | scavenger receptor class A, member 3 | 0.011 | ||
| Otog | otogelin | 0.011 | ||
| Efemp1 | epidermal growth factor-containing fibulin-like extracellular matrix protein 1 | 0.011 | ||
| Fcnb | ficolin B | 0.011 | ||
| Nkx2-4 | NK2 transcription factor related, locus 4 (Drosophila) | 0.011 | ||
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.011 | ||
| C1qa | complement component 1, q subcomponent, alpha polypeptide | 0.011 | ||
| Scube1 | signal peptide, CUB domain, EGF-like 1 | 0.011 | ||
| Angpt4 | angiopoietin 4 | 0.011 | ||
| Matn2 | matrilin 2 | 0.011 | ||
| Srpx | sushi-repeat-containing protein | 0.011 | ||
| Tgfb3 | transforming growth factor, beta 3 | 0.011 | ||
| Phf19 | PHD finger protein 19 | 0.010 | ||
| Otof | otoferlin | 0.010 | ||
| Abca8a | ATP-binding cassette, sub-family A (ABC1), member 8a | 0.010 | ||
| Slc13a2 | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 | 0.010 | ||
| Mmp10 | matrix metallopeptidase 10 | 0.010 | ||
| Atp7b | ATPase, Cu++ transporting, beta polypeptide | 0.010 | ||
| Jph3 | junctophilin 3 | 0.010 | ||
| Capn8 | calpain 8 | 0.010 | ||
| Pth2 | parathyroid hormone 2 | 0.010 | ||
| Fstl1 | follistatin-like 1 | 0.010 | ||
| Zp2 | zona pellucida glycoprotein 2 | 0.010 | ||
| Lysmd3 | LysM, putative peptidoglycan-binding, domain containing 3 | 0.010 | ||
| Fkbp9 | FK506 binding protein 9 | 0.010 | ||
| Igll1 | immunoglobulin lambda-like polypeptide 1 | 0.010 | ||
| Oas1h | 2'-5' oligoadenylate synthetase 1H | 0.010 |