IMP

Process View

Mus musculus

15 genes annotated in mouse

ectoderm development

The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ectoderm development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "ectoderm development" (in gray)

Name	Description	Probability	Func Analog Organism
Pax2	paired box gene 2	0.969
Otx2	orthodenticle homolog 2 (Drosophila)	0.880
Sox2	SRY-box containing gene 2	0.819
Shh	sonic hedgehog	0.731
Sall4	sal-like 4 (Drosophila)	0.697	Mouse
Gli3	GLI-Kruppel family member GLI3	0.685
Fgf8	fibroblast growth factor 8	0.547
Pax6	paired box gene 6	0.396
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.329
Emx2	empty spiracles homolog 2 (Drosophila)	0.308
Fgfr2	fibroblast growth factor receptor 2	0.308
Foxc1	forkhead box C1	0.258	Mouse
Emx1	empty spiracles homolog 1 (Drosophila)	0.242
Lhx1	LIM homeobox protein 1	0.238
Nodal	nodal	0.200
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.175
Hmx3	H6 homeobox 3	0.162
Bmp4	bone morphogenetic protein 4	0.158
Lhx3	LIM homeobox protein 3	0.150	Mouse
Otx1	orthodenticle homolog 1 (Drosophila)	0.145
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.144
Nanog	Nanog homeobox	0.140
Sall3	sal-like 3 (Drosophila)	0.132	Mouse
Nkx2-1	NK2 homeobox 1	0.128
Sox3	SRY-box containing gene 3	0.127
Pitx2	paired-like homeodomain transcription factor 2	0.113
Eya1	eyes absent 1 homolog (Drosophila)	0.112
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.107
Chd7	chromodomain helicase DNA binding protein 7	0.107
Tgfbr2	transforming growth factor, beta receptor II	0.102	Mouse
Isl1	ISL1 transcription factor, LIM/homeodomain	0.100	Mouse
Gbx2	gastrulation brain homeobox 2	0.098
Ctnnb1	catenin (cadherin associated protein), beta 1	0.097
Hes5	hairy and enhancer of split 5 (Drosophila)	0.097
Pax8	paired box gene 8	0.097
Sall1	sal-like 1 (Drosophila)	0.088
Tcfcp2l1	transcription factor CP2-like 1	0.088	Mouse
Vangl2	vang-like 2 (van gogh, Drosophila)	0.087
Zic3	zinc finger protein of the cerebellum 3	0.081
Tcfap2a	transcription factor AP-2, alpha	0.081
Nog	noggin	0.076
Smad4	MAD homolog 4 (Drosophila)	0.067
Pou5f1	POU domain, class 5, transcription factor 1	0.064
Pax3	paired box gene 3	0.061
Atoh7	atonal homolog 7 (Drosophila)	0.061
Dlx5	distal-less homeobox 5	0.060
Lmx1a	LIM homeobox transcription factor 1 alpha	0.054	Mouse
Ptprq	protein tyrosine phosphatase, receptor type, Q	0.051
Sox9	SRY-box containing gene 9	0.050
Pou4f2	POU domain, class 4, transcription factor 2	0.047	Mouse
Chrd	chordin	0.047
Wnt7a	wingless-related MMTV integration site 7A	0.047
Nab2	Ngfi-A binding protein 2	0.046
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.045
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.044
Insm1	insulinoma-associated 1	0.042
Lmx1b	LIM homeobox transcription factor 1 beta	0.041	Mouse
Matn3	matrilin 3	0.040
Foxd2	forkhead box D2	0.039	Mouse
Jag1	jagged 1	0.039
Gdnf	glial cell line derived neurotrophic factor	0.038
Tsc1	tuberous sclerosis 1	0.038
Atoh1	atonal homolog 1 (Drosophila)	0.038
Zic2	zinc finger protein of the cerebellum 2	0.037
Hoxa1	homeobox A1	0.037
Hoxd13	homeobox D13	0.035
Tgfbr1	transforming growth factor, beta receptor I	0.034	Mouse
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.034
Tbx10	T-box 10	0.033
Foxh1	forkhead box H1	0.033
Cxadr	coxsackie virus and adenovirus receptor	0.032
Sox1	SRY-box containing gene 1	0.032
Foxe3	forkhead box E3	0.032	Mouse
Vax1	ventral anterior homeobox containing gene 1	0.032
Pou3f1	POU domain, class 3, transcription factor 1	0.031	Mouse
Egr1	early growth response 1	0.031	Fly
Wnt3a	wingless-related MMTV integration site 3A	0.030
Sim1	single-minded homolog 1 (Drosophila)	0.030
Lrp2	low density lipoprotein receptor-related protein 2	0.030
Pthlh	parathyroid hormone-like peptide	0.029
Grhl2	grainyhead-like 2 (Drosophila)	0.029	Mouse
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.029
Inhbb	inhibin beta-B	0.028
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.028
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.028
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.027
Tbx1	T-box 1	0.027
Tcfap2c	transcription factor AP-2, gamma	0.026
Tlx2	T-cell leukemia, homeobox 2	0.026
En1	engrailed 1	0.026
Sox21	SRY-box containing gene 21	0.026
Fgf3	fibroblast growth factor 3	0.026
Cdx1	caudal type homeobox 1	0.025
Dlx6	distal-less homeobox 6	0.024
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.024
Fgfr3	fibroblast growth factor receptor 3	0.023
Pou3f2	POU domain, class 3, transcription factor 2	0.023	Mouse
Hand1	heart and neural crest derivatives expressed transcript 1	0.022
Wt1	Wilms tumor 1 homolog	0.022
Ppl	periplakin	0.022
Rarg	retinoic acid receptor, gamma	0.022
Cldn3	claudin 3	0.022
Foxa2	forkhead box A2	0.021
Egr2	early growth response 2	0.021	Fly
Nacc1	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	0.021
Bmp7	bone morphogenetic protein 7	0.020
Apc	adenomatosis polyposis coli	0.020
T	brachyury	0.020
Lhx4	LIM homeobox protein 4	0.020	Mouse
Efnb2	ephrin B2	0.020
Dlx1	distal-less homeobox 1	0.019
Nab1	Ngfi-A binding protein 1	0.019
Hoxb7	homeobox B7	0.019
Myo6	myosin VI	0.019
Ctnna1	catenin (cadherin associated protein), alpha 1	0.019
Tmprss2	transmembrane protease, serine 2	0.019
Evx2	even skipped homeotic gene 2 homolog	0.019
Sox13	SRY-box containing gene 13	0.018
Prop1	paired like homeodomain factor 1	0.018
Dlg1	discs, large homolog 1 (Drosophila)	0.018
Klf5	Kruppel-like factor 5	0.018
Fgf4	fibroblast growth factor 4	0.018
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.017
Qk	quaking	0.017
Foxb1	forkhead box B1	0.017
Cldn2	claudin 2	0.017
Hoxd9	homeobox D9	0.017
Alx4	aristaless-like homeobox 4	0.017
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.016
Foxf1a	forkhead box F1a	0.016
Foxq1	forkhead box Q1	0.016	Mouse
Smad7	MAD homolog 7 (Drosophila)	0.016
Epn3	epsin 3	0.016
Prkcc	protein kinase C, gamma	0.016
Srcrb4d	scavenger receptor cysteine rich domain containing, group B (4 domains)	0.015
Smad6	MAD homolog 6 (Drosophila)	0.015
Rab25	RAB25, member RAS oncogene family	0.015
Wnt4	wingless-related MMTV integration site 4	0.014
Lef1	lymphoid enhancer binding factor 1	0.014
Oprd1	opioid receptor, delta 1	0.014
Wnt3	wingless-related MMTV integration site 3	0.014
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.014
Sox7	SRY-box containing gene 7	0.014
Bdnf	brain derived neurotrophic factor	0.013
Phox2b	paired-like homeobox 2b	0.013
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.013
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.013
Klf4	Kruppel-like factor 4 (gut)	0.013
Bnc1	basonuclin 1	0.013
Fgf10	fibroblast growth factor 10	0.013
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.013
Usp25	ubiquitin specific peptidase 25	0.013
Hoxd11	homeobox D11	0.013
Hoxa9	homeobox A9	0.013
Zfp185	zinc finger protein 185	0.013
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.013
Hmx1	H6 homeobox 1	0.013
Onecut1	one cut domain, family member 1	0.013
Zfp771	zinc finger protein 771	0.013
Mlph	melanophilin	0.012
Usp43	ubiquitin specific peptidase 43	0.012
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.012
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.012
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.012	Zebrafish
Fgf15	fibroblast growth factor 15	0.012
Pgr	progesterone receptor	0.012
Fosb	FBJ osteosarcoma oncogene B	0.012
Lrrc58	leucine rich repeat containing 58	0.012
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.012
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.012
Inhba	inhibin beta-A	0.012
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.011
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.011
Psg17	pregnancy specific glycoprotein 17	0.011
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.011
Mpzl2	myelin protein zero-like 2	0.011
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.011
Hoxb13	homeobox B13	0.011
Isl2	insulin related protein 2 (islet 2)	0.011	Mouse
Foxc2	forkhead box C2	0.011	Mouse
Hoxb9	homeobox B9	0.011
Cdh3	cadherin 3	0.011	Zebrafish
Fshr	follicle stimulating hormone receptor	0.011
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.011
Nppc	natriuretic peptide type C	0.011
Srrm4	serine/arginine repetitive matrix 4	0.011
S1pr2	sphingosine-1-phosphate receptor 2	0.011
Kiss1	KiSS-1 metastasis-suppressor	0.011
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.011
Bmp2	bone morphogenetic protein 2	0.011
Fst	follistatin	0.011
Tead3	TEA domain family member 3	0.011
Sox8	SRY-box containing gene 8	0.011
Mta1	metastasis associated 1	0.011
Tbx15	T-box 15	0.011
Efna4	ephrin A4	0.011
Eef1a1	eukaryotic translation elongation factor 1 alpha 1	0.011
Msx1	homeobox, msh-like 1	0.010
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.010
Hoxa4	homeobox A4	0.010
Hnf1b	HNF1 homeobox B	0.010
Hoxa10	homeobox A10	0.010
Cldn8	claudin 8	0.010
En2	engrailed 2	0.010
Gata3	GATA binding protein 3	0.010
Cldn7	claudin 7	0.010
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.010
Dmrt3	doublesex and mab-3 related transcription factor 3	0.010