IMP

Process View

Rattus norvegicus

3 genes annotated in rat

cellular response to histamine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to histamine"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to histamine" (in gray)

Name	Description	Probability	Func Analog Organism
Kcnc2	potassium voltage gated channel, Shaw-related subfamily, member 2	0.953
Fgf14	fibroblast growth factor 14	0.866
Kcnab1	potassium voltage-gated channel, shaker-related subfamily, beta member 1	0.752
Gabrg1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	0.636	Rat
Nxph1	neurexophilin 1	0.626
Gabra4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	0.583	Rat
Epha5	EphA5	0.563
Gabra1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.524
Gria4	glutamate receptor, ionotrophic, AMPA 4	0.469
Camk4	calcium/calmodulin-dependent protein kinase IV	0.425
Gad2	glutamate decarboxylase 2	0.417
Cnksr2	connector enhancer of kinase suppressor of Ras 2	0.395
Gabra3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.308	Rat
Unc13c	unc-13 homolog C (C. elegans)	0.297
Drd1a	dopamine receptor D1A	0.274
Hapln1	hyaluronan and proteoglycan link protein 1	0.269
Grm7	glutamate receptor, metabotropic 7	0.236
Aqp4	aquaporin 4	0.226
Kcnv1	potassium channel, subfamily V, member 1	0.209
Cntn1	contactin 1	0.207
Nrcam	neuronal cell adhesion molecule	0.200
Ccbp2	chemokine binding protein 2	0.196
Csn3	casein kappa	0.161
Slc5a5	solute carrier family 5 (sodium iodide symporter), member 5	0.136
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.135
Gabrg2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	0.128	Mouse Rat
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.116
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, beta 3	0.103	Human Rat
Cntn4	contactin 4	0.099
Gabrb1	gamma-aminobutyric acid (GABA) A receptor, beta 1	0.098
Cntn6	contactin 6	0.096
Cdh6	cadherin 6	0.091
Olr1469	olfactory receptor Olr1469	0.089
Kcna3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.081
Chrna2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	0.081
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, beta 2	0.080
Rasgrp1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	0.077
Neurod1	neurogenic differentiation 1	0.076
Opcml	opioid binding protein/cell adhesion molecule-like	0.073
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.073
Lrrc7	leucine rich repeat containing 7	0.072
Rgs8	regulator of G-protein signaling 8	0.071
Syt7	synaptotagmin VII	0.070
Folh1	folate hydrolase 1	0.069
Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	0.068
Syt9	synaptotagmin IX	0.067
Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	0.067
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	0.067
Dgkb	diacylglycerol kinase, beta	0.066
Cnr1	cannabinoid receptor 1 (brain)	0.065
Gria2	glutamate receptor, ionotropic, AMPA 2	0.064
Ceacam3	carcinoembryonic antigen-related cell adhesion molecule 3	0.064
Gcm1	glial cells missing homolog 1 (Drosophila)	0.063
Rin1	Ras and Rab interactor 1	0.063
Kcnt1	potassium channel, subfamily T, member 1	0.062
Drd2	dopamine receptor D2	0.062
Vom2r31	vomeronasal 2 receptor, 31	0.060
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.060
Kcnh7	potassium voltage-gated channel, subfamily H (eag-related), member 7	0.060
Avp	arginine vasopressin	0.052
Grm1	glutamate receptor, metabotropic 1	0.052
Cx3cr1	chemokine (C-X3-C motif) receptor 1	0.050
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.050
Kalrn	kalirin, RhoGEF kinase	0.050
Synpr	synaptoporin	0.050
Psg29	pregnancy-specific glycoprotein 29	0.049
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	0.048
Cml3	camello-like 3	0.047
Nefl	neurofilament, light polypeptide	0.047
Gabra2	gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2	0.047	Rat
Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	0.046
Slco1a5	solute carrier organic anion transporter family, member 1a5	0.046
Syt4	synaptotagmin IV	0.046
Gja6	gap junction protein, alpha 6	0.046
Cntn3	contactin 3 (plasmacytoma associated)	0.045
Mog	myelin oligodendrocyte glycoprotein	0.045
Oprl1	opiate receptor-like 1	0.043
Sstr2	somatostatin receptor 2	0.042
Foxg1	forkhead box G1	0.042
Prph2	peripherin 2	0.042
Gng7	guanine nucleotide binding protein (G protein), gamma 7	0.041
Hpcal4	hippocalcin-like 4	0.041
Necab1	N-terminal EF-hand calcium binding protein 1	0.040
Rit2	Ras-like without CAAX 2	0.040
Grm4	glutamate receptor, metabotropic 4	0.040
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, gamma 3	0.040	Rat
Camk1g	calcium/calmodulin-dependent protein kinase IG	0.039
Sh3gl2	SH3-domain GRB2-like 2	0.039
Pmch	pro-melanin-concentrating hormone	0.038
Hrh2	histamine receptor H 2	0.037
Hpca	hippocalcin	0.037
Gipr	gastric inhibitory polypeptide receptor	0.036
Prkcg	protein kinase C, gamma	0.036
Cyp11b3	cytochrome P450, family 11, subfamily b, polypeptide 3	0.036
Snap91	synaptosomal-associated protein 91	0.035
Kcnb2	potassium voltage gated channel, Shab-related subfamily, member 2	0.035
Hoxa1	homeo box A1	0.035
Omg	oligodendrocyte-myelin glycoprotein	0.034
Nrsn1	neurensin 1	0.034
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.034
Kcnq3	potassium voltage-gated channel, KQT-like subfamily, member 3	0.034
Megf10	multiple EGF-like domains 10	0.034
Ucn	urocortin	0.033
Chrna7	cholinergic receptor, nicotinic, alpha 7	0.033
Trpc4	transient receptor potential cation channel, subfamily C, member 4	0.033
Syt1	synaptotagmin I	0.033
Gabra5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	0.032	Rat
Chrna6	cholinergic receptor, nicotinic, alpha 6	0.032
Vsnl1	visinin-like 1	0.032
Grin2a	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.032
Hist1h2aa	histone cluster 1, H2aa	0.031
Dync1i1	dynein cytoplasmic 1 intermediate chain 1	0.031
Myt1l	myelin transcription factor 1-like	0.031
Npy5r	neuropeptide Y receptor Y5	0.031
Pnmt	phenylethanolamine-N-methyltransferase	0.031
Stox2	storkhead box 2	0.031
St18	suppression of tumorigenicity 18	0.030
Crhbp	corticotropin releasing hormone binding protein	0.030
Accn1	amiloride-sensitive cation channel 1, neuronal	0.030
Atp2c1	ATPase, Ca++ transporting, type 2C, member 1	0.030
Mr1	major histocompatibility complex, class I-related	0.030
P2ry12	purinergic receptor P2Y, G-protein coupled, 12	0.029
Sv2b	synaptic vesicle glycoprotein 2b	0.029
Nhlh1	nescient helix loop helix 1	0.029
Tac1	tachykinin 1	0.029
Nrl	neural retina leucine zipper	0.029
Grid2	glutamate receptor, ionotropic, delta 2	0.028
Npy1r	neuropeptide Y receptor Y1	0.028
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.028
Epha3	Eph receptor A3	0.028
Epha7	Eph receptor A7	0.028
Rims1	regulating synaptic membrane exocytosis 1	0.028
Lim2	lens intrinsic membrane protein 2	0.028
Hcrtr1	hypocretin (orexin) receptor 1	0.027
Cdc2l5	cell division cycle 2-like 5 (cholinesterase-related cell division controller)	0.027
Rhag	Rh-associated glycoprotein	0.027
Trhr	thyrotropin releasing hormone receptor	0.026
Pgr	progesterone receptor	0.026
Lrfn5	leucine rich repeat and fibronectin type III domain containing 5	0.026
Hcn1	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	0.026
Glrb	glycine receptor, beta	0.026	Rat
Syt11	synaptotagmin XI	0.026
Gria1	glutamate receptor, ionotropic, AMPA 1	0.026
Impg2	interphotoreceptor matrix proteoglycan 2	0.026
Gnal	guanine nucleotide binding protein, alpha stimulating, olfactory type	0.025
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.025
Sv2c	synaptic vesicle glycoprotein 2c	0.025
Gabbr2	gamma-aminobutyric acid (GABA) B receptor 2	0.025
Hbe2	hemoglobin, epsilon 2	0.025
Ptgdr	prostaglandin D receptor	0.025
Ppp1r9a	protein phosphatase 1, regulatory (inhibitor) subunit 9A	0.025
Cuzd1	CUB and zona pellucida-like domains 1	0.025
Htr6	5-hydroxytryptamine (serotonin) receptor 6	0.025
Rorb	RAR-related orphan receptor B	0.025
Prl3c1	Prolactin family 3, subfamily c, member 1	0.025
Lif	leukemia inhibitory factor	0.024
Il8rb	interleukin 8 receptor, beta	0.024
Snap25	synaptosomal-associated protein 25	0.024
Prl7d1	prolactin family 7, subfamily d, member 1	0.024
Lalba	lactalbumin, alpha	0.024
Ccr5	chemokine (C-C motif) receptor 5	0.024
Syt6	synaptotagmin VI	0.024
Slc1a6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.024
Vtcn1	V-set domain containing T cell activation inhibitor 1	0.023
Il1rl2	interleukin 1 receptor-like 2	0.023
LOC100360165	rCG29588-like	0.023
Scn2b	sodium channel, voltage-gated, type II, beta	0.023
Lep	leptin	0.022
Neurod6	neurogenic differentiation 6	0.022
Slc5a7	solute carrier family 5 (choline transporter), member 7	0.022
Nlgn1	neuroligin 1	0.022
Chl1	cell adhesion molecule with homology to L1CAM	0.022
Mpp2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	0.022
Nrxn3	neurexin 3	0.022
Slco1c1	solute carrier organic anion transporter family, member 1c1	0.022
Il13	interleukin 13	0.022
Tshb	thyroid stimulating hormone, beta	0.021
Chrm5	cholinergic receptor, muscarinic 5	0.021
Spam1	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	0.021
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.021
Tsga10	testis specific 10	0.021
Fgf17	fibroblast growth factor 17	0.021
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.021
Defb22	defensin beta 22	0.020
Cyp4a8	cytochrome P450, family 4, subfamily a, polypeptide 8	0.020
Slc1a1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	0.020
Opn1mw	opsin 1 (cone pigments), medium-wave-sensitive	0.020
Calb1	calbindin 1	0.020
Tacstd2	tumor-associated calcium signal transducer 2	0.020
Nrxn1	neurexin 1	0.020
Slc8a3	solute carrier family 8 (sodium/calcium exchanger), member 3	0.020
Amph	amphiphysin	0.019
Klhl14	kelch-like 14 (Drosophila)	0.019
Pgf	placental growth factor	0.019
Csf3	colony stimulating factor 3 (granulocyte)	0.019
Olr825	olfactory receptor 825	0.019
Olr1366	olfactory receptor 1366	0.019
Pde1c	phosphodiesterase 1C	0.019
Pcsk2	proprotein convertase subtilisin/kexin type 2	0.019
Kcnk9	potassium channel, subfamily K, member 9	0.019
Trhde	thyrotropin-releasing hormone degrading enzyme	0.019
LOC24906	RoBo-1	0.019
Zmat4	zinc finger, matrin type 4	0.019
Fgf15	fibroblast growth factor 15	0.019
Slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	0.019
Rpe65	retinal pigment epithelium 65	0.018
Tmod2	tropomodulin 2	0.018
Sfrp4	secreted frizzled-related protein 4	0.018
Rph3a	rabphilin 3A	0.018
Mamdc4	MAM domain containing 4	0.018
Hnmt	histamine N-methyltransferase	0.018
Mobp	myelin-associated oligodendrocyte basic protein	0.018
Rgs9	regulator of G-protein signaling 9	0.018
Kcnk1	potassium channel, subfamily K, member 1	0.018
Adarb2	adenosine deaminase, RNA-specific, B2	0.018
Mas1	MAS1 oncogene	0.018
Arpp21	cAMP-regulated phosphoprotein 21	0.018
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.017
Kap	kidney androgen regulated protein	0.017
Mgat5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	0.017
Gprc5a	G protein-coupled receptor, family C, group 5, member A	0.017
Gpr12	G protein-coupled receptor 12	0.017
Grm2	glutamate receptor, metabotropic 2	0.017
Olr1278	olfactory receptor 1278	0.017
Cplx1	complexin 1	0.017
Gp5	glycoprotein V (platelet)	0.017
Slc6a11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.017
Kcnn2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	0.017
Bdkrb1	bradykinin receptor B1	0.017
Kcns2	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	0.016
Chia	chitinase, acidic	0.016
Edn1	endothelin 1	0.016
Fev	FEV (ETS oncogene family)	0.016
Dcc	deleted in colorectal carcinoma	0.016
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.016
Olr1493	olfactory receptor gene Olr1493	0.016
Kcnip4	Kv channel interacting protein 4	0.016
Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	0.016
Slc14a1	solute carrier family 14 (urea transporter), member 1	0.016
Neurod2	neurogenic differentiation 2	0.016
Itpr2	inositol 1,4,5-triphosphate receptor, type 2	0.015
Dnm3	dynamin 3	0.015
Vip	vasoactive intestinal peptide	0.015
Dck	deoxycytidine kinase	0.015
Sgp158	proline-rich glycoprotein (sgp158)	0.015
Prp15	proline-rich protein 15	0.015
Plcd4	phospholipase C, delta 4	0.015
Sidt1	SID1 transmembrane family, member 1	0.015
Mpp3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.015
Strn	striatin, calmodulin binding protein	0.015
Oprk1	opioid receptor, kappa 1	0.015
Cpne9	copine family member IX	0.015
Accn3	amiloride-sensitive cation channel 3	0.015
Dnah5	dynein, axonemal, heavy chain 5	0.015
Cd80	Cd80 molecule	0.014
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.014
Has2	hyaluronan synthase 2	0.014
Scn8a	sodium channel, voltage gated, type VIII, alpha subunit	0.014
Gcnt3	glucosaminyl (N-acetyl) transferase 3, mucin type	0.014
Mc5r	melanocortin 5 receptor	0.014
St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.014
Apba1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.014
Kcnh4	potassium voltage-gated channel, subfamily H (eag-related), member 4	0.014
RGD1560559	similar to RIKEN cDNA 2310042E22	0.014
Cnga4	cyclic nucleotide gated channel alpha 4	0.014
Slc24a1	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	0.014
Cdh10	cadherin 10	0.014
Grik1	glutamate receptor, ionotropic, kainate 1	0.013
LOC690418	similar to Acidic proline-rich protein PRP25 precursor	0.013
Grik3	glutamate receptor, ionotropic, kainate 3	0.013
Adra2c	adrenergic, alpha-2C-, receptor	0.013
Znf483	zinc finger protein 483	0.013
Pcp2	Purkinje cell protein 2	0.013
Begain	brain-enriched guanylate kinase-associated	0.013
Adam6	a disintegrin and metallopeptidase domain 6	0.013
Chrm2	cholinergic receptor, muscarinic 2	0.013
Pde4d	phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)	0.013
Ambn	ameloblastin	0.013
Ptprz1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.013
Grp	gastrin releasing peptide	0.013
Crybb3	crystallin, beta B3	0.013
Krt20	keratin 20	0.013
Svs5	seminal vesicle secretory protein 5	0.013
Reg3g	regenerating islet-derived 3 gamma	0.013
Dbc1	deleted in bladder cancer 1 (human)	0.013
Ghrl	ghrelin/obestatin prepropeptide	0.013
Dhrs9	dehydrogenase/reductase (SDR family) member 9	0.013
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.013
Crygd	crystallin, gamma D	0.013
Pkia	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	0.013
Slc6a20	solute carrier family 6 (proline IMINO transporter), member 20	0.012
Osbp2	oxysterol binding protein 2	0.012
Kcnj15	potassium inwardly-rectifying channel, subfamily J, member 15	0.012
Crp	C-reactive protein, pentraxin-related	0.012
ND4	NADH dehydrogenase subunit 4	0.012
Fgf2	fibroblast growth factor 2	0.012
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.012
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1	0.012
Tbxas1	thromboxane A synthase 1, platelet	0.012
Glra2	glycine receptor, alpha 2	0.012	Rat
Usp29	ubiquitin specific peptidase 29	0.012
Mfrp	membrane frizzled-related protein	0.012
Il2	interleukin 2	0.012
Mmp7	matrix metallopeptidase 7	0.012
Tg	thyroglobulin	0.012
Kcng1	potassium voltage-gated channel, subfamily G, member 1	0.012
Wisp1	WNT1 inducible signaling pathway protein 1	0.012
Slc35f4	solute carrier family 35, member F4	0.012
Zcwpw1	zinc finger, CW-type with PWWP domain 1	0.012
Crybg3	beta-gamma crystallin domain containing 3	0.011
Cd46	CD46 molecule, complement regulatory protein	0.011
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.011
Atp4a	ATPase, H+/K+ exchanging, alpha polypeptide	0.011
Cnga1	cyclic nucleotide gated channel alpha 1	0.011
LOC361188	similar to WD repeat domain 17	0.011
Robo2	roundabout homolog 2 (Drosophila)	0.011
Ldb3	LIM domain binding 3	0.011
Slc13a2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.011
LOC171161	common salivary protein 1	0.011
Mak	male germ cell-associated kinase	0.011
Sftpb	surfactant protein B	0.011
Psp	parotid secretory protein	0.011
Gphn	gephyrin	0.011
Grm5	glutamate receptor, metabotropic 5	0.011
Pak3	p21 protein (Cdc42/Rac)-activated kinase 3	0.011
Hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.011
Dmd	dystrophin	0.011
Mcpt3	mast cell peptidase 3	0.011
Mapk10	mitogen activated protein kinase 10	0.011
Chrm3	cholinergic receptor, muscarinic 3	0.011
Mtnr1a	melatonin receptor 1A	0.011
Tacr3	tachykinin receptor 3	0.011
Crx	cone-rod homeobox	0.011
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.011
Ralyl	RALY RNA binding protein-like	0.011
Kcnv2	potassium channel, subfamily V, member 2	0.011
Spock1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	0.011
N5	DNA binding protein N5	0.010
Rbm11	RNA binding motif protein 11	0.010
Prol1	proline rich, lacrimal 1	0.010
Glra3	glycine receptor, alpha 3	0.010
Olfm3	olfactomedin 3	0.010
Kcna5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.010
Gpr6	G protein-coupled receptor 6	0.010
Lrrc15	leucine rich repeat containing 15	0.010
Neu2	sialidase 2 (cytosolic sialidase)	0.010
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.010
Dio2	deiodinase, iodothyronine, type II	0.010
Lhx9	LIM homeobox 9	0.010
Vom2r40	vomeronasal 2 receptor, 40	0.010
Ppp2r2c	protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform	0.010
Gpr150	G protein-coupled receptor 150	0.010