IMP

Process View

Rattus norvegicus

23 genes annotated in rat

tube morphogenesis

The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "tube morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "tube morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
Dchs1	dachsous 1 (Drosophila)	0.196
Pfn1	profilin 1	0.168
LOC100364212	heterogeneous nuclear ribonucleoprotein K-like	0.146
Sirpa	signal-regulatory protein alpha	0.142
Bcl2	B-cell CLL/lymphoma 2	0.129	Mouse
Fgfr1	Fibroblast growth factor receptor 1	0.117	Zebrafish Mouse Rat Worm Fly
Tgfbr2	transforming growth factor, beta receptor II	0.080	Mouse
Lamc1	laminin, gamma 1	0.078
Calcrl	calcitonin receptor-like	0.066
Gna12	guanine nucleotide binding protein (G protein) alpha 12	0.064
Acta2	smooth muscle alpha-actin	0.064
Pak2	p21 protein (Cdc42/Rac)-activated kinase 2	0.063
Nek9	NIMA (never in mitosis gene a)- related kinase 9	0.062
Tgfbr3	transforming growth factor, beta receptor III	0.061
Tnc	tenascin C	0.060
Itpr2	inositol 1,4,5-triphosphate receptor, type 2	0.060
Fstl1	follistatin-like 1	0.051
Smad7	SMAD family member 7	0.047	Fly
Dag1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.046
Bgn	biglycan	0.046
Vcan	versican	0.046
Akap1	A kinase (PRKA) anchor protein 1	0.046
Arnt	aryl hydrocarbon receptor nuclear translocator	0.046
Kit	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.044
S1pr2	sphingosine-1-phosphate receptor 2	0.044
Sox17	SRY (sex determining region Y)-box 17	0.044	Human
Unc5b	unc-5 homolog B (C. elegans)	0.043	Zebrafish
Prkacb	protein kinase, cAMP dependent, catalytic, beta	0.040	Mouse
Dmd	dystrophin	0.039
Stxbp2	syntaxin binding protein 2	0.038
Stat5b	signal transducer and activator of transcription 5B	0.037	Fly
Twist2	twist homolog 2 (Drosophila)	0.036	Worm Fly
Foxd3	forkhead box D3	0.036
Mapk9	mitogen-activated protein kinase 9	0.036	Fly
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.033	Zebrafish
Ebf1	early B-cell factor 1	0.033
RGD1564327	similar to integrin alpha 8	0.032	Human
Gja5	gap junction protein, alpha 5	0.032
Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	0.031
Acvr1	activin A receptor, type I	0.030	Human Mouse
Fgfr2	fibroblast growth factor receptor 2	0.030
Myo9a	myosin IXA	0.029
Shc2	SHC (Src homology 2 domain containing) transforming protein 2	0.029	Fly
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.029
Loxl1	lysyl oxidase-like 1	0.029
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.028
Dab2	disabled homolog 2 (Drosophila)	0.028
Ptger4	prostaglandin E receptor 4 (subtype EP4)	0.027
Fn1	fibronectin 1	0.027	Human Zebrafish
Lig3	ligase III, DNA, ATP-dependent	0.026
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.025
Sardh	sarcosine dehydrogenase	0.025
Muc1	mucin 1, cell surface associated	0.025
Igfbp3	insulin-like growth factor binding protein 3	0.025
Reg3a	regenerating islet-derived 3 alpha	0.025
Rps6ka1	ribosomal protein S6 kinase polypeptide 1	0.024
Serpine2	serine (or cysteine) peptidase inhibitor, clade E, member 2	0.024
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.024
Col12a1	collagen, type XII, alpha 1	0.024	Human
Znf598	zinc finger protein 598	0.024
Glra1	glycine receptor, alpha 1	0.024
Nppc	natriuretic peptide precursor C	0.023
Jak1	Janus kinase 1	0.023
Prrx1	paired related homeobox 1	0.023
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.023	Human Mouse
Gpc1	glypican 1	0.023
Creb1	cAMP responsive element binding protein 1	0.023
Hoxb7	homeo box B7	0.023	Mouse
Fcgr2a	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.022
Myo1b	myosin Ib	0.022
LOC286992	peptide HP (rs14)	0.022
Enpp1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.022
Aif1l	allograft inflammatory factor 1-like	0.022
Capn6	calpain 6	0.022
Postn	periostin, osteoblast specific factor	0.022
Nrp2	neuropilin 2	0.022
Sh2b1	SH2B adaptor protein 1	0.021
Ppp2r2c	protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform	0.021
Slc20a2	solute carrier family 20 (phosphate transporter), member 2	0.021
Adam17	ADAM metallopeptidase domain 17	0.021
Tgfb3	transforming growth factor, beta 3	0.021
Il1r1	interleukin 1 receptor, type I	0.021
Ednrb	endothelin receptor type B	0.020
Vegfa	vascular endothelial growth factor A	0.020	Human
Clec9a	C-type lectin domain family 9, member a	0.020
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.020
Cyth3	cytohesin 3	0.020
Avpr2	arginine vasopressin receptor 2	0.019
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.019	Fly
Emp1	epithelial membrane protein 1	0.019
Itpr3	inositol 1,4,5-triphosphate receptor, type 3	0.019
Esr1	estrogen receptor 1	0.019	Mouse
LOC246267	resection-induced TPI (rs11)	0.019
Edn1	endothelin 1	0.019
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.019
Plagl1	pleiomorphic adenoma gene-like 1	0.019
Vim	vimentin	0.019
Itgb1	integrin, beta 1	0.019	Human
Add3	adducin 3 (gamma)	0.019
P2ry12	purinergic receptor P2Y, G-protein coupled, 12	0.019
Efna5	ephrin A5	0.018
Ptafr	platelet-activating factor receptor	0.018
Scarf2	scavenger receptor class F, member 2	0.018
Col3a1	collagen, type III, alpha 1	0.018
Nr4a2	nuclear receptor subfamily 4, group A, member 2	0.018
Slit3	slit homolog 3 (Drosophila)	0.018	Fly
Fgf1	fibroblast growth factor 1	0.018	Human
Umod	uromodulin	0.018
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.018
Sdc3	syndecan 3	0.018
Slc13a1	solute carrier family 13 (sodium/sulfate symporters), member 1	0.018
Mapk6	mitogen-activated protein kinase 6	0.018
Arhgap28	Rho GTPase activating protein 28	0.018
Socs7	suppressor of cytokine signaling 7	0.018
Hist1h1d	histone cluster 1, H1d	0.018
Lims1	LIM and senescent cell antigen-like domains 1	0.018
Slco2a1	solute carrier organic anion transporter family, member 2a1	0.017
Cd37	CD37 molecule	0.017
Cux1	cut-like homeobox 1	0.017	Fly
Megf6	multiple EGF-like-domains 6	0.017
Ptger3	prostaglandin E receptor 3 (subtype EP3)	0.017
Slc18a3	solute carrier family 18 (vesicular acetylcholine), member 3	0.017
Prkcd	protein kinase C, delta	0.017
Snai2	snail homolog 2 (Drosophila)	0.017
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.017
Mrgprf	MAS-related GPR, member F	0.016
Actr2	ARP2 actin-related protein 2 homolog (yeast)	0.016
Bcl6b	B-cell CLL/lymphoma 6, member B (zinc finger protein)	0.016
Ccr2	chemokine (C-C motif) receptor 2	0.016	Rat
Map6	microtubule-associated protein 6	0.016
Nr2f6	nuclear receptor subfamily 2, group F, member 6	0.016
Kcnk1	potassium channel, subfamily K, member 1	0.016
Atxn1	ataxin 1	0.016
Nos2	nitric oxide synthase 2, inducible	0.016
Bmp3	bone morphogenetic protein 3	0.016
Ahr	aryl hydrocarbon receptor	0.015	Mouse
Snap25	synaptosomal-associated protein 25	0.015
Myh9	myosin, heavy chain 9, non-muscle	0.015
Pax8	paired box 8	0.015	Human Mouse
Hoxc4	homeo box C4	0.015
Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1	0.015
Tp53	tumor protein p53	0.015
Hes3	hairy and enhancer of split 3 (Drosophila)	0.015
Pkia	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	0.015
Ncan	neurocan	0.015
Rab10	RAB10, member RAS oncogene family	0.015
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.015
Nos3	nitric oxide synthase 3, endothelial cell	0.015
Irs1	insulin receptor substrate 1	0.015
Anxa5	annexin A5	0.015
Fut4	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	0.015
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.015	Fly
Runx1	runt-related transcription factor 1	0.015
Mllt4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.015
Npr3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	0.015
Lox	lysyl oxidase	0.015
RY2G5	potential ligand-binding protein	0.015
Mos	Moloney sarcoma oncogene	0.015
Dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.015
Tubg1	tubulin, gamma 1	0.015
Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	0.015
Stxbp1	syntaxin binding protein 1	0.014
Slc1a3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	0.014
Prkar2a	protein kinase, cAMP dependent regulatory, type II alpha	0.014
Runx3	runt-related transcription factor 3	0.014
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.014
Galr3	galanin receptor 3	0.014
Plod1	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	0.014
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.014	Fly
Trhr2	thyrotropin releasing hormone receptor 2	0.014
Tnfaip2	tumor necrosis factor, alpha-induced protein 2	0.014
Rhoa	ras homolog gene family, member A	0.014
Golph3	golgi phosphoprotein 3 (coat-protein)	0.014
Crybb2	crystallin, beta B2	0.014
Gria4	glutamate receptor, ionotrophic, AMPA 4	0.014
Vom2r44	vomeronasal 2 receptor 44	0.014	Rat
Socs3	suppressor of cytokine signaling 3	0.014
Hand2	heart and neural crest derivatives expressed 2	0.014
Foxs1	forkhead box S1	0.014
Robo1	roundabout homolog 1 (Drosophila)	0.014	Mouse
Cacna1g	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.014
Flnb	filamin, beta	0.014
Gpc3	glypican 3	0.014
Klf13	Kruppel-like factor 13	0.014
Dnah8	dynein, axonemal, heavy chain 8	0.014
Cga	glycoprotein hormones, alpha polypeptide	0.014
Fnbp1	formin binding protein 1	0.014
Agtr1a	angiotensin II receptor, type 1a	0.013
Serbp1	Serpine1 mRNA binding protein 1	0.013
Amph	amphiphysin	0.013
Rgs19	regulator of G-protein signaling 19	0.013
Tgfb2	transforming growth factor, beta 2	0.013	Rat
Met	met proto-oncogene	0.013	Human
Rac1	ras-related C3 botulinum toxin substrate 1	0.013	Fly
Smad3	SMAD family member 3	0.013	Mouse
Ptpn7	protein tyrosine phosphatase, non-receptor type 7	0.013
Igfbp5	insulin-like growth factor binding protein 5	0.013
Smad1	SMAD family member 1	0.013
Slc9a1	solute carrier family 9 (sodium/hydrogen exchanger), member 1	0.013
Shox2	short stature homeobox 2	0.013	Mouse
Pawr	PRKC, apoptosis, WT1, regulator	0.013
Serpinb2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.013
Dlgap2	discs, large (Drosophila) homolog-associated protein 2	0.013
Srpx	sushi-repeat-containing protein, X-linked	0.013
Adra2b	adrenergic, alpha-2B-, receptor	0.013
Scnn1b	sodium channel, nonvoltage-gated 1, beta	0.013
Tle4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0.013
Utrn	utrophin	0.013
Smo	smoothened homolog (Drosophila)	0.013	Zebrafish Mouse
Mlana	melan-A	0.013
Figf	c-fos induced growth factor	0.013
Cd4	Cd4 molecule	0.012
Mrf	myelin gene regulatory factor	0.012
Snrk	SNF related kinase	0.012	Zebrafish
Smc2	structural maintenance of chromosomes 2	0.012
Csnk1d	casein kinase 1, delta	0.012
Cmklr1	chemokine-like receptor 1	0.012
Grm7	glutamate receptor, metabotropic 7	0.012
Tcfe2a	transcription factor E2a	0.012	Mouse
Scamp2	secretory carrier membrane protein 2	0.012
Lrrc15	leucine rich repeat containing 15	0.012
F13a1	coagulation factor XIII, A1 polypeptide	0.012
Epas1	endothelial PAS domain protein 1	0.012
Ptprc	protein tyrosine phosphatase, receptor type, C	0.012
Kcna6	potassium voltage gated channel, shaker related subfamily, member 6	0.012
Pde5a	phosphodiesterase 5A, cGMP-specific	0.012
Ube2g1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.012
Adam9	ADAM metallopeptidase domain 9 (meltrin gamma)	0.012
Bmp6	bone morphogenetic protein 6	0.012
Has2	hyaluronan synthase 2	0.012
Fam63b	family with sequence similarity 63, member B	0.012
Npy1r	neuropeptide Y receptor Y1	0.012
Gpam	glycerol-3-phosphate acyltransferase, mitochondrial	0.012
Pde4b	phosphodiesterase 4B, cAMP specific	0.012
Prss32	protease, serine, 32	0.012
Plau	plasminogen activator, urokinase	0.011
Csn1s2a	casein alpha s2-like A	0.011
LOC64038	sertolin	0.011
Irs3	insulin receptor substrate 3	0.011
Tcf12	transcription factor 12	0.011
RT1-Ha	RT1 class II, locus Ha	0.011
Ets1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.011	Fly
Galnt10	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	0.011
Mprip	myosin phosphatase Rho interacting protein	0.011
Efhd2	EF-hand domain family, member D2	0.011
Adora2a	adenosine A2a receptor	0.011
Cdk2	cyclin dependent kinase 2	0.011
Mcam	melanoma cell adhesion molecule	0.011
Ankrd1	ankyrin repeat domain 1 (cardiac muscle)	0.011
Kl	Klotho	0.011
Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	0.011
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.011
A2m	alpha-2-macroglobulin	0.011
Gper	G protein-coupled estrogen receptor 1	0.011
Insrr	insulin receptor-related receptor	0.011
Crygb	crystallin, gamma B	0.011
Fat1	FAT tumor suppressor homolog 1 (Drosophila)	0.011
Marcks	myristoylated alanine rich protein kinase C substrate	0.011
Btc	betacellulin	0.011
Il1rap	interleukin 1 receptor accessory protein	0.011
F2r	coagulation factor II (thrombin) receptor	0.011
Ptov1	prostate tumor overexpressed 1	0.011
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.011
Ntf3	neurotrophin 3	0.011
Galr2	galanin receptor 2	0.011
Foxc2	forkhead box C2	0.011
Cyp21a1	cytochrome P450, family 21, subfamily a, polypeptide 1	0.011
Svs1	seminal vesicle secretory protein 1	0.011
Lamb2	laminin, beta 2	0.011
Trpm7	transient receptor potential cation channel, subfamily M, member 7	0.011
Wt1	Wilms tumor 1	0.011	Human Mouse
Testin	testin gene	0.011
Fst	follistatin	0.011
Hoxd3	homeo box D3	0.011
Gdf10	growth differentiation factor 10	0.011
Ar	androgen receptor	0.011	Mouse
Lnpep	leucyl/cystinyl aminopeptidase	0.011
Cask	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.011
Ldlr	low density lipoprotein receptor	0.011
Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide	0.011
Pde4d	phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)	0.011
Prkca	protein kinase C, alpha	0.010
Itga6	integrin, alpha 6	0.010
Arpc4	actin related protein 2/3 complex, subunit 4	0.010
Grpca	glutamine/glutamic acid-rich protein A	0.010
Vcsa2	variable coding sequence A2	0.010
Crybb1	crystallin, beta B1	0.010
Col5a1	collagen, type V, alpha 1	0.010	Human
Mafg	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.010
Crtap	cartilage associated protein	0.010
Cdgap	Cdc42 GTPase-activating protein	0.010
Gata6	GATA binding protein 6	0.010
Flt1	FMS-related tyrosine kinase 1	0.010	Mouse Fly
Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.010	Mouse Worm
Ager	advanced glycosylation end product-specific receptor	0.010
Trhr	thyrotropin releasing hormone receptor	0.010
Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	0.010
Hpcal1	hippocalcin-like 1	0.010
Ugt8	UDP glycosyltransferase 8	0.010