IMP

Process View

Rattus norvegicus

2 genes annotated in rat

calcitriol biosynthetic process from calciol

Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "calcitriol biosynthetic process from calciol"

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Name	Description	Probability	Func Analog Organism
Cyp3a18	cytochrome P450, family 3, subfamily a, polypeptide 18	0.958	Human
LOC293989	cytochrome P450-like	0.957
Ugt2b	UDP glycosyltransferase 2 family, polypeptide B	0.742
Sult1c3	sulfotransferase family, cytosolic, 1C, member 3	0.585
Sult1b1	sulfotransferase family, cytosolic, 1B, member 1	0.562
Abcb11	ATP-binding cassette, subfamily B (MDR/TAP), member 11	0.558
Cyp2c13	cytochrome P450, family 2, subfamily c, polypeptide 13	0.531
Cyp1a1	cytochrome P450, family 1, subfamily a, polypeptide 1	0.479
Cyp2a2	cytochrome P450, family 2, subfamily a, polypeptide 2	0.455
Akr1c18	aldo-keto reductase family 1, member C18	0.441
Cyp3a2	cytochrome P450, family 3, subfamily a, polypeptide 2	0.425	Human
Ugt2b5	UDP glucuronosyltransferase 2 family, polypeptide B5	0.409
Ugt2b1	UDP glucuronosyltransferase 2 family, polypeptide B1	0.394
Sult1c2	sulfotransferase family, cytosolic, 1C, member 2	0.332
Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11	0.330
Cyp2b1	cytochrome P450, family 2, subfamily b, polypeptide 1	0.263
Cyp2a1	cytochrome P450, family 2, subfamily a, polypeptide 1	0.246
Apob	apolipoprotein B	0.245
Omd	osteomodulin	0.241
Sult1e1	sulfotransferase family 1E, estrogen-preferring, member 1	0.230
Sult2a1	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.228
Cyp3a23/3a1	cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1	0.163	Human
Spink1	serine peptidase inhibitor, Kazal type 1	0.133
Si	sucrase-isomaltase (alpha-glucosidase)	0.132
Slco1a1	solute carrier organic anion transporter family, member 1a1	0.123
Rup2	urinary protein 2	0.117
Pfkfb1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.117
Cyp2d3	cytochrome P450, family 2, subfamily d, polypeptide 3	0.108
Kl	Klotho	0.106
Hsd3b5	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	0.103
Ugt2b37	UDP-glucuronosyltransferase 2 family, member 37	0.103
Cyp2b3	cytochrome P450, family 2, subfamily b, polypeptide 3	0.090
Clcn5	chloride channel 5	0.084
LOC100361547	Cytochrome P450, family 2, subfamily c, polypeptide 7-like	0.079
Nmu	neuromedin U	0.071
Ccl11	chemokine (C-C motif) ligand 11	0.066
Cdcp1	CUB domain containing protein 1	0.065
Cyp2d2	cytochrome P450, family 2, subfamily d, polypeptide 2	0.062
Cyp2c12	cytochrome P450, family 2, subfamily c, polypeptide 12	0.062
Cyp4a10	cytochrome P450, family 4, subfamily a, polypeptide 10	0.061
LOC494499	LOC494499 protein	0.061
Ces1c	carboxylesterase 1C	0.060
Cyp3a9	cytochrome P450, family 3, subfamily a, polypeptide 9	0.059	Human
Sult2al1	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring-like 1	0.056
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.052
Selp	selectin P	0.050
Ces1f	carboxylesterase 1F	0.050
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.049
Cyp2c22	cytochrome P450, family 2, subfamily c, polypeptide 22	0.048
Il17f	interleukin 17F	0.047
Kynu	kynureninase (L-kynurenine hydrolase)	0.047
Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	0.046
Dpyd	dihydropyrimidine dehydrogenase	0.045
Clca4	chloride channel accessory 4	0.045
Tdo2	tryptophan 2,3-dioxygenase	0.044
Cyp2b21	cytochrome P450, family 2, subfamily b, polypeptide 21	0.041
Slc9a3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.040
Cyp2d4	cytochrome P450, family 2, subfamily d, polypeptide 4	0.038
Fut1	fucosyltransferase 1	0.034
Cyp4f4	cytochrome P450, family 4, subfamily f, polypeptide 4	0.034
G6pc	glucose-6-phosphatase, catalytic subunit	0.034
Hoxb8	homeo box B8	0.033
Fut9	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	0.032
Ugt1a5	UDP glucuronosyltransferase 1 family, polypeptide A5	0.032
Akp3	alkaline phosphatase 3, intestine, not Mn requiring	0.032
Slco1a4	solute carrier organic anion transporter family, member 1a4	0.029
Tg	thyroglobulin	0.029
Cyp2c23	cytochrome P450, family 2, subfamily c, polypeptide 23	0.029
Hes2	hairy and enhancer of split 2 (Drosophila)	0.028
Slco1b3	solute carrier organic anion transporter family, member 1b3	0.027
Fat2	FAT tumor suppressor homolog 2 (Drosophila)	0.027
Vcsa2	variable coding sequence A2	0.027
Klrh1	killer cell lectin-like receptor subfamily H, member 1	0.027
Cox6a2	cytochrome c oxidase, subunit VIa, polypeptide 2	0.027
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.026
Vom1r105	vomeronasal 1 receptor 105	0.026
LOC299282	Serine protease inhibitor	0.026
Slc9a2	solute carrier family 9 (sodium/hydrogen exchanger), member 2	0.026
Sycp1	synaptonemal complex protein 1	0.025
Hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.024
Adhfe1	alcohol dehydrogenase, iron containing, 1	0.023
Olr416	olfactory receptor 416	0.023
Cyp2b12	cytochrome P450, family 2, subfamily b, polypeptide 12	0.023
Adh4	alcohol dehydrogenase 4 (class II), pi polypeptide	0.023
Olr59	olfactory receptor 59	0.023
Obp1f	odorant binding protein I f	0.022
Gfi1	growth factor independent 1 transcription repressor	0.022	Human
Prl8a9	prolactin family 8, subfamily a, member 9	0.021
Tas2r118	taste receptor, type 2, member 118	0.021
Adh1	alcohol dehydrogenase 1 (class I)	0.021
Mc5r	melanocortin 5 receptor	0.021
Svs3a	seminal vesicle secretory protein 3A	0.021
Chrna9	cholinergic receptor, nicotinic, alpha 9	0.021
Slc34a1	solute carrier family 34 (sodium phosphate), member 1	0.020
Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2	0.020
Pon1	paraoxonase 1	0.020
Olr1082	olfactory receptor 1082	0.020
Dmgdh	dimethylglycine dehydrogenase	0.020
Mgst2	microsomal glutathione S-transferase 2	0.020
Glp2r	glucagon-like peptide 2 receptor	0.019
Sval1	seminal vesicle antigen-like 1	0.019
Ms4a8a	membrane-spanning 4-domains, subfamily A, member 8A	0.018
Prl7a4	prolactin family 7, subfamily a, member 4	0.018
A1i3	alpha-1-inhibitor III	0.018
Cyp4f1	cytochrome P450, family 4, subfamily f, polypeptide 1	0.018
Ust5r	integral membrane transport protein UST5r	0.018
Sstr4	somatostatin receptor 4	0.018
Cubn	cubilin (intrinsic factor-cobalamin receptor)	0.018
Zfp37	zinc finger protein 37	0.017
Otc	ornithine carbamoyltransferase	0.017
Dnase1	deoxyribonuclease I	0.017
Acsm2	acyl-CoA synthetase medium-chain family member 2	0.017
Aqp9	aquaporin 9	0.017
Apoh	apolipoprotein H (beta-2-glycoprotein I)	0.017
Hao2	hydroxyacid oxidase 2 (long chain)	0.017
Pdzk1	PDZ domain containing 1	0.016
Acot12	acyl-CoA thioesterase 12	0.016
Akr1d1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.016
ND4	NADH dehydrogenase subunit 4	0.016
Hnmt	histamine N-methyltransferase	0.015
Il1rap	interleukin 1 receptor accessory protein	0.015
Phex	phosphate regulating endopeptidase homolog, X-linked	0.015
Slc22a7	solute carrier family 22 (organic anion transporter), member 7	0.015
Akr1c1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.015
Agtr1b	angiotensin II receptor, type 1b	0.015
Ces1e	carboxylesterase 1E	0.015
Il1a	interleukin 1 alpha	0.015
Dgkb	diacylglycerol kinase, beta	0.015
Mettl7b	methyltransferase like 7B	0.014
LOC100365112	carboxylesterase-like	0.014
Ugt2b36	UDP glucuronosyltransferase 2 family, polypeptide B36	0.014
RT1-M4	RT1 class Ib, locus M4	0.014
Serpina5	serine (or cysteine) peptidase inhibitor, clade A, member 5	0.014
Kcnv1	potassium channel, subfamily V, member 1	0.013
Hamp	hepcidin antimicrobial peptide	0.013
Ctsql2	cathepsin Q-like 2	0.013
Prl7d1	prolactin family 7, subfamily d, member 1	0.013
Nr1i3	nuclear receptor subfamily 1, group I, member 3	0.013
Sprr1al	small proline-rich protein 1A-like	0.013
Cd46	CD46 molecule, complement regulatory protein	0.013
Ocm	oncomodulin	0.012
Bhmt	betaine-homocysteine methyltransferase	0.012
Crygf	crystallin, gamma F	0.012
Tore	trispanning orphan	0.012
Atxn3	ataxin 3	0.012
Cst12	cystatin 12	0.012
Cyp4a2	cytochrome P450, family 4, subfamily a, polypeptide 2	0.012
Kcnj15	potassium inwardly-rectifying channel, subfamily J, member 15	0.012
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.012
Slc12a1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	0.012
Hrh4	histamine receptor H4	0.012
Vtcn1	V-set domain containing T cell activation inhibitor 1	0.011
Sult1d1	sulfotransferase family 1D, member 1	0.011
Cyp2c7	cytochrome P450, family 2, subfamily c, polypeptide 7	0.011
Il2ra	interleukin 2 receptor, alpha	0.011
Abcc2	ATP-binding cassette, subfamily C (CFTR/MRP), member 2	0.011
Tnni3k	TNNI3 interacting kinase	0.011
Ceacam3	carcinoembryonic antigen-related cell adhesion molecule 3	0.011
Prl8a4	prolactin family 8, subfamily a, member 4	0.011
Fabp1	fatty acid binding protein 1, liver	0.011
Akr1c14	aldo-keto reductase family 1, member C14	0.011
Crisp2	cysteine-rich secretory protein 2	0.011
Lpar3	lysophosphatidic acid receptor 3	0.010
Btnl7	butyrophilin-like 7	0.010
As3mt	arsenic (+3 oxidation state) methyltransferase	0.010
Aadac	arylacetamide deacetylase (esterase)	0.010
Pnpla8	patatin-like phospholipase domain containing 8	0.010
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.010
Galnt5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	0.010
Akr1c12	aldo-keto reductase family 1, member C12	0.010
Slc10a2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	0.010
Sycp3	synaptonemal complex protein 3	0.010
Keg1	kidney expressed gene 1	0.010
Cyp17a1	cytochrome P450, family 17, subfamily a, polypeptide 1	0.010