IMP

Process View

Danio rerio

7 genes annotated in zebrafish

cytokine mediated signaling pathway

GO:0019221

A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cytokine mediated signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cytokine mediated signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
il6st	interleukin 6 signal transducer	0.369	Human Mouse Rat
il6r	interleukin 6 receptor	0.283	Human Rat
mmp9	matrix metalloproteinase 9	0.237
stc1l	stanniocalcin 1, like	0.181
cxcl12a	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)	0.176	Human
fgfr3	fibroblast growth factor receptor 3	0.157
anxa1a	annexin A1a	0.141
ghra	growth hormone receptor a	0.138	Mouse Rat
il7r	interleukin 7 receptor	0.111
pcsk5a	proprotein convertase subtilisin/kexin type 5a	0.105
tlr3	toll-like receptor 3	0.092
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.087
smad1	MAD homolog 1 (Drosophila)	0.082
cav1	caveolin 1	0.076
stat1b	signal transducer and activator of transcription 1b	0.075
il8	interleukin 8	0.073
bcl2l1	bcl2-like 1	0.072
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.070
tlr21	toll-like receptor 21	0.070
ntrk3b	neurotrophic tyrosine kinase, receptor, type 3b	0.068
igfbp1a	insulin-like growth factor binding protein 1a	0.068
spry4	sprouty (Drosophila) homolog 4	0.066
adipor1b	adiponectin receptor 1b	0.065	Mouse
mef2a	myocyte enhancer factor 2a	0.064
cish	cytokine inducible SH2-containing protein	0.058	Rat
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.056	Mouse
tyr	tyrosinase	0.050
taf3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto	0.050
socs3a	suppressor of cytokine signaling 3a	0.049	Zebrafish
cast	calpastatin	0.048
LOC100000934	hypothetical protein LOC100000934	0.047
pabpc1b	poly A binding protein, cytoplasmic 1 b	0.047
fabp2	fatty acid binding protein 2, intestinal	0.041
rarga	retinoic acid receptor gamma a	0.040
rbm22	RNA binding motif protein 22	0.040
cmyb	transcription factor cmyb	0.039
nrp2b	neuropilin 2b	0.039
mpx	myeloid-specific peroxidase	0.036
tnfsf10l2	tumor necrosis factor (ligand) superfamily, member 10 like 2	0.033
tagln2	transgelin 2	0.032
cntn2	contactin 2	0.031
sh3gl1b	SH3-domain GRB2-like 1b	0.031
zgc:64051	zgc:64051	0.030
adipor2	adiponectin receptor 2	0.029	Mouse
tgfbr2	transforming growth factor, beta receptor II	0.029
furinb	furin (paired basic amino acid cleaving enzyme) b	0.029
cdh23	cadherin-like 23	0.028
dnm2	dynamin 2	0.028
mcl1a	myeloid cell leukemia sequence 1a	0.028
igf2b	insulin-like growth factor 2b	0.026
ptger4b	prostaglandin E receptor 4 (subtype EP4) b	0.026
ca2	carbonic anhydrase II	0.026
si:dkey-261h17.1	si:dkey-261h17.1	0.026
alcama	activated leukocyte cell adhesion molecule a	0.025
fgf10a	fibroblast growth factor 10a	0.025
cxcr4b	chemokine (C-X-C motif), receptor 4b	0.025	Rat
adipor1a	adiponectin receptor 1a	0.025	Mouse
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.024
epas1b	endothelial PAS domain protein 1b	0.024
atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.023
epor	erythropoietin receptor	0.023	Human Rat
pax2b	paired box gene 2b	0.022
igfbp1b	insulin-like growth factor binding protein 1b	0.022
slc25a14	solute carrier family 25 (mitochondrial carrier, brain), member 14	0.022
neb	nebulin	0.022
slc2a13	solute carrier family 2 (facilitated glucose transporter), member 13	0.022
xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5	0.021
ptk2.1	protein tyrosine kinase 2a	0.021
serpinb1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.021
abcg2c	ATP-binding cassette, sub-family G (WHITE), member 2c	0.020
anxa2a	annexin A2a	0.020
egr2a	early growth response 2a	0.020
zgc:171553	zgc:171553	0.020
anxa1b	annexin A1b	0.020
kita	kit receptor a	0.019	Human Mouse
mbtps1	membrane-bound transcription factor protease, site 1	0.019
s1pr3	sphingosine-1-phosphate receptor 3	0.019
pcsk2	proprotein convertase subtilisin/kexin type 2	0.018
ccr12.2	chemokine (C-C motif) receptor 12.2	0.018
atf3	activating transcription factor 3	0.018
hmx2	H6 family homeobox 2	0.018
acta1b	actin, alpha 1b, skeletal muscle	0.018
stat3	signal transduction and activation of transcription 3	0.018	Human
jak1	Janus kinase 1	0.018	Human Mouse
krt4	keratin 4	0.017	Mouse
ugt1b1	UDP glucuronosyltransferase 1 family, polypeptide B1	0.017
pcsk1	proprotein convertase subtilisin/kexin type 1	0.016
junb	jun B proto-oncogene	0.016
angpt2	angiopoietin 2	0.016
caspb	caspase b and caspase b-like	0.016
cdc42	cell division cycle 42	0.016
bcl2	B-cell leukemia/lymphoma 2	0.016
csf3r	colony stimulating factor 3 receptor (granulocyte)	0.015
casp8	caspase 8, apoptosis-related cysteine peptidase	0.015
zgc:56005	zgc:56005	0.015
pcsk7	proprotein convertase subtilisin/kexin type 7	0.015
il1b	interleukin 1, beta and interleukin 1, beta	0.015	Human
lyz	lysozyme	0.015
il22	interleukin 22	0.014
adrb2a	adrenergic receptor, beta 2a	0.014
ctbp2l	C-terminal binding protein 2, like	0.014
jun	jun proto-oncogene	0.014
nos1	nitric oxide synthase 1 (neuronal)	0.014
slc2a1b	solute carrier family 2 (facilitated glucose transporter), member 1b	0.014
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.014
txnipa	thioredoxin interacting protein a	0.014
socs1	suppressor of cytokine signaling 1	0.014
ahcyl2	S-adenosylhomocysteine hydrolase-like 2	0.014
ccr6a	chemokine (C-C motif) receptor 6a	0.013
camk2g1	calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1	0.013
irak4	interleukin-1 receptor-associated kinase 4	0.013
copb2	coatomer protein complex, subunit beta 2	0.013
slit3	slit (Drosophila) homolog 3	0.013	Human
ptger2a	prostaglandin E receptor 2a (subtype EP2)	0.013
hspb1	heat shock protein, alpha-crystallin-related, 1	0.013
pglyrp5	peptidoglycan recognition protein 5	0.013
atp1b1a	ATPase, Na+/K+ transporting, beta 1a polypeptide	0.013
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.012
plekha7	pleckstrin homology domain containing, family A member 7	0.012
ptena	phosphatase and tensin homolog A	0.012
kal1b	Kallmann syndrome 1b sequence	0.012
stat5.2	signal transducer and activator of transcription 5.2	0.012	Mouse
proc	protein C (inactivator of coagulation factors Va and VIIIa)	0.012
ifnphi1	interferon phi 1	0.012
igf2a	insulin-like growth factor 2a	0.012
fryl	furry homolog-like (Drosophila)	0.012
gapdhs	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.011
slc14a2	solute carrier family 14 (urea transporter), member 2	0.011
wasb	Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b	0.011
pfn1	profilin 1	0.011
m17	IL-6 subfamily cytokine M17	0.011
cecr1a	cat eye syndrome chromosome region, candidate 1a	0.011
fgf3	fibroblast growth factor 3	0.011
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.011
c1qc	complement component 1, q subcomponent, C chain	0.011
per2	period homolog 2 (Drosophila)	0.011
ckmb	creatine kinase, muscle b	0.011
sema3d	semaphorin 3d	0.011
eppk1	epiplakin 1	0.011
scinlb	scinderin like b	0.011
elk4	ELK4, ETS-domain protein	0.011
gas6	growth arrest-specific 6	0.010	Human
zgc:112211	zgc:112211	0.010
hdac4	histone deacetylase 4	0.010
plce1	phospholipase C, epsilon 1	0.010
fas	Fas (TNF receptor superfamily, member 6)	0.010