The network for 'epithelial cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epithelial cell development

The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.

Drosophila melanogaster
Name Description Probability Func Analog Organism
par-1 CG8201 gene product from transcript CG8201-RA 1.000
Stat92E Signal-transducer and activator of transcription protein at 92E 1.000
ttk tramtrack 0.999
Rac1 CG2248 gene product from transcript CG2248-RA 0.999
baz bazooka 0.998
sqh spaghetti squash 0.998
shg shotgun 0.998
dsh dishevelled 0.995
par-6 CG5884 gene product from transcript CG5884-RA 0.995
hpo hippo 0.991
dome domeless 0.991
cos costa 0.990
wg wingless 0.990
alpha-Cat alpha Catenin 0.990
ci cubitus interruptus 0.989
Rala Ras-related protein 0.987
Cortactin CG3637 gene product from transcript CG3637-RA 0.985
N Notch 0.984
crb crumbs 0.983
os outstretched 0.983
p53 CG33336 gene product from transcript CG33336-RB 0.982
babo baboon 0.981
Krn Keren 0.978
Su(var)2-10 Suppressor of variegation 2-10 0.977
fng fringe 0.974
phl pole hole 0.972
jing CG9397 gene product from transcript CG9397-RI 0.970
Ser Serrate 0.969
kibra kibra ortholog 0.968
kel kelch 0.967
mbc myoblast city 0.967
fz frizzled 0.965
ecd ecdysoneless 0.964
hh hedgehog 0.958
CalpB Calpain-B 0.958
emc extra macrochaetae 0.957
kuz kuzbanian 0.956
Pvf1 PDGF- and VEGF-related factor 1 0.952
l(2)gl lethal (2) giant larvae 0.952
Trl Trithorax-like 0.948
Rab5 Rab-protein 5 0.944
Rho1 CG8416 gene product from transcript CG8416-RB 0.944
rl rolled 0.941
dlg1 discs large 1 0.936
Tm1 Tropomyosin 1 0.935
ara araucan 0.933
kug kugelei 0.931
Dad Daughters against dpp 0.931
aop anterior open 0.931
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.930
Mrtf Myocardin-related transcription factor 0.928
gbb glass bottom boat 0.926
lkb1 CG9374 gene product from transcript CG9374-RJ 0.922
shn schnurri 0.920
Pvr PDGF- and VEGF-receptor related 0.918
CycE Cyclin E 0.918
rok Rho-kinase 0.913
Shc SHC-adaptor protein 0.912
ndl nudel 0.912
cindr CIN85 and CD2AP orthologue 0.890
Lis-1 Lissencephaly-1 0.889
Ced-12 CG5336 gene product from transcript CG5336-RA 0.889
Btk29A Btk family kinase at 29A 0.884
chic chickadee 0.882
EcR Ecdysone receptor 0.881
sgg shaggy 0.880
usp ultraspiracle 0.876
BicD Bicaudal D 0.874
Doc2 Dorsocross2 0.873
Dcr-2 Dicer-2 0.873
CtBP C-terminal Binding Protein 0.866
yu CG3249 gene product from transcript CG3249-RA 0.859
slbo slow border cells 0.858
kni knirps 0.854
L Lobe 0.850
mirr mirror 0.849
mew multiple edematous wings 0.848
cpb capping protein beta 0.847
lat latheo 0.844
nyo nyobe 0.839
Egfr Epidermal growth factor receptor 0.830
dia diaphanous 0.830
pyd polychaetoid 0.828
Vm26Ab Vitelline membrane 26Ab 0.828
CG8155 CG8155 gene product from transcript CG8155-RA 0.827
ex expanded 0.824
brk brinker 0.818
kis kismet 0.811
ed echinoid 0.807
toc toucan 0.805
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.800
zip zipper 0.800
Rbf Retinoblastoma-family protein 0.799
ik2 IkappaB kinase-like 2 0.776
mael maelstrom 0.774
Rheb CG1081 gene product from transcript CG1081-RA 0.765
Gug Grunge 0.761
nudE CG8104 gene product from transcript CG8104-RB 0.760
sha shavenoid 0.759
bam bag of marbles 0.757
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
dla deltaA 0.976
kdrl kinase insert domain receptor like 0.976
cxcr4a chemokine (C-X-C motif) receptor 4a 0.894
dlc deltaC 0.882
shha sonic hedgehog a 0.868
cdh1 cadherin 1, epithelial 0.831
osr2 odd-skipped related 2 (Drosophila) 0.821
notch3 notch homolog 3 0.785
pax2a paired box gene 2a 0.760
foxa1 forkhead box A1 0.711
dlb deltaB 0.687
lhx1a LIM homeobox 1a 0.676
neurog1 neurogenin 1 0.628
wt1a wilms tumor 1a 0.622
jag1b jagged 1b 0.620
sox3 SRY-box containing gene 3 0.594
isl1 islet1 0.587
hnf1ba HNF1 homeobox Ba 0.543
sox9a SRY-box containing gene 9a 0.539
boc brother of CDO 0.536
eya1 eyes absent homolog 1 0.531
tp53 tumor protein p53 0.530
gata2a GATA-binding protein 2a 0.517
gli2a GLI-Kruppel family member GLI2a 0.490
tal1 T-cell acute lymphocytic leukemia 1 0.467
rag1 recombination activating gene 1 0.465
cdh23 cadherin-like 23 0.457
mecom MDS1 and EVI1 complex locus 0.423
dll4 delta-like 4 (Drosophila) 0.413
pax8 paired box gene 8 0.407
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.406
crygm4 crystallin, gamma M4 0.376
cldnb claudin b 0.375
pdgfaa platelet-derived growth factor alpha a 0.374
cxcr4b chemokine (C-X-C motif), receptor 4b 0.374
rag2 recombination activating gene 2 0.363
fras1 Fraser syndrome 1 0.357
gdf6a growth differentiation factor 6a 0.349
tp63 tumor protein p63 0.344
wt1b wilms tumor 1b 0.330
osr1 odd-skipped related 1 (Drosophila) 0.327
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.325
tfap2a transcription factor AP-2 alpha 0.322
fbn2b fibrillin 2b 0.315
hoxb3a homeo box B3a 0.308
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.304
crygmxl2 crystallin, gamma MX, like 2 0.293
sox19a SRY-box containing gene 19a 0.288
pitx3 paired-like homeodomain transcription factor 3 0.266
plcg1 phospholipase C, gamma 1 0.251
fzd8a frizzled homolog 8a 0.250
hoxc4a homeo box C4a 0.237
dag1 dystroglycan 1 0.231
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.218
cx43.4 connexin 43.4 0.214
cyp19a1a cytochrome P450, family 19, subfamily A, polypeptide 1a 0.209
notch1a notch homolog 1a 0.205
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.198
her9 hairy-related 9 0.197
emx3 empty spiracles homeobox 3 0.195
LOC560602 novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6) 0.195
appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.194
pax6b paired box gene 6b 0.181
foxa2 forkhead box A2 0.177
nrarpa notch-regulated ankyrin repeat protein a 0.168
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.164
prox1 prospero-related homeobox gene 1 0.161
six4b sine oculis homeobox homolog 4b 0.160
six2a sine oculis-related homeobox 2a 0.160
crygm6 crystallin, gamma M6 0.159
spint1a serine peptidase inhibitor, Kunitz type 1 a 0.158
ptgs2a prostaglandin-endoperoxide synthase 2a 0.153
her6 hairy-related 6 0.153
hoxb1b homeo box B1b 0.152
epcam epithelial cell adhesion molecule 0.151
etv2 ets variant gene 2 0.150
evx1 even-skipped homeobox 1 0.149
sox1a SRY-box containing gene 1a 0.147
ctrl chymotrypsin-like 0.146
gli1 GLI-Kruppel family member 1 0.145
akap12b A kinase (PRKA) anchor protein (gravin) 12b 0.142
cx55.5 connexin 55.5 0.137
unc45a unc-45 homolog A (C. elegans) 0.136
slc2a9l1 solute carrier family 2 (facilitated glucose transporter), member 9-like 1 0.136
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.136
foxd3 forkhead box D3 0.135
ephb4b eph receptor B4b 0.135
tbx2b T-box 2b 0.135
met met proto-oncogene (hepatocyte growth factor receptor) 0.130
crygm2f crystallin, gamma M2f 0.130
neurod4 neurogenic differentiation 4 0.129
jag1a jagged 1a 0.129
lef1 lymphocyte enhancer binding factor 1 0.129
cdh2 cadherin 2, neuronal 0.126
ascl1a achaete-scute complex-like 1a (Drosophila) 0.125
sars seryl-tRNA synthetase 0.125
bmp4 bone morphogenetic protein 4 0.125
pou5f1 POU domain, class 5, transcription factor 1 0.122
shhb sonic hedgehog b 0.121
plce1 phospholipase C, epsilon 1 0.121
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Homo sapiens
Name Description Probability Func Analog Organism
ESR1 estrogen receptor 1 0.993
EGFR epidermal growth factor receptor 0.977
CAV1 caveolin 1, caveolae protein, 22kDa 0.972
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.934
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.926
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.900
TJP1 tight junction protein 1 (zona occludens 1) 0.878
TAL1 T-cell acute lymphocytic leukemia 1 0.830
MYH9 myosin, heavy chain 9, non-muscle 0.792
FLNA filamin A, alpha 0.790
BCAR1 breast cancer anti-estrogen resistance 1 0.772
RB1 retinoblastoma 1 0.746
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.733
DNM2 dynamin 2 0.732
ACTB actin, beta 0.719
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.719
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.691
GRB2 growth factor receptor-bound protein 2 0.679
FGF1 fibroblast growth factor 1 (acidic) 0.637
JAG1 jagged 1 0.588
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.577
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.568
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.517
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.466
CCNE1 cyclin E1 0.457
CCND1 cyclin D1 0.456
QKI quaking homolog, KH domain RNA binding (mouse) 0.428
BMPR1A bone morphogenetic protein receptor, type IA 0.403
LAT linker for activation of T cells 0.399
PBX1 pre-B-cell leukemia homeobox 1 0.385
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.361
CAB39 calcium binding protein 39 0.350
EZR ezrin 0.329
UBQLN1 ubiquilin 1 0.308
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.307
RHOA ras homolog gene family, member A 0.297
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.289
ENG endoglin 0.268
TJP2 tight junction protein 2 (zona occludens 2) 0.257
CALCA calcitonin-related polypeptide alpha 0.254
SORBS2 sorbin and SH3 domain containing 2 0.245
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.238
ADRB1 adrenergic, beta-1-, receptor 0.200
PECAM1 platelet/endothelial cell adhesion molecule 0.200
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.196
CD44 CD44 molecule (Indian blood group) 0.187
SCHIP1 schwannomin interacting protein 1 0.180
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.170
TCF4 transcription factor 4 0.170
DNM1 dynamin 1 0.169
E2F1 E2F transcription factor 1 0.168
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.167
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.165
SOCS3 suppressor of cytokine signaling 3 0.165
AXIN1 axin 1 0.164
CDK2 cyclin-dependent kinase 2 0.158
DTNA dystrobrevin, alpha 0.155
AR androgen receptor 0.145
SOS2 son of sevenless homolog 2 (Drosophila) 0.138
BCR breakpoint cluster region 0.136
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.133
TRIP6 thyroid hormone receptor interactor 6 0.132
FERMT2 fermitin family member 2 0.131
ARID4B AT rich interactive domain 4B (RBP1-like) 0.130
NOTCH1 notch 1 0.123
WIPF1 WAS/WASL interacting protein family, member 1 0.123
CTNND1 catenin (cadherin-associated protein), delta 1 0.121
RET ret proto-oncogene 0.118
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 0.118
NKX3-1 NK3 homeobox 1 0.117
SOS1 son of sevenless homolog 1 (Drosophila) 0.113
CTTN cortactin 0.110
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.109
ACTN1 actinin, alpha 1 0.108
HNF4A hepatocyte nuclear factor 4, alpha 0.107
CCND3 cyclin D3 0.105
PSEN1 presenilin 1 0.105
POU5F1 POU class 5 homeobox 1 0.103
TBC1D10A TBC1 domain family, member 10A 0.103
PIAS1 protein inhibitor of activated STAT, 1 0.103
COL2A1 collagen, type II, alpha 1 0.101
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.101
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.101
ADAM15 ADAM metallopeptidase domain 15 0.100
HDAC1 histone deacetylase 1 0.096
DAXX death-domain associated protein 0.096
APC adenomatous polyposis coli 0.093
PTEN phosphatase and tensin homolog 0.093
PLCG1 phospholipase C, gamma 1 0.093
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.092
MAPK6 mitogen-activated protein kinase 6 0.091
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.091
BMPR1B bone morphogenetic protein receptor, type IB 0.088
GAB1 GRB2-associated binding protein 1 0.087
FOXA2 forkhead box A2 0.081
ERBB2IP erbb2 interacting protein 0.080
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 0.080
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.076
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.076
NOTCH3 notch 3 0.076
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Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.999
Gli3 GLI-Kruppel family member GLI3 0.999
Shh sonic hedgehog 0.999
Sox9 SRY-box containing gene 9 0.996
Sox2 SRY-box containing gene 2 0.994
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.992
Msx1 homeobox, msh-like 1 0.992
Bmp4 bone morphogenetic protein 4 0.990
Pten phosphatase and tensin homolog 0.986
Gli2 GLI-Kruppel family member GLI2 0.984
Ar androgen receptor 0.982
Pbx1 pre B-cell leukemia transcription factor 1 0.979
Tgfb2 transforming growth factor, beta 2 0.974
Foxc1 forkhead box C1 0.974
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.968
Otx2 orthodenticle homolog 2 (Drosophila) 0.967
Hoxa2 homeobox A2 0.961
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.957
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.947
Trp63 transformation related protein 63 0.946
Tcfap2a transcription factor AP-2, alpha 0.928
Ush1g Usher syndrome 1G homolog (human) 0.922
Fgf8 fibroblast growth factor 8 0.919
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.918
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.918
Dlx5 distal-less homeobox 5 0.914
Foxd1 forkhead box D1 0.909
Foxa2 forkhead box A2 0.907
Pthlh parathyroid hormone-like peptide 0.902
Pax3 paired box gene 3 0.898
Hand1 heart and neural crest derivatives expressed transcript 1 0.885
Msx2 homeobox, msh-like 2 0.883
Hoxa5 homeobox A5 0.863
Neurod1 neurogenic differentiation 1 0.862
Dlx1 distal-less homeobox 1 0.860
Hoxd13 homeobox D13 0.854
Onecut1 one cut domain, family member 1 0.854
Twist2 twist homolog 2 (Drosophila) 0.843
Fgf10 fibroblast growth factor 10 0.839
Pou3f3 POU domain, class 3, transcription factor 3 0.839
Alx4 aristaless-like homeobox 4 0.833
Hand2 heart and neural crest derivatives expressed transcript 2 0.823
Col4a2 collagen, type IV, alpha 2 0.817
Hoxd11 homeobox D11 0.816
Prrx1 paired related homeobox 1 0.809
Grid1 glutamate receptor, ionotropic, delta 1 0.803
Lhx1 LIM homeobox protein 1 0.803
Dok1 docking protein 1 0.803
Pax8 paired box gene 8 0.797
Pax6 paired box gene 6 0.793
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.790
Kiss1 KiSS-1 metastasis-suppressor 0.781
Ahr aryl-hydrocarbon receptor 0.777
Tbx15 T-box 15 0.774
Hoxd3 homeobox D3 0.772
Hoxa13 homeobox A13 0.771
Sall4 sal-like 4 (Drosophila) 0.768
Atoh7 atonal homolog 7 (Drosophila) 0.767
Bmp7 bone morphogenetic protein 7 0.766
Cftr cystic fibrosis transmembrane conductance regulator homolog 0.749
Zic3 zinc finger protein of the cerebellum 3 0.744
Gata6 GATA binding protein 6 0.743
Egfr epidermal growth factor receptor 0.738
Sall1 sal-like 1 (Drosophila) 0.737
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.735
Hoxa10 homeobox A10 0.732
Gata4 GATA binding protein 4 0.728
Runx2 runt related transcription factor 2 0.723
Tbx1 T-box 1 0.719
Lhx5 LIM homeobox protein 5 0.709
Pax9 paired box gene 9 0.706
Nos3 nitric oxide synthase 3, endothelial cell 0.703
Dlx2 distal-less homeobox 2 0.700
Hes1 hairy and enhancer of split 1 (Drosophila) 0.685
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.683
Rarg retinoic acid receptor, gamma 0.673
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.673
Stat3 signal transducer and activator of transcription 3 0.673
Lhx3 LIM homeobox protein 3 0.668
Dcc deleted in colorectal carcinoma 0.664
Ptk2 PTK2 protein tyrosine kinase 2 0.661
Ctnnb1 catenin (cadherin associated protein), beta 1 0.655
Foxh1 forkhead box H1 0.653
Notch2 Notch gene homolog 2 (Drosophila) 0.651
En1 engrailed 1 0.648
Nog noggin 0.639
Sfn stratifin 0.635
Foxc2 forkhead box C2 0.631
Amh anti-Mullerian hormone 0.621
Hoxc5 homeobox C5 0.618
Hoxb5 homeobox B5 0.617
Gata5 GATA binding protein 5 0.616
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.615
Bmp2 bone morphogenetic protein 2 0.611
Wnt4 wingless-related MMTV integration site 4 0.611
Arid4a AT rich interactive domain 4A (RBP1-like) 0.609
Eya1 eyes absent 1 homolog (Drosophila) 0.608
Hoxb4 homeobox B4 0.594
Kl klotho 0.589
Lef1 lymphoid enhancer binding factor 1 0.586
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism